UGT2B7 Inhibitors

Name

UGT2B7 Inhibitors

Accession Number

DBCAT004456

Description

Not Available

Drugs

Drug	Drug Description
Flunitrazepam	A benzodiazepine used to manage anxiety disorders and insomnia.
Indomethacin	A nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants.
Chenodeoxycholic acid	A bile acid used for the treatment of primary biliary cirrhosis.
Ketoconazole	A broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections.
Dovitinib	Investigated for use/treatment in multiple myeloma and solid tumors.
Eltrombopag	A thrombopoietin receptor agonist used to treat thrombocytopenia or aplastic anemia associated with various etiologies.
Umifenovir	A dual direct-acting antiviral/host-targeting agent used in the treatment and prophylaxis of influenza and other respiratory viruses.
Mefenamic acid	An NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea.
Cannabidiol	An active cannabinoid used as an adjunctive treatment for the management of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome and symptomatic relief of moderate to severe neuropathic pain or other painful conditions, like cancer.
Perampanel	A non-competitive AMPA glutamate receptor antagonist used to treat partial-onset seizures with or without secondarily generalized seizures, and as adjunctive treatment of primary generalized tonic-clonic seizures in patients with epilepsy.
Medical Cannabis	The use of the plant species Cannabis sativa and Cannabis indica, popularly known as marijuana, has gained popularity in recent years for the management of a wide variety of medical...
Trofinetide	A drug used to treat Rett syndrome in children and adults.
Aprocitentan	An endothelin receptor antagonist used for the treatment of uncontrolled hypertension in patients inadequately controlled on other treatments.

