OCT2 Substrates with a Narrow Therapeutic Index

Accession Number

DBCAT004582

Description

Not Available

Drugs

Drug	Drug Description
Procainamide	A medication used to treat life threatening ventricular arrhythmias.
Cisplatin	A platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors.
Oxaliplatin	A platinum based chemotherapy agent used to treat carcinoma of the colon or rectum or stage III colon cancer.
Dalfampridine	A potassium channel blocker used for the improvement of motor function in patients with multiple sclerosis (MS).
Tipiracil	A thymidine phosphorylase inhibitor used as an adjunct treatment of adult patients with certain types of gastric or colorectal malignancies.
Dofetilide	A class III antiarrhythmic drug used for the maintenance of normal sinus rhythm and cardioversion in cases of atrial fibrillation and atrial flutter.
Clofarabine	A purine nucleoside used to treat relapsed or refractory acute lymphoblastic leukemia in patients 1 to 21 years old.
Gentamicin	An aminoglycoside used to treat a wide variety of aerobic infections in the body.

Drugs & Drug Targets

Drug	Target	Type
Procainamide	Sodium channel protein type 5 subunit alpha	target
Procainamide	DNA (cytosine-5)-methyltransferase 1	target
Procainamide	Cytochrome P450 2D6	enzyme
Procainamide	Cholinesterase	enzyme
Procainamide	Solute carrier family 22 member 2	transporter
Procainamide	Solute carrier family 22 member 1	transporter
Procainamide	Solute carrier family 22 member 3	transporter
Procainamide	Solute carrier family 22 member 5	transporter
Procainamide	Solute carrier family 22 member 4	transporter
Procainamide	Potassium voltage-gated channel subfamily H member 2	target
Procainamide	Multidrug and toxin extrusion protein 1	transporter
Procainamide	Multidrug and toxin extrusion protein 2	transporter
Cisplatin	DNA	target
Cisplatin	Canalicular multispecific organic anion transporter 2	transporter
Cisplatin	Multidrug resistance-associated protein 5	transporter
Cisplatin	Canalicular multispecific organic anion transporter 1	transporter
Cisplatin	Solute carrier family 22 member 2	transporter
Cisplatin	High affinity copper uptake protein 1	transporter
Cisplatin	Probable low affinity copper uptake protein 2	transporter
Cisplatin	Multidrug resistance-associated protein 6	transporter
Cisplatin	Copper-transporting ATPase 2	transporter
Cisplatin	Copper-transporting ATPase 1	transporter
Cisplatin	Prostaglandin G/H synthase 2	enzyme
Cisplatin	Myeloperoxidase	enzyme
Cisplatin	Xanthine dehydrogenase/oxidase	enzyme
Cisplatin	Arylamine N-acetyltransferase	enzyme
Cisplatin	Cytochrome P450 2C9	enzyme
Cisplatin	Cytochrome P450 2B6	enzyme
Cisplatin	Cholinesterase	enzyme
Cisplatin	Cytochrome P450 4A11	enzyme
Cisplatin	ATP-binding cassette sub-family G member 2	transporter
Cisplatin	Glutathione S-transferase theta-1	enzyme
Cisplatin	Metallothionein-1A	enzyme
Cisplatin	Metallothionein-2	enzyme
Cisplatin	Superoxide dismutase [Cu-Zn]	enzyme
Cisplatin	Glutathione S-transferase P	enzyme
Cisplatin	NAD(P)H dehydrogenase [quinone] 1	enzyme
Cisplatin	Glutathione S-transferase Mu 1	enzyme
Cisplatin	DNA-3-methyladenine glycosylase	target
Cisplatin	Alpha-2-macroglobulin	target
Cisplatin	Serum albumin	carrier
Cisplatin	Serotransferrin	target
Cisplatin	Copper transport protein ATOX1	target
Oxaliplatin	DNA	target
