Gonadotropin Releasing Hormone Receptor Antagonists

Name
Gonadotropin Releasing Hormone Receptor Antagonists
Accession Number
DBCAT004323
Description

Not Available

Drugs
DrugDrug Description
GanirelixA GnRH antagonist used in assisted reproduction in women undergoing controlled ovarian hyperstimulation to control ovulation by inhibiting the premature LH surges.
CetrorelixA synthetic peptide antagonist of gonadotropin releasing hormone used to prevent luteinizing hormone surges in women undergoing assisted reproduction therapy.
DegarelixA GnRH receptor antagonist used in the management of advanced prostate cancer.
ElagolixA gonadotropin releasing hormone receptor antagonist used to treat moderate to severe pain in endometriosis.
RelugolixAn oral GnRH receptor antagonist for androgen deprivation therapy in the treatment of advanced prostate cancer.
LinzagolixA selective gonadotropin-releasing hormone (GnRH) receptor antagonist used for the symptomatic treatment of uterine fibroids.
Drugs & Drug Targets
DrugTargetType
GanirelixGonadotropin-releasing hormone receptortarget
CetrorelixLutropin-choriogonadotropic hormone receptortarget
CetrorelixGonadotropin-releasing hormone receptortarget
DegarelixGonadotropin-releasing hormone receptortarget
ElagolixGonadotropin-releasing hormone receptortarget
ElagolixCytochrome P450 3A Subfamilyenzyme
ElagolixCytochrome P450 2D6enzyme
ElagolixCytochrome P450 2C8enzyme
ElagolixP-glycoprotein 1transporter
ElagolixSolute carrier organic anion transporter family member 1B1transporter
RelugolixSerum albumincarrier
RelugolixAlpha-1-acid glycoprotein 1carrier
RelugolixP-glycoprotein 1transporter
RelugolixATP-binding cassette sub-family G member 2transporter
RelugolixCytochrome P450 3A Subfamilyenzyme
RelugolixCytochrome P450 2C8enzyme
RelugolixCytochrome P450 2B6enzyme
RelugolixGonadotropin-releasing hormone receptortarget
LinzagolixCytochrome P450 2C8enzyme
LinzagolixGonadotropin-releasing hormone receptortarget
LinzagolixSerum albumincarrier
LinzagolixCytochrome P450 2C9enzyme
LinzagolixCytochrome P450 3A4enzyme
LinzagolixSolute carrier organic anion transporter family member 1B1transporter
LinzagolixSolute carrier organic anion transporter family member 1B3transporter
LinzagolixSolute carrier family 22 member 8transporter
LinzagolixATP-binding cassette sub-family G member 2transporter
LinzagolixSolute carrier family 22 member 6transporter