Drugs & Drug Targets

Drug	Target	Type
Flunitrazepam	Cytochrome P450 2C19	enzyme
Flunitrazepam	UDP-glucuronosyltransferase 2B7	enzyme
Flunitrazepam	Cytochrome P450 2A6	enzyme
Flunitrazepam	Cytochrome P450 2B6	enzyme
Flunitrazepam	Cytochrome P450 2C9	enzyme
Flunitrazepam	Cytochrome P450 3A4	enzyme
Flunitrazepam	Cytochrome P450 2E1	enzyme
Flunitrazepam	UDP-glucuronosyltransferase 1-1	enzyme
Flunitrazepam	UDP-glucuronosyltransferase 1-3	enzyme
Flunitrazepam	GABA(A) Receptor	target
Flunitrazepam	GABA(A) Receptor Benzodiazepine Binding Site	target
Indomethacin	Prostaglandin G/H synthase 1	target
Indomethacin	Prostaglandin G/H synthase 2	target
Indomethacin	Cytochrome P450 2C19	enzyme
Indomethacin	UDP-glucuronosyltransferase 1-9	enzyme
Indomethacin	Phospholipase A2, membrane associated	target
Indomethacin	Prostaglandin reductase 2	target
Indomethacin	Lactoylglutathione lyase	target
Indomethacin	Prostaglandin D2 receptor 2	target
Indomethacin	Peroxisome proliferator-activated receptor gamma	target
Indomethacin	Serum albumin	carrier
Indomethacin	Canalicular multispecific organic anion transporter 2	transporter
Indomethacin	Multidrug resistance-associated protein 4	transporter
Indomethacin	Multidrug resistance-associated protein 6	transporter
Indomethacin	P-glycoprotein 1	transporter
Indomethacin	Multidrug resistance-associated protein 1	transporter
Indomethacin	Solute carrier organic anion transporter family member 1A2	transporter
Indomethacin	Solute carrier family 22 member 6	transporter
Indomethacin	Solute carrier family 22 member 8	transporter
Indomethacin	Canalicular multispecific organic anion transporter 1	transporter
Indomethacin	ATP-binding cassette sub-family C member 11	transporter
Indomethacin	Solute carrier family 22 member 11	transporter
Indomethacin	Sodium/bile acid cotransporter	transporter
Indomethacin	Solute carrier family 22 member 7	transporter
Indomethacin	Cytochrome P450 2C9	enzyme
Indomethacin	UDP-glucuronosyltransferase 1-1	enzyme
Indomethacin	Liver carboxylesterase 1	enzyme
Indomethacin	UDP-glucuronosyltransferase 2B7	enzyme
Indomethacin	Peroxisome proliferator-activated receptor alpha	target
Indomethacin	Aldo-keto reductase family 1 member C3	target
Indomethacin	Solute carrier organic anion transporter family member 1B1	transporter
Indomethacin	Bile salt export pump	transporter
Indomethacin	Interferon-induced, double-stranded RNA-activated protein kinase	target
Indomethacin	Human Cyclooxygenases	target
Chenodeoxycholic acid	Bile acid receptor	target
Chenodeoxycholic acid	Sterol 26-hydroxylase, mitochondrial	enzyme
Chenodeoxycholic acid	Cytochrome P450 3A4	enzyme
Chenodeoxycholic acid	UDP-glucuronosyltransferase 2B7	enzyme
Chenodeoxycholic acid	Nuclear receptor subfamily 1 group I member 2	target
Chenodeoxycholic acid	G-protein coupled bile acid receptor 1	target
Chenodeoxycholic acid	Aldo-keto reductase family 1 member C2	target
Ketoconazole	Cytochrome P450 3A4	enzyme
Ketoconazole	Cytochrome P450 2C9	enzyme
Ketoconazole	Cytochrome P450 2C19	enzyme
Ketoconazole	Cytochrome P450 3A5	enzyme
Ketoconazole	Cytochrome P450 1A2	enzyme
Ketoconazole	Cytochrome P450 2C8	enzyme
Ketoconazole	Cytochrome P450 1A1	enzyme
Ketoconazole	Cytochrome P450 2D6	enzyme
Ketoconazole	Bile salt export pump	transporter
Ketoconazole	P-glycoprotein 1	transporter
Ketoconazole	Cytochrome P450 11B1, mitochondrial	enzyme
Ketoconazole	Cytochrome P450 1B1	enzyme
Ketoconazole	Cytochrome P450 2A6	enzyme
Ketoconazole	Cytochrome P450 2B6	enzyme
Ketoconazole	Lanosterol 14-alpha demethylase	target
Ketoconazole	Androgen receptor	target
Ketoconazole	Steroid 17-alpha-hydroxylase/17,20 lyase	target
Ketoconazole	Steroid 21-hydroxylase	target
Ketoconazole	Potassium voltage-gated channel subfamily H member 2	target
Ketoconazole	Nuclear receptor subfamily 1 group I member 2	target