Oxaliplatin	Solute carrier family 22 member 2	transporter
Oxaliplatin	High affinity copper uptake protein 1	transporter
Oxaliplatin	Solute carrier family 22 member 3	transporter
Oxaliplatin	ATP-binding cassette sub-family G member 2	transporter
Oxaliplatin	Glutathione S-transferase theta-1	enzyme
Oxaliplatin	Metallothionein-1A	enzyme
Oxaliplatin	Metallothionein-2	enzyme
Oxaliplatin	Myeloperoxidase	enzyme
Oxaliplatin	Superoxide dismutase [Cu-Zn]	enzyme
Oxaliplatin	Glutathione S-transferase P	enzyme
Oxaliplatin	Glutathione S-transferase Mu 1	enzyme
Oxaliplatin	NAD(P)H dehydrogenase [quinone] 1	enzyme
Oxaliplatin	Canalicular multispecific organic anion transporter 1	transporter
Oxaliplatin	Copper-transporting ATPase 2	transporter
Oxaliplatin	Copper-transporting ATPase 1	transporter
Oxaliplatin	Serum albumin	carrier
Dalfampridine	Cytochrome P450 2E1	enzyme
Dalfampridine	Potassium voltage-gated channel subfamily D member 2	target
Dalfampridine	Potassium voltage-gated channel subfamily D member 3	target
Dalfampridine	Potassium voltage-gated channel subfamily A member 1	target
Dalfampridine	Potassium voltage-gated channel subfamily A member 4	target
Dalfampridine	Potassium voltage-gated channel subfamily A member 2	target
Dalfampridine	Potassium voltage-gated channel subfamily A member 3	target
Dalfampridine	Potassium voltage-gated channel subfamily A member 5	target
Dalfampridine	Potassium voltage-gated channel subfamily A member 6	target
Dalfampridine	Potassium voltage-gated channel subfamily A member 7	target
Dalfampridine	Potassium voltage-gated channel subfamily A member 10	target
Dalfampridine	Potassium voltage-gated channel subfamily B member 1	target
Dalfampridine	Potassium voltage-gated channel subfamily B member 2	target
Dalfampridine	Potassium voltage-gated channel subfamily C member 1	target
Dalfampridine	Potassium voltage-gated channel subfamily C member 2	target
Dalfampridine	Potassium voltage-gated channel subfamily C member 3	target
Dalfampridine	Potassium voltage-gated channel subfamily D member 1	target
Dalfampridine	Solute carrier family 22 member 2	transporter
Tipiracil	Thymidine phosphorylase	target
Tipiracil	Solute carrier family 22 member 2	transporter
Tipiracil	Multidrug and toxin extrusion protein 1	transporter
Dofetilide	Potassium channel subfamily K member 2	target
Dofetilide	Potassium voltage-gated channel subfamily H member 2	target
Dofetilide	ATP-sensitive inward rectifier potassium channel 12	target
Dofetilide	Cytochrome P450 3A4	enzyme
Dofetilide	Solute carrier family 22 member 2	transporter
Clofarabine	DNA polymerase alpha catalytic subunit	target
Clofarabine	Ribonucleoside-diphosphate reductase large subunit	target
Clofarabine	Deoxycytidine kinase	enzyme
Clofarabine	DNA	target
Clofarabine	ATP-binding cassette sub-family G member 2	transporter
Gentamicin	30S ribosomal protein S12	target
Gentamicin	16S ribosomal RNA	target
Gentamicin	NH(3)-dependent NAD(+) synthetase	target
Gentamicin	Dihydrofolate reductase	target
Gentamicin	23S ribosomal RNA	target
Gentamicin	Bacterial outer membrane	target
Gentamicin	Cytoplasmic membrane	target
Gentamicin	Low-density lipoprotein receptor-related protein 2	transporter
Gentamicin	Solute carrier family 22 member 2	transporter
Gentamicin	Canalicular multispecific organic anion transporter 1	transporter