Heterocyclic Compounds, Fused-Ring
- Name
- Heterocyclic Compounds, Fused-Ring
- Accession Number
- DBCAT004973
- Description
Multiple ring heterocyclic compounds containing two or more rings that share two atoms and one bond in common.
- Drugs
Drug Drug Description Cyanocobalamin A vitamin available in many formulations to correct vitamin B12 deficiency. Tetrahydrofolic acid For nutritional supplementation, also for treating dietary shortage or imbalance. Ademetionine S-Adenosylmethionine (SAMe) is used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis. It has also been introduced into the United States market as... Adenosine phosphate For nutritional supplementation, also for treating dietary shortage or imbalance Riboflavin A vitamin used to correct vitamin B2 deficiency. NADH A nutrient used in some supplement products. Folic acid A nutrient used to treat megaloblastic anemia and is found in many supplements. Vitamin E An antioxidant vitamin used in many skin creams and multivitamin preparations. ATP For nutritional supplementation, also for treating dietary shortage or imbalance Adenine A purine base which forms a component of DNA among other functions and is present in many multivitamins. Ramipril An ACE inhibitor used for the management of hypertension and the reduction of cardiovascular mortality following myocardial infarction in hemodynamically stable patients with clinical signs of congestive heart failure. Lorazepam A short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures. Vidarabine An antiviral agent used to treat various viral infections. Troglitazone For the treatment of Type II diabetes mellitus. It is used alone or in combination with a sulfonylurea, metformin, or insulin as an adjunct to diet and exercise. Hydroxocobalamin A synthetic form of vitamin B12 used to treat vitamin B12 associated disorders and cyanide poisoning. Caffeine A stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth. Sildenafil A phosphodiesterase inhibitor used for the treatment of erectile dysfunction. Reserpine For the treatment of hypertension Ticlopidine A platelet aggregation inhibitor used in the prevention of conditions associated with thrombi, such as stroke and transient ischemic attacks (TIA). Pantoprazole A proton pump inhibitor used to treat erosive esophagitis, gastric acid hypersecretion, and to promote healing of tissue damage caused by gastric acid. Citalopram A selective serotonin reuptake inhibitor (SSRI) used in the treatment of depression. Eletriptan A triptan used for the treatment of migraines. Moxifloxacin A fluoroquinolone antibiotic used to treat various bacterial infections. Nelfinavir A viral protease inhibitor used in the treatment of HIV infection. Cefotiam A cephalosporin antibiotic used to treat a variety of bacterial infections. Temazepam A short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and insomnia. Cladribine A purine antimetabolite used for the management of relapsing forms of Multiple Sclerosis (MS), used in patients who have not responded to or who were unable to tolerate alternative MS drugs. Methysergide An ergot alkaloid used for the prophylaxis of migraine and cluster headaches. Cabergoline A dopamine receptor agonist used for the treatment of hyperprolactinemic conditions due to various causes. Anagrelide A platelet-reducing agent used to treat thrombocythemia, and its related complications, secondary to myeloproliferative neoplasms. Dicoumarol For decreasing blood clotting. Often used along with heparin for treatment of deep vein thrombosis. Cefmenoxime Used to treat female gynecologic and obstetric infections caused by susceptible aerobic (including the gonococcus) and anaerobic bacteria. Ropinirole A non-ergoline dopamine agonist used to treat the symptoms of Parkinson's disease and Restless Legs Syndrome. Cefmetazole A cephalosporin antibiotic used to treat a variety of bacterial infections. Amsacrine A cytotoxic agent used to induce remission in acute adult leukemia that is not adequately responsive to other agents. Theophylline A xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction. Raltitrexed A folate analog thymidylate synthase inhibitor used in the treatment of advanced colorectal cancer. Morphine An opioid agonist used for the relief of moderate to severe acute and chronic pain. Penciclovir A topical nucleoside polymerase inhibitor used in the treatment of recurrent herpes labialis. Tenofovir disoproxil A nucleotide analog reverse transcriptase inhibitor used in the treatment of Hepatitis B infection and used in the management of HIV-1 infection. Flucloxacillin A narrow spectrum penicillin antibiotic that exerts specific activity against Gram positive organisms in skin and soft tissue infections, except those caused by methicillin resistant staphylococcus aureus (MRSA). Ertapenem A carbapenem antibiotic used for the treatment of moderate to severe infections caused by susceptible bacteria. Mitomycin An antimetabolite used as an adjunct to ab externo (outside approach) eye surgeries for the treatment of glaucoma and used as a chemotherapeutic agent for various malignancies. Vindesine A vinca alkaloid derived from vinblastine used for various types of malignancies, but mainly acute lymphocytic leukemia (ALL). Chlorthalidone A diuretic used to treat hypertension or edema caused by heart failure, renal failure, hepatic cirrhosis, estrogen therapy, and other conditions. Zolmitriptan A member of the triptan class of 5-HT(1B/1D/1F) receptor agonist drugs used for the acute treatment of migraine with or without aura in adults. Gefitinib A tyrosine kinase inhibitor used as first-line therapy to treat non-small cell lung carcinoma (NSCLC) that meets certain genetic mutation criteria. Codeine An opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated. Piperacillin A penicillin antibiotic combined with tazobactam to treat piperacillin-resistant, piperacillin/tazobactam susceptible, β-lactamase generating strains of several bacteria. Dihydroergotamine An ergot alkaloid used in the acute treatment of migraine headache and cluster headache. Hydromorphone An opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated. Indomethacin A nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. Olanzapine An antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders. Omeprazole A proton pump inhibitor used to treat GERD associated conditions such as heartburn and gastric acid hypersecretion, and to promote healing of tissue damage and ulcers caused by gastric acid and H. pylori infection. Metixene Used for the symptomatic treatment of parkinsonism. Diltiazem A calcium channel blocker used to treat hypertension and to manage chronic stable angina. Alfuzosin An alpha-1 adrenergic antagonist used in the symptomatic management of benign prostatic hypertrophy (BPH). Clobazam A benzodiazepine used as adjunct treatment in seizures associated with Lennox-Gastaut syndrome. Tioguanine A purine analogue antineoplastic agent used for the induction of remission, and for remission consolidation in patients with acute nonlymphocytic anemias. Methylergometrine An ergot alkaloid used to prevent and control uterine atony and hemorrhage before and after delivery. Chlorzoxazone A drug with muscle relaxant properties that is used as an adjunct to physical therapy and analgesics to treat stiffness and pain caused by a variety of musculoskeletal conditions. Mefloquine An antimalarial agent used in the prophylaxis and treatment of malaria caused by Plasmodium falciparum and Plasmodium vivax. Sapropterin A cofactor used as an adjunct to phenylalanine restriction in the treatment of phenylketonuria (PKU). Vinorelbine A vinca alkaloid used in the treatment of metastatic non-small cell lung carcinoma (NSLC) and in conjunction with other drugs in locally advanced NSCLC. Clozapine An atypical or second-generation antipsychotic drug used in treatment-resistant schizophrenia and to decrease suicide risk in schizophrenic patients. Grepafloxacin A fluoroquinolone antibiotic used to treat various gram positive and gram negative bacterial infections. Mirtazapine A tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite. Thiethylperazine A drug used for the treatment of nausea and vomiting. Palonosetron A serotonin antagonist used in the prophylaxis or management of vomiting that results from emetogenic chemotherapy, and for the management of postoperative nausea and vomiting. Tacrine An anticholinesterase drug used for the management of Alzheimer's disease symptoms. Triamterene A potassium-sparing diuretic used in the treatment of edema and in the management of hypertension. Profenamine An antidyskinetic phenothiazine used to treat the symptoms of Parkinson's disease. Griseofulvin An antifungal agent used to treat a variety of superficial tinea infections and fungal infections of the fingernails and toes. Alprazolam A triazolobenzodiazepine with intermediate onset commonly used to treat panic disorders and generalized anxiety in addition to anxiety associated with depression. Loxapine A antipsychotic used for the treatment of schizophrenia. Pramipexole A non-ergot dopamine agonist used to treat the signs and symptoms of idiopathic Parkinson's disease and Restless Legs Syndrome (RLS). Ampicillin A penicillin derivative used for the treatment of a variety of infections caused by gram-positive and gram-negative bacteria as well as some anaerobes. Metocurine iodide For use as an anesthesia adjunct to induce skeletal muscle relaxation and to reduce the intensity of muscle contractions in convulsive therapy. Phenoxymethylpenicillin A penicillin antibiotic used to prevent and treat mild to moderately severe infections in the respiratory tract, skin, and soft tissues. Promazine A phenothiazine used to manage schizophrenia. Methylphenidate A stimulant used in the management of Attention Deficit Hyperactivity Disorder (ADHD). Famciclovir A nucleoside analog DNA polymerase inhibitor used for the treatment of recurrent cold sores and genital herpes in healthy patients and patients with HIV, and to manage herpes zoster. Cefpiramide For treatment of severe infections caused by susceptible bacteria such as P. aeruginosa. Prochlorperazine A phenothiazine derivative used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting. Bendroflumethiazide A diuretic used to suppress lactation and to treat hypertension and edema. Allopurinol A xanthine oxidase inhibitor used to reduce urinary and serum uric acid concentrations in patients with gout, recurrent calcium oxalate calculi, and various malignancies. Ceftazidime An injected broad-spectrum third-generation cephalosporin beta-lactam antibiotic used to treat or prevent a variety of bacterial infections, including pneumonia, gynecological infections, bone and joint infections, and septicemia, among others. Entecavir A nucleoside analogue used in the treatment of chronic hepatitis B for patients with active viral replication, histological evidence of active disease, or persistent elevations in liver transaminases. Loracarbef Used to treat upper respiratory tract bacterial infections, chronic bronchitis, pneumonia, sinusitis, pharyntitis and tonsillitis, skin absceses, urinary tract infections and pyelonephritis caused by E. coli, S. pyogenes, S. aureus,... Lansoprazole A proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome. Droperidol A butyrophenone derivative and dopamine antagonist used to prevent and treat postoperative nausea and vomiting. Cefalotin A broad-spectrum cephalosporin antibiotic used for the treatment of serious bacterial infections in various locations, such as the urinary tract, skin, bone, and lower respiratory tract. Prazosin An alpha-blocker that causes a decrease in total peripheral resistance and is used to treat hypertension. Imipramine A tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis. Verteporfin A benzoporphyrin derivative used to treat pathological myopia, ocular histoplasmosis, and choroidal neovascularization in macular degeneration. Ketorolac An NSAID used to treat moderate to severe pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders, and headaches. Enoxacin For the treatment of adults (≥18 years of age) with the following infections caused by susceptible strains of the designated microorganisms: (1) uncomplicated urethral or cervical gonorrhea due to Neisseria... Quinine An alkaloid used to treat uncomplicated Plasmodium falciparum malaria. Montelukast A leukotriene receptor antagonist used as part of an asthma therapy regimen, to prevent exercise induced bronchoconstriction, and to treat seasonal allergic rhinitis. Chlordiazepoxide A benzodiazepine used to treat the withdrawal symptoms of acute alcoholism, to treat preoperative anxiety, and to treat anxiety over a short term period. Chlorpromazine A phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. Lenalidomide A thalidomide derivative used to treat multiple myeloma and anemia in low to intermediate risk myelodysplastic syndrome. Brimonidine An alpha-2 adrenergic agonist used to treat glaucoma and ocular hypertension, as well as facial erythema in rosacea. Dicloxacillin A penicillin used to treat penicillinase-producing bacterial infections that are susceptible to the drug. Pefloxacin An antibiotic used to treat a variety of bacterial infections. Cefotaxime A third generation cephalosporin used to treat susceptible Gram negative and Gram positive bacterial infections. Darifenacin An M3 muscarinic receptor blocker used to treat urinary incontinence. Oxycodone An opioid used in the management of moderate to severe pain. Triflupromazine Used mainly in the management of psychoses. Also used to control nausea and vomiting. Dextromethorphan An NMDA receptor antagonist used to treat cases of dry cough. Albendazole A benzimidazole anthelmintic used to treat parenchymal neurocysticercosis and other helminth infections. Trandolapril A prodrug of an ACE inhibitor used to treat hypertension, congestive heart failure, and to improve survival following a myocardial infarction. Carteolol A beta adrenergic antagonist used to treat arrhythmia, angina, hypertension, and glaucoma. Metolazone A thiazide-like diuretic used to treat hypertension. Cinchocaine An anesthetic used for local or regional anesthesia. Erlotinib An EGFR tyrosine kinase inhibitor used to treat certain small cell lung cancers or advanced metastatic pancreatic cancers. Cefdinir A third generation cephalosporin used to treat susceptible Gram negative and Gram positive bacterial infections. Ciprofloxacin A second generation fluoroquinolone used to treat various susceptible bacterial infections. Vincristine A vinca alkaloid used to treat acute leukemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis. Benazepril An ACE inhibitor prodrug used to treat hypertension. Amoxapine A tricyclic antidepressant used in the treatment of neurotic or reactive depressive disorders and endogenous or psychotic depression. Adinazolam For the treatment of anxiety and status epilepticus. Methoxsalen A furocoumarin used to treat psoriasis and vitiligo. Benzthiazide For the treatment of high blood pressure and management of edema. Methotrexate An antineoplastic agent used the treatment of a wide variety of cancers as well as severe psoriasis, severe rheumatoid arthritis, and juvenile rheumatoid arthritis. Carbamazepine An anticonvulsant used to treat various types of seizures and pain resulting from trigeminal neuralgia. Cisatracurium A skeletal muscle relaxant used to facilitate tracheal intubation, muscle relaxation in surgery, or mechanical ventilation. Cephalexin A first generation cephalosporin used to treat certain susceptible bacterial infections. Vinblastine A vinca alkaloid used to treat breast cancer, testicular cancer, neuroblastoma, Hodgkin's and non-Hodgkins lymphoma, mycosis fungoides, histiocytosis, and Kaposi's sarcoma. Valaciclovir An guanine nucleoside antiviral used to treat herpes exacerbations. Carbenicillin For the treatment of acute and chronic infections of the upper and lower urinary tract and in asymptomatic bacteriuria due to susceptible strains of bacteria. Mazindol A sympathomimetic used to treat obesity in combination with lifestyle modifications. Lisuride For the management of Parkinson's Disease Doxazosin An alpha-1 adrenergic receptor used to treat mild to moderate hypertension and urinary obstruction due to benign prostatic hyperplasia. Cyclothiazide Cyclothiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. It is also indicated in the management of hypertension either... Nafcillin A penicillin derivative antibiotic used to treat susceptible staphylococcal infections. Chloroquine An antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis. Butorphanol An opioid agonist-antagonist used to treat moderate to severe pain. Amodiaquine An antimalarial drug. Rifabutin An antibiotic used to treat mycobacterium avium complex disease in patients with HIV. Fluphenazine A phenothiazine used to treat patients requiring long-term neuroleptic therapy. Efavirenz A non-nucleoside reverse transcriptase inhibitor used to treat HIV infection or prevent the spread of HIV. Clorazepic acid A benzodiazepine used to treat anxiety, partial seizures, and alcohol withdrawal. Clofarabine A purine nucleoside used to treat relapsed or refractory acute lymphoblastic leukemia in patients 1 to 21 years old. Astemizole A second generation antihistamine used to treat allergy symptoms. Adenosine A medication used in myocardial perfusion scintigraphy and to treat supraventricular tachycardia. Pemetrexed A folate analog used to treat mesothelioma and non-small cell lung cancer. Mebendazole A benzimidazole anthelmintic used to treat helminth infections. Leucovorin A folate analog used to treat the toxic effects of methotrexate and other folate antagonists, to treat megaloblastic anemia, and to provide palliative treatment of colorectal cancer. Dyphylline A theophylline derivative used to treat asthma, bronchospasm, and COPD. Pentazocine An analgesic used to treat moderate to severe pain. Sumatriptan A serotonin receptor agonist used to treat migraines and cluster headaches. Pirenzepine An antimuscarinic agent used to treat peptic ulcers, gastric ulcers, and duodenal ulcers. Cefixime A third generation cephalosporin used to treat susceptible Gram negative and Gram positive bacterial infections. Thioridazine A phenothiazine antipsychotic used to treat schizophrenia and generalized anxiety disorder. Moricizine An antiarrhythmic used to treat arrhythmias. Warfarin A vitamin K antagonist used to treat venous thromboembolism, pulmonary embolism, thromboembolism with atrial fibrillation, thromboembolism with cardiac valve replacement, and thromboembolic events post myocardial infarction. Midazolam A short-acting benzodiazepine with rapid onset that is commonly used in seizures, anesthesia and anxiety disorders. Trovafloxacin An antibiotic used to treat gonorrhea and chlamydia. Cephaloglycin For treatment of severe infections caused by susceptible bacteria. Flurazepam A long-acting benzodiazepine with a rapid onset of action that is commonly used to treat insomnia. Moexipril An angiotensin converting enzyme inhibitor prodrug used to treat hypertension. Fluorescein A dye used in angiography or angioscopy of the iris and retina. Ergotamine An alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches. Nicergoline An ergot derivative use for the treatment of symptoms associated with cerebrovascular abnormalities. Naltrexone A narcotic antagonist used in opioid overdose. Delavirdine A non-nucleoside reverse transcriptase inhibitor used to treat HIV infection. Oxacillin A penicillin antibiotic used to treat a number of susceptible bacterial infections. Apomorphine A morphine derivative D2 dopamine agonist used to treat hypomobile "off" episodes of advanced Parkinson's disease. Nedocromil A pyrano quinoline used to treat allergic conjunctivitis. Adefovir dipivoxil A nucleotide analog used to treat chronic hepatitis B. Imiquimod A toll-like receptor 7 agonist used to treat non hyperkeratotic, non hypertrophic actinic keratosis, basal cell carcinoma, genital or perianal warts, and condyloma acuminata. Trimipramine A tricyclic antidepressant used to treat depression. Thiabendazole A benzimidazole used in the treatment of strongyloides, cutaneous larva migrans, visceral larva migrans, and trichinosis infections. Atracurium besylate A non-depolarizing neuromuscular blocker used to facilitate endotracheal intubation and relax skeletal muscles during surgery. Esomeprazole A proton pump inhibitor used to treat GERD, reduce the risk of NSAID associated gastric ulcers, eradicate H. pylori, and to treat conditions causing gastric acid hypersecretion. Hetacillin Hetacillin is a beta-lactam antibiotic prodrug used to treat bacterial infections. In the body it gets converted to ampicillin. Riluzole A glutamate antagonist used to treat amyotrophic lateral sclerosis. Etodolac An NSAID used to treat osteoarthritis and rheumatoid arthritis, as well as acute pain. Epinastine An H1 receptor antagonist used to prevent itching in allergic conjunctivitis. Dolasetron An antinauseant and antiemetic used in chemotherapy and postoperatively. Clopidogrel An antiplatelet agent used to prevent blood clots in peripheral vascular disease, coronary artery disease, and cerebrovascular disease. Meropenem A carbapenem antibiotic used to treat a wide variety of infections in the body. Clavulanic acid A beta lactamase inhibitor used to enhance the effectiveness of beta lactam antibiotics. Olopatadine A histamine H1 antagonist used to treat allergic conjunctivitis and rhinitis. Hydroflumethiazide A thiazide diuretic used to treat hypertension as well as edema due to congestive heart failure and liver cirrhosis. Oxcarbazepine An anti-epileptic used in the treatment of partial-onset seizures. Propiomazine Propiomazine is largely used for its antihistamininc sleep inducing effects in treating insomnia. Nalidixic acid A quinolone antibiotic used to treat urinary tract infections. Propantheline An antimuscarinic agent used to treat urinary incontinence, hyperhidrosis, as well as cramps and spasms of the stomach, intestines, and bladder. Cryptenamine For the treatment of hypertension. Acyclovir A guanosine analog used to treat herpes simplex, varicella zoster, herpes zoster. Perindopril An ACE inhibitor prodrug used to treat hypertension, mild to moderate congestive heart failure, and to reduce cardiovascular risk in patients with hypertension or post-myocardial infarction. Candesartan cilexetil An angiotensin receptor blocker used to treat hypertension, systolic hypertension, left ventricular hypertrophy, and delay progression of diabetic nephropathy. Fenoldopam A dopamine D1 receptor agonist used for the short term management of hypertension. Halazepam Used to relieve anxiety, nervousness, and tension associated with anxiety disorders. Pentoxifylline A methylxanthine derivative used to treat intermittent claudication caused by chronic occlusive arterial disease of the limbs. Indapamide A thiazide diuretic used to treat hypertension as well as edema due to congestive heart failure. Rosoxacin For the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients. Tadalafil A phosphodiesterase 5 inhibitor used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. Carprofen For use as a pain reliever in the treatment of joint pain and post-surgical pain. Enprofylline Used in the management of symptoms of asthma. Also used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy. Cinoxacin For the treatment of initial and recurrent urinary tract infections in adults caused by the following susceptible microorganisms: Escherichia coli, Proteus mirabilis, Proteus vulgaris, Klebsiella species (including K. pneumoniae), and... Diazepam A long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. Trifluoperazine A phenothiazine used to treat depression, anxiety, and agitation. Cefaclor A second generation cephalosporin used to treat a wide variety of infections in the body. Oxazepam An intermediate-acting benzodiazepine with slow onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawals, and insomnia. Clofazimine A riminophenazine antimycobacterial used to treat leprosy. Perphenazine A phenothiazine used to treat schizophrenia as well as nausea and vomiting. Levorphanol An opioid analgesic used to treat moderate to severe pain. Conivaptan An antidiuretic hormone inhibitor used to raise serum sodium levels. Flupentixol A thioxanthene neuroleptic used to treat schizophrenia and depression. Chlorothiazide A thiazide diuretic used to treat hypertension and edema in congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Quinapril An ACE inhibitor prodrug used to treat hypertension, congestive heart failure, and slow rate of progression of renal disease. Granisetron A 5HT3 antagonist used to treat nausea and vomiting in cancer therapy and postoperatively. Triazolam A benzodiazepine used for short term treatment of insomnia. Didanosine