Zaleplon

DB00962ApprovedIllicitSmall moleculegamma-Aminobutyric Acid A Receptor Agonist Miscellaneous Anxiolytics Sedatives and Hypnotics

Zaleplon is a sedative used for short term treatment of insomnia in adults. It is known as a nonbenzodiazepine hypnotic.

Mechanism: Zaleplon exerts its action through subunit modulation of the GABABZ receptor chloride channel macromolecular complex. Zaleplon also binds selectively to the brain omega-1 receptor located on the alpha subunit of the GABA-A/chloride ion channel receptor complex and potentiates t-butyl-bicyclophosphorothionate (TBPS) binding.
Curator reviewed
Primary indication: For the treatment of short-term treatment of insomnia in adults.Curator reviewed · 1 structured indication
Formula / weight: C₁₇H₁₅N₅O · 305.3339 g/mol (avg)
First approval: Canada, 2000 · United States, 1999
Code names: CL-284846 · DEA No. 2781 · L846 · LJC-10846 · SKP-1041 · ZAL-846
Brand names: Sonata

Resolves to

Compound

UNIIS62U433RMHCAS151319-34-5ChEMBLCHEMBL1521ChEBI10102PubChem5719KEGGD00530

Clinical / RWD

RxNorm74667ATCN05CF03PharmGKBPA451952

Structure

InChIKeyHUNXMJYCHXQEGX-UHFFFAOYSA-NSMILESCCN(C(C)=O)C1=CC=CC(=C1)C1=CC=NC2=C(C=NN12)C#N

Targets

P14867GABRA1

What you can answer from here — as of September 30, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1,637Drug interactionsStructured to mechanism, not free text

10Clinical trialsPhase, status and sponsor resolved per trial

1Structured indicationCondition, population, route and combination as fields, not prose

94Marketed productsAcross 5 countries and 33 labellers

1ATC codeIncluding every combination product, plus 25 drug categories

21+ReferencesStructured and connected to the statements they support

Which drugs share a target with Zaleplon, and which of those have an active Phase 3 trial?

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