UGT2B17 substrates

Name

UGT2B17 substrates

Accession Number

DBCAT005464

Description

Not Available

Drugs

Drug	Drug Description
Losartan	An angiotensin receptor blocker used to treat hypertension and diabetic nephropathy, and is used to reduce the risk of stroke.
Tamoxifen	A selective estrogen receptor modulator used to treat estrogen receptor positive breast cancer, reduce the risk of invasive breast cancer following surgery, or reduce the risk of breast cancer in high risk women.
Gemfibrozil	A lipid regulator that is used in the reduction of serum triglyceride levels in high-risk patients with hyperlipidemia.
Dextromethorphan	An NMDA receptor antagonist used to treat cases of dry cough.
Belzutifan	An inhibitor of hypoxia-inducible factor 2α used as an antineoplastic in the treatment of certain cancers associated with von Hippel-Lindau (VHL) disease.
Asciminib	An inhibitor of ABL/BCR-ABL1 tyrosine kinase for the treatment of patients with Philadelphia chromosome-positive CML, including those with the T315I mutation.
Cannabidiol	An active cannabinoid used as an adjunctive treatment for the management of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome and symptomatic relief of moderate to severe neuropathic pain or other painful conditions, like cancer.
Medical Cannabis	The use of the plant species Cannabis sativa and Cannabis indica, popularly known as marijuana, has gained popularity in recent years for the management of a wide variety of medical...
Edaravone	A free radical scavenger used to delay the progression of ALS.
Desvenlafaxine	An antidepressant agent and SNRI used for the treatment of major depressive disorders in adults.
Vamorolone	A synthetic glucocorticoid used as an anti-inflammatory and immunosuppressant in the management of Duchenne muscular dystrophy (DMD).