A reverse transcriptase inhibitor used to treat HIV. Methdilazine Used for the symptomatic relief of hypersensitivity reactions and particularly for the control of pruritic skin disorders Ondansetron A serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively. Quinidine A medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias. Almotriptan A 5-HT1B/1D receptor agonist used to treat migraines. Spectinomycin An aminocyclitol antibiotic used to treat susceptible strains of Neisseria gonorrhoeae. Buprenorphine A partial opioid agonist used for management of severe pain that is not responsive to alternative treatments. Also used for maintenance treatment of opioid addiction. Ceforanide For the treatment of infections caused by susceptible organisms. Mesoridazine A phenothiazine antipsychotic used to treat schizophrenia, organic brain disorders, alcoholism, and psychoneuroses. Phenprocoumon An anticoagulant drug used for the prevention of thrombosis. Mezlocillin Used to treat serious gram–negative infections of the lungs, urinary tract, and skin. Naratriptan A 5-HT1B/1D receptor agonist used to treat migraines. Rizatriptan A triptan used to treat migraines with or without aura. Hydrocodone An opioid agonist used as an analgesic and antitussive agent. Telmisartan An ARB used to treat hypertension, diabetic nephropathy, and congestive heart failure. Alosetron A 5-HT3 antagonist used to treat diarrhea-predominant IBS. Dactinomycin An actinomycin used to treat a wide variety of cancers. Lomefloxacin A fluoroquinolone used to prevent and treat a wide variety of infections in the body. Physostigmine A cholinesterase inhibitor used to treat glaucoma and anticholinergic toxicity. Dimenhydrinate A medication used to prevent and treat nausea, vomiting, vertigo, and motion sickness. Azathioprine An immunosuppressant used to prevent renal transplant rejection, treat rheumatoid arthritis, Crohn's disease, and ulcerative colitis. Frovatriptan A 5-HT1B/1D receptor agonist used to treat migraines. Hydrochlorothiazide A thiazide diuretic used to treat edema associated with a number of conditions, and hypertension. Cyclacillin For the treatment of bacterial infections caused by susceptible organisms. Cromoglicic acid A medication used to treat asthma, allergic reactions of the eyes and nose, as well as other mast cell reactions. Ganciclovir A DNA polymerase inhibitor used to treat cytomegalovirus and herpetic keratitis of the eye. Trichlormethiazide Used in the treatment of oedema (including that associated with heart failure) and hypertension. Mercaptopurine An antineoplastic agent used to treat acute lymphocytic leukemia. Thalidomide A medication used to treat cancers, particularly newly diagnosed multiple myeloma, and erythema nodosum leprosum. Gatifloxacin A fourth generation fluoroquinolone used to treat a wide variety of infections in the body. Rifampicin An antibiotic used to treat several types of mycobacterial infections including Mycobacterium avium complex, leprosy, and in combination with other antibacterials to treat latent or active tuberculosis. Novobiocin For the treatment of infections due to staphylococci and other susceptible organisms Benzylpenicillin A penicillin used for the treatment of infections caused by gram-positive cocci, in particular streptococcal infections. This form of penicillin is typically used in intravenous or long-acting injectable formulations due to poor oral absorption. Praziquantel An anthelmintic medication used to treat a number of parasitic worm infections such as schistosomiasis. Norfloxacin A broad-spectrum fluoroquinolone antibiotic with variable activity against gram-positive and gram-negative bacteria. Typically reserved for the treatment of UTIs due to accumulation in the urine. Amoxicillin A penicillin derivative used for the treatment of infections caused by gram-positive bacteria, in particular streptococcal bacteria causing upper respiratory tract infections. Azlocillin For the treatment of infections caused by Pseudomonas aeruginosa, Escherichia coli, and Haemophilus influenzae. Acetophenazine For the treatment of disorganized and psychotic thinking. Also used to help treat false perceptions (e.g. hallucinations or delusions.) Melatonin An endogenous hormone produced by the pineal gland that regulates sleep-wake cycles and when provided exogenously has beneficial effects on sleep-onset latency; available as an over-the-counter supplement. Cefditoren A broad-spectrum third-generation cephalosporin antibiotic typically used to treat bacterial infections of the skin and respiratory tract. Clonazepam A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, and seizures. Promethazine A first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness. Mequitazine For the treatment of Hay fever, urticaria (hives) and allergic rhinitis Fludarabine A purine analog antimetabolite that inhibits DNA synthesis. Tegaserod A serotonin-4 (5-HT4) receptor agonist indicated for the treatment of constipation predominant irritable bowel syndrome (IBS-C) specifically in women under the age of 65. There is currently no safety or efficacy data for use of tegaserol in men. Emedastine A selective H1-receptor antagonist used topically to manage symptoms of allergic conjunctivitis. Primaquine An antimalarial indicated to prevent relapse of vivax malaria. Deserpidine An alkaloid that has been used to manage hypertension. Hesperetin For lowering cholesterol and, possibly, otherwise favorably affecting lipids. In vitro research also suggests the possibility that hesperetin might have some anticancer effects and that it might have some anti-aromatase... Fluvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Oxamniquine For treatment of Schistosomiasis caused by Schistosoma mansoni Pimozide An antipsychotic used to manage debilitating motor and phonic tics in patients with Tourette's Disorder. Cefuroxime A cephalosporin indicated for the treatment of a variety of infections including acute bacterial otitis media, several upper respiratory tract infections, skin infections, urinary tract infections, gonorrhea, early Lyme disease, and impetigo. Papaverine An alkaloid used to treat many types of smooth muscle spasms such as "vascular spasms" associated with acute myocardial infarction and angina pectoris, as well as "visceral spasms". Amiodarone A class III antiarrhythmic indicated for the treatment of recurrent hemodynamically unstable ventricular tachycardia and recurrent ventricular fibrillation. Diazoxide A non diuretic benzothiadiazine indicated for the management of hypoglycemia in patients who produce an excess of insulin caused by a variety of conditions. Proflavine A topical antiseptic agent used in wound dressings to prevent infections. Rabeprazole A proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome. Doxacurium A nondepolarizing neuromuscular blocking agent used as an adjunct to general anesthesia to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgical procedures. Carvedilol A non selective beta-adrenergic antagonist used to treat mild to severe chronic heart failure, hypertension, and left ventricular dysfunction following myocardial infarction in clinically stable patients. Levofloxacin A fluoroquinolone antibiotic used to treat infections caused by susceptible bacteria of the upper respiratory tract, skin and skin structures, urinary tract, and prostate, as well as for post-exposure treatment of inhaled anthrax and the plague. Cefapirin A first generation cephalosporin indicated in the treatment of susceptible bacterial infections. Cefadroxil A cephalosporin antibiotic used in the treatment of various bacterial infections, such as urinary tract infections, skin and skin structure infections, and tonsillitis. Doxepin A psychotropic agent used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia. Cloxacillin An antibiotic agent used for the treatment of beta-hemolytic streptococcal and pneumococcal infections as well as staphylococcal infections. Flavoxate A muscarinic antagonist and spasmolytic used for the symptomatic relief of conditions associated with lack of muscle control in the bladder, such as dysuria, urgency, and nocturia. Cefprozil A cephalosporin antibiotic used in the treatment of various bacterial infections, such as pharyngitis, tonsillitis, otitis media, and uncomplicated skin infections. Desipramine A tricyclic antidepressant used in the treatment of depression. Gemifloxacin A quinolone antibacterial agent used for the treatment of acute bacterial exacerbation of chronic bronchitis and mild to moderate community-acquired pneumonia caused by susceptible bacteria. Trimetrexate A folate antagonist used for the treatment of moderate-to-severe Pneumocystis carinii pneumonia (PCP) in immunocompromised patients as an alternative therapy in combination with leucovorin. Terazosin An alpha-1 adrenergic antagonist used in the treatment of symptomatic benign prostatic hyperplasia and management of hypertension. Ofloxacin An antibacterial agent used for the treatment of bacterial infections in many parts of the body, including the respiratory tract, kidney, skin, soft tissue, and urinary tract. Cilostazol An antiplatelet agent and vasodilator used for the symptomatic relief of intermittent claudication. Escitalopram A selective serotonin re-uptake inhibitor used in the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), and other select psychiatric disorders such as obsessive-compulsive disorder (OCD). Rescinnamine For the treatment of hypertension. Naloxone An opioid receptor antagonist used to rapidly reverse an opioid overdose. Also included in some drug formulations as an abuse deterrent to prevent injection. Domperidone A dopamine receptor antagonist used as a peristaltic stimulant and anti-emetic agent for dyspepsia, indigestion, epigastric pain, nausea, and vomiting. Pergolide A long-acting dopamine agonist that is uncommonly used for the management of Parkinson's disease, due to the risk for cardiac valvulopathy. Oxymorphone An opioid analgesic used in the management of moderate-to-severe pain and for analgesic therapies. Tubocurarine Tubocurarine is a non-depolarizing neuromuscular blocking agent and the first identified curare alkaloid. Curare is one of the names used to describe plant-derived poisons used by indigenous South Americans to... Bromocriptine A dopamine D2 receptor agonist used for the treatment of galactorrhea due to hyperprolactinemia and other prolactin-related conditions, as well as in early Parkinsonian Syndrome. Rifapentine An antibiotic agent used in the treatment of pulmonary tuberculosis. Flumazenil A benzodiazepine antagonist that is used for the complete or partial reversal of the sedative effects caused by benzodiazepines in various clinical settings, such as induced general anesthesia for diagnostic and therapeutic procedures. Sparfloxacin A fluoroquinolone antibiotic used to treat bacterial respiratory infections and sinusitis. Ceftriaxone A broad-spectrum cephalosporin antibiotic used for the treatment of bacterial infections in various locations, such as in the respiratory tract, skin, soft tissue, and urinary tract. Estazolam A benzodiazepine used for the short-term management of insomnia. Rifaximin A rifamycin-based non-systemic antibiotic used for the treatment of gastrointestinal bacterial infections, such as traveler's diarrhea and irritable bowel syndrome, and reduction of overt hepatic encephalopathy recurrence in adults. Aminophylline A bronchodilator consisting of theophylline that is used for the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis. Quetiapine A psychotropic agent used for the management of bipolar disorder, schizophrenia, and major depressive disorder. Mivacurium A short-acting non-depolarizing neuromuscular blocking agent used to induce anesthesia during intubation and promote skeletal muscle relaxation during surgery or mechanical ventilation. Saquinavir An HIV protease inhibitor used in combination with other antiretroviral agents for the treatment of HIV-1 with advanced immunodeficiency. Aripiprazole An atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome. Chlorprothixene A thioxanthene antipsychotic. Clomipramine A tricyclic antidepressant used in the treatment of obsessive-compulsive disorder and disorders with an obsessive-compulsive component, such as depression, schizophrenia, and Tourette’s disorder. Chloroxine An antibacterial agent used for the treatment of dandruff and mild to moderately severe seborrheic dermatitis of the scalp. Alimemazine An antihistamine agent used to prevent and relieve allergic conditions which cause pruritus and other allergic skin conditions, including urticaria. Ergometrine An ergot alkaloid used for the treatment of postpartum haemorrhage and post abortion hemorrhage in patients with uterine atony. Lapatinib An antineoplastic agent and tyrosine kinase inhibitor used for the treatment of advanced or metastatic HER-positive breast cancer in patients who received prior chemotherapeutic treatments. Sunitinib A receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). Varenicline A partial agonist at nicotinic acetylcholine receptors used as an aid in smoking cessation. Oxtriphylline A bronchodilator used for the treatment of asthma, bronchitis, COPD, and emphysema. Polythiazide A thiazide diuretic used in the management of hypertension and treatment of edema. Quinethazone Used to treat hypertension. Cefamandole A beta-lactam antibiotic used in the treatment of various infections caused by susceptible strains of bacteria, such as lower respiratory infections, urinary tract infections, skin infections, and bone and joint infections. Cefazolin A broad-spectrum cephalosporin antibiotic mainly used for the treatment of skin bacterial infections and other moderate to severe bacterial infections in the lung, bone, joint, stomach, blood, heart valve, and urinary tract. Cefonicid For the treatment of bacterial infections caused by susceptible microorganisms. Cefoperazone A broad-spectrum cephalosporin antibiotic used for the treatment of bacterial infections in various locations, including the respiratory tract, abdomen, skin, and female genital tracts. Cefotetan An antibiotic medication used for the prophylaxis and treatment of various bacterial infections, including urinary tract infections, bone and joint infection, and lower respiratory tract infections. Cefoxitin A semi-synthetic, broad-spectrum antibiotic for parenteral administration used for the treatment of serious bacterial infections, such as urinary tract infection, blood infection, bone and joint infection, and lower respiratory tract infection. Ceftizoxime A third-generation cephalosporin antibiotic used in the treatment of various bacterial infections, including lower respiratory tract infection, urinary tract infection, and gonorrhea. Cefradine A first-generation cephalosporin antibiotic used in the treatment of bacterial infections of the respiratory and urinary tracts and of the skin and soft tissues. Metocurine Metocurine is a muscle relaxant. Saprisartan Saprisartan is used in the treatment of hypertension and heart failure. Procaterol A beta-2 adrenergic receptor agonist and bronchodilator used for the treatment of asthma and chronic obstructive pulmonary disease (COPD). Yohimbine An alpha-2-adrenergic blocker and sympatholytic found in supplements used to. Methotrimeprazine A phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder. Cefepime A fourth-generation cephalosporin antibiotic used in the treatment of infections caused by susceptible bacteria, such as pneumonia, urinary tract infections, and skin infections. Ceftibuten A third-generation cephalosporin antibiotic commonly used in the treatment of acute bacterial exacerbations of chronic bronchitis (ABECB), acute bacterial otitis media, pharyngitis, and tonsillitis. Cefpodoxime A third-generation cephalosporin antibiotic used in the treatment of various bacterial infections, including gonorrhea, community acquired pneumonia, and sinusitis. Acenocoumarol An anticoagulant drug used in the prevention of thromboembolic diseases in infarction and transient ischemic attacks, as well as management of deep vein thrombosis and myocardial infarction. Nitroxoline Nitroxoline is an antibiotic agent. Ajmaline An antiarrhythmic used to manage a variety of forms of tachycardias. Diamorphine An opioid analgesic agent used in the relief of severe pain associated with surgical procedures, myocardial infarction or pain in the terminally ill and for the relief of dyspnea in acute pulmonary edema. Fenethylline Not Available Flunitrazepam A benzodiazepine used to manage anxiety disorders and insomnia. Dihydrocodeine An opioid analgesic agent used for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Cloxazolam Used primarily as an anti-anxiety agent. Typically used short term, and may be given as a single dose of up to 100mcg/kg to reduce anxiety and tension experienced prior to... Bromazepam A short-acting benzodiazepine with intermediate onset commonly used to treat panic disorders and severe anxiety. Ketazolam A long-acting benzodiazepine used to manage anxiety and insomnia. Prazepam A benzodiazepine used to manage more severe forms of anxiety disorders. Quazepam A long-acting benzodiazepine used to manage insomnia. Solifenacin A muscarinic antagonist with antispasmodic properties used to treat urge urinary incontinence, urgency, and urinary frequency associated with an overactive bladder. Cinolazepam A benzodiazepine used to manage severe and debilitating forms of sleep disorders of various origins in adults. Nitrazepam A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, insomnia, and seizures. Imipenem A carbapenem antibiotic normally administered with cilastatin to treat a variety of infections. Bacampicillin An ampicillin prodrug used to treat various susceptible bacterial infections in the body, such as respiratory infections and skin and subcutaneous tissue infections. Meticillin Used to treat infections caused by susceptible Gram-positive bacteria, particularly beta-lactamase-producing organisms such as Staphylococcus aureus that would otherwise be resistant to most penicillins. Pivampicillin An ampicillin prodrug used to treat a variety of infections. Pivmecillinam A prodrug of the beta lactam antibiotic mecillinam, indicated for the treatment of uncomplicated urinary tract infections (UTIs). Tazobactam A beta lactamase inhibitor administered with antibiotics such as piperacillin and ceftolozane to prevent their degradation, resulting in increased efficacy. Ticarcillin A beta lactam antibiotic used to treat a variety of infections in the body. Periciazine A phenothiazine used with other medications to treat aggressiveness, impulsiveness, and hostility associated with psychiatric conditions such as schizophrenia. Valganciclovir An antiviral medication used to treat cytomegalovirus (CMV) retinitis in patients diagnosed with acquired immunodeficiency syndrome (AIDS). Hydroxychloroquine An antimalarial medication used to treat uncomplicated cases of malaria and for chemoprophylaxis in specific regions. Also a disease modifying anti-rheumatic drug (DMARD) indicated for treatment of rheumatoid arthritis and lupus erythematosus. Aceprometazine Aceprometazine is often used in combination with meprobamate for the treatment of sleep disorders. Molindone An antipsychotic used to treat schizophrenia. Pipotiazine An antipsychotic indicated for the management of chronic, non-agitated schizophrenic patients. Thioproperazine An antipsychotic indicated for the management of acute and chronic schizophrenia, including cases that are refractory to more common neuroleptics. May also be used to treat manic syndromes. Thiothixene An antipsychotic indicated for the management of schizophrenia. Zuclopenthixol An antipsychotic indicated for the management of schizophrenia. The acuphase formulation is indicated for initial treatment of acute psychosis or exacerbation of psychosis, while the depot formulation is best for maintenance. 4-hydroxybenzoyl-CoA Not Available 1-(5-phospho-D-ribosyl)-ATP Not Available 8-azaguanine 8-azaguanine is one of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids. Methacrylyl-Coenzyme A Not Available Rutin A flavonoid found in over-the-counter vitamin supplements. S-adenosyl-L-homocysteine 5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions. Castanospermine Not Available Desulfo-coenzyme A Not Available Bacteriochlorophyll A A specific bacteriochlorophyll that is similar in structure to CHLOROPHYLL A. Cordycepin Triphosphate Not Available 8-azaxanthine Not Available Sinefungin Sinefungin is a solid. This compound belongs to the purine nucleosides and analogues. These are compounds comprising a purine base attached to a sugar. The proteins that adenosyl-ornithine target include... N-Methylmesoporphyrin N-methylmesoporphyrin is a solid. This compound belongs to the porphyrins. These are compounds containing a fundamental skeleton of four pyrrole nuclei united through the alpha-positions by four methine groups to... 7,9-Dimethylguanine Not Available 3-Bromo-7-Nitroindazole Not Available Staurosporine An indolocarbazole that is a potent protein kinase C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20) Alrestatin Not Available Indirubin-3'-monoxime Not Available CP-526423 Not Available Isatin Isatin is an indole derivative first obtained by Erdman and Laurent in 1841 as an oxidation product of Indigo dye with nitric acid and chromic acids. The compound is found... 