Ketoconazole	Nuclear receptor subfamily 1 group I member 3	target
Ketoconazole	UDP-glucuronosyltransferase 1-1	enzyme
Ketoconazole	UDP-glucuronosyltransferase 2B7	enzyme
Ketoconazole	Solute carrier organic anion transporter family member 1B1	transporter
Ketoconazole	Cytochrome P450 4F12	enzyme
Ketoconazole	Leukotriene-B(4) omega-hydroxylase 1	enzyme
Ketoconazole	Serum albumin	carrier
Ketoconazole	Sex hormone-binding globulin	carrier
Ketoconazole	Cytochrome P450 19A1	enzyme
Ketoconazole	UDP-glucuronosyltransferase 1-7	enzyme
Dovitinib	Cytochrome P450 1A1	enzyme
Dovitinib	Cytochrome P450 1A2	enzyme
Dovitinib	Canalicular multispecific organic anion transporter 2	transporter
Dovitinib	ATP-binding cassette sub-family G member 2	transporter
Dovitinib	UDP-glucuronosyltransferase 1-3	enzyme
Dovitinib	UDP-glucuronosyltransferase 2B7	enzyme
Dovitinib	Nuclear receptor subfamily 1 group I member 2	target
Dovitinib	Solute carrier organic anion transporter family member 1B1	transporter
Dovitinib	Solute carrier organic anion transporter family member 2B1	transporter
Dovitinib	Cytochrome P450 2C19	enzyme
Dovitinib	Cytochrome P450 3A4	enzyme
Dovitinib	Solute carrier organic anion transporter family member 1B3	transporter
Dovitinib	P-glycoprotein 1	transporter
Eltrombopag	Thrombopoietin receptor	target
Eltrombopag	Cytochrome P450 2C8	enzyme
Eltrombopag	Cytochrome P450 1A2	enzyme
Eltrombopag	UDP-glucuronosyltransferase 1-1	enzyme
Eltrombopag	UDP-glucuronosyltransferase 1-3	enzyme
Eltrombopag	Solute carrier organic anion transporter family member 1B1	transporter
Eltrombopag	ATP-binding cassette sub-family G member 2	transporter
Eltrombopag	UDP-glucuronosyltransferase 1-9	enzyme
Umifenovir	UDP-glucuronosyltransferase 1-9	enzyme
Umifenovir	UDP-glucuronosyltransferase 2B7	enzyme
Umifenovir	Cytochrome P450 3A4	enzyme
Umifenovir	Cytochrome P450 2E1	enzyme
Umifenovir	Cytochrome P450 1A2	enzyme
Umifenovir	Cytochrome P450 2D6	enzyme
Umifenovir	Cytochrome P450 2C9	enzyme
Umifenovir	Cytochrome P450 3A5	enzyme
Umifenovir	Dimethylaniline monooxygenase [N-oxide-forming] 3	enzyme
Umifenovir	Dimethylaniline monooxygenase [N-oxide-forming] 1	enzyme
Mefenamic acid	Prostaglandin G/H synthase 2	target
Mefenamic acid	Prostaglandin G/H synthase 1	target
Mefenamic acid	Cytochrome P450 2C9	enzyme
Mefenamic acid	Cytochrome P450 2C8	enzyme
Mefenamic acid	Serum albumin	carrier
Mefenamic acid	UDP-glucuronosyltransferase 1-9	enzyme
Mefenamic acid	Cytochrome P450 1A2	enzyme
Mefenamic acid	UDP-glucuronosyltransferase 2B7	enzyme
Cannabidiol	Cytochrome P450 2C9	enzyme
Cannabidiol	Cytochrome P450 2C19	enzyme
Cannabidiol	Cytochrome P450 2D6	enzyme
Cannabidiol	Cytochrome P450 3A4	enzyme
Cannabidiol	Cannabinoid receptor 1	target
Cannabidiol	Cannabinoid receptor 2	target
Cannabidiol	G-protein coupled receptor 12	target
Cannabidiol	Glycine receptor subunit alpha-1	target
Cannabidiol	Glycine receptor (alpha-1/beta)	target
Cannabidiol	Glycine receptor subunit alpha-3	target
Cannabidiol	N-arachidonyl glycine receptor	target
Cannabidiol	G-protein coupled receptor 55	target
Cannabidiol	5-hydroxytryptamine receptor 1A	target
Cannabidiol	5-hydroxytryptamine receptor 2A	target
Cannabidiol	Neuronal acetylcholine receptor subunit alpha-7	target
Cannabidiol	Delta-type opioid receptor	target
Cannabidiol	Mu-type opioid receptor	target
Cannabidiol	Peroxisome proliferator-activated receptor gamma	target
Cannabidiol	Cytochrome P450 3A5	enzyme
Cannabidiol	Serotonin N-acetyltransferase	enzyme
Cannabidiol	Cytochrome P450 1A1	enzyme
Cannabidiol	Fatty-acid amide hydrolase 1	enzyme
Cannabidiol	Arachidonate 5-lipoxygenase	enzyme
Cannabidiol	Arachidonate 15-lipoxygenase	enzyme
Cannabidiol	Quinone oxidoreductase	enzyme
Cannabidiol	Multidrug resistance-associated protein 1	transporter
Cannabidiol	ATP-binding cassette sub-family G member 2	transporter