6-Methylpurine Not Available Daidzin Not Available Olomoucine Not Available 6-Hydroxymethyl-7,8-Dihydropterin Not Available Zenarestat Investigated for use/treatment in neuropathy (diabetic). Chlorophyll A Not Available Xanthine A drug used to manage uncomplicated liver dysfunction in combination with orotic acid. Flavin adenine dinucleotide A coenzyme form of vitamin B2 used in clinical conditions associated with vitamin B2 deficiency. Flavin mononucleotide A form of vitamin B2 used to restore riboflavin in anemia, migraine, alcoholism, and hyperhomocysteinemia. Hemin An iron-containing porphyrin injection used for the relief of recurrent attacks of acute intermittent porphyria (AIP) associated with the menstrual cycle when carbohydrate therapy is not effective. Mecobalamin Not Available Berberine An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal... Dequalinium A quaternary ammonium cation antimicrobial agent used to treat common infections of the mouth and throat, as well as vaginal candidiasis. Latamoxef Latamoxef is an oxacephem antibiotic usually grouped with the cephalosporins. It is used to treat bacterial infections. Latamoxef is primarily indicated in conditions like Bone and joint infection, GI infections,... Trioxsalen A psoralen derivative that has been used in combination with UV light to treat vitiligo, but has been discontinued by its manufacturer. Hesperidin A bioflavonoid found in a variety of nutritional supplements that is touted to have various beneficial effects on blood vessel disorders and various other conditions. Clioquinol An antifungal cream used to treat a variety of fungal infections. Nomifensine Nomifensine, formerly marketed as Merital capsules, was associated with an increased incidence of hemolytic anemia. The approved application holder removed Merital capsules from the market on January 23, 1986. FDA... Debrisoquine For the treatment of moderate and severe hypertension, either alone or as an adjunct, and for the treatment of renal hypertension. Tetrabenazine A vesicular monoamine transporter 2 (VMAT) inhibitor used for the management of chorea associated with Huntington's Disease. Dronedarone An antiarrhythmic agent used in the reduce the risk of hospitalization in patients with paroxysmal or persistent atrial fibrillation. Nebivolol A beta blocking agent used to treat hypertension and aid in the management of heart failure. Omacetaxine mepesuccinate A cephalotaxine used in the treatment of Chronic Myeloid Leukemia (CML) that is intolerant to or resistant to two or more tyrosine kinase inhibitors. Lorcaserin A serotonin 2C receptor agonist used in conjunction with physical activity and calorie restriction for weight loss in obese patients with a body mass index (BMI) of 30 and above, and in overweight patients with weight-related comorbidities. Flibanserin A 5-HT receptor modulator used for the treatment of selected premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD). Ceftobiprole A cephalosporin antibiotic used to treat both community and hospital-acquired pneumonia caused by susceptible bacteria. Crofelemer An antidiarrheal agent used for the symptomatic relief of drug-induced non-infectious diarrhea in adult patients with HIV/AIDS receiving antiretroviral therapy. Indacaterol An inhaled long-acting beta-2 adrenergic agonist used to relax bronchial smooth muscle and improve symptoms and airflow obstruction caused by Chronic Obstructive Pulmonary Disease (COPD) and moderate to severe asthma. Trabectedin An alkylating agent approved for the treatment of unresectable or metastatic soft tissue sarcoma (liposarcoma or leiomyosarcoma). Vandetanib An antineoplastic kinase inhibitor used to treat symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease. Dexlansoprazole A proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome. Apremilast A non-steroidal medication used for the treatment of inflammatory conditions such as psoriasis and psoriatic arthritis. Sertindole An atypical antipsychotic indicated in the treatment of schizophrenia. Mianserin A tetracyclic antidepressant with therapeutic activity similar to amitriptyline used to treat depression and anxiety. Noscapine A non-sedating isoquinoline alkaloid used primarily for its antitussive properties. Pixantrone An antineoplastic agent use to treat patients with relapsed or refractory aggressive Non-Hodgkin B-cell Lymphomas (NHL). Silodosin An alpha-1 adrenergic receptor antagonist used to treat symptoms associated with benign prostatic hyperplasia (BPH). Doripenem An antibiotic of the penem class used to treat complicated intra-abdominal and urinary tract infections. Tolvaptan A selective vasopressin V2-receptor antagonist to slow kidney function decline in patients at risk for rapidly progressing autosomal dominant polycystic kidney disease (ADPKD). Also used to treat hypervolemic and euvolemic hyponatremia. Regadenoson A coronary vasodilator used in radionuclide myocardial perfusion imaging (MPI). Asenapine An atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia. Nalmefene An opioid antagonist used to reduce alcohol consumption in adults with alcohol dependence and treat and prevent opioid overdose. Maribavir A cytomegalovirus (CMV) pUL97 kinase inhibitor used for the treatment of refractory post-transplant CMV infection. Simeprevir A direct-acting antiviral agent that inhibits HCV NS3/4A protease to treat chronic hepatitis C virus (HCV) infection in adults with HCV genotype 1 or 4. Bazedoxifene A selective estrogen receptor modulator (SERM) used to treat moderate to severe vasomotor symptoms in menopause and osteoporosis alone or in combination with conjugated estrogens. Cangrelor A P2Y12 platelet receptor antagonist used during percutaneous coronary intervention to reduce the risk for periprocedural myocardial infarction (MI), repeat coronary revascularization, and stent thrombosis (ST). Prucalopride A 5-HT4 receptor agonist indicated to treat adults with chronic idiopathic constipation. Ceftaroline fosamil An antibacterial agent used to treat various bacterial infections, such as acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia. Midostaurin An antineoplastic agent used to treat high-risk acute myeloid leukemia (AML) with specific mutations, aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematologic neoplasm (SM-AHN), or mast cell leukemia (MCL). Panobinostat A non-selective histone deacetylase inhibitor used to treat multiple myeloma in combination with other antineoplastic agents. Tafenoquine An antiparasitic agent used for the treatment and prevention of relapse of Vivax malaria. Bosutinib An antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. Axitinib An oral VEGFR and kinase inhibitor used for the treatment of advanced renal cell carcinoma after failure of one prior systemic therapy. Vilazodone An antidepressant agent used for the treatment of major depressive disorder that targets the 5-HT transporter and 5-HT1A receptors. Dabigatran etexilate An anticoagulant used for the prevention of venous thromboembolic events or stroke in patients with recent elective hip or knee replacement surgery and atrial fibrillation. Drotaverine A phosphodiesterase-4 inhibitor used to alleviate gastrointestinal and genitourinary smooth muscle spasms. Alcaftadine A H1 histamine receptor antagonist for ophthalmic use to prevent itching associated with allergic conjunctivitis. Bendamustine An antineoplastic agent used for the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed following rituximab therapy. Besifloxacin A fluoroquinolone antibiotic agent used for the treatment of bacterial conjunctivitis. Methylnaltrexone A μ-opioid antagonist used for the treatment of opioid-induced constipation in palliative patients that are inadequately responding to laxative therapy. Pralatrexate An antineoplastic agent used for the treatment of relapsed or refractory peripheral T-cell lymphoma. Pyrvinium An anthelmintic agent used for the treatment of pinworm infestations. Flavone Not Available Lurasidone An atypical antipsychotic used to treat schizophrenia and depressive episodes associated with bipolar I disorder. Ticagrelor A P2Y12 platelet inhibitor used in patients with a history of myocardial infarction or with acute coronary syndrome (ACS) to prevent future myocardial infarction, stroke and cardiovascular death. Ivacaftor A cystic fibrosis transmembrane conductance regulator (CFTR) potentiator used alone or in combination products to treat cystic fibrosis in patients who have specific genetic mutations that are responsive to the medication. Azilsartan medoxomil An angiotensin II receptor blocker used to treat hypertension alone or in combination with other antihypertensive agents, such as chlorthalidone. Lomitapide A microsomal triglyceride transfer protein inhibitor used to lower cholesterol associated with homozygous familial hypercholesterolemia (HoFH), reducing risk of cardiovascular events such as myocardial infarction and stroke. Pitavastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Vemurafenib A kinase inhibitor used to treat patients with Erdheim-Chester Disease who have the BRAF V600 mutation, and melanoma in patients who have the BRAF V600E mutation. Linagliptin A dipeptidyl peptidase-4 (DPP-4) inhibitor used to manage hyperglycemia in patients with type 2 diabetes mellitus. Bedaquiline A diarylquinoline antimycobacterial used in combination with other antibacterials to treat pulmonary multidrug resistant tuberculosis (MDR-TB). Pomalidomide A thalidomide analogue used in combination with dexamethasone to treat patients with multiple myeloma. Afatinib An antineoplastic agent used for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) with non-resistant EGFR mutations or resistance to platinum-based chemotherapy. Dolutegravir An antiviral agent used for the treatment of HIV-1 infections in combination with other antiretroviral agents. Indoramin Indoramin is a discontinued piperidine antiadrenergic drug with the trade names Baratol and Doralese. It is a selective alpha-1 adrenergic antagonist with no reflex tachycardia and direct myocardial depression action. Dimetotiazine Dimetotiazine has considerable antiemetic & serotonin antagonistic action used mainly in allergic skin conditions. Diosmin A citrus flavonoid medication used to support vascular health. Ledipasvir A direct-acting antiviral agent used to treat specific hepatitis C virus (HCV) infections in combination with other antiviral agents. Finafloxacin Finafloxacin is indicated for the treatment of acute otitis externa (AOE) with or without an otowick, caused by susceptible strains of Pseudomonas aeruginosa and Staphylococcus aureus in patients age 1... Ceftolozane A cephalosporin antibiotic used to treat complicated intra-abdominal infections in combination with metronidazole, complicated urinary tract infections, and hospital-acquired pneumonia. Idelalisib An antineoplastic kinase inhibitor used to treat chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). Tasimelteon A melatonin receptor agonist used to treat Non- 24-Hour Sleep-Wake Disorder. Lenvatinib A receptor tyrosine kinase inhibitor used for the treatment of metastatic thyroid cancer, advanced renal cell carcinoma in combination with everolimus, and unresectable hepatocellular carcinoma. Nintedanib A triple angiokinase inhibitor indicated for the treatment of idiopathic pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and in combination with docetaxel for non-small cell lung cancer. Olodaterol A long-acting beta2-adrenergic agonist used in the management of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema. Ivabradine A HCN channel blocker used to reduce the risk of hospitalization for worsening heart failure in adult patients and for treatment of stable symptomatic heart failure as a result of dilated cardiomyopathy in pediatric patients. Benzydamine A locally-acting NSAID indicated for the symptomatic relief of pain in acute sore throat and for the symptomatic relief of oropharyngeal mucositis caused by radiation therapy. Xanthinol A vasodilatory niacin found in diet supplements. Quinagolide A dopamine D2 receptor agonist used for the treatment of hyperprolactinemia. Elvitegravir An antiretroviral agent used in combination with other antiretrovirals for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults. Diiodohydroxyquinoline Used in the treatment of amoebiasis. Eslicarbazepine acetate An anticonvulsant agent used as an adjunct to treat partial-onset seizures in patients with inadequate clinical response to conventional antiepileptic therapy. Brexpiprazole A serotonin–dopamine activity modulator used in the treatment of major depressive disorder as an adjunct, schizophrenia, and agitation associated with dementia due to Alzheimer’s disease. Flutemetamol (18F) A radiopharmaceutical diagnostic agent used during Positron Emission Tomography (PET) imaging of the brain to estimate β-amyloid neuritic plaque density in adult patients to diagnose the causes of cognitive impairment. Dosulepin A tricyclic antidepressant commonly used only in patients for whom alternative therapies are ineffective due to its toxicity potential. Pholcodine An opioid antitussive used to suppress unproductive coughing. Zotepine Zotepine, like other atypical antipsychotics, is considered as the first-line treatment in newly diagnosed schizophrenia. It is usually thought to be an option of choice for managing acute schizophrenic episodes... Methylene blue An oxidation-reduction agent used for the treatment of pediatric and adult patients with acquired methemoglobinemia. Lumacaftor A protein chaperone used in combination with ivacaftor for the treatment of cystic fibrosis in patients who are homozygous for the F508del mutation in the CFTR gene. Tenofovir alafenamide A nucleoside analog reverse transcriptase inhibitor used for the treatment of chronic hepatitis B virus infection in adults with compensated liver disease. Carindacillin A penicillin antibiotic used to treat a variety of infections, but is no longer marketed in the USA. Procaine benzylpenicillin A local anesthetic and antibiotic combination for intramuscular injection to treat a variety of bacterial infections while reducing pain from a deep intramuscular injection. Sulbactam An beta-lactamase inhibitor antibiotic combined with other antibiotics to treat a variety of susceptible bacterial infections. Alatrofloxacin A fluoroquinolone antibiotic used to treat a variety of bacterial infections. Piperonyl butoxide A pesticide used as a potentiator ingredient in the treatment of pediculosis (head lice, body lice or crabs) to boost efficacy of treatment. Ensulizole An ingredient used in sunscreens to absorb UVB radiation. Oxyquinoline A medication used in combination with other medications to restore vaginal pH. Cobamamide An ingredient found in a variety of supplements and vitamins. Tocopherol Tocopherol can be used as a dietary supplement for patients with a deficit of vitamin E; this is mainly prescribed in the alpha form. Vitamin E deficiency is rare, and... Levomefolic acid A folate supplement used to prevent neural tube defects in pregnancy or folate deficiency. Dihydroergocornine A nootropic with an unknown mechanism of action indicated in individuals over sixty who manifest signs and symptoms of an idiopathic decline in mental capacity. Kinetin Kinetin is a cytokinin which are plant hormones promotes cell division and plant growth. It was shown to naturally exist in DNA of organisms including humans and various plants. While... Alectinib A kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer. 2-mercaptobenzothiazole Not Annotated Elbasvir An antiviral and NS5A inhibitor used to treat hepatitis C infections. Grazoprevir An antiviral and NS3/4A protease inhibitor used to treat hepatitis C infections. Indigotindisulfonic acid A medication used to visualize ureteral orifices during cystoscopy and ureteral catheterization. Asunaprevir An NS3 protease inhibitor used to treat hepatitis C genotype 1b. Bilastine A peripheral histamine H1-antagonist used to treat seasonal allergic rhinitis and chronic spontaneous urticaria. Levoleucovorin A folate analog used after high dose methotrexate for osteosarcoma, to reduce the toxic effects of folate analogs, and with 5-fluorouracil in palliative treatment of advanced metastatic colorectal cancer. Velpatasvir A NS5A inhibitor used to treat chronic hepatitis C infections in patients without cirrhosis or with compensated cirrhosis. Laropiprant Laropiprant is an ingredient in the EMA-withdrawn product Pelzont. Temoporfin A photosensitizer used to treat squamous cell carcinomas of the head and neck. Tocofersolan A derivative of alpha tocopherol used to treat vitamin E deficiencies. Vinflunine A vinca alkaloid used to treat advanced or metastatic transitional cell carcinoma of the urothelial tract after a platinum containing treatment has failed. Tafamidis A medication used to treat transthyretin-mediated amyloidosis. Rebamipide A gastroprotective agent used in combination with other similar therapies (e.g. proton pump inhibitors) to treat gastritis and protect the gastric mucosa. Galidesivir Galidesivir is an adenosine analogue that has been investigated for use against Zaire Ebolavirus. In animal studies, galidesivir was effective in increasing the survival rates from infections caused by various... Selumetinib A MEK 1/2 inhibitor used in pediatric patients to treat neurofibromatosis type 1 (NF1) accompanied by symptomatic, inoperable plexiform neurofibromas (PN). Naldemedine An opioid antagonist used to to treat opioid-induced constipation. Tropisetron A 5HT-3 receptor antagonist used as an antiemetic in the treatment of chemotherapy-induced nausea and vomiting. Tezacaftor A medication used to treat homozygous or heterozygous F508del mutation cystic fibrosis. Ribociclib A kinase inhibitor used to treat HR+, HER2- advanced or metastatic breast cancer. Rifamycin An antibacterial used to treat traveler's diarrhea. Istradefylline A selective adenoside A2A receptor antagonist indicated in adjunct to levodopa and carbidopa for the treatment of Parkinson's Disease. Tenapanor An NHE3 inhibitor indicated for the treatment of constipation-predominant irritable bowel syndrome (IBS-C). Niraparib A poly-ADP ribose polymerase inhibitor used to treat recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer responding to platinum based chemotherapy. Bictegravir An integrase inhibitor used to treat HIV infections. Tivozanib A kinase inhibitor to treat adult patients with renal cell carcinoma (RCC) who have failed prior systemic therapies or experienced relapsed disease. Neratinib A protein kinase inhibitor used to treat breast cancer that over expresses the HER2 receptor. Valbenazine A vesicular monoamine transporter 2 inhibitor used to treat tardive dyskinesia and chorea associated with Huntington's disease. Kynurenic Acid Kynurenic Acid is under investigation in clinical trial NCT02340325 (FS2 Safety and Tolerability Study in Healthy Volunteers). Delafloxacin A fluoroquinolone antibiotic used to treat skin and skin structure infections. Duvelisib An inhibitor of phosphatidylinositol 3-kinase delta and gamma used to treat relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma. Dacomitinib A medication used to treat non small cell lung cancer with EGFR exon 19 deletion of exon 21 L858R substitution. Binimetinib A medication used to treat metastatic melanoma with specific mutations. Glasdegib A sonic hedgehog receptor inhibitor used to treat newly diagnosed acute myeloid leukemia in patients over 75 years who cannot receive intense chemotherapy. Entrectinib Entrectinib is indicated for the treatment of metastatic ROS1-positive non-small cell lung cancer in adults. Entrectinib is also indicated in adults and children over 12 years old for the treatment... Abemaciclib A medication used to treat HR+ HER2- advanced or metastatic breast cancer. Tecovirimat An antiviral medication used to treat smallpox, monkeypox, and cowpox. Letermovir An antiviral medication used for prophylaxis in adult transplant recipients at risk of cytomegalovirus (CMV) infection and disease. Sultamicillin A mutual prodrug of ampicillin and sulbactam useful in the treatment of infections caused by beta-lactamase-producing bacteria. Erdafitinib A fibroblast growth factor receptor tyrosine kinase inhibitor used to treat locally advanced or metastatic urothelial carcinoma. Deutetrabenazine A vesicular monoamine transporter 2 inhibitor used for the symptomatic treatment of tardive dyskinesia and chorea associated with Huntington's disease. Triclabendazole An anthelmintic drug used to treat fascioliasis. Cantharidin A natured product indicated to treat molluscum contagiosum Rucaparib A poly (ADP-ribose) polymerase (PARP) inhibitor used to treat recurrent ovarian and prostate cancers in previously treated adults. Temocillin Temocillin has been investigated in Infection, Liver Dysfunction, and Urinary Tract Infection. Remimazolam An ultra short-acting benzodiazepine used for the induction and maintenence of procedural sedation during short procedures. Copanlisib A medication used to treat relapsed follicular lymphoma who have attempted at least two other treatments. Mizolastine A second-generation non-sedating antihistamine used to treat symptoms of allergic rhinoconjunctivitis and urticaria. 1,2-Benzodiazepine Benzodiazepine is under investigation for the prevention of Delirium and C.Surgical Procedure; Cardiac. Benzodiazepine has been investigated for the treatment of Obesity, Sleep Apnea, Obstructive, and Disorders of Gallbladder, Biliary... Samidorphan A novel opioid-system modulator, similar to naltrexone, that functions primarily as a μ-opioid receptor antagonist in vivo and is used primarily in combination with antipsychotics to reduce their metabolic dysfunction-associated adverse effects. Lurbinectedin A chemotherapeutic DNA alkylating agent used in the treatment of metastatic small-cell lung cancer. Perazine A phenothiazine antipsychotic used in the acute and chronic treatment of psychotic disorders. Ozenoxacin A quinolone antibiotic used to treat impetigo caused by susceptible bacteria. Macimorelin A medication used to treat adult growth hormone deficiency. Esculin As medication, esculin is sometimes used as a vasoprotective agent. Esculin is also used in a microbiology laboratory to aid in the identification of bacterial species (especially Enterococci and Listeria),... Inosine pranobex A medication used to treat subacute sclerosing panencephalitis. Butaperazine Butaperazine was approved in 1967 , and possibly discontinued in the 1980s . Tilbroquinol Tilbroquinol was approved in France, Morocco, and Saudi Arabia but it has been withdrawn in France and Saudi Arabia markets mainly due to its hepatotoxicity risk outweighing the drug benefit... Dibenzepin Dibenzepin is approved for use in Europe. Flosequinan Flosequinan was approved in the USA and the UK for a year prior to being withdrawn from the market due to increased mortality in chronic heart failure patients, found in... Quinupramine Quinupramine has been approved in France under the brand name Kinupril, as an antidepressant . Clothiapine An atypical antipsychotic indicated in the treatment of acute psychosis, exacerbations of chronic psychosis, chronic psychosis, paranoid psychosis, and anxiety. Benziodarone Benziodarone is a uricostatic and a uricosuric agent which is sold also under the name Amplivex-Labaz. It is used in the treatment of gout . It was withdrawn from France... Carbocromen Carbocromen was marketed for use in Germany as a vasodilator, however, it has been discontinued due to the risk of arrhythmia development . Pimethixene Pimethixene is approved for use in Brazil and is marketed under the trade name Muricalm. It is an anticholinergic used in the treatment of bronchitis. Atracurium A neuromuscular blocker indicated to relax muscles during mechanical ventilation under general anesthesia or intubation. Chlorquinaldol Chlorquinaldol was used historically as a topical antiseptic agent for skin infections. It maintains use in European countries as a combination vaginal tablet with promestriene for use in the treatment... Dihydroergocristine An ergot alkaloid used to delay progressive mental decline in conditions like Alzheimer's. Bendazac A non-steroidal anti-inflammatory drug (NSAID) available as an eye drop for the treatment of cataracts and as a topical cream for the treatment of dermatitis, eczema, hives, skin ulcers and other inflammatory skin conditions. Metergoline An ergot-derivative that acts as an antagonist at certain 5-HT receptor subtypes and as an agonist at dopamine receptors. It is often used in situations where inhibition of prolactin is desirable. Cyclopenthiazide Cyclopenthiazide is a thiazide diuretic with antihypertensive properties. In a double blind, randomized crossover study, cyclopenthiazide was effective in reducing diastolic blood pressure in mildly hypertensive non-insulin dependent diabetic patients... Umifenovir A dual direct-acting antiviral/host-targeting agent used in the treatment and prophylaxis of influenza and other respiratory viruses. Cefpirome An antibiotic indicated in the treatment of a wide variety of infections in the body. Tritoqualine Not Annotated Acemetacin A NSAID indicated in the treatment of pain and inflammation. Lormetazepam A benzodiazepine indicated in the treatment of anxiety and the induction of anesthesia. Pibrentasvir A Hepatitis C NS5A inhibitor used to treat Hepatitis C. Glecaprevir A Hepatitis C NS3/4A protease inhibitor used to treat Hepatitis C. Phloxine B For use in dental disclosing products, allowing for highlighting of bacterial placques. Piperaquine For the treatment of uncomplicated Plasmodium falciparum infection in adults, children, and infants aged 6 months and up weighing over 5 kg [FDA Label]. Used in combination with DB11638. alpha-Tocopherol succinate A form of vitamin E used to treat and prevent vitamin deficiencies. alpha-Tocopherol acetate A form of vitamin E used to treat and prevent vitamin deficiencies. Bromotheophylline Bromotheophylline is used as a diuretic and also, in combination with DB00316, it is used for the relief of temporary water weight gain, bloating, swelling and full feeling associated with... Cianidanol An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms. Tenofovir A nucleotide analog indicated in the treatment of HIV infections. Thiohexam Thiohexam is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6 years... 2,2'-Dibenzothiazyl disulfide 2,2'-Dibenzothiazyl disulfide is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6... Morpholinylmercaptobenzothiazole Not Annotated Oxyphenisatin acetate Oxyphenisatin acetate is the pro-drug of oxyphenisatin (3,3-bis(4-hydroxyphenyl)-1H-indol-2-one). The FDA withdrew its approval for the use of oxyphenisatin acetate due to safety reasons. Cefamandole nafate A second generation cephalosporin indicated in the prevention of infections during surgery. Cefiderocol A cephalosporin antibiotic used in complicated urinary tract infections. Umbralisib A kinase inhibitor used to treat rare forms of refractory lymphoma. Upadacitinib An oral Janus kinase (JAK)1-selective inhibitor used in the treatment of moderate to severe rheumatoid arthritis, active psoriatic arthritis, ankylosing spondylitis, and severe atopic dermatitis, including in patients who did not respond well to other therapies. RSV-604 RSV-604 is under investigation in clinical trial NCT00416442 (Safety, Tolerability and Pharmacokinetic Study of Single and Multiple Intravenous Doses of RSV604 in Healthy Subjects.). Vericiguat A soluble guanylate cyclase stimulator used to reduce heart failure-related hospitalization and cardiovascular death in patients with chronic systolic heart failure. Eslicarbazepine An antiepileptic indicated as a monotherapy or adjunct therapy in the treatment of epilepsy. Rose bengal Indicated as a diagnostic agent in routine ocular examinations or when superficial conjunctiva or corneal tissue change is suspected, and as an aid in the diagnosis of keratoconjunctivitis sicca, keratitis,... Padeliporfin A vascular-acting photosensitizer used to treat low-risk prostate cancer in adults. Casimiroin Casimiroin is a quinone reductase 2 inhibitor isolated from Casimiroa edulis. Flortaucipir F-18 A small lipophilic tracer containing [18F]fluoride capable of crossing the blood-brain barrier and binding to aggregated tau protein; used in PET imaging for the diagnosis of Alzheimer's disease. Maritime pine extract A plant extract in nutritional supplements for healthy hair, skin, and nails. Finerenone A nonsteroidal mineralocorticoid receptor antagonist indicated to lower the risk of eGFR decline, end stage kidney disease, cardiovascular death, heart attack, and hospitalization for heart failure in chronic kidney disease associated with type 2 diabetes. Oxymatrine Oxymatrine is under investigation in clinical trial NCT02202473 (Oxymatrine Plus Lamivudine Combination Therapy Versus Lamivudine Monotherapy for Chronic Hepatitis B Infected Subjects). Fosdenopterin An exogenous form of cyclic pyranopterin monophosphate (cPMP) used as a replacement substrate in patients with molybdenum cofactor deficiency (MoCD) type A. Galantamine A cholinesterase inhibitor used to manage mild to moderate dementia associated with Alzheimer's Disease. Belumosudil An oral inhibitor of rho-associated coiled-coil-containing protein kinases (ROCK) used in the treatment of chronic graft-versus-host disease (GVHD). Aztreonam A beta-lactam antibiotic used to treat select aztreonam sensitive gram negative bacteria. Zafirlukast A leukotriene receptor antagonist used for prophylaxis and chronic treatment of asthma. Benzylpenicilloyl polylysine A penicillin derivative used to determine penicillin allergies. Pranlukast A leukotriene receptor antagonist for the treatment of allergic rhinitis and asthma symptoms. Bufotenine A hallucinogenic serotonin analog found in frog or toad skins, mushrooms, higher plants, and mammals, especially in the brains, plasma, and urine of schizophrenics. Bufotenin has been used as a... Indopan Indopan (alpha-methyltryptamine) is a stimulant and psychoactive drug which produces effects similar to 3,4-methylenedioxy-N-methylamphetamine (MDMA), despite being structurally dissimilar. It was developed in the 1960's by Upjohn with the intention... Bezitramide A narcotic analgesic once used for the treatment of severe chronic pain. Diethyltryptamine Diethyltryptamine (DET) is an orally active hallucinogenic agent and a substituted form of tryptamine. Etonitazene Not Available Haloxazolam Not Available Cyprenorphine Not Available Dimethyltryptamine Some people use this compound as a psychedelic inducing agent. Camazepam Camazepam has been used in placebo controlled studies for the treatment of patients suffering from anxiety and depression. Delorazepam A benzodiazepine used to manage severe anxiety disorders and insomnia. Ethyl loflazepate Not Available Etryptamine Developed in the 1960's for use as an antidepressant before market withdrawal in 1962. Fludiazepam Used for the short-term treatment of anxiety disorders. Bisindolylmaleimide VIII Not Available 7-Nitroindazole Not Available 7-Deazaguanine Not Available Ilomastat Not Available 5'-S-methyl-5'-thioadenosine Not Available Myricetin Not Available Guanine Not Available 9-Methylguanine Not Available Peldesine Peldesine is a potent inhibitor of human CCRF-CEM T-cell proliferation. It has undergone phase I trials for the treatment of Human Immunodeficiency Virus (HIV) infections. 5,6-Dimethylbenzimidazole Not Available LY-294002 Specific inhibitor of phosphatidylinositol 3-kinase. 3-Indolebutyric Acid Not Available Indolepropionic acid Not Available Benzimidazole Not Available 7-cyano-7-deazaguanine Not Available IC261 Not Available 6-Nitroindazole Not Available 5-methylbenzimidazole Not Available 6-Hydroxymethylpterin Not Available CP-320626 Not Available 4-hydroxycoumarin Not Available SU9516 Not Available 6-bromoindirubin-3'-oxime Not Available Alvocidib Investigated for use/treatment in esophageal cancer, leukemia (lymphoid), lung cancer, liver cancer, and lymphoma (unspecified). 2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide Not Available Isopenicillin N Not Available Dibenzofuran-4,6-Dicarboxylic Acid Not Available N-(2-Aminoethyl)-5-Chloroisoquinoline-8-Sulfonamide Not Available FG-9041 Not Available D-Eritadenine Not Available Bisindolylmaleimide I Not Available Biopterin A natural product that has been considered as a growth factor for some insects. [PubChem] Alsterpaullone Not Available 6-hydroxymethylpterin diphosphate Not Available 9-Deazahypoxanthine Not Available 3-Methyladenine Not Available Mdl-29951 Not Available Benzofuran Not Available Pteroic acid Not Available N-acetylserotonin Not Available Genz-10850 Not Available Trichostatin A Not Available Isoquinoline Not Available 9-Deazaguanine Not Available L-erythro-7,8-dihydrobiopterin 7,8-Dihydrobiopterin is an inhibitor of the enzyme dihydroneopterin aldolase (DHNA), which catalyzes the conversion of 7,8-Dihydrobiopterin to 6-hydroxymethyl-7,8-dihydropterin and glycolaldehyde. Chlorophyll B A light, silvery, metallic element. It has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. Its salts are essential in nutrition, being required for the activity of... Indole Not Available 5-Nitroindazole Not Available 5-Aminoisoquinoline Not Available OLOMOUCINE II Not Available Coumarin Not Available 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one Not Available Purvalanol A Not Available (2R)-2-({6-[benzyl(methyl)amino]-9-isopropyl-9H-purin-2-yl}amino)butan-1-ol Not Available Roxadustat A hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor used to treat symptomatic anemia associated with chronic kidney disease. Implitapide For the treatment of atherosclerosis. Brasofensine For the treatment of Parkinson's Disease. Zanapezil For the treatment of dementia in subjects with Alzheimer’s disease. Piboserod For the treatment of atrial fibrillation and irritable bowel syndrome (IBS). Pralnacasan For the treatment of rheumatoid arthritis (RA). Bifeprunox Bifeprunox is being evaluated for the treatment of schizophrenia, psychosis, and Parkinson's disease. Oxibendazole Investigated for use/treatment in infectious and parasitic disease (unspecified) and pediatric indications. Talampanel For the treatment of epilepsy. Apadenoson Investigated for use/treatment in cardiovascular disorders and inflammatory disorders (unspecified). Besifovir dipivoxil Investigated for use/treatment in hepatitis (viral, B). Amonafide Investigated for use/treatment in breast cancer, ovarian cancer, and prostate cancer. ADL5859 Investigated for use/treatment in pain (acute or chronic). AT9283 Investigated for use/treatment in cancer/tumors (unspecified), leukemia (myeloid), and solid tumors. EPC2407 Investigated for use/treatment in cancer/tumors (unspecified). Atl146e Investigated for use/treatment in inflammatory disorders (unspecified). SF1126 For the treatment of various forms of cancer. Pracinostat For the treatment of various forms of cancer. AM103 For the treatment of asthma and cardiovascular disease. XL765 For the treatment of various forms of cancer. Fx-1006A Investigated for use/treatment in amyloidosis. Talmapimod Investigated for use/treatment in pain (acute or chronic) and rheumatoid arthritis. Pipendoxifene Investigated for use/treatment in breast cancer. ADX-10061 Investigated for use/treatment in sleep disorders, smoking cessation, and substance abuse. Pradefovir mesylate Investigated for use as a prodrug for Hepsera in treating hepatitis (viral, B). Custirsen Investigated for use/treatment in brain cancer and breast cancer. KW-7158 Investigated for use/treatment in urinary incontinence. Mavorixafor Investigated for use/treatment in HIV infection. Budiodarone Investigated for use/treatment in arrhythmia and atrial fibrillation. BMS-488043 Investigated for use/treatment in HIV infection. SB-743921 Investigated for use/treatment in cancer/tumors (unspecified) and lymphoma (non-hodgkin's). INO-1001 Investigated for use/treatment in brain cancer, cardiovascular disorders, and myocardial infarction. TG100-115 Investigated for use/treatment in angioedema and myocardial infarction. Motesanib Investigated for use/treatment in solid tumors. Facinicline Investigated for use/treatment in alzheimer's disease, neurologic disorders, and schizophrenia and schizoaffective disorders. MKC-1 Investigated for use/treatment in breast cancer, leukemia (unspecified), lung cancer, and solid tumors. Faropenem medoxomil Investigated for use/treatment in bacterial infection, bronchitis, otitis media, and pediatric indications. SLx-4090 Investigated for use/treatment in hyperlipidemia. Gantacurium Investigated for use/treatment in anesthesia (unspecified). EVT 201 Investigated for use/treatment in insomnia. Varespladib methyl Investigated for use/treatment in atherosclerosis and coronary artery disease. Rabeximod Investigated for use/treatment in rheumatoid arthritis. Daglutril Investigated for use/treatment in congestive heart failure and hypertension. OPC-51803 Investigated for use/treatment in nocturia (frequent nighttime urination) and urinary incontinence. CHF 4227 Investigated for use/treatment in osteoporosis. Dovitinib Investigated for use/treatment in multiple myeloma and solid tumors. Denibulin Investigated for use/treatment in solid tumors. CVT-6883 Investigated for use/treatment in asthma. SNX-5422 Investigated for use/treatment in cancer/tumors (unspecified). Lumateperone A novel 2nd generation antipsychotic used to manage both positive and negative symptoms in patients with schizophrenia. Linifanib Investigated for use/treatment in leukemia (myeloid), myelodysplastic syndrome, and solid tumors. Bradanicline Investigated for use/treatment in neurologic disorders. SUVN-502 Investigated for use/treatment in neurologic disorders. Fosdevirine Investigated for use/treatment in HIV infection and acquired immune deficiency syndrome (AIDS) and aids-related infections. Indibulin Investigated for use/treatment in solid tumors. Talotrexin Investigated for use/treatment in solid tumors, lung cancer, leukemia (unspecified), and leukemia (lymphoid). Lonidamine Investigated for use/treatment in benign prostatic hyperplasia, prostate disorders, and cancer/tumors (unspecified). BNC105 Investigated for use/treatment in cancer/tumors (unspecified). Fiboflapon Investigated for use/treatment in inflammatory disorders (unspecified). Tezampanel Investigated for use/treatment in pain (acute or chronic) and migraine and cluster headaches. Alamifovir Investigated for use/treatment in hepatitis (viral, B). Tarazepide Investigated for use/treatment in gastrointestinal diseases and disorders (miscellaneous). Semaxanib Investigated for use/treatment in colorectal cancer and lung cancer. Tecastemizole Investigated for use/treatment in allergic rhinitis. Sumanirole Investigated for use/treatment in parkinson's disease. Enzastaurin Investigated for use/treatment in brain cancer, lymphoma (non-hodgkin's), and lung cancer. Furaprofen Investigated for use/treatment in hepatitis (viral, C). S-8510 Investigated for use/treatment in alzheimer's disease and dementia. Repinotan Investigated for use/treatment in strokes, cerebral ischemia, and depression. Robalzotan Investigated for use/treatment in anxiety disorders and depression. Siramesine Investigated for use/treatment in anxiety disorders. Valomaciclovir Investigated for use/treatment in herpes zoster infections and viral infection. Tonabersat Investigated for use/treatment in migraine and cluster headaches. Dextofisopam Investigated for use/treatment in irritable bowel syndrome (IBS). Pazopanib An antineoplastic agent used in the treatment of advanced renal cell cancer and advanced soft tissue sarcoma in patients with prior chemotherapy. Ilepatril Investigated for use/treatment in hypertension. Aplindore Investigated for use/treatment in parkinson's disease and neurologic disorders. Almorexant Investigated for use/treatment in sleep disorders and insomnia. Zaltoprofen A non-steroidal anti-inflammatory drug approved for use in Japan in 1993. Gavestinel Highly potent and selective non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (Kd = 0.8 nM). Gavestinel displays > 1000-fold selectivity over NMDA, AMPA... PLX-4720 Not Available Veliparib Not Available Nesbuvir Nesbuvir has been investigated for the treatment of Hepatitis C. AKI-001 AKI-001 is an aurora kinase inhibitor. Reversine Not Available alpha-Naphthoflavone Not Available CCT-018159 Not Available Opaviraline Not Available Talviraline Talviraline has been used in trials studying the treatment of HIV Infections. Erteberel Erteberel is an estrogen receptor beta agonist that has been used in trials studying the treatment of Benign Prostatic Hyperplasia. H-89 Not Available SU-11652 SU-11652 is a tyrosine kinase inhibitor. Coumarin 120 Not Available Tricetin Not Available Sakuranetin Not Available A-674563 Not Available R-82913 Not Available Tryptamine Not Available Azidocillin For treatment of infection (Respiratory, GI, UTI and meningitis) due to E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, nonpenicillinase-producing N. gononhoeae, H. influenzae, staphylococci, streptococci including... Pipazethate For the treatment of cough. Tofisopam For the treatment of anxiety and alcohol withdrawal. Serotonin For temporary relief of nervousness, anxiety, mood swings, joint pains, weakness, drowsiness, itching and lethargy. Not evaluated by the FDA, homeopathic product. GS 0573 Not Annotated Cyamemazine Cyamemazine (Tercian), also known as cyamepromazine, is a typical antipsychotic drug of the phenothiazine class used primarily in the treatment of schizophrenia and psychosis-associated anxiety. Cyamemazine actually behaves like an... Naloxegol A peripherally-selective opioid antagonist used to treat opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain. Ibrutinib An antineoplastic agent used to treat chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's Macroglobulinemia. Lortalamine Lortalamine (LM-1404) is a selective norepinephrine reuptake inhibitor developed in the 1980s. This drug never made it past clinical trials, likely due to ocular toxicity in animals, but has been... Daledalin Daledin (UK-3557-15) is a selective norepinephrine reuptake inhibitor. It has no effects on the reuptake of serotonin or dopamine, and no antihistamine or anticholinergic properties. It was in trials for... Talopram Talopram is a selective norepinephrine reuptake inhibitor (SNRI) that is structurally similar to citalopram and melitracen. It was researched in the 1960s and 1970s but never marketed. Tandamine Tandamine was researched in 1970s as an antidepressant but was never commercialized. Tandamine is an analog of pirandamine and it acts as a selective serotonin reuptake inhibitor (SSRI). Ramosetron A selective 5-HT3 antagonist used as an antiemetic for chemotherapy- and postoperative-associated nausea and vomiting. It may also possess efficacy in irritable bowel syndrome. Talniflumate Talnifumate is a phthalidyl ester of nifumic acid, which has potent analgesic and anti-inflammatory effects and is widely used to treat inflammatory disorders, such as rheumatoid arthritis and osteoarthritis ,... Aptazapine Investigated for the treatment of depression. Metralindole Investigated for the treatment of depression. Diosmetin Diosmetin is an O-methylated flavone and the aglycone part of the flavonoid glycosides diosmin that occurs naturally in citrus fruits . Pharmacologically, diosmetin is reported to exhibit anticancer, antimicrobial, antioxidant,... Dirlotapide Dirlotapide is a drug employed in the treatment of obesity in dogs. It is marketed by Pfizer and Zoetis under the brand name, Slentrol, and is not intended for human... Oxfendazole Oxfendazole is a sulfoxide metabolite of fenbendazole. This benzimidazole antihelminthic protects livestock from roundworm. strongyles, and pinworn. Phenothiazine Phenothiazine (PTZ) is an organic thiazine compound. Zilpaterol Zilpaterol is a β2 adrenergic agonist sold under the trade name, Zilmax, produced by Intervet, a subsidiary of Merck & Co. Zilpaterol is typically fed to cattle in the last... Bicuculline Bicuculline is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and... Evacetrapib Evacetrapib has been used in trials studying the basic science and treatment of Dyslipidemia, Hyperlipidemia, Hypercholesterolemia, Hepatic Insufficiency, and Cardiovascular Disease. Pictilisib Pictilisib has been used in trials studying the treatment of Solid Cancers, Breast Cancer, Advanced Solid Tumours, Metastatic Breast Cancer, and Non-Hodgkin's Lymphoma, Solid Cancers, among others. Fruquintinib Fruquintinib is under investigation for the treatment of NSCLC. Fruquintinib has been investigated for the treatment of ColoRectal Cancer. Tofimilast Tofimilast has been used in trials studying the treatment of Asthma and Pulmonary Disease, Chronic Obstructive. Ruzasvir Ruzasvir has been used in trials studying the treatment of Hepatitis C, Hepatitis C, Chronic, and Hepatitis C Infection. Latrepirdine Latrepirdine has been investigated for the treatment of Alzheimer's Disease and Huntington's Disease. PF-00489791 PF-00489791 has been used in trials studying the treatment of Hypertension, Raynaud's Disease, Diabetic Nephropathies, Hypertension, Pulmonary, and Peripheral Vascular Disease. Famitinib Famitinib has been used in trials studying the treatment of Colorectal Cancer, Renal Cell Cancer, Colorectal Cancer Recurrent, Colorectal Cancer Metastatic, and Metastatic Renal Cell Cancer, among others. Otenabant Otenabant has been investigated for the treatment of Obesity. Funapide Funapide has been used in trials studying the treatment of Pharmacokinetics, Postherpetic Neuralgia, and Osteoarthritis of the Knee. Pilaralisib Pilaralisib is an orally available small molecule that selectively inhibits the activity of phosphoinositide-3 kinase (PI3K). Pilaralisib has been used in trials studying the treatment of Cancer, Lymphoma, Solid Tumors,... Birinapant Birinapant has been investigated for the treatment of Myelodysplastic Syndrome (MDS) and Chronic Myelomonocytic Leukemia (CMML). Tanzisertib Tanzisertib has been used in trials studying the treatment of Fibrosis, Discoid Lupus, Pulmonary Fibrosis, Interstitial Lung Disease, and Lung Diseases, Interstitial, among others. PF-03882845 PF-03882845 has been used in trials studying the basic science of Diabetes Mellitus, Type 2 and Type 2 Diabetic Nephropathy. Baricitinib A Janus kinase inhibitor used to treat moderate to severe rheumatoid arthritis that has responded poorly to at least one TNF antagonist. ASP-4058 ASP4058 has been used in trials studying Food Effect of ASP4058 and Pharmacokinetics of ASP4058. TMC-647055 TMC647055 has been used in trials studying the treatment of Hepatitis C, Chronic Hepatitis C, Hepatitis C, Chronic, and Chronic Hepatitis C Virus. Ruboxistaurin Ruboxistaurin has been investigated for the basic science of Type 2 Diabetes Mellitus and Type 1 Diabetes Mellitus. Crenolanib Crenolanib is under investigation for the treatment of Diffuse Intrinsic Pontine Glioma and Progressive or Refractory High-Grade Glioma. Sapanisertib Sapanisertib has been used in trials studying the treatment of HCC, Solid Tumor, Gliosarcoma, Liver Cancer, and Glioblastoma, among others. Tegobuvir Tegobuvir has been investigated for the treatment of Hepatitis C, Chronic. RG-4733 Ro4929097 has been used in trials studying the treatment of Sarcoma, LYMPHOMA, Neoplasms, Wilm's Tumor, and OSTEOSARCOMA, among others. 3,3'-diindolylmethane Diindolylmethane has been used in trials studying the prevention and treatment of SLE, Prostate Cancer, Cervical Dysplasia, Stage I Prostate Cancer, and Stage II Prostate Cancer, among others. Vadastuximab talirine Vadastuximab Talirine has been used in trials studying the treatment of Acute myeloid leukemia, Myelodysplastic Syndrome, Acute Myelogenous Leukemia, and Acute Promyelocytic Leukemia. Anlotinib Anlotinib has been investigated for the treatment of Non-small Cell Lung Cancer and Metastatic Colorectal Cancer. Varespladib Varespladib has been investigated for the treatment and prevention of Sickle Cell Disease, Vaso-occlusive Crisis, and Acute Coronary Syndrome. LY-2090314 Ly2090314 has been used in trials studying the treatment of Leukemia, Advanced Cancer, and Pancreatic Cancer. 6-O-benzylguanine 6-O-benzylguanine has been used in trials studying the treatment of HIV Infection, Adult Gliosarcoma, Adult Glioblastoma, Stage I Adult Hodgkin Lymphoma, and Stage II Adult Hodgkin Lymphoma, among others. Idalopirdine Idalopirdine has been used in trials studying the treatment of Cognition, Schizophrenia, and Alzheimer's Disease. SJG-136 SJG-136 has been used in trials studying the treatment of Recurrent Fallopian Tube Cancer, Secondary Acute Myeloid Leukemia, de Novo Myelodysplastic Syndromes, Recurrent Ovarian Epithelial Cancer, and Secondary Myelodysplastic Syndromes,... MK-7145 MK-7145 has been used in trials studying the treatment of Hypertension and Renal Insufficiency. GSK-2018682 GSK2018682 has been investigated for the treatment of Multiple Sclerosis, Relapsing-Remitting. Omarigliptin Omarigliptin has been used in trials studying the treatment of Type 2 Diabetes Mellitus and Chronic Renal Insufficiency. Osugacestat Osugacestat (BMS-906024) has been used in trials studying the treatment of Cancer, Lymphoblastic Leukemia, Acute T-cell, and Precursor T-Cell Lymphoblastic Lymphoma. Voxilaprevir A nonstructural protein 3 and 4a protease inhibitor used to treat Hepatitis C infections. Serdemetan Serdemetan has been used in trials studying the treatment of Neoplasms. Mapracorat Mapracorat has been investigated for the treatment of Eczema and Atopic Dermatitis. Dasolampanel etibutil Dasolampanel etibutil has been used in trials studying the treatment of Diabetic Neuropathy, Painful. LY-3039478 LY3039478 has been used in trials studying the treatment and basic science of LYMPHOMA, Neoplasms, Solid Tumor, COLON CANCER, and BREAST CANCER, among others. Setrobuvir Setrobuvir has been used in trials studying the treatment of Hepatitis C, Chronic. Icariin Icariin has been investigated for the basic science of the Pharmacokinetic Profile of Icariin in Humans. ORM-12741 ORM-12741 has been used in trials studying the basic science and treatment of Alzheimer's Disease. Recoflavone Recoflavone has been used in trials studying the treatment of Acute Gastritis, Dry Eye Syndrome, and Chronic Gastritis. Pardoprunox Pardoprunox has been used in trials studying the treatment of Early Stage Parkinson's Disease and Advanced Stage Parkinson's Disease. Pardoprunox is a partial dopamine D2 agonist and noradrenergic agonist with... Volasertib Volasertib has been used in trials studying the treatment of Leukemia, Neoplasms, Leukemia, Myeloid, Acute, Myelodysplastic Syndromes, and Leukemia, Monocytic, Acute, among others. Vabicaserin Vabicaserin has been used in trials studying the health services research and treatment of Schizophrenia. Tetrahydropalmatine Tetrahydropalmatine is under investigation in clinical trial NCT02118610 (Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity). Entospletinib Entospletinib has been used in trials studying the treatment of Oncology, Follicular Lymphoma, B-cell Malignancies, Mantle Cell Lymphoma, and Non-Hodgkin Lymphoma, among others. Dianicline Dianicline has been used in trials studying the treatment of Smoking, Smoking Cessation, and Tobacco Use Cessation. Gepotidacin Gepotidacin has been used in trials studying the treatment of Gonorrhea, Infections, Bacterial, and Infections, Respiratory Tract. S-3304 S-3304 has been used in trials studying the treatment of Lung Cancer, Solid Tumors, Non Small Cell Lung Cancer, Stage IIIB Non Small Cell Lung Cancer, and Stage IIIA Non... Napabucasin Napabucasin has been investigated for the treatment of Colorectal Carcinoma. Presatovir Presatovir has been used in trials studying the treatment of RSV Infection, Respiratory Syncytial Virus (RSV), Respiratory Syncytial Virus Infections, and Respiratory Syncytial Virus (RSV) Infections. Veledimex Veledimex has been used in trials studying the treatment of Glioblastoma Multiforme, Metastatic Breast Cancer, and Anaplastic Oligoastrocytoma. SRT-2104 SRT2104 has been investigated for the basic science and treatment of Sepsis, PSORIASIS, Atrophy, Muscular, and Diabetes Mellitus, Type 2. Faropenem Faropenem has been used in trials studying the treatment of Tuberculosis, Pulmonary Tuberculosis, and Community Acquired Pneumonia. Obatoclax Obatoclax has been used in trials studying the treatment of AML, Leukemia, Myelofibrosis, Hodgkin's Lymphoma, and Mantle-Cell Lymphoma, among others. AZD-6280 AZD6280 has been used in trials studying the basic science of Anxiety. Beclabuvir Beclabuvir has been used in trials studying the treatment of Hepatitis C, Chronic. Cerlapirdine Cerlapirdine has been investigated for the treatment of Alzheimer Disease. Iguratimod Iguratimod is under investigation in Rheumatoid Arthritis. BMS-214662 BMS-214662 has been used in trials studying the treatment of Childhood Myelodysplastic Syndromes, Refractory Anemia With Excess Blasts, Recurrent Adult Acute Myeloid