Cannabidiol	Equilibrative nucleoside transporter 1	transporter
Cannabidiol	Transient receptor potential cation channel subfamily V member 1	target
Cannabidiol	Voltage-dependent T-type calcium channel subunit alpha-1G	target
Cannabidiol	Voltage-dependent T-type calcium channel subunit alpha-1H	target
Cannabidiol	Voltage-dependent T-type calcium channel subunit alpha-1I	target
Cannabidiol	Transient receptor potential cation channel subfamily A member 1	target
Cannabidiol	Transient receptor potential cation channel subfamily M member 8	target
Cannabidiol	Transient receptor potential cation channel subfamily V member 2	target
Cannabidiol	Transient receptor potential cation channel subfamily V member 3	target
Cannabidiol	Transient receptor potential cation channel subfamily V member 4	target
Cannabidiol	Voltage-dependent anion-selective channel protein 1	target
Cannabidiol	5-hydroxytryptamine receptor 3A	target
Cannabidiol	Adenosine receptor A1	target
Cannabidiol	Prostaglandin G/H synthase 1	target
Cannabidiol	Prostaglandin G/H synthase 2	target
Cannabidiol	Acetyl-CoA acetyltransferase, mitochondrial	target
Cannabidiol	Steroid 17-alpha-hydroxylase/17,20 lyase	target
Cannabidiol	3-hydroxy-3-methylglutaryl-coenzyme A reductase	target
Cannabidiol	Glutathione reductase, mitochondrial	target
Cannabidiol	Glutathione peroxidase 1	target
Cannabidiol	Indoleamine 2,3-dioxygenase 1	target
Cannabidiol	Cytochrome P450 1B1	target
Cannabidiol	NAD(P)H dehydrogenase [quinone] 1	target
Cannabidiol	Catalase	target
Cannabidiol	Cytochrome P450 3A5	target
Cannabidiol	Cytochrome P450 2D6	target
Cannabidiol	Superoxide dismutase [Cu-Zn]	target
Cannabidiol	Cytochrome P450 1A2	target
Cannabidiol	Cytochrome P450 3A7	target
Cannabidiol	Serotonin N-acetyltransferase	target
Cannabidiol	N-acylethanolamine-hydrolyzing acid amidase	target
Cannabidiol	Cytochrome P450 1A2	enzyme
Cannabidiol	Cytochrome P450 1B1	enzyme
Cannabidiol	Cytochrome P450 2A6	enzyme
Cannabidiol	Cytochrome P450 2B6	enzyme
Cannabidiol	Cytochrome P450 2C8	enzyme
Cannabidiol	Cytochrome P450 2E1	enzyme
Cannabidiol	Cytochrome P450 3A7	enzyme
Cannabidiol	UDP-glucuronosyltransferase 1-7	enzyme
Cannabidiol	UDP-glucuronosyltransferase 1-9	enzyme
Cannabidiol	UDP-glucuronosyltransferase 2B7	enzyme
Cannabidiol	UDP-glucuronosyltransferase 2B17	enzyme
Cannabidiol	P-glycoprotein 1	transporter
Cannabidiol	Cytochrome P450 2J2	enzyme
Cannabidiol	Liver carboxylesterase 1	enzyme
Perampanel	Glutamate receptor 1	target
Perampanel	Cytochrome P450 3A4	enzyme
Perampanel	Cytochrome P450 3A5	enzyme
Perampanel	Cytochrome P450 1A2	enzyme
Perampanel	Cytochrome P450 2B6	enzyme
Medical Cannabis	Cannabinoid receptor 1	target
Medical Cannabis	Cannabinoid receptor 2	target
Medical Cannabis	Cytochrome P450 2C9	enzyme
Medical Cannabis	Cytochrome P450 2C19	enzyme
Medical Cannabis	Cytochrome P450 2D6	enzyme
Medical Cannabis	Cytochrome P450 3A4	enzyme
Medical Cannabis	G-protein coupled receptor 12	target
Medical Cannabis	Glycine receptor subunit alpha-1	target
Medical Cannabis	Glycine receptor (alpha-1/beta)	target
Medical Cannabis	Glycine receptor subunit alpha-3	target
Medical Cannabis	N-arachidonyl glycine receptor	target
Medical Cannabis	G-protein coupled receptor 55	target
Medical Cannabis	5-hydroxytryptamine receptor 1A	target
Medical Cannabis	5-hydroxytryptamine receptor 2A	target
Medical Cannabis	Neuronal acetylcholine receptor subunit alpha-7	target
Medical Cannabis	Delta-type opioid receptor	target
Medical Cannabis	Mu-type opioid receptor	target
Medical Cannabis	Peroxisome proliferator-activated receptor gamma	target
Medical Cannabis	Cytochrome P450 3A5	enzyme
Medical Cannabis	Cytochrome P450 3A7	enzyme
Medical Cannabis	Cytochrome P450 1A1	enzyme
Medical Cannabis	Cytochrome P450 1A2	enzyme
Medical Cannabis	Cytochrome P450 1B1	enzyme