Leukemia, Relapsing Chronic Myelogenous Leukemia, and Adult Acute... GDC-0810 ARN-810 has been used in trials studying the basic science and treatment of Breast Cancer. CRS-3123 CRS3123 has been used in trials studying the treatment of Clostridial Infection and Clostridium Difficile Colitis. Ecopipam Ecopipam has been used in trials studying the treatment of Tourette's Syndrome, Lesch-Nyhan Disease, Pathological Gambling, and Self-injurious Behavior. AZD-5423 AZD5423 has been used in trials studying the basic science and treatment of Asthma, Bioavailability and AUC, and Chronic Obstructive Pulmonary Disease (COPD). Piromelatine Piromelatine has been used in trials studying the treatment of Alzheimer's Disease. Motolimod Motolimod has been used in trials studying the treatment of Lymphoma, Tongue Cancer, Ovarian Cancer, Adult Solid Neoplasm, and Fallopian Tube Cancer, among others. Cipargamin Cipargamin has been used in trials studying the treatment of Malaria, Cure Rate, and Plasmodium Falciparum Malaria. GI-181771X Gski181771 X is under investigation in clinical trial NCT00600743 (Effect of a CCK-1R Agonist on Food Intake in Humans). Benzbromarone A uricosuric agent which is taken daily for the prevention of gout flares. Netazepide Netazepide has been used in trials studying the prevention and treatment of Dyspepsia, Hypergastrinaemia, Barrett's Esophagus, ECL-cell Hyperplasia, and Rebound Hyperacidity, among others. BIIB021 BIIB021 has been investigated for the treatment of Tumors and Lymphoma. AZD-3839 AZD3839 has been used in trials studying the basic science of Safety, Tolerability, Alzheimer's Disease, and Blood Concentration. Indirubin Indirubin is under investigation in clinical trial NCT01735864 (Dosage Determination Trial for Indigo Naturalis Extract in Oil Ointment). Merestinib Merestinib has been used in trials studying the treatment of Cancer, Solid Tumor, Advanced cancer, ColoRectal Cancer, and Metastatic Cancer, among others. Zamicastat Zamicastat has been used in trials studying the treatment of Hypertension and Chronic Heart Failure. Fanapanel Fanapanel has been investigated for the treatment of Visual Acuity. Voxtalisib Voxtalisib has been used in trials studying the treatment of Cancer, Melanoma, Lymphoma, Glioblastoma, and Breast Cancer, among others. Galeterone Galeterone has been used in trials studying the treatment of Prostate Cancer. Fasiglifam Fasiglifam has been used in trials studying the treatment of Chronic Kidney Disease, Type 2 Diabetes Mellitus, and Diabetes Mellitus, Type 2. E-7820 E7820 has been investigated for the treatment of Colon Cancer and Rectal Cancer. Toreforant Toreforant has been used in trials studying the treatment of Asthma, Psoriasis, Hepatic Impairment, and Rheumatoid Arthritis. Lobucavir Lobucavir has been used in trials studying the treatment of HIV Infections and Cytomegalovirus Infections. SAR-405838 SAR405838 has been used in trials studying the treatment of Neoplasm Malignant. LY-2886721 LY2886721 has been used in trials studying the basic science of Alzheimer's Disease. AEE-788 AEE788 has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors. Setipiprant Setipiprant has been investigated for the treatment of Seasonal Allergic Rhinitis. Abexinostat Abexinostat has been used in trials studying the treatment of Sarcoma, Lymphoma, Leukemia, Lymphocytic, and Hodgkin Disease, among others. It is a novel, broad-spectrum hydroxamic acid-based inhibitor of histone deacetylase... Decernotinib Decernotinib has been used in trials studying the treatment of Drug Interactions and Rheumatoid Arthritis. LY-295501 ILX-295501 has been used in trials studying the treatment of Ovarian Cancer, Metastatic Cancer, Fallopian Tube Cancer, and Primary Peritoneal Cavity Cancer. Ronopterin Ronopterin has been used in trials studying the treatment of Traumatic Brain Injury. Indiplon Indiplon has been used in trials studying the treatment of Insomnia and Depression. BMS-911543 BMS-911543 has been used in trials studying the treatment of Cancer. PF-477736 PF-00477736 has been used in trials studying the treatment of Neoplasms. Zelavespib Zelavespib (PU-H71) has been used in trials studying the treatment of LYMPHOMA, Solid Tumors, Metastatic Solid Tumor, and Myeloproliferative Neoplasms (MPN). Nelivaptan Nelivaptan has been used in trials studying the treatment of Anxiety Disorders, Depressive Disorder, and Major Depressive Disorder. AFN-1252 AFN-1252 has been used in trials studying the treatment of Cellulitis, Burn Infection, Wound Infection, Cutaneous Abscess, and Skin and Subcutaneous Tissue Bacterial Infections. SJ-733 SJ-733 has been used in trials studying Malaria. Samatasvir Samatasvir has been used in trials studying the treatment of Hepatitis C, Chronic, Chronic Hepatitis C Virus, and Chronic Hepatitis C Infection. Emapunil Emapunil has been used in trials studying the basic science and diagnostic of Baseline, Blocking Receptor Binding, and Neurodegenerative Disorders. Icaritin Icaritin has been used in trials studying the treatment of Solid Tumors, Metastatic Breast Cancer, and Hepatocellular Carcinoma (HCC). Vesatolimod Vesatolimod has been used in trials studying the treatment of Hepatitis B and Chronic Hepatitis B. CE-326597 CE-326,597 has been used in trials studying the treatment of Obesity. Nerispirdine Nerispirdine has been used in trials studying the treatment of Neuritis, Optic Nerve, and Multiple Sclerosis. Turofexorate isopropyl Fxr 450 is under investigation in clinical trial NCT00509756 (Study Evaluating Turofexorate isopropyl in Healthy Japanese Men). RO-5028442 RO5028442 has been used in trials studying Autistic Disorder. Felcisetrag Felcisetrag (TD-8954) has been used in trials studying the treatment of Enteral Feeding Intolerance and Gastrointestinal Motility Disorder. Bindarit Bindarit has been used in trials studying the prevention and treatment of Coronary Restenosis and Diabetic Nephropathy. CGI-1842 JI-101 has been used in trials studying the treatment of Cancer, Colon Cancer, Neuroendocrine, Ovarian Cancer, and Advanced Solid Tumors. Butylphthalide Butylphthalide has been used in trials studying the prevention of Restenosis. TAK-901 TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among others. Rabacfosadine Rabacfosadine has been used in trials studying the treatment of Multiple Myeloma, Non-Hodgkin's Lymphoma, and Chronic Lymphocytic Leukemia. Laniquidar Laniquidar has been used in trials studying the treatment of Breast Cancer. Palomid 529 Palomid 529 has been used in trials studying the treatment of Age-Related Macular Degeneration. Tecarfarin Tecarfarin has been used in trials studying the prevention of Thrombosis and Thromboembolism. Cebranopadol Cebranopadol has been used in trials studying the treatment of Pain, Neoplasms, and Chronic Pain. Intoplicine Intoplicine has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific. Mavatrep Mavatrep has been used in trials studying the treatment of Osteoarthritis, Knee. Indole-3-carbinol Indole 3 Carbinol is under investigation in clinical trial NCT00033345 (Indole-3-Carbinol in Preventing Breast Cancer in Nonsmoking Women Who Are at High Risk For Breast Cancer). Ezutromid Ezutromid has been investigated for the treatment of Muscular Dystrophy, Duchenne. DEBIO-1347 Ch5183284 has been used in trials studying the treatment of Solid Tumours. Pinometostat Pinometostat has been used in trials studying the treatment of Leukemia, Acute Leukemias, Acute Myeloid Leukemia, Myelodysplastic Syndrome, and Acute Lymphocytic Leukemia, among others. Chlorsulfaquinoxaline Chlorsulfaquinoxaline has been used in trials studying the treatment of Lung Cancer and Colorectal Cancer. Crolibulin Crolibulin has been used in trials studying the treatment of Solid Tumor and Anaplastic Thyroid Cancer. Lerisetron Lerisetron has been used in trials studying the supportive care of Nausea and Vomiting and Testicular Germ Cell Tumor. VS-5584 VS-5584 has been used in trials studying the treatment of Lymphoma, Metastatic Cancer, and Non Hematologic Cancers. PCI-27483 PCI-27483 has been used in trials studying the treatment of Pancreatic Cancer, Ductal Adrenocarcinoma, and Exocrine Pancreatic Cancer. Mavoglurant Mavoglurant has been used in trials studying the treatment of Patient Diagnosed With OCD and and Resistant to SSRI Treatment (Failed SSRI Over 12 Weeks at Appropriate Doses). Carbendazim Carbendazim has been used in trials studying the treatment of Lymphoma and Unspecified Adult Solid Tumor, Protocol Specific. Rovalpituzumab tesirine Rovalpituzumab Tesirine has been used in trials studying the treatment of GLIOBLASTOMA, Malignant Melanoma, Other Solid Tumors, Small Cell Lung Cancer, and Medullary Thyroid Cancer, among others. Henatinib Henatinib has been used in trials studying the treatment of Advanced Solid Cancer. LY-2874455 LY2874455 has been used in trials studying the treatment of Advanced Cancer. AG-24322 AG-024322 has been used in trials studying the treatment of Neoplasms and Lymphoma, Non-Hodgkin. Odalasvir Odalasvir has been used in trials studying the treatment of Hepatitis C, Chronic and Chronic Hepatitis C Infection. Fenoverine A phenothiazine based anti-spasmodic agent indicated in the treatment of irritable bowel syndrome. PF-03814735 PF-03814735 has been used in trials studying the treatment of Solid Tumors. MLN8054 MLN8054 has been used in trials studying the treatment of Colon Neoplasm, Breast Neoplasm, Bladder Neoplasm, Pancreatic Neoplasm, and Advanced Malignancies. Roluperidone Roluperidone has been used in trials studying the treatment of Schizophrenia. Trabodenoson Trabodenoson has been used in trials studying the treatment of Ocular Hypertension (OHT) and Primary Open-Angle Glaucoma (POAG). BMS-986115 BMS-986115 has been used in trials studying the treatment of Various Advanced Cancer. Ripasudil A rho kinase inhibitor indicated to treat ocular hypertension and open-angle glaucoma. Daidzein Not Annotated Cloridarol Cloridarol is an experimental medication in the treatment of heart disease, which acts through vasodilation. It was studied for the treatment of coronary insufficiency in Italy in the 1970s . Epicillin Not Annotated Ormeloxifene A selective estrogen receptor modulator used as a non-hormonal, non-steroidal oral contraceptive. Flunoxaprofen Not Annotated Tetrazepam Not Annotated Efloxate Not Annotated Pinazepam A benzodiazepine indicated in the treatment of anxiety and severe insomnia. Mebutizide Not Annotated Tioclomarol Not Annotated Oxetorone Not Annotated Ciclobendazole Not Annotated Nalfurafine Not Annotated Dimefline Not Annotated Pranoprofen A topical anti-inflammatory agent used for the treatment of non-infectious inflammatory conditions such as blepharitis and conjunctivitis. Pranoprofen ophthalmic solution may also be used post-operatively to manage inflammation. Carumonam Not Annotated Thiopropazate Not Annotated Chlormidazole Not Annotated Loprazolam Loprazolam is an imidazobenzodiazepine with anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. It is indicated for the short-term treatment of insomnia including difficulty in falling asleep and/or frequent... Ethacizine Not Annotated Mosapramine Not Annotated Quinisocaine Not Annotated Penamecillin Not Annotated Dixyrazine Not Annotated Linopirdine Not Annotated Mebhydrolin An antihistamine indicated in the treatment of allergies. Dimemorfan Not Annotated Oxomemazine A phenothiazine derivative antihistamine indicated in the treatment of allergies. Caroverine A calcium channel blocker indicated in the treatment of smooth muscle spasms, alcohol and drug withdrawal, and tinnitus. Metampicillin Metampicillin is a penicillin antibiotic prepared by the reaction of ampicillin with formaldehyde. It is hydrolysed in aqueous solution to form ampicillin. Hydrolysis is rapid under acid conditions like the... Doxefazepam Not Annotated Adefovir Not Annotated Volixibat Volixibat is an investigational drug that has not been approved for use in any conditions. Candesartan An angiotensin-receptor blocker indicated in the treatment of hypertension. Relcovaptan Not Annotated MRK-409 MRK-409 is a GABA-A receptor agonist . AZD-7325 AZD7325 is a high affinity, selective modulator of the GABAA receptor system. Englitazone Englitazone is a hypoglycemic agent. Tetrandrine Not Annotated HM-30181 Not Annotated Benazeprilat Not Annotated Loxicodegol Loxicodegol was developed as an opioid analgesic with low abuse potential for use in treating chronic pain . An application has been filed for FDA approval of Loxicodegol for use... Trandolaprilat The active metabolite of the prodrug Trandolapril. Perindoprilat The active metabolite of the prodrug Perindopril. CPI-1205 Potent and selective histone methyltransferase EZH2 inhibitor. Citrus bioflavonoids Not Annotated Cinazepam Not Annotated Clonazolam Not Annotated Pyrazolam Not Annotated Queuine Current and on-going research suggests queuine is a natural biochemical compound that can be found endogenously in the human body and plays an essential role in the generation of other... Etrasimod Etrasimod is under investigation in clinical trial NCT03945188 (Etrasimod Versus Placebo for the Treatment of Moderately to Severely Active Ulcerative Colitis). Lifirafenib Lifirafenib is under investigation in clinical trial NCT03641586 (The Study of BGB-283 in Chinese Subjects With Local Advanced or Metastatic Malignant Solid Tumor). GDC-0425 GDC-0425 is under investigation in clinical trial NCT01359696 (A Study Evaluating the Safety, Tolerability, and Pharmacokinetics of GDC-0425 Administered With and Without Gemcitabine in Patients With Refractory Solid Tumors or... ONO-2952 ONO-2952 is under investigation in clinical trial NCT01887002 (Study to Evaluate the Effects of ONO-2952 on Pain Perception Produced by Rectal Distention in Female Subjects With Diarrhea-Predominant Irritable Bowel Syndrome... SB-649868 SB-649868 is under investigation in clinical trial NCT01030939 (Study to Investigate Safety, Tolerability, Pharmacokinetics and Cardiac Function After Repeat Doses of SB-649868 in Healthy-volunteers). Balovaptan Balovaptan is under investigation in clinical trial NCT01793441 (A Study of RG7314 to Investigate Efficacy and Safety in Individuals With Autism Spectrum Disorders (ASD)). Deleobuvir Deleobuvir is under investigation in clinical trial NCT01983566 (Effect of Food and Increased Gastric pH Value on Bioavailability of a Single Dose of BI 207127 in Healthy Caucasian and Japanese... Liafensine Liafensine is under investigation in clinical trial NCT00892840 (Multiple-Ascending Dose Study). Lorecivivint Lorecivivint is under investigation in clinical trial NCT03246399 (A Study of the Safety, Tolerability, and Pharmacokinetics of SM04690 Injectable Suspension Following Single Intradiscal Injection in Subjects With Degenerative Disc Disease). Galicaftor Galicaftor is under investigation in clinical trial NCT03540524 (A Study Looking at the Safety, Tolerability and Efficacy of the Combination of the Study Drugs GLPG2451 and GLPG2222 With or Without... Rovafovir etalafenamide Rovafovir etalafenamide is under investigation in clinical trial NCT03472326 (Efficacy of GS-9131 Functional Monotherapy in HIV-1-Infected Adults Failing a Nucleos(t)Ide Reverse Transcriptase Inhibitor-Containing Regimen). Ceralasertib Ceralasertib is under investigation in clinical trial NCT03682289 (Phase II Trial of AZD6738 Alone and in Combination With Olaparib). Tenofovir exalidex Tenofovir exalidex is under investigation in clinical trial NCT01080820 (A Safety, Tolerability and Pharmacokinetic Study of a Single Dose of CMX157 in Healthy Volunteers). Serabelisib Serabelisib is under investigation in clinical trial NCT02625259 (A Study to Evaluate the Relative Bioavailability, Effect of Food, and Gastric Potential Hydrogen (pH) Modification on the Pharmacokinetics of TAK-117 (MLN1117)... Etirinotecan pegol Etirinotecan pegol is under investigation in clinical trial NCT01663012 (Phase II NKTR-102 In Bevacizumab-Resistant High Grade Glioma). Relacorilant Relacorilant is under investigation in clinical trial NCT02804750 (Study to Evaluate CORT125134 in Patients With Cushing's Syndrome). PF-04937319 PF-04937319 is under investigation in clinical trial NCT01513928 (A Study To Compare The Pharmacokinetics Of Different Formulations Of PF-04937319 In Healthy Subjects). BMS-791826 BMS-791826 is under investigation in clinical trial NCT03198013 (A Study of Pharmacokinetics (PK) and Pharmacodynamics (PD) in Relation to Prednisolone in Healthy Males). AZD-8186 AZD-8186 is under investigation in clinical trial NCT03218826 (PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot Be... Flortaucipir Flortaucipir is under investigation in clinical trial NCT03507257 (Longitudinal Early-onset Alzheimer's Disease Study Protocol). ITI-214 ITI-214 is under investigation in clinical trial NCT03489772 (Study of ITI-214 in Healthy Volunteers to Determine CNS Engagement). TAS-117 TAS-117 is under investigation in clinical trial NCT03017521 (K-BASKET, TAS-117, PI3K/AKT Gene Aberration). ABT-639 ABT-639 is under investigation in clinical trial NCT01345045 (A Multicenter Study Comparing the Analgesic Effects and Safety of ABT-639 Compared to Placebo in Subjects With Diabetic Neuropathic Pain). Surufatinib Surufatinib is under investigation in clinical trial NCT02588170 (Phase III Study of Surufatinib in Treating Advanced Extrapancreatic Neuroendocrine Tumors). GSK-239512 GSK-239512 is under investigation in clinical trial NCT00474513 (An Imaging Study to Investigate the Distribution of GSK239512 in the Brain.). AZD-9496 AZD-9496 is under investigation in clinical trial NCT02248090 (AZD9496 First Time in Patients Ascending Dose Study). PF-06650833 PF-06650833 is under investigation in clinical trial NCT02609139 (Study to Evaluate Pharmacokinetics of A Modified Release Formulation of PF-06650833 in Healthy Subjects). Tinostamustine Tinostamustine is under investigation in clinical trial NCT03452930 (Tinostamustine With or Without Radiation Therapy in Treating Patients With Newly Diagnosed MGMT-Unmethylated Glioblastoma). Voruciclib Voruciclib is under investigation in clinical trial NCT03547115 (A Phase 1 Study of Voruciclib in Subjects With B-Cell Malignancies or AML). H3B-6527 H3B-6527 is under investigation in clinical trial NCT03424577 (A Study to Evaluate the Food-Effect of H3B-6527). Birabresib Birabresib is under investigation in clinical trial NCT02698176 (A Dose Exploration Study With MK-8628 in Participants With Selected Advanced Solid Tumors (MK-8628-006)). Pemafibrate Pemafibrate is under investigation in clinical trial NCT03350165 (A Study of Pemafibrate in Patients With Nonalcoholic Fatty Liver Disease (NAFLD)). PF-06260414 PF-06260414 is under investigation in clinical trial NCT02070939 (Study To Evaluate Safety And Tolerability Of Single And Multiple Ascending Doses Of PF- 06260414 In Healthy Western And Japanese Male Subjects). Lisavanbulin Lisavanbulin is under investigation in clinical trial NCT02895360 (Phase 1/2a Study of BAL101553 as 48-hour Infusions in Patients With Advanced Solid Tumors or Recurrent Glioblastoma). 2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide-a 2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide-a is under investigation in clinical trial NCT01668823 (Photodynamic Therapy in Treating Patients With Lung Cancer). Vorolanib Vorolanib is under investigation in clinical trial NCT03904719 (CM082 and JS001 in Patients With Advanced Small-cell Lung Cancer (SCLC)). Avutometinib Avutometinib (RO-5126766 free base) is under investigation in clinical trial NCT03875820 (Phase I Trial of VS-6063 and RO5126766.). Milademetan Milademetan is under investigation in clinical trial NCT02319369 (Safety, Tolerability and Pharmacokinetics of Milademetan Alone and With 5-Azacitidine (AZA) in Acute Myelogenous Leukemia (AML) or High-Risk Myelodysplastic Syndrome (MDS)). Afabicin Afabicin is under investigation in clinical trial NCT03723551 (Study to Assess Safety, Tolerability and Efficacy of Afabicin in The Treatment of Participants With Bone or Joint Infection Due to Staphylococcus). Etamicastat Etamicastat is under investigation in clinical trial NCT02840565 (Tolerability, Pharmacokinetics and Pharmacodynamics of Six Multiple Rising Dose Regimens of BIA 5-453). SB-1578 SB-1578 is under investigation in clinical trial NCT01235871 (A Single and Multiple-Dose Study of SB1578). Tenalisib Tenalisib is under investigation in clinical trial NCT03711604 (Compassionate Use Study of Tenalisib (RP6530)). Ridinilazole Ridinilazole is under investigation in clinical trial NCT02092935 (A Study of SMT19969 Compared With Vancomycin for the Treatment of Clostridium Difficile-Associated Diarrhoea (CDAD)). AZD-1386 AZD-1386 is under investigation in clinical trial NCT00945178 (Double-blind Placebo-controlled 2-part Study Assessing the Safety, Tolerability and PK of AZD1386 in Healthy Volunteers). GSK-945237 GSK-945237 is under investigation in clinical trial NCT01039610 (A Single Center Four Part Study in Healthy Adult Subjects to Evaluate: the Safety, Tolerability and Pharmacokinetics of a Single Oral Dose... Branebrutinib Branebrutinib is under investigation in clinical trial NCT02705989 (Safety, Tolerability and Relative Bioavailability Study of BMS-986195 in Healthy Subjects). Xanthohumol Xanthohumol is under investigation in clinical trial NCT01367431 (Xanthohumol and Metabolic Syndrome). Danicopan Danicopan is under investigation in clinical trial NCT03459443 (A Proof of Concept Study for a 12 Month Treatment in Patients With C3 Glomerulopathy (C3G) or Immune-Complex Membranoproliferative Glomerulonephritis (IC-MPGN)). Navoximod Navoximod is under investigation in clinical trial NCT02048709 (Indoleamine 2,3-Dioxygenase (IDO) Inhibitor in Advanced Solid Tumors). Urolithin A Urolithin A is a metabolite of ellagic acid. It has been demonstrated to stimulate mitophagy and improve muscle health in old animals and in preclinical models of aging. Mexazolam A benzodiazepine indicated to treat anxiety with or without psychoneurotic conditions. Oxazolam Not Annotated Rocaglamide Rocaglamide, also referred to as rocaglamide-A, is the eponymous member of a class of anti-cancer phytochemicals known as rocaglamides. Rocaglamides are secondary metabolites of the plant genus Aglaia, and extracts... Pradefovir Pradefovir is a prodrug of adefovir. Chrysin Not Annotated Brensocatib Brensocatib is under investigation in clinical trial NCT03218917 (Assessment of INS1007 in Subjects With Non-cystic Fibrosis Bronchiectasis). Dihydromyricetin Dihydromyricetin is under investigation in clinical trial NCT03606694 (Effect of Dihydromirycetin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Type 2 Diabetes Mellitus). Valomaciclovir stearate Valomaciclovir stearate is under investigation in clinical trial NCT00831103 (A Phase 2b Trial of EPB-348 for the Treatment of Herpes Zoster). Ravidasvir Ravidasvir is under investigation in clinical trial NCT02961426 (Sofosbuvir Plus Ravidasvir for the Treatment of HCV Chronic Infection). Fezolinetant A non-hormonal drug used to treat moderate to severe vasomotor symptoms due to menopause Besifovir Not Annotated Rilematovir Rilematovir is under investigation in clinical trial NCT04056611 (Effects of JNJ-53718678 in Adult and Adolescent Participants Who Had a Hematopoietic Stem Cell Transplantation and Who Are Infected With Respiratory Syncytial... Lenacapavir A first-in-class capsid inhibitor being investigated for use in HIV-1 treatment. Sisunatovir Sisunatovir is under investigation in clinical trial NCT04267822 (Study of RV521 in the Treatment of Adult Subjects Who Have Undergone HCT With an URTI With RSV). Zavegepant A calcitonin gene-related peptide receptor antagonist indicated for the acute treatment of migraine with or without aura. Clemizole Not Annotated Azapentacene Not Annotated Tripamide Not Annotated Parathiazine Not Annotated Celivarone Celivarone is under investigation in clinical trial NCT00233441 (Placebo Controlled Double-blind Dose Ranging Study of the Efficacy and Safety of SSR149744C 50, 100, 200 or 300 Mg OD With Amiodarone... GSK2798745 GSK2798745 is under investigation in clinical trial NCT03372603 (A Study to Assess the Effectiveness and Side Effects of GSK2798745 in Participants With Chronic Cough). PLX8394 PLX8394 is under investigation in clinical trial NCT02428712 (A Study of PLX8394 as a Single Agent in Patients With Advanced Unresectable Solid Tumors). AK106-001616 AK106-001616 is under investigation in clinical trial NCT01285752 (A Study of AK106-001616 in Patients With Rheumatoid Arthritis (RA)). Ro 24-7429 Ro 24-7429 is under investigation in clinical trial NCT00002314 (A Study of Ro 24-7429 in Patients With Hiv-related Kaposi's Sarcoma). 2X-121 2X-121 is under investigation in clinical trial NCT03562832 (Investigation of Anti-tumour Effect and Tolerability of the PARP Inhibitor 2X-121 in Patients With Metastatic Breast Cancer Selected by the 2X-121 DRP). AZD8529 AZD8529 is under investigation in clinical trial NCT00921804 (Study to Assess the Efficacy, Safety, and Tolerability of AZD8529 in Adult Schizophrenia Patients). LY2828360 LY2828360 is under investigation in clinical trial NCT01319929 (A Study of LY2828360 in Patients With Osteoarthritic Knee Pain). GSK2245035 GSK2245035 is under investigation in clinical trial NCT02833974 (Effect of the GSK2245035 on the Allergen-induced Asthmatic Response). Acrizanib Acrizanib is under investigation in clinical trial NCT02355028 (LHA510 Proof-of-concept Study as a Maintenance Therapy for Patients With Wet Age-related Macular Degeneration). Alflutinib Alflutinib is under investigation in clinical trial NCT03452592 (Efficacy and Safety of Alflutinib in Locally Advanced or Metastatic Non-small Cell Lung Cancer Patients With T790M). BI 2536 BI 2536 is under investigation in clinical trial NCT00376623 (Efficacy and Safety of BI 2536 in Advanced or Metastatic Non Small Cell Lung Cancer). Ensifentrine Ensifentrine is under investigation in clinical trial NCT04535986 (A Phase 3 Clinical Trial to Evaluate the Safety and Efficacy of Ensifentrine in Patients With COPD). Loncastuximab tesirine An antibody-drug conjugate used for the treatment of relapsed and refractory B-cell lymphomas. Molibresib Molibresib is under investigation in clinical trial NCT01943851 (A Dose Escalation Study to Investigate the Safety, Pharmacokinetics (PK), Pharmacodynamics (PD) and Clinical Activity of GSK525762 in Subjects With Relapsed, Refractory... CC-11050 CC-11050 is under investigation in clinical trial NCT01300208 (To Evaluate the Preliminary Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of CC-11050 in Subjects With Discoid Lupus Erythematosus and Subacute Cutaneous Lupus... Nazartinib Nazartinib is under investigation in clinical trial NCT03529084 (Phase III Study of Nazartinib (EGF816) Versus Erlotinib/gefitinib in First-line Locally Advanced / Metastatic NSCLC With EGFR Activating Mutations). Nemiralisib Nemiralisib is under investigation in clinical trial NCT03345407 (Dose Finding Study of Nemiralisib (GSK2269557) in Subjects With an Acute Moderate or Severe Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)). Odevixibat An ileal sodium/bile acid cotransporter inhibitor indicated in the treatment of pruritus in patients with progressive familial intrahepatic cholestasis. Olodanrigan Olodanrigan is under investigation in clinical trial NCT03297294 (Safety and Efficacy of EMA401 in Patients With Painful Diabetic Neuropathy (PDN)). Pegcantratinib Pegcantratinib is under investigation in clinical trial NCT03448081 (Safety, Tolerability and Efficacy of SNA-120 for Treatment of Pruritus and Psoriasis in Subjects Treated With Calcipotriene). Pexmetinib Pexmetinib is under investigation in clinical trial NCT04074967 (Study of ARRY-614 Plus Either Nivolumab or Ipilimumab). IPI-549 IPI-549 is under investigation in clinical trial NCT03795610 (Window of Opportunity Study of IPI-549 in Patients With Locally Advanced HPV+ and HPV- Head and Neck Squamous Cell Carcinoma). Sepiapterin Sepiapterin is under investigation in clinical trial NCT03519711 (A Study of CNSA-001 in Primary Tetrahydrobiopterin (BH4) Deficient Participants With Hyperphenylalaninemia). Velsecorat Velsecorat is under investigation in clinical trial NCT02479412 (A Multiple Dosing (14 Days) Study to Assess Efficacy and Safety of Three Dose Levels of AZD7594, Given Once Daily by Inhalation,... PF-07304814 PF-07304814 is a small molecule prodrug that targets the 3CLpro protease (Mpro), which is used by viruses like SARS-CoV-2 to assemble and multiply . Once administered through intravenous infusion, the... KW-2450 free base Not Annotated Almonertinib Almonertinib is a third-generation EGFR tyrosine kinase inhibitor targeting EGFR-sensitizing and T790M resistance mutations.[A231859, A231864, A231869] It is being investigated against advanced or metastatic EGFR-mutated non-small cell lung cancer (NSCLC). Zotiraciclib Zotiraciclib is under investigation in clinical trial NCT02942264 (Zotiraciclib (TG02) Plus Dose-dense or Metronomic Temozolomide Followed by Randomized Phase II Trial of Zotiraciclib (TG02) Plus Temozolomide Versus Temozolomide Alone in... MK-886 MK-886 is an experimental inhibitor of leukotriene synthesis. Methyclothiazide A diuretic drug used to treat hypertension and edema caused by heart failure, renal conditions, treatment with corticosteroids, and estrogen therapy. Ethoxzolamide For use in the treatment of duodenal ulcers, as a diuretic, and in the treatment of glaucoma, and may also be useful in the treatment of seizures associated with epilepsy. Levallorphan For the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids. Porfimer sodium A hematoporphyrin derivative used to treat esophageal cancer, endobronchial cancer, and high grade dysplasia in Barrett's Esophagus. Benzquinamide Used to prevent and treat nausea and vomiting associated with anesthesia and surgery, administered intramuscularly or intravenously. Nalbuphine An opioid agonist-antagonist used to treat pain, for pre and postoperative analgesia, and for analgesia in labor and delivery. Ergoloid mesylate A nootropic with an unknown mechanism of action indicated in individuals over sixty who manifest signs and symptoms of an idiopathic decline in mental capacity. Quinacrine For the treatment of giardiasis and cutaneous leishmaniasis and the management of malignant effusions. Amdinocillin Used in the treatment of urinary tract infections caused by some strains of E. coli and klebsiella and enterobacter species. Used mainly against Gram negative organisms. Mitiglinide For the treatment of type 2 diabetes. Mibefradil For the treatment of angina and high blood pressure. Temafloxacin For the treatment of lower respiratory tract infections, genital and urinary infections like prostatitis, and skin infections. Theobromine theobromine is used as a vasodilator, a diuretic, and heart stimulant. And similar to caffeine, it may be useful in management of fatigue and orthostatic hypotension. Cefacetrile A broad-spectrum first-generation cephalosporin used for the treatment of susceptible bacterial infections. Almitrine For the treatment of chronic obstructive pulmonary disease. 5-Methoxy-N,N-diisopropyltryptamine 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) is a tryptamine derivative and shares many similarities with schedule I tryptamine hallucinogens such as alpha-ethyltryptamine, N,N-dimethyltryptamine, N,N-diethyltryptamine, bufotenine, psilocybin and psilocin. Since 1999, there has been a... Dihydroetorphine Not Available Ethylmorphine An opioid analgesic and antitussive agent used to reduce coughs caused by colds and lung infections in combination with codeine. Etorphine Etorphine is only available for its use in veterinary. This main usage is related to the immobilization of large mammals. Desomorphine Not Available Drotebanol Not Available Diprenorphine Diprenorphine is indicated to reverse the effects of powerful opioids including etorphine and carfentanil, often used for tranquilizing large animals. This drug is not approved for use in humans. Dihydromorphine Dihydromorphine is an opioid analgesic used for moderate to severe pain relief. Acepromazine Acepromazine was first used in humans in the 1950s as an antipsychotic agent. It is now rarely used in humans. Acepromazine is frequently used in animals as a sedative and... Genistein Currently Genistein is being studied in clinical trials as a treatment for prostate cancer. (Rp)-cAMPS Not Available Adenosine 3',5'-diphosphate Not Available 5,7-Dichlorokynurenic acid Not Available 7-Hydroxystaurosporine Not Available Guanosine-2'-monophosphate Not Available Coenzyme A Coenzyme A (CoA, CoASH, or HSCoA) is a coenzyme, well known for it's role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric... 8-oxo-dGMP Not Available Phosphoaminophosphonic acid guanylate ester A non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly to G-protein in the... K-252a Not Available Propidium Quaternary ammonium analog of ethidium; an intercalating dye with a specific affinity to certain forms of DNA and, used as diiodide, to separate them in density gradients; also forms fluorescent... Myristoyl-Coa Not Available 2',3'-Dideoxyadenosine triphosphate Not Available Taxifolin Not Available Quinacrine mustard Not Available Protoporphyrin Not Available Cyclic GMP Cyclic guanosine monophosphate (Cyclic GMP) is a guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular... NADPH Not Available 1,10-Phenanthroline Not Available Deoxyinosine Not Available D-threo-neopterin A pteridine derivative present in body fluids; elevated levels result from immune system activation, malignant disease, allograft rejection, and viral infections. (From Stedman, 26th ed) Neopterin also serves as a... Quinaldic Acid Not Available Hydrogenobyrinic acid Not Available 8-hydroxy-2'-deoxyguanosine Not Available Cyclic adenosine monophosphate Cyclic adenosine monophosphate (cAMP, cyclic AMP or 3'-5'-cyclic adenosine monophosphate) is a molecule that is important in many biological processes; it is derived from adenosine triphosphate (ATP). Hexanoyl-CoA Not Available Mesoheme The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins. alpha,beta-Methyleneadenosine 5'-triphosphate Not Available Adenosine Phosphonoacetic Acid Not Available 6-hydroxy-FAD Not Available NU1025 Not Available Pyroquilon Pyroquilon is a commercial blasticide which binds in the naphthol pocket of fungal trihydroxynaphthalene reductase active site. 4-methyl-umbelliferyl-N-acetyl-chitobiose Not Available 9-deazainosine Not Available Siroheme Not Available S-Adenosyl-1,8-Diamino-3-Thiooctane Not Available Guanosine Guanosine is a nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine can be phosphorylated to become GMP (guanosine monophosphate), cGMP (cyclic guanosine monophosphate), GDP... Deacetoxyvinzolidine Not Available Methylthioinosine An analog of inosine with a methylthio group replacing the hydroxyl group in the 6-position. Octanoyl-Coenzyme A Not Available Propanoyl-CoA Not Available Adenosine 5'-[gamma-thio]triphosphate A nucleoside triphosphate analogue that is ATP in which one of the oxygens attached to 3-phosphate group is replaced by sulfur. Acetoacetyl-CoA Not Available Mant-Adp Not Available 3-(2-Benzothiazolylthio)-1-Propanesulfonic Acid Not Available Adenosine 5'-methylenediphosphate Not Available Tubercidin An antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic... Pyrroloquinoline Quinone A pyrrolo-quinoline having two adjacent keto-groups at the 4 and 5 positions and three acidic carboxyl groups. It is a coenzyme of some DEHYDROGENASES. [PubChem] dATP Not Available RWJ-51084 Not Available Isoliquiritigenin Isoliquiritigenin is a precursor to several flavonones in many plants. Cephalosporin C Not Available Guanosine 3'-monophosphate Not Available Ferroheme C Not Available Deoxycytidylyl-3',5'-guanosine Not Available 3-Acetylpyridine Adenine Dinucleotide A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves... 5'-O-(N-(Alanyl)sulfamoyl)adenosine Not Available Diacetyldeuteroheme Not Available Nicotinamide adenine dinucleotide phosphate Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of... Naringenin Not Available Heme D Not Available 7-Methylguanosine Not Available 7-methyl-5'-guanylic acid Not Available 3-Hydroxybutyryl-Coenzyme A Not Available Succinyl-Coenzyme A Not Available Adenosine 5'-phosphosulfate 5'-Adenylic acid, monoanhydride with sulfuric acid. The initial compound formed by the action of ATP sulfurylase on sulfate ions after sulfate uptake. Synonyms: adenosine sulfatophosphate; APS. 5'-Fluoro-5'-Deoxyadenosine Not Available 5'-Guanylylmethylenebisphosphonate Not Available Coproporphyrin I Not Available Epigallocatechin Not Available Rhodamine 6G Not Available Coenzyme F420 Not Available Zinc protoporphyrin Not Available Deacetoxycephalosporin C Not Available Clorobiocin Clorobiocin is an aminocoumarin antibiotic, similar to novobiocin and coumermycin A1. Guanosine tetraphosphate Guanosine tetraphosphate is a guanine nucleotide containing four phosphate groups. Two phosphate groups are esterified to the sugar moiety in the 5' position and the other two in the 2'... Coenzyme A persulfide Coenzyme A persulfide is a possible in vivo inhibitor of mammalian short chain acyl-CoA dehydrogenase. (R)-methylmalonyl-CoA Not Available Hypoxanthine Hypoxanthine is a purine and a reaction intermediate in the metabolism of adenosine and in the formation of nucleic acids by the salvage pathway. Isoformononetin Not Available Quercetin A natural flavonoid found in foods and natural supplement products. CGP 4832 Not Available Inosine A nutritional supplement touted to improve athletic performance and a drug used in vitro as a red blood cell rejuvenator for a unit of red blood cells that will be used in a clinical setting. Lumichrome Not Available Adenylosuccinic acid Not Available 7,8-Dihydroneopterin Not Available 4'-Hydroxyflavanone Not Available Nebularine Not Available 2-Fluoroadenosine Not Available 3,4-Dichloroisocoumarin Not Available Coproporphyrinogen III Not Available Malonyl-CoA A coenzyme A derivative which plays a key role in the fatty acid synthesis in the cytoplasmic and microsomal systems. 3-Deazaadenosine Not Available Inosinic Acid Inosine 5'-Monophosphate. A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety. Fleroxacin Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone. Imazaquin Not Available 5-iodotubercidin Not Available Hydroxyfasudil Not Available Lumiflavin Not Available 2-Hydroxyquinoline Not Available Tanaproget Tanaproget (NSP-989) is an investigational non-steroidal progestin. It is a high affinity, high efficacy agonist of the progesterone receptor (PR) with a much more selective binding profile relative to most... 5-methyltetrahydrofolic acid 5-methyltetrahydrofolic acid is a methylated derivate of tetrahydrofolate. It is generated by methylenetetrahydrofolate reductase from 5,10-methylenetetrahydrofolate and used to recycle homocysteine back to methionine by 5-methyltetrahydrofolate-homocysteine methyltransferases (also called methionine... Verdoheme Not Available Oxyphenisatin A laxative that undergoes enterohepatic circulation. It may cause jaundice. Lysergic acid diethylamide Debate continues over the nature and causes of chronic flashbacks. Explanations in terms of LSD physically remaining in the body for months or years after consumption have been discounted by... Methaqualone For the treatment of insomnia, and as a sedative and muscle relaxant. Cediranib For the treatment of liver cancer, advanced non-small cell lung cancer (NSCLC), advanced colorectal cancer (CRC) and other solid tumors. Binodenoson For cardiac pharmacologic stress SPECT imaging, which is used to diagnose coronary artery disease. Isatoribine For the treatment of Hepatitis C. Halofuginone For the treatment of scleroderma, cancer, and restenosis. Lintitript For the treatment of pancreatic cancer and appetite disorders. Olcegepant For the treatment of migraine headaches. Voacamine For the treatment of malaria. Also under investigation for the modulation of multidrug resistance in cancer cells. Elacridar For the treatment of solid tumors. Edotecarin Clinical studies with edotecarin have shown activity in subjects with colorectal cancer, esophageal cancer and other solid tumors. Cilansetron For the treatment of symptoms associated with irritable bowel syndrome. Calanolide A For use in combination treatment of HIV infection (AIDS). Brecanavir For the treatment of HIV-1 infection in combination with other antiretroviral agents. Phenserine For the treatment of Alzheimer's disease (AD). Pagoclone For the potential treatment of panic and anxiety disorders. Sitamaquine Investigated for use/treatment in infectious and parasitic disease (unspecified). Stannsoporfin Investigated for use/treatment in liver disease, metabolic disease, and pediatric indications. Idronoxil Intended for the treatment of various forms of cancer. Rifalazil Investigated for use/treatment in atherosclerosis, bacterial infection, and peripheral vascular disease. Tecadenoson Investigated for use/treatment in arrhythmia and atrial fibrillation. Tipifarnib Investigated for use/treatment in colorectal cancer, leukemia (myeloid), pancreatic cancer, and solid tumors. Lucanthone Intended for use as a radiation sensitizer in the treatment of brain cancer. Lemuteporfin Intended for the treatment of benign prostatic hyperplasia and prostrate disorders. Anatibant Investigated for use/treatment in traumatic brain injuries. CDP323 Investigated for use/treatment in multiple sclerosis. Rilapladib Investigated for use/treatment in atherosclerosis and cardiovascular disorders. Vintafolide Investigated for use/treatment in solid tumors. PTC299 Investigated for use/treatment in cancer/tumors (unspecified) and solid tumors. Elafibranor Investigated for use/treatment in atherosclerosis and diabetes mellitus type 2. Sofalcone Investigated for use/treatment in gastroenteritis and ulcers. Tetrodotoxin For the treatment of chronic and breakthrough pain in advanced cancer patients as well as for the treatment of opioid dependence. LGD2941 For the treatment and prevention of osteoporosis. Motexafin lutetium Investigated for use/treatment in brain cancer, breast cancer, cervical dysplasia/cancer, prostate cancer, cancer/tumors (unspecified), coronary artery disease, macular degeneration, and peripheral vascular disease. CEP-1347 Investigated for use/treatment in asthma and parkinson's disease. GW 468816 Investigated for use/treatment in tobacco dependence. OPC-14523 Investigated for use/treatment in bulimia, depression, and obsessive-compulsive disorders. ORG-34517 Investigated for use/treatment in depression. Motexafin gadolinium Investigated for use/treatment in brain cancer, cancer/tumors (unspecified), lung cancer, and lymphoma (non-hodgkin's). OSI-7904L Investigated for use/treatment in gastric cancer. Tandutinib Investigated for use/treatment in leukemia (myeloid). Technetium Tc-99m ciprofloxacin Investigated for use/treatment in infectious and parasitic disease (unspecified). AMG-131 Investigated for use/treatment in diabetes mellitus type 2. Piclidenoson Investigated for use/treatment in cancer/tumors (unspecified), eye disorders/infections, psoriasis and psoriatic disorders, and rheumatoid arthritis. Can-Fite BioPharma has reported that by targeting the adenosine A3-receptor, CF101 may also be used... Pelitinib Investigated for use/treatment in colorectal cancer and lung cancer. Regrelor Investigated for use/treatment in cardiac surgery, coronary artery disease, thrombosis, and transfusion. Verubulin Investigated for use/treatment in brain cancer, lung cancer, melanoma, and solid tumors. 4'-Methylene-5,8,10-trideazaaminopterin Investigated for use/treatment in inflammatory disorders (unspecified), psoriasis and psoriatic disorders, and rheumatoid arthritis. BL-1020 Investigated for use/treatment in schizophrenia and schizoaffective disorders. Cefilavancin Investigated for use/treatment in bacterial infection, skin infections/disorders, and staph bacterial infections. Tasquinimod Investigated for use/treatment in prostate cancer. Ciluprevir Investigated for use/treatment in hepatitis (viral, C). AEOL-10150 Investigated for use/treatment in amyotrophic lateral sclerosis (ALS). OSI-930 Investigated for use/treatment in solid tumors. Varlitinib Investigated for use/treatment in cancer/tumors (unspecified). AV-412 Investigated for use/treatment in cancer/tumors (unspecified). Garenoxacin Investigated for use/treatment in bacterial infection. Plevitrexed Investigated for use/treatment in pancreatic cancer, solid tumors, gastric cancer, lung cancer, and colorectal cancer. Forodesine Investigated for use/treatment in lymphoma (non-hodgkin's) and leukemia (lymphoid). Ispinesib Investigated for use/treatment in breast cancer, lung cancer, solid tumors, renal cell carcinoma, pediatric indications, ovarian cancer, and head and neck cancer. Zosuquidar Investigated for use/treatment in leukemia (myeloid) and myelodysplastic syndrome. Seliciclib Investigated for use/treatment in breast cancer, lung cancer, lymphoma (unspecified), multiple myeloma, leukemia (lymphoid), and cancer/tumors (unspecified). Atrasentan Investigated for use/treatment in prostate cancer and cancer/tumors (unspecified). Vadimezan Investigated for use/treatment in solid tumors, lung cancer, ovarian cancer, and prostate cancer. Tariquidar Investigated for use/treatment in ovarian cancer, lung cancer, and breast cancer. Torcetrapib Investigated for use/treatment in peripheral vascular disease and hyperlipidemia. Onalespib Investigated for use/treatment in cancer/tumors (unspecified). Elinogrel Investigated for use/treatment in cardiovascular disorders and myocardial infarction. Becatecarin Investigated for use/treatment in cancer/tumors (unspecified), liver cancer, gastric cancer, and leukemia (unspecified). XR5944 Investigated for use/treatment in solid tumors. Morphine glucuronide Investigated for use/treatment in pain (acute or chronic). Talnetant Investigated for use/treatment in schizophrenia and schizoaffective disorders, irritable bowel syndrome (IBS), and chronic obstructive pulmonary disease (COPD). Meclinertant Investigated for use/treatment in colorectal cancer, prostate cancer, schizophrenia and schizoaffective disorders, psychosis, depression, and lung cancer. Lestaurtinib Investigated for use/treatment in pancreatic cancer, prostate cancer, and leukemia (myeloid). Naxifylline Investigated for use/treatment in congestive heart failure. Porfiromycin Investigated for use/treatment in head and neck cancer. Propentofylline Investigated for use/treatment in alzheimer's disease. MLN576 Investigated for use/treatment in solid tumors. Celgosivir Investigated for use/treatment in hepatitis (viral, C). Cetilistat Investigated for use/treatment in obesity. Triphendiol Investigated for use/treatment in cancer/tumors (unspecified). Nemonoxacin Investigated for use/treatment in bacterial infection and pneumonia. Amdoxovir Investigated for use/treatment in HIV infection and acquired immune deficiency syndrome (AIDS) and aids-related infections. Quarfloxin Investigated for use/treatment in leukemia (lymphoid). Rostaporfin Investigated for use/treatment in macular degeneration. Esmirtazapine Investigated for use/treatment in insomnia and sleep disorders. Laquinimod Investigated for use/treatment in multiple sclerosis. Sparteine Sparteine is a plant alkaloid derived from Cytisus scoparius and Lupinus mutabilis which may chelate calcium and magnesium. It is a sodium channel blocker, so it falls in the category... beta-Naphthoflavone β-Naphthoflavone, also known as 5,6-benzoflavone, is a potent agonist of the aryl hydrocarbon receptor and induces cytochromes P450 (CYPs) and uridine 5'-diphospho-glucuronosyltransferases (UGTs). It may be a chemopreventive agent. CHIR-124 CHIR-124 is a potent inhibitor of Chk1 that potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo. Bisphenol A Not Available Lidorestat Not Available Hymecromone A coumarin derivative that lacks anticoagulant properties but possesses choleretic and biliary antispasmodic activity. Carbazole Not Available Apigenin Not Available S-23 An androgen receptor modulator. CP-94707 Not Available PD-168393 PD-168393 is an epidermal growth factor receptor inhibitor. Fisetin Not Available 2-heptyl-4-hydroxyquinoline N-oxide Not Available Harmine Not Available Indoleacetic acid Not Available N-(indole-3-acetyl)-L-aspartic acid Not Available 3-isobutyl-1-methyl-7H-xanthine Not Available Indoxyl sulfate Not Available 5-(2-methylpiperazine-1-sulfonyl)isoquinoline Not Available LGD-2226 An androgen receptor modulator. Fasudil Fasudil has been investigated in Carotid Stenosis. 1-(2-cyclopropylethyl)-3-(1,1-dioxo-2H-1,2,4-benzothiadiazin-3-yl)-6-fluoro-4-hydroxy-2(1H)-quinolinone Not Available Nocodazole Nocodazole is an antineoplastic agent which exerts its effect by depolymerizing microtubules. Mardepodect Not Available Puromycin Puromycin is an antibiotic that prevents bacterial protein translation. It is utilized as a selective agent in laboratory cell cultures. Puromycin is toxic to both prokaryotic and eukaryotic cells, resulting... 