Medical Cannabis	Arachidonate 5-lipoxygenase	enzyme
Medical Cannabis	Arachidonate 15-lipoxygenase	enzyme
Medical Cannabis	Superoxide dismutase [Cu-Zn]	enzyme
Medical Cannabis	Multidrug resistance-associated protein 1	transporter
Medical Cannabis	ATP-binding cassette sub-family G member 2	transporter
Medical Cannabis	Equilibrative nucleoside transporter 1	transporter
Medical Cannabis	Transient receptor potential cation channel subfamily V member 1	target
Medical Cannabis	Voltage-dependent T-type calcium channel subunit alpha-1G	target
Medical Cannabis	Voltage-dependent T-type calcium channel subunit alpha-1H	target
Medical Cannabis	Voltage-dependent T-type calcium channel subunit alpha-1I	target
Medical Cannabis	Transient receptor potential cation channel subfamily A member 1	target
Medical Cannabis	Transient receptor potential cation channel subfamily M member 8	target
Medical Cannabis	Transient receptor potential cation channel subfamily V member 2	target
Medical Cannabis	Transient receptor potential cation channel subfamily V member 3	target
Medical Cannabis	Transient receptor potential cation channel subfamily V member 4	target
Medical Cannabis	Voltage-dependent anion-selective channel protein 1	target
Medical Cannabis	N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D	target
Medical Cannabis	N-acylethanolamine-hydrolyzing acid amidase	target
Medical Cannabis	Serotonin N-acetyltransferase	target
Medical Cannabis	Phospholipase A2	target
Medical Cannabis	Superoxide dismutase [Cu-Zn]	target
Medical Cannabis	Fatty-acid amide hydrolase 1	target
Medical Cannabis	Catalase	target
Medical Cannabis	Quinone oxidoreductase	target
Medical Cannabis	Sphingomyelin phosphodiesterase	target
Medical Cannabis	Glutathione peroxidase 1	target
Medical Cannabis	Glutathione reductase, mitochondrial	target
Medical Cannabis	3-hydroxy-3-methylglutaryl-coenzyme A reductase	target
Medical Cannabis	Indoleamine 2,3-dioxygenase 1	target
Medical Cannabis	Prostaglandin G/H synthase 1	target
Medical Cannabis	Prostaglandin G/H synthase 2	target
Medical Cannabis	Steroid 17-alpha-hydroxylase/17,20 lyase	target
Medical Cannabis	Acetyl-CoA acetyltransferase, mitochondrial	target
Medical Cannabis	Cytochrome P450 2A6	enzyme
Medical Cannabis	Cytochrome P450 2B6	enzyme
Medical Cannabis	Cytochrome P450 2C8	enzyme
Medical Cannabis	Cytochrome P450 2E1	enzyme
Medical Cannabis	Cytochrome P450 2J2	enzyme
Medical Cannabis	UDP-glucuronosyltransferase 1-7	enzyme
Medical Cannabis	UDP-glucuronosyltransferase 1-8	enzyme
Medical Cannabis	UDP-glucuronosyltransferase 1-9	enzyme
Medical Cannabis	UDP-glucuronosyltransferase 1-10	enzyme
Medical Cannabis	UDP-glucuronosyltransferase 2B17	enzyme
Medical Cannabis	Liver carboxylesterase 1	enzyme
Medical Cannabis	P-glycoprotein 1	transporter
Medical Cannabis	UDP-glucuronosyltransferase 2B7	enzyme
Trofinetide	Cytochrome P450 3A4	enzyme
Trofinetide	UDP-glucuronosyltransferase 1-9	enzyme
Trofinetide	UDP-glucuronosyltransferase 2B7	enzyme
Trofinetide	UDP-glucuronosyltransferase 2B15	enzyme
Trofinetide	Solute carrier organic anion transporter family member 1B1	transporter
Trofinetide	Solute carrier organic anion transporter family member 1B3	transporter
Aprocitentan	Endothelin-1 receptor	target
Aprocitentan	Endothelin B receptor	target
Aprocitentan	UDP-glucuronosyltransferase 1-1	enzyme
Aprocitentan	UDP-glucuronosyltransferase 2B7	enzyme
Aprocitentan	Serum albumin	carrier
Aprocitentan	Cytochrome P450 3A4	enzyme
Aprocitentan	Cytochrome P450 2C8	enzyme
Aprocitentan	Cytochrome P450 2C9	enzyme
Aprocitentan	Cytochrome P450 2C18	enzyme
Aprocitentan	Cytochrome P450 2C19	enzyme
Aprocitentan	P-glycoprotein 1	transporter
Aprocitentan	ATP-binding cassette sub-family G member 2	transporter
Aprocitentan	Bile salt export pump	transporter
Aprocitentan	Sodium/bile acid cotransporter	transporter