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline Potent reversible inhibitor of phenylethanolamine N-methyltransferase. Indoleacetamide Not Available N(6)-dimethylallyladenine Not Available Zopolrestat Not Available Ethyl biscoumacetate Ethyl biscoumacetate is a courmarin that is used as an anticoagulant. It has actions similar to those of Warfarin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p226) Uric acid At present (August 2013), there is no approved indication for uric acid. The potential therapeutic use for uric acid is as an adjunct in acute ischemic stroke. Ellagic acid Ellagic acid is being investigated for use in follicular lymphoma, brain injury in intrauterine growth restricted babies, obese adolescents, and solar lentigines. Aminopterin Prior to its withdrawal, aminopterin was initially used in the treatment of childhood leukemia; specifically to induce remissions. Later, aminopterin was used off-label in the United States to treat psoriasis,... Perospirone For the treatment of schizophrenia and acute cases of bipolar mania. Indoprofen A drug that has analgesic and anti-inflammatory properties. Following reports of adverse reactions including reports of carcinogenicity in animal studies it was withdrawn from the market worldwide. Flumequine Flumequine is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class used to treat bacterial infections. Flubendazole Flubendazole is an anthelmintic that is used to treat worm infection in humans. It is available OTC in Europe. Dimetacrine Dimetacrine is also known as dimethacrine or acripamine. It is marketed under the names Istonil, Istonyl, Linostil, and Miroistonil. Dimetacrine is a tricyclic antidepressant (TCA) with imipramine-like effects used in... Clocapramine Clocapramine is an atypical antipsychotic of the imidobenzyl class which was introduced in Japan in 1974 for the treatment of schizophrenia. In addition to psychosis, clocapramine has also been used... Cefaloridine Cephaloridine or cefaloridine is a first generation semisynthetic cephalosporin. It is derived from cephalosporin C and is a zwitterion at physiological pH. Carbazochrome Indicated for capillary and parenchymal hemorrhage (trauma, tonsillectomy, during surgery), intestinal bleeding, and thrombocytopenic purpura. Cytisine An alkaloid with partial agonist activity at the α4β2 nicotinic acetylcholine receptor used to aid smoking cessation. Cefminox Cefminox (INN) is a second generation cephalosporin antibiotic. It is approved for use in Japan. Etizolam A thienodiazepine derivative used to treat anxiety and insomnia. Pirlindole For the treatment of major depression. It is being studied in the treatment of fibromyalgia pain syndrome. One study determined that the effect of pirlindole on sensorimotor performance while driving... Doxofylline A methylxanthine derivative used in chronic obstructive pulmonary disease, asthma, and bronchospasms. Silibinin A flavonolignan with hepatoprotective effects used to treat toxic liver damage and as an adjunct in the management of chronic conditions such as cirrhosis and hepatitis. Setiptiline For the treatment of depression . Rauwolfia serpentina root Rauwolfia alkaloids are indicated in the treatment of hypertension . Rauwolfia alkaloids have been used for relief of symptoms in agitated psychotic states such as schizophrenia; however, use as antipsychotics... Indocyanine green acid form A diagnostic agent used for the determination of cardiac output, hepatic function and liver blood flow, and for ophthalmic angiography. Zeatin An aminopurine factor in plant extracts that induces cell division. (Grant & Hackh's Chemical Dict, 5th ed) Roquinimex Roquinimex is investigated to be used as a treatment of a number of cancers and autoimmune conditions. As well, roquinimex is researched to be used as adjuvant therapy after bone... Cefroxadine Was used for the treatment of bacterial infections. Buquinolate Not Annotated Cambendazole Not Annotated Cefalonium Not Annotated Coumaphos This drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a... Danofloxacin Danofloxacin is an antibiotic agent from the family of the fluoroquinolones used in veterinary medicine. Decoquinate Decoquinate is used in veterinary to delay the growth and reproduction of coccidian parasites. Enrofloxacin Enrofloxacin is an antibiotic agent from the fluoroquinolone family produced by the Bayer Corporation. Enrofloxacin is approved by the FDA for its veterinary use. Due to the identification of fluoroquinolone-resistant... Fenbendazole Fenbendazole is a benzimidazole that presents a wide spectrum anthelmintic effect. It is used against a number of gastrointestinal parasites including giardia, roundworms, hookworms, whipworms, the Taenia genus of tapeworms,... Haloxon Not Annotated Marbofloxacin Marbofloxacin is a carboxylic acid, part of the third generation of antibiotic fluoroquinolones. It is used in veterinary medicine. A formulation of marbofloxacin combined with clotrimazole and dexamethasone is available... Nequinate Nequinate is an antiprotozoan used as a coccidiostat for poultry and rabbits. Nequinate belongs to the family of Hydroquinolones. These are compounds containing an hydrogenated quinoline bearing a ketone group. Orbifloxacin Orbifloxacin is a fluoroquinolone antibiotic. It is marketed by Schering-Plough Animal Health and approved for certain infections in dogs. Phosmet Phosmet is a phthalimide-derived organophosphate. It is a non-specific insecticide. It is mainly used on apple trees to control codling moths. It is also used on other fruit crops, ornamentals,... Pradofloxacin Pradofloxacin is a 3rd generation fluoroquinolone antibiotic developed by Bayer HealthCare AG, Animal Health GmBH. It was approved by the European Commission in April 2011 for bacterial infections in dogs... Rotenone Rotenone is an isoflavone compound that naturally occurs in the jicama vine plant as well as many Fabaceae plants. It has broad spectrum insecticide and pesticide activity and is also... Ceftiofur Ceftiofur is a third generation cephalosporin antibiotic, first described in 1987, and now used in veterinary medicine. It is marketed by pharmaceutical company Zoetis as Excenel, and is the active... Nalorphine Used to reverse opioid overdose. Sarafloxacin Sarafloxacin is a quinolone antibiotic drug, which was discontinued by its manufacturer, Abbott Laboratories, before receiving approval for use in the US or Canada. Cefovecin Cefovecin is a cephalosporin antibiotic used for the treatment of skin infections in cats and dogs. It is the first single-dose injectable antibiotic for dogs and cats that assures owner... Difloxacin Difloxacin is a synthetic fluoroquinolone used in veterinary. As an antibacterial, it presents a broad bactericidal spectrum and its effects are dependent on its concentration. However, it presents a reduced... Dithiazanine Dithiazanine is a highly potent anthelmintic, introduced in 1959 for the treatment of strongyloid worms and whipworms. However, its use is severely limited due to its toxicity. Dithiazanine iodide was... Metoserpate Not Annotated Propiopromazine Not Annotated Zolazepam Zolazepam is a pyrazolodiazepinone derivative used as an anaesthetic in veterinary medicine. Zolazepam is typically used in combination with the NMDA antagonist tiletamine or the α2 adrenoceptor agonist xylazine. It... Aminacrine A slow-acting germicide effective against bacteria and fungi which is included in drug formulations for its anti-septic properties. Nitrocefin Nitrocefin is a chromogenic cephalosporin substrate used to detect the presence of beta-lactamase enzymes, an important mediator of bacterial antibiotic resistance. While other detection methods exist, such as PCR, nitrocefin... Dactolisib Dactolisib has been used in trials studying the treatment of Cancer, Solid Tumor, Renal Cancer, Breast Cancer, and Cowden Syndrome, among others. Tucatinib A kinase inhibitor used to treat certain types of unresectable/metastatic HER-2 positive breast cancer. QAV-680 QAV680 has been used in trials studying the treatment of Asthma, Allergic Rhinitis, and Seasonal Allergic Rhinitis. Psilocybin Psilocybin has been investigated for the treatment of Anxiety and Stage IV Melanoma. In November, 2019, it was granted Breakthrough Therapy status by the FDA. Equol Equol has been used in trials studying the treatment of Breast Cancer. Pavinetant Pavinetant has been used in trials studying the basic science and treatment of Safety and Schizophrenia. Icotinib Icotinib hydrochloride is a novel epidermal growth factor receptor (EGFR)–tyrosine kinase inhibitor, exhibits encouraging efficacy and tolerability in patients with advanced non-small-cell lung cancer (NSCLC) who failed previous chemotherapy. Barasertib Barasertib has been used in trials studying the treatment of Tumors, Lymphoma, Solid Tumors, Solid Tumours, and Myeloid Leukemia, among others. Pazufloxacin Pazufloxacin is under investigation in clinical trial NCT02592096 (Pazufloxacin Mesilate Ear Drops Clinical Trial Protocol). Danoprevir Danoprevir has been used in trials studying the treatment of Hepatitis C, Chronic. Saracatinib Saracatinib has been investigated for the treatment of Cancer, Osteosarcoma, Ovarian Cancer, Fallopian Tube Cancer, and Primary Peritoneal Cancer. Faldaprevir Faldaprevir has been investigated for the treatment of Chronic Hepatitis C. Talaporfin Talaporfin has been investigated for the treatment of Port-Wine Stain and Benign Prostatic Hyperplasia. Lucitanib Lucitanib has been used in trials studying the treatment of ER+, MBC, SCLC, HER2+, and NSCLC, among others. Acridine Carboxamide Acridine Carboxamide has been used in trials studying the treatment of Lung Cancer and Brain and Central Nervous System Tumors. Prulifloxacin A broad-spectrum fluoroquinolone antibiotic used to treat a variety of susceptible bacterial infections. OC-459 OC000459 is under investigation for the treatment of Severe Eosinophilic Asthma. OC000459 has been investigated for the treatment of Bronchial Asthma. MK-0249 MK0249 has been used in trials studying the treatment of Hypopnea Syndrome, Alzheimer's Disease, Paranoid Schizophrenia, Sleep Apnea, Obstructive, and Excessive Daytime Sleepiness, among others. Galunisertib Galunisertib has been used in trials studying the basic science and treatment of Glioma, Neoplasms, Solid Tumor, GLIOBLASTOMA, and Prostate Cancer, among others. Vaniprevir Vaniprevir has been used in trials studying the treatment and diagnostic of Hepatitis C, Chronic Hepatitis C, Hepatitis C, Chronic, Chronic Hepatitis C Infection, and Chronic Genotype 1 Hepatitis C... Flomoxef Flomoxef has been used in trials studying the treatment of Urinary Tract Infection. Ilaprazole Ilaprazole has been investigated in Helicobacter Infections. BMS-986094 INX-08189 has been used in trials studying the treatment of Hepatitis C, HCV (Genotype 1), and Hepatitis C Virus. Tesevatinib Tesevatinib has been used in trials studying the treatment of Cancer, Stomach Cancer, Brain Metastases, Esophageal Cancer, and Leptomeningeal Metastases, among others. Tesevatinib is a potent inhibitor of multiple RTKs... Vosaroxin Vosaroxin is under investigation for the treatment of Leukemia, Myeloid, Acute. Apabetalone Apabetalone has been investigated for the treatment of Diabetes, Atherosclerosis, and Coronary Artery Disease. Isoflavone A biologically active phytoestrogen found in high concentrations in soy and other legumes. Fevipiprant Fevipiprant has been used in trials studying the treatment of Asthma, Atopic Dermatitis, and Allergic Rhinitis. Dinaciclib Dinaciclib has been used in trials studying the treatment of rrMM, rrCLL, rrDLBCL, Solid Tumors, and Solid Neoplasm, among others. Fluorescein lisicol Fluorescein lisicol has been used in trials studying the diagnostic of Pharmacokinetics, Hepatic Cirrhosis, Hepatitis, Viral, Human, Nonalcoholic Steatohepatitis, and Non-Alcoholic Fatty Liver Disease. Vedroprevir Vedroprevir has been investigated for the treatment of Hepatitis C, Chronic. Epicatechin Epicatechin has been used in trials studying the treatment of Pre-diabetes. Orantinib Orantinib has been used in trials studying the treatment of Lung Cancer, Breast Cancer, Kidney Cancer, Gastric Cancer, and Prostate Cancer, among others. Albaconazole Albaconazole has been used in trials studying the basic science of Onychomycosis. Vesnarinone Vesnarinone has been used in trials studying the treatment of HIV Infections and Sarcoma, Kaposi. Abediterol Abediterol has been used in trials studying the treatment of Asthma, Chronic Obstructive Pulmonary Disease (COPD), and Chronic Obstructive Pulmonary Disease (COPD) and Asthma. Iberdomide Iberdomide (CC-220) has been used in trials studying the treatment of Systemic Lupus Erythematosus. Poziotinib Poziotinib has been used in trials studying the treatment of Breast Cancer, Metastatic Breast Cancer, Increased Drug Resistance, Adenocarcinoma of Lung Stage IV, and Adenocarcinoma of Lung Stage IIIB, among... Epigallocatechin gallate Epigallocatechin gallate has been investigated for the treatment of Hypertension and Diabetic Nephropathy. Vinpocetine A synthetic derivative of a vinca alkaloid used to treat neurological symptoms of cerebrovascular disease. GSK-256066 Gsk256066 has been used in trials studying the treatment and diagnostic of SAR, Asthma, Mild Asthma, Allergic Rhinitis, and Seasonal Allergic Rhinitis, among others. Cordycepin Cordycepin has been used in trials studying the treatment of Leukemia. LY-3023414 LY3023414 has been used in trials studying the treatment of Neoplasm, Solid Tumor, COLON CANCER, BREAST CANCER, and Advanced Cancer, among others. CUDC-101 CUDC-101 has been used in trials studying the treatment of Cancer, Tumors, Liver Cancer, Breast Cancer, and Gastric Cancer, among others. Sapitinib Sapitinib has been used in trials studying the treatment and basic science of Neoplasms, Breast Cancer, Breast Neoplasms, Metastatic Cancer, and Metastatic Breast Cancer, among others. Tivantinib Tivantinib has been investigated in Solid Tumors. Tozadenant Tozadenant has been investigated for the basic science of Cocaine Dependence. PSI-697 PSI-697 has been used in trials studying the treatment of Scleritis. Bergapten Bergapten is under investigation in clinical trial NCT00533195 (Comparison of UVA1 Phototherapy Versus Photochemotherapy for Patients With Severe Generalized Atopic Dermatitis). Bunazosin Bunazosin has been used in trials studying the treatment of High Blood Pressure. Moxaverine Moxaverine has been investigated for the treatment of Retina, Ocular Physiology, and Regional Blood Flow. Epofolate Epofolate has been used in trials studying the treatment of Advanced Solid Tumors. Epofolate (BMS-753493) is a folate conjugate of the epothilone analog BMS-748285 that was designed to selectively target... Carmegliptin Carmegliptin has been used in trials studying the treatment of Diabetes Mellitus Type 2. Puerarin Puerarin has been investigated for the treatment of Alcohol Abuse. GLPG-0187 GLPG0187 has been used in trials studying the treatment of Solid Tumors. CP-724714 CP-724,714 has been used in trials studying the treatment of Breast Cancer, Breast Neoplasms, and Neoplasm Metastasis. Foretinib Foretinib has been used in trials studying the treatment of Cancer, Breast Cancer, Carcinoma, Renal Cell, Recurrent Breast Cancer, and Neoplasms, Head and Neck, among others. Foretinib is an orally... Bizelesin Bizelesin has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific. Selurampanel Selurampanel has been investigated in Adrenocortical Adenoma and Sarcoma, Endometrial Stromal. Sotrastaurin Sotrastaurin has been used in trials studying the basic science and treatment of Uveal Melanoma, Richter Syndrome, Prolymphocytic Leukemia, Recurrent Mantle Cell Lymphoma, and Recurrent Small Lymphocytic Lymphoma, among others. Sagopilone Sagopilone has been used in trials studying the treatment of Melanoma, Neoplasms, CNS Disease, Breast Cancer, and Breast Neoplasms, among others. It is a so-called fully synthetic epothilone and is... Lisofylline Lisofylline has been investigated for the treatment of Type 1 Diabetes Mellitus. Saccharin A non-nutritive artificial sweetener for sweetening foods and drinks. Diazepinomicin Diazepinomicin has been used in trials studying the treatment of Glioblastoma Multiforme. It is a proprietary first-in-class small molecule with the potential to treat multiple solid tumours like the well... Sonedenoson Sonedenoson has been used in trials studying the treatment of Foot Ulcer, Diabetic and Diabetes Complications. Nadifloxacin A topical fluoroquinolone used in the treatment of acne and topical bacterial skin infections. Zalypsis Zalypsis has been used in trials studying the treatment of Lymphoma, Solid Tumors, Ewing's Sarcoma, Endometrial Cancer, and Uterine Cervical Cancer, among others. Ketanserin Ketanserin has been investigated for the treatment of Septic Shock, Severe Sepsis, and Diabetic Foot Ulcer. Zabofloxacin Zabofloxacin has been used in trials studying the treatment of Community Acquired Pneumonia and Chronic Obstructive Pulmonary Disease. Batefenterol Batefenterol has been used in trials studying the treatment of Pulmonary Disease, Chronic Obstructive. Indobufen A reversible platelet aggregation inhibitor used to prevent coronary and peripheral artery occlusion. Pyrazoloacridine Pyrazoloacridine has been used in trials studying the treatment of Lung Cancer, Liver Cancer, Breast Cancer, Melanoma (Skin), and Metastatic Cancer, among others. Idazoxan Idazoxan has been used in trials studying the basic science of Molecular Imaging, Alzheimer Disease, and Major Depressive Disorder. Tonapofylline Tonapofylline has been used in trials studying the treatment of Heart Failure, Renal Insufficiency, and Congestive Heart Failure. Piperine Bioperine has been used in trials studying the treatment of Multiple Myeloma and Deglutition Disorders. Razupenem Razupenem has been used in trials studying the treatment of Skin Infections. Apaziquone Apaziquone has been investigated for the treatment of Bladder Cancer and Bladder Neoplasms. Ebselen Ebselen has been investigated for the treatment and basic science of Meniere's Disease, Type 2 Diabetes Mellitus, and Type 1 Diabetes Mellitus. CP-609754 LNK 754 has been investigated in Mild Alzheimer's Disease. Tocotrienol Tocotrienol has been investigated for the treatment of Cholesterol Lowering. Isoquercetin Isoquercetin has been used in trials studying the treatment of Kidney Cancer, Renal cell carcinoma, Advanced Renal Cell Carcinoma, Thromboembolism of Vein in Pancreatic Cancer, and Thromboembolism of Vein VTE... Rolofylline Rolofylline is under clinical development by pharmaceutical company NovaCardia for the treatment of congestive heart failure. ATX-914 Axt914 is under investigation in clinical trial NCT00417261 (Safety, Tolerability, Pharmacodynamic and Pharmacokinetic Effects of Single and Multiple-Doses of ATF936 and AXT914 Administered Orally in Healthy Subjects.). Intepirdine Intepirdine has been used in trials studying the treatment of Alzheimer's Disease. K-134 K-134 has been used in trials studying the treatment of Intermittent Claudication. UK-432097 UK-432,097 has been used in trials studying the treatment of Pulmonary Disease, Chronic Obstructive. Omipalisib Omipalisib has been used in trials studying the treatment of CANCER, Solid Tumours, and Idiopathic Pulmonary Fibrosis. Seletalisib Seletalisib has been used in trials studying the treatment and basic science of Primary Sjogren's Syndrome. NB-001 NB-001 has been investigated for the treatment of Recurrent Herpes Labialis. Lometrexol Lometrexol has been used in trials studying the treatment of Lung Cancer, Drug/Agent Toxicity by Tissue/Organ, and Unspecified Adult Solid Tumor, Protocol Specific. E-6005 E6005 has been used in trials studying the treatment of Atopic Dermatitis. Higenamine Higenamine is under investigation in clinical trial NCT01451229 (Pharmacokinetics and Pharmacodynamics of Higenamine in Chinese Healthy Subjects). Quinfamide Quinfamide has been used in trials studying the treatment of Amoebiasis and Helminthiasis. Balaglitazone Balaglitazone has been used in trials studying the treatment of Diabetes Mellitus, Type 2. Daniquidone Daniquidone has been used in trials studying the treatment of Neoplasms. Tandospirone Tandospirone has been used in trials studying the treatment of Schizophrenia. Reproterol A short-acting β2 adrenoreceptor agonist used to treat various types of asthma including allergic asthma, non-allergic asthma, and exercise-induced asthma. Quizartinib A FLT3 inhibitor used in combination with cytarabine and anthracycline to treat acute myeloid leukemia with FLT3 internal tandem duplication Dihydrexidine Dihydrexidine has been used in trials studying the treatment of SPD, Cocaine-Related Disorders, and Schizotypal Personality Disorder. Nolatrexed Nolatrexed is under investigation in clinical trial NCT00012324 (Nolatrexed Dihydrochloride Compared With Doxorubicin in Treating Patients With Recurrent or Unresectable Liver Cancer). Cafedrine Cafedrine is under investigation in clinical trial NCT01311414 (Effect of Cafedrine/Theodrenaline and Urapidil on Cerebral Oxygenation). Theodrenaline Theodrenaline is under investigation in clinical trial NCT01311414 (Effect of Cafedrine/Theodrenaline and Urapidil on Cerebral Oxygenation). Opipramol A medication to treat general anxiety and somatoform disorders. DPCPX CPX has been used in trials studying the treatment of Cystic Fibrosis. Pactimibe Pactimibe has been used in trials studying the treatment of Atherosclerosis and Coronary Heart Disease. Serlopitant Serlopitant has been investigated for the treatment of Prurigo Nodularis. Pyronaridine A benzonaphthyridine derivative indicated in the treatment of acute malaria caused by P. falciparum or P. vivax in area with low rates of infection and low resistance to artemisinin. Phthalocyanine Phthalocyanine is under investigation in clinical trial NCT00103246 (Photodynamic Therapy Using Silicon Phthalocyanine 4 in Treating Patients With Actinic Keratosis, Bowen's Disease, Skin Cancer, or Stage I or Stage II... Neosaxitoxin Neosaxitoxin is under investigation in clinical trial NCT01786655 (Safety Study of Long-Acting Local Anesthetic). PF-00217830 PF-00217830 has been used in trials studying the treatment of Schizophrenia. Tinoridine Tinoridine is under investigation in clinical trial NCT01224756 (Efficacy of Tinoridine in Treating Pain and Inflammation in Adults). Rebastinib Rebastinib has been used in trials studying the treatment of Chronic Myeloid Leukemia. It is an inhibitor of Tie2 tyrosine kinase receptor and an antineoplastic agent. Biapenem A carbapenem antibiotic indicated in the treatment of bacterial infections. MK-0873 MK-0873 has been used in trials studying the treatment of Rheumatoid Arthritis. Ramatroban Ramatroban has been used in trials studying the treatment of Asthma. Tocladesine Tocladesine has been used in trials studying the treatment of Colorectal Cancer and Multiple Myeloma and Plasma Cell Neoplasm. CP-195543 CP-195,543 has been used in trials studying the treatment of Arthritis, Rheumatoid. ME-344 ME-344 has been used in trials studying the treatment of Solid Tumors. Talarozole Talarozole has been investigated for the treatment of Psoriasis and Cutaneous Inflammation. AZD-0424 AZD0424 has been used in trials studying the treatment of Advanced Solid Tumours. CT-2584 CT-2584 has been used in trials studying the treatment of Prostate Cancer. Chromanol Chromanol has been used in trials studying the treatment of Prostate Cancer. Paquinimod Paquinimod is developed for the treatment of SLE (Systemic Lupus Erythematosus), which is an autoimmune disease. The disease affects mainly women of fertile age and progresses in flares with relatively... GSK-364735 GSK-364735 (Naphthyridinone) has been used in trials studying the treatment of HIV-1 Infection and Infection, Human Immunodeficiency Virus. Troxerutin Troxerutin has been used in trials studying the treatment of Chronic Venous Insufficiency. AGN-201904 Agn 201904 has been used in trials studying the prevention of Peptic Ulcer. Ambroxol acefyllinate A bronchodilator indicated in the symptomatic treatment of bronchopulmonary disorders associated with bronchospasm. 4-methylumbelliferyl beta-D-glucoside Not Annotated Ethacridine Not Annotated Bamifylline A methylxanthine derivative indicated in the treatment of bronchial asthma and other conditions with bronchospasm. Bucladesine Not Annotated Tropatepine Tropatepine has been used in France for its antiparkinsons activities . Sitafloxacin A fluoroquinolone antibiotic indicated in the treatment of susceptible bacterial infections. Penimepicycline Penimepicycline is a tetracycline-class antibiotic. It is mentioned on List A produced by the Government of Canada, which is a list of antimicrobial active pharmaceutical ingredients . In the classification... Cefatrizine Not Annotated Euflavine A topical disinfectant indicated in the treatment of wounds, blisters, insect bites, and infected wounds. Visnadine Not Annotated Cloricromen Not Annotated Acriflavine A topical antiseptic indicated in the treatment of infected wounds and for skin disinfection. Vincamine Vincamine is a monoterpenoid indole alkaloid obtained from the leaves of Vinca minor with a vasodilatory property. Studies indicate that vincamine increases the regional cerebral blood flow. Chiniofon Not Annotated Chlorproethazine Not Annotated Dihydroergocryptine A dopamine agonist indicated in the treatment of cerebrovascular diseases and atherosclerosis. Hematin Not Annotated Emetine Not Annotated Terguride Not Annotated Lofepramine Not Annotated Thiazinam Not Annotated Medazepam A long-acting benzodiazepine used for its sedative and anxiolytic properties. Proxyphylline Not Annotated Nicomorphine Not Annotated Phanquinone Not Annotated Cefodizime A broad-spectrum, third-generation cephalosporin used to treat serious infections caused by susceptible bacteria. Tenidap Not Annotated Hidrosmin A synthetic bioflavonoid used for the short-term treatment of symptoms associated with chronic venous insufficiency. Iprindole Not Annotated Cefsulodin Not Annotated Cefetamet Not Annotated Carfecillin Not Annotated Proglumetacin A non-steroidal anti-inflammatory medication used to manage pain associated with various inflammatory conditions including rheumatoid arthritis and osteoarthritis. Broxyquinoline Not Annotated Iprazochrome Not Annotated Cinchophen Not Annotated Prajmaline Not Annotated Acefylline Not Annotated Bietaserpine Not Annotated Mepixanox Not Annotated Etamiphylline Not Annotated Clorexolone Not Annotated Ipriflavone Not Annotated Oxolinic acid Not Annotated Pentifylline Not Annotated Tiracizine Not Annotated Cefbuperazone Not Annotated Metisazone Not Annotated Alcuronium A non-depolarizing skeletal muscle relaxant similar to tubocurarine. It is used as an anesthesia adjuvant. Proquazone Not Annotated Lorajmine Not Annotated Propicillin Not Annotated Cefozopran Not Annotated Ipidacrine Not Annotated Cridanimod Not Annotated Tretoquinol Not Annotated Sulbenicillin Not Annotated Eosin A medication used to disinfect small skin wounds, bug bites, and sores. Fenquizone Not Annotated Hydroquinine Not Annotated Azapetine Not Annotated Dexrabeprazole A proton pump inhibitor indicated in the treatment of gastroesophageal reflux disease and gastrointestinal ulcers. Rufloxacin A fluoroquinolone antibiotic indicated in the treatment of susceptible respiratory infections and uncomplicated cystitis. Cefazedone Not Annotated Imipramine oxide Not Annotated Vinburnine Not Annotated Tisopurine Not Annotated Bufylline Not Annotated Talampicillin Not Annotated Aspoxicillin Not Annotated Ceftezole Not Annotated Clopenthixol Clopenthixol is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors. Dehydroemetine Not Annotated Albendazole oxide Not Annotated Harmaline Not Annotated Coumermycin A1 Not Annotated Emrusolmin Emrusolmin restores hippocampal synaptic and transcriptional plasticity as well as spatial memory in a mouse model for Alzheimer's disease, when given orally before or after the onset of pathology. LGD-3303 An androgen receptor modulator. S-40503 S-40503 is an investigational selective androgen receptor modulator (SARM) developed for the treatment of osteoporosis by the Japanese company Kaken Pharmaceuticals. WIN 55212-2 WIN 55,212-2 is a chemical described as an aminoalkylindole derivative, which produces effects similar to those of cannabinoids such as tetrahydrocannabinol (THC) but has an entirely different chemical structure. It... Selisistat Selective inhibitor of SIRT1 that does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50 values are 98, 19600, 48700, > 100000 and > 100000 nM for... Pipequaline Pipequaline is an anticonflict & anticonvulsant quinoline derivative. It is an anxiolytic drug that was never marketed. It presents a unique chemical structure that does not follow the structural properties... Baloxavir marboxil A polymerase acidic endonuclease inhibitor used to treat uncomplicated influenza. D-alpha-Tocopherol acetate A form of vitamin E used to treat and prevent vitamin deficiencies. Hispidulin Hispidulin (4',5,7-trihydroxy-6-methoxyflavone) is a potent benzodiazepine (BZD) receptor ligand with positive allosteric properties . 5-methoxy-N,N-dimethyltryptamine 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a tryptamine with psychedelic properties. It is found in a wide variety of plant species, and a single psychoactive toad species, the Colorado River toad. This drug,... Clinafloxacin Clinafloxacin is a fluoroquinolone antibacterial currently under research. It has been proven to present good antibiotic properties. However, its approval and release have been halted due to the presence of... Nordazepam A benzodiazepine indicated in the treatment of insomnia. Furafylline Furafylline is a derivative of methylxanthine derivative. It was developed on the context of asthma as a long-acting alternative for theophylline. Hycanthone Potentially toxic, but effective antischistosomal agent, it is a metabolite of LUCANTHONE. Hycanthone was approved by the FDA in 1975 but is no longer used. Dofequidar Dofequidar is an antineoplastic agent. Tocopherylquinone Not Annotated Cobalamin Not Annotated 7-Aminodesacetoxycephalosporanic acid Not Annotated Dihydroxymethoxychalcone Cardamonin (also known as Dihydroxymethoxychalcone), as shown by the increasing number of publications, has received growing attention from the scientific community due to the expectations toward its benefits to human... Nadide A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves... 8-chlorotheophylline When used in combination with DB01075 as the antiemetic DB00985, 8-chlorotheophylline is indicated for the prevention and treatment of nausea, vomiting, or vertigo of motion sickness. Aripiprazole lauroxil An antipsychotic used to treat schizophrenia in adults. Ramiprilat The active metabolite of the prodrug Ramipril. Moexiprilat The active metabolite of the prodrug Moexipril. Quinaprilat The active metabolite of the prodrug quinapril. Quinoline Yellow WS A yellow colouring used around the world as a dye for food and medications. Bilberry Not Annotated Mangostin Mangostin is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. Perphenazine enanthate Not Annotated Oxazepam acetate Not Annotated Dextrorphan Not Annotated Dabigatran Dabigatran is the active form of the orally bioavailable prodrug dabigatran etexilate. Riboflavin tetrabutyrate Not Annotated Rebeccamycin Rebeccamycin is a weak topoisomerase I inhibitor isolated from Nocardia sp. Ceftobiprole medocaril A cephalosporin indicated in the treatment of pneumonia. beta-Isosparteine Not Annotated Remdesivir A nucleoside analog used to treat RNA virus infections including COVID-19. AZD-3759 AZD-3759 is under investigation in clinical trial NCT03360929 (Evaluate Safety, Tolerability, Pharmacokinetics and Anti-tumor Activity of AZD3759). Lanifibranor Lanifibranor is under investigation in clinical trial NCT03008070 (Phase 2b Study in NASH to Assess IVA337). ABX-464 ABX-464 is under investigation in clinical trial NCT03905109 (Safety Evaluation of ABX464 in Patients With Moderate to Severe Active Crohn's Disease). Ripretinib A kinase inhibitor used to treat advanced gastrointestinal stromal tumor (GIST). Avadomide Avadomide is under investigation in clinical trial NCT02031419 (Novel Combinations of CC-122, CC-223, CC-292, and Rituximab in Diffuse Large B-cell Lymphoma and Follicular Lymphoma). AZD-8848 AZD-8848 is under investigation in clinical trial NCT01818869 (To Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses AZD8848 in Healthy Subjects). CEP-9722 CEP-9722 is under investigation in clinical trial NCT01345357 (Study of CEP-9722 in Combination With Gemcitabine and Cisplatin in Patients With Advanced Solid Tumors or Mantle Cell Lymphoma). Obicetrapib Obicetrapib is under investigation in clinical trial NCT02241772 (A Study on the Effects of TA-8995 on Lp(a) in Subjects With Elevated Lp(a)). Iomazenil Iomazenil is under investigation in clinical trial NCT01590277 (Ability of Partial Inverse Agonist, Iomazenil, to Block Ethanol Effects in Humans). Linrodostat Linrodostat is under investigation in clinical trial NCT03247283 (Pharmacokinetics and Metabolism Study in Healthy Male Participants). Pyrotinib Pyrotinib is under investigation in clinical trial NCT03756064 (Neoadjuvant Study of Pyrotinib in Patients With HER2 Positive Breast Cancer). Neopterin Neopterin is under investigation in clinical trial NCT02974192 (Neopterin Effects on Ischemic Stroke). Flutemetamol Flutemetamol is under investigation in clinical trial NCT02353949 (Investigating the Clinical Consequences of Flutemetamol-PET-scanning). Agerafenib Agerafenib is under investigation in clinical trial NCT03052569 (Expanded Access to RXDX-105 for Cancers With RET Alterations). 18-methoxycoronaridine 18-methoxycoronaridine is under investigation in clinical trial NCT03084952 (Phase 2 Trial to Evaluate 18-Methoxycoronaridine Efficacy, Safety and Tolerability in Cutaneous Leishmaniasis Patients). GW-468816 GW-468816 is under investigation in clinical trial NCT00218465 (Effectiveness of GW468816, an NMDA Glycine Site Antagonist, for Prevention of Relapse to Smoking). Onvansertib Onvansertib is under investigation in clinical trial NCT03303339 (Onvansertib in Combination With Either Low-dose Cytarabine or Decitabine in Adult Patients With Acute Myeloid Leukemia (AML).). PCS-499 PCS-499 is under investigation in clinical trial NCT01487109 (A Phase 2 Study to Evaluate the Safety and Efficacy of CTP-499 in Type 2 Diabetic Nephropathy Patients). Dexpramipexole Dexpramipexole is under investigation in clinical trial NCT01511029 (Study to Evaluate the QTC Interval in Healthy Volunteers Dosed With Dexpramipexole (QTC = Electrocardiogram (ECG) Interval Measured From the Onset of... Ziresovir Ziresovir is under investigation in clinical trial NCT03699202 (Anti-RSV Study in Chinese Patients (ASCENT)). 25-desacetylrifapentine 25-desacetylrifapentine is under investigation in clinical trial NCT00023387 (TBTC Study 25PK: Intensive Pharmacokinetic Study of Three Doses of Rifapentine and 25-Desacetyl Rifapentine). KRN-5500 KRN-5500 is under investigation in clinical trial NCT00002923 (KRN5500 in Treating Patients With Metastatic Solid Tumors). GS-6620 GS-6620 is under investigation in clinical trial NCT01316237 (A Study Evaluating the Safety, Tolerability, Pharmacokinetics and Antiviral Activity of GS-6620 in Treatment Naïve Subjects With Chronic Hepatitis C Virus Infection). Hydroquinidine A medication indicated in the maintenance of a normal sinus rhythm, as well as the treatment and prevention of abnormal rhythm. Posiphen Posiphen is under investigation in clinical trial NCT02925650 (Safety, Tolerability, PK and PD of Posiphen® in Subjects With Early Alzheimer's Disease). Biochanin A Biochanin A is under investigation in clinical trial NCT02174666 (Isoflavone Treatment for Postmenopausal Osteopenia.). Formononetin Formononetin is under investigation in clinical trial NCT02174666 (Isoflavone Treatment for Postmenopausal Osteopenia.). Dihematoporphyrin ether Dihematoporphyrin ether is under investigation in clinical trial NCT00118222 (High Light and Low Light Dose PDT in Glioma). Tozuleristide Tozuleristide is under investigation in clinical trial NCT02464332 (Safety Study of BLZ-100 in Adult Subjects With Sarcoma Undergoing Surgery). SAR-125844 SAR-125844 is under investigation in clinical trial NCT01391533 (Study of SAR125844 Single Agent Administered as Slow Intravenous Infusion in Adult Patients With Advanced Malignant Solid Tumors). gamma-Tocopherol gamma-Tocopherol is under investigation in clinical trial NCT00836368 (In Vitro Basophil Responsiveness to Allergen Challenge After Gamma-tocopherol Supplementation in Allergic Asthmatics). Silmitasertib Silmitasertib is under investigation in clinical trial NCT03904862 (Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have Surgery). Pafolacianine An optical imaging agent indicated in adult patients with ovarian cancer as an adjunct for intraoperative identification of malignant lesions. CYC-065 CYC-065 is under investigation in clinical trial NCT03739554 (CYC065 CDK Inhibitor and Venetoclax Study in Relapsed/Refractory CLL). Echinomycin Echinomycin is a cytotoxic polypeptide quinoxaline antibiotic isolated from Streptomyces echinatus that binds to DNA and inhibits RNA synthesis. Luteolin Not Annotated TMC-310911 TMC-310911 (also known as ASC-09) is a novel investigational protease inhibitor (PI) that is structurally similar to the currently available darunavir. It is being investigated for use in HIV-1 infections.... Islatravir Islatravir is under investigation in clinical trial NCT04233216 (Doravirine/islatravir (DOR/ISL) in Heavily Treatment-experienced (HTE) Participants for Human Immunodeficiency Virus Type 1 (HIV-1) Infection (MK-8591A-019)). Baloxavir Baloxavir is under investigation in clinical trial NCT04327791 (Combination Therapy With Baloxavir and Oseltamavir 1 for Hospitalized Patients With Influenza (The COMBO Trial 1)). GS-441524 An experimental nucleoside analog antiviral investigated for its use in the treatment of Ebola and SARS-CoV-2 infections. Sulbactam pivoxil A prodrug of a beta-lactamase inhibitor used to improve the efficacy of beta lactam antibiotics Carmoterol A long acting beta-2 agonist indicated in the treatment of COPD, asthma, and chronic bronchitis. Buthiazide A diuretic indicated in the treatment of edema caused by congestive heart failure, as well as hepatic and renal diseases. Tocopheryl nicotinate A vitamin E supplement indicated in the treatment of high cholesterol and narrowing of peripheral arteries. Cloxyquin Not Annotated Hesperidin methylchalcone Not Annotated Raubasine Not Annotated Strychnine Not Annotated Carbazochrome sulfonic acid A hemostatic agent indicated to treat bleeding in capillary fragility. Clorotepine Not Annotated Indocyanine green A diagnostic agent for vascular imagine and radiography of the eye, as well as liver function tests. BTRX-335140 BTRX-335140 is under investigation in clinical trial NCT04221230 (Study in Major Depressive Disorder With BTRX-335140 vs Placebo). 8-Chloroadenosine 8-Chloroadenosine is under investigation in clinical trial NCT02509546 (8-chloroadenosine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia). Baicalein Baicalein is under investigation in clinical trial NCT03830684 (A Randomized, Double-blind, Placebo-controlled, Multicenter and Phase ⅡA Clinical Trial for the Effectiveness and Safety of Baicalein Tablets in the Treatment of... Carotegrast methyl Carotegrast methyl is under investigation in clinical trial NCT03531892 (A Study to Evaluate the Safety and Efficacy of AJM300 in Participants With Active Ulcerative Colitis). Epigallo Catechin Gallate Epigallo Catechin Gallate is under investigation in clinical trial NCT00799890 (Sunphenon in Progressive Forms of Multiple Sclerosis). Chiauranib Chiauranib is under investigation in clinical trial NCT03974243 (Chiauranib in Combination With Chidamide in Patients With Relapsed/refractory Non-hodgkin's Lymphoma). Desidustat Desidustat is under investigation in clinical trial NCT04012957 (Desidustat in the Treatment of Anemia in CKD). DAR-0100A DAR-0100A is under investigation in clinical trial NCT01466205 (Clinical Testing of a D1 Agonist for Cognitive Enhancement in Schizotypal Personality Disorder). Dotinurad Dotinurad is under investigation in clinical trial NCT03372200 (Febuxostat-controlled, Double-blind, Comparative Study of FYU-981 in Hyperuricemia With or Without Gout). Fisogatinib Fisogatinib is under investigation in clinical trial NCT04194801 (A Phase Ib/ii Study of Fisogatinib(blu-554) in Subjects With Hepatocellular Carcinoma). Hemoporfin A porphyrin derivative combined with vitamin B12 for the treatment of asthenia. Levonadifloxacin Levonadifloxacin is under investigation in clinical trial NCT03405064 (Comparative Study of Levonadifloxacin (IV and Oral) With Linezolid (IV and Oral) in Acute Bacterial Skin and Skin Structure Infections (ABSSSI)). Milciclib Maleate Milciclib Maleate is under investigation in clinical trial NCT01301391 (Study of Oral PHA-848125AC in Patients With Malignant Thymoma Previously Treated With Multiple Lines of Chemotherapy). Mitapivat A pyruvate kinase activator used to treat hemolytic anemia in adults with pyruvate kinase (PK) deficiency. Nangibotide Nangibotide is under investigation in clinical trial NCT04055909 (Efficacy, Safety and Tolerability of Nangibotide in Patients With Septic Shock). Naphthoquine Naphthoquine is under investigation in clinical trial NCT01930331 (Safety, Tolerability, Pharmacokinetics and Efficacy of ARCO). Nedisertib Nedisertib is under investigation in clinical trial NCT03770689 (Study of M3814 in Combination With Capecitabine and Radiotherapy in Rectal Cancer). Olutasidenib An isocitrate dehydrogenase-1 (IDH1) inhibitor indicated for the treatment of patients with relapsed or refractory acute myeloid leukemia with a susceptible IDH1 mutation as detected by an FDA-approved test. Revaprazan Revaprazan is under investigation in clinical trial NCT01750437 (Phase 2 Clinical Trial to Investigate the Safety, Tolerability and Efficacy of YH1885L in Patients With Non-erosive Reflux Disease(nerd)). TNP-2092 TNP-2092 is under investigation in clinical trial NCT03964493 (TNP-2092 to Treat Acute Bacterial Skin and Skin Structure Infection). Selodenoson Selodenoson is under investigation in clinical trial NCT00040001 (Safety and Efficacy Study of an A1-adenosine Receptor Agonist to Slow Heart Rate in Atrial Fibrillation). Tropifexor Tropifexor is under investigation in clinical trial NCT02516605 (A Multi-part, Double Blind Study to Assess Safety, Tolerability and Efficacy of Tropifexor (LJN452) in PBC Patients). Veliflapon Veliflapon is under investigation in clinical trial NCT00353067 (Veliflapon (Dg-031)to Prevent Heart Attacks or Stroke in Patients With a History of Heart Attack or Unstable Angina). Isoquercitrin Isoquercitrin is under investigation in clinical trial NCT04622865 (Masitinib Combined With Isoquercetin and Best Supportive Care in Hospitalized Patients With Moderate and Severe COVID-19). Tin protoporphyrin IX Not Available AT-527 Not Available Sodium copper chlorophyllin Sodium copper chlorophyllin (SCC) is a water-soluble and bright green mixture derived from natural chlorophyll that has potential antimutagenic and antioxidant properties . This compound is used as a food... Dihydroergotoxine Not Annotated Bentracimab Bentracimab is under investigation in clinical trial NCT04286438 (Bentracimab (PB2452) in Ticagrelor-treated Patients With Uncontrolled Major or Life-threatening Bleeding or Requiring Urgent Surgery or Invasive Procedure). Izencitinib Izencitinib is under investigation in clinical trial NCT03920254 (TD-1473 Long-term Safety (LTS) Ulcerative Colitis (UC) Study). Reproxalap Reproxalap (previously ADX 102 or NS-2) is a small molecule inhibitor being developed by Aldeyra Therapeutics investigated against dry eye disease, allergic conjunctivitis, noninfectious anterior uveitis, and Sjögren-Larsson syndrome. NS-2... MM3122 Not Annotated RP-67580 Not Annotated BAY-876 Not Annotated Tyrphostin B44 Not Annotated Norclozapine Investigated for use/treatment in schizophrenia and schizoaffective disorders. Cytochalasin B Not Annotated Isorhamnetin Not Annotated Morin Not Annotated Rhamnetin Not Annotated Tyrphostin AG 555 Not Annotated Tyrphostin B48 Not Annotated Tyrphostin B56 Not Annotated Tyrphostin AG 879 Not Annotated S-49076 Not Annotated Cepharanthine Not Annotated MK-2206 Not Annotated Adenosine disphosphate Not Annotated AZD-7648 Not Annotated Vitexin Not Annotated BLZ-945 Not Annotated Tebipenem pivoxil Not Annotated BMS-833923 Not Annotated Pidnarulex Not Annotated Tosufloxacin Not Annotated Bentamapimod Not Annotated Rhodamine B Not Annotated Naringin Not Annotated Indigo Not Annotated Ethoxyquin Not Annotated Hematoxylin Not Annotated CB-5083 Not Annotated AMG-319 Not Annotated Eupatilin Not Annotated GSK-2881078 Not Annotated Sinomenine Not Annotated NS13001 Not Annotated Hydromethylthionine mesylate Not Annotated Flindokalner Not Annotated TIK-301 Not Annotated D-157495 Not Annotated PBT-434 Not Annotated Enadoline Not Annotated AZD-5153 Not Annotated Chelerythrine A benzophenanthridine alkaloid evaluated as a kinase-inhibitor. Ellipticine Ellipticine is a potent antineoplastic agent. Go-6976 An inhibitor of calcium-dependent isoforms of protein kinase C.[A253002,A253007] Homidium Homidium is a group II compound with trypanocidal effects. JTC-801 free base An antagonist of nociceptin receptor and analgesic agent, evaluated for its use in cancer treatment. NSC-663284 NSC-663284 is a potent quinolinedione Cdc25 phosphatase inhibitor. PD-98059 PD-98059 is an inhibitor of MAP-kinase kinase activation. Scriptaid Scriptaid is a histone deacetylase (HDAC) inhibitor researched for its anti-tumor properties. SNX-2112 SNX-2112 is a heat shock protein 90 (Hsp90) inhibitor. SRT-1720 SRT-1720 is an activator of NAD(+)-dependent histone deacetylase SIRT1. ZK-93423 ZK-93423 is a beta-carboline with muscle relaxant activity with agonistic properties at the benzodiazepine receptor. Norclobazam Not Annotated SC 41930 Not Annotated Folitixorin Not Annotated Pelabresib anhydrous Not Annotated Namodenoson Namodenoson has been used in trials studying the treatment of Chronic Hepatitis C and Hepatocellular Carcinoma. APTO-253 Not Annotated Lansoprazole sulfone Not Annotated TH-9402 free base Not Annotated Ukrain cation Not Annotated Redaporfin Not Available TRX-E-002-1 Not Annotated Chrysoeriol Not Annotated Heme arginate Not Available S-3APG S-3APG (S-3-[3-amino-phthalimido]-glutarimide) is a derivative of thalidomide with dual activity against B-cell neoplasias. YK-4-279 Not Annotated Bioymifi Bioymifi is a small molecule that acts as a tumor necrosis factor-related apoptosis-induced ligand (TRAIL) mimetic. Upon binding to the death receptor 5 (DR5) on cancer cells, bioymifi triggers apoptosis,... Loxoribine Not Available Abacavir An antiviral nucleoside reverse transcriptase inhibitor used in combination with other antiretrovirals for the treatment of HIV. Brequinar Not Available Acetyleneurea Not Available Ibudilast For the treatment of multiple sclerosis, asthma, and cerebrovascular disease. Lixivaptan Investigated for use/treatment in hyponatremia and congestive heart failure. Osimertinib A tyrosine kinase inhibitor used in the treatment of certain types of non-small cell lung carcinoma. SP-8203 SP-8203 has been used in trials studying the treatment of Ischemic Stroke. PF-03715455 PF-03715455 has been used in trials studying the treatment of Asthma, Pulmonary Disease, Chronic Obstructive, and Chronic Obstructive Pulmonary Disease (COPD). Abacavir hydroxyacetate Prurisol is under investigation for the treatment of Chronic Stable Plaque Psoriasis. Prurisol has been investigated for the treatment of Plaque Psoriasis. Merbromin A topical antiseptic indicated in the disinfection of lacerations. Derazantinib Derazantinib is under investigation in clinical trial NCT03230318 (Derazantinib in Subjects With FGFR2 Gene Fusion Positive Inoperable or Advanced Intrahepatic Cholangiocarcinoma). AT-001 AT-001 is under investigation in clinical trial NCT03062384 (AT-001 for Long-term Preservation of Brain Health in Aging). Tovorafenib Tovorafenib (TAK-580) is under investigation in clinical trial NCT02723006 (Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of Investigational Treatments in Combination With Standard of Care Immune Checkpoint Inhibitors in... GLPG-1205 GLPG-1205 is under investigation in clinical trial NCT03725852 (A Clinical Study to Test How Effective and Safe GLPG1205 is for Patients With Idiopathic Pulmonary Fibrosis (IPF)). Ibezapolstat Ibezapolstat is under investigation in clinical trial NCT04247542 (ACX-362E Ibezapolstat for Oral Treatment of Clostridioides Difficile Infection). Maralixibat An ileal bile acid transporter inhibitor indicated to treat cholestatic pruritus in patients with Alagille syndrome. Mobocertinib An oral kinase inhibitor targeted against EGFR and used in the treatment of NSCLC with EGFR exon 20 insertion mutations. SY-5609 Not Annotated α-Melanocyte-Stimulating Hormone Not Annotated Sonlicromanol Sonlicromanol is under investigation in clinical trial NCT04165239 (The KHENERGYZE Study). Vamifeport Vamifeport is being investigated for the treatment of beta-thalassemia. Amotosalen Not Available Zinc mesoporphyrin Not Annotated Allopurinol riboside Allopurinol riboside is a nucleoside analogue of allopurinol with a beta-D-ribofuranosyl moiety at the 1-position. Dideoxyadenosine Not Annotated Tapencarium Not Annotated Soraprazan Not Annotated TAK-603 Not Annotated Methylliberine Not Annotated Isoindolin-1,3-Dithione Not Annotated Sinecatechins A topical agent used to treat external genital and perianal warts in immunocompetent adult patients. WP-1066 WP1066 has been used in trials studying the treatment of Melanoma, Brain Cancer, Solid Tumors, and Central Nervous System Neoplasms. BLU-9931 Not Annotated Lomifylline Not Annotated AB-001 Not Annotated Emvododstat Not Annotated Quinoline Not Annotated Unesbulin Not Annotated TQS-168 Not Annotated 2'-deoxythioguanosine Not Annotated Berbamine Not Annotated ESK981 Not Annotated Ibutamoren Not Annotated Nanvuranlat Not Annotated Ferroheme Not Annotated S-55746 Not Annotated - Drugs & Drug Targets