Drugs & Drug Targets

Drug	Target	Type
Losartan	Type-1 angiotensin II receptor	target
Losartan	Cytochrome P450 3A4	enzyme
Losartan	Cytochrome P450 2C9	enzyme
Losartan	P-glycoprotein 1	transporter
Losartan	Solute carrier family 22 member 6	transporter
Losartan	UDP-glucuronosyltransferase 1-1	enzyme
Losartan	UDP-glucuronosyltransferase 1-3	enzyme
Losartan	UDP-glucuronosyltransferase 1-10	enzyme
Losartan	UDP-glucuronosyltransferase 2B7	enzyme
Losartan	UDP-glucuronosyltransferase 2B17	enzyme
Losartan	Cytochrome P450 2C19	enzyme
Losartan	Serum albumin	carrier
Losartan	Solute carrier family 22 member 12	transporter
Losartan	Solute carrier family 2, facilitated glucose transporter member 9	transporter
Losartan	Bile salt export pump	transporter
Losartan	Cytochrome P450 2C8	enzyme
Tamoxifen	Estrogen receptor alpha	target
Tamoxifen	Estrogen receptor beta	target
Tamoxifen	Cytochrome P450 2C9	enzyme
Tamoxifen	Cytochrome P450 3A4	enzyme
Tamoxifen	Cytochrome P450 2D6	enzyme
Tamoxifen	Cytochrome P450 2C8	enzyme
Tamoxifen	Cytochrome P450 2B6	enzyme
Tamoxifen	Liver carboxylesterase 1	enzyme
Tamoxifen	Cytochrome P450 3A5	enzyme
Tamoxifen	Cytochrome P450 1A1	enzyme
Tamoxifen	Cytochrome P450 1B1	enzyme
Tamoxifen	Cytochrome P450 2C19	enzyme
Tamoxifen	Dimethylaniline monooxygenase [N-oxide-forming] 1	enzyme
Tamoxifen	Dimethylaniline monooxygenase [N-oxide-forming] 3	enzyme
Tamoxifen	Cytochrome P450 3A7	enzyme
Tamoxifen	P-glycoprotein 1	transporter
Tamoxifen	ATP-binding cassette sub-family G member 2	transporter
Tamoxifen	Cytochrome P450 19A1	enzyme
Tamoxifen	Cytochrome P450 2A6	enzyme
Tamoxifen	Cytochrome P450 2E1	enzyme
Tamoxifen	UDP-glucuronosyltransferase 1-10	enzyme
Tamoxifen	Sulfotransferase 1A1	enzyme
Tamoxifen	Canalicular multispecific organic anion transporter 1	transporter
Tamoxifen	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	target
Tamoxifen	Protein kinase C	target
Tamoxifen	Androgen receptor	target
Tamoxifen	Potassium voltage-gated channel subfamily H member 2	target
Tamoxifen	Nuclear receptor subfamily 1 group I member 2	target
Tamoxifen	Estrogen-related receptor gamma	target
Tamoxifen	Sex hormone-binding globulin	target
Tamoxifen	Bile salt export pump	transporter
Tamoxifen	Thyroxine-binding globulin	carrier
Tamoxifen	Bile salt sulfotransferase	enzyme
Tamoxifen	Cytochrome P450 1A2	enzyme
Tamoxifen	UDP-glucuronosyltransferase 2B7	enzyme
Tamoxifen	UDP-glucuronosyltransferase 2B17	enzyme
Tamoxifen	Estrogen sulfotransferase	enzyme
Tamoxifen	ATP-binding cassette sub-family A member 1	transporter
Tamoxifen	Mitogen-activated protein kinase 8	target
Tamoxifen	Serum albumin	carrier
Gemfibrozil	Peroxisome proliferator-activated receptor alpha	target
Gemfibrozil	Cytochrome P450 2C9	enzyme
Gemfibrozil	Cytochrome P450 2C8	enzyme
Gemfibrozil	Cytochrome P450 1A2	enzyme
Gemfibrozil	Cytochrome P450 2C19	enzyme
Gemfibrozil	UDP-glucuronosyltransferase 1-1	enzyme
Gemfibrozil	Cytochrome P450 3A4	enzyme
Gemfibrozil	UDP-glucuronosyltransferase 1-3	enzyme
Gemfibrozil	Solute carrier organic anion transporter family member 1B1	target
Gemfibrozil	UDP-glucuronosyltransferase 2B7	enzyme
Gemfibrozil	UDP-glucuronosyltransferase 1-9	enzyme
Gemfibrozil	UDP-glucuronosyltransferase 2B4	enzyme
Gemfibrozil	UDP-glucuronosyltransferase 2B17	enzyme
Gemfibrozil	Serum albumin	carrier
Gemfibrozil	Solute carrier family 22 member 8	target
Gemfibrozil	Solute carrier organic anion transporter family member 2B1	target
Gemfibrozil	Solute carrier organic anion transporter family member 1B3	target
Dextromethorphan	Sigma non-opioid intracellular receptor 1	target
Dextromethorphan	Neuronal acetylcholine receptor subunit alpha-2	target
Dextromethorphan	Sodium-dependent serotonin transporter	target
Dextromethorphan	Glutamate receptor ionotropic, NMDA 3A	target
Dextromethorphan	Cytochrome P450 2D6	enzyme
Dextromethorphan	Cytochrome P450 3A4	enzyme
Dextromethorphan	Cytochrome P450 3A7	enzyme
Dextromethorphan	Cytochrome P450 2C9	enzyme
Dextromethorphan	Cytochrome P450 2B6	enzyme
Dextromethorphan	Cytochrome P450 2C19	enzyme
Dextromethorphan	Membrane-associated progesterone receptor component 1	target
Dextromethorphan	Neuronal acetylcholine receptor subunit alpha-3	target
Dextromethorphan	Neuronal acetylcholine receptor subunit alpha-4	target
Dextromethorphan	Neuronal acetylcholine receptor subunit beta-4	target
Dextromethorphan	Neuronal acetylcholine receptor subunit beta-2	target
Dextromethorphan	Neuronal acetylcholine receptor subunit alpha-7	target
Dextromethorphan	Mu-type opioid receptor	target
Dextromethorphan	Delta-type opioid receptor	target
Dextromethorphan	Kappa-type opioid receptor	target
Dextromethorphan	NADPH oxidase	target
Dextromethorphan	Sodium-dependent noradrenaline transporter	target
Dextromethorphan	UDP-glucuronosyltransferase 2B4	enzyme
Dextromethorphan	UDP-glucuronosyltransferase 2B7	enzyme
Dextromethorphan	UDP-glucuronosyltransferase 2B15	enzyme
Dextromethorphan	UDP-glucuronosyltransferase 2B17	enzyme
Belzutifan	Endothelial PAS domain-containing protein 1	target
Belzutifan	UDP-glucuronosyltransferase 2B17	enzyme
Belzutifan	Cytochrome P450 2C19	enzyme
Belzutifan	Cytochrome P450 3A4	enzyme
Belzutifan	P-glycoprotein 1	transporter
Belzutifan	Solute carrier organic anion transporter family member 1B1	transporter
Belzutifan	Solute carrier organic anion transporter family member 1B3	transporter
Belzutifan	Multidrug and toxin extrusion protein 2	transporter
Asciminib	Cytochrome P450 3A4	enzyme
Asciminib	UDP-glucuronosyltransferase 2B7	enzyme
Asciminib	UDP-glucuronosyltransferase 2B17	enzyme
Asciminib	Tyrosine-protein kinase ABL1	target
Asciminib	ATP-binding cassette sub-family G member 2	transporter
Asciminib	UDP-glucuronosyltransferase 1-1	enzyme
Asciminib	Cytochrome P450 2C19	enzyme
Asciminib	P-glycoprotein 1	transporter
Asciminib	Solute carrier organic anion transporter family member 1B1	transporter
Asciminib	Solute carrier organic anion transporter family member 1B3	transporter
Asciminib	Solute carrier family 22 member 1	transporter
Asciminib	Cytochrome P450 2C9	enzyme
Cannabidiol	Cytochrome P450 2C9	enzyme
Cannabidiol	Cytochrome P450 2C19	enzyme
Cannabidiol	Cytochrome P450 2D6	enzyme
Cannabidiol	Cytochrome P450 3A4	enzyme
Cannabidiol	Cannabinoid receptor 1	target
Cannabidiol	Cannabinoid receptor 2	target
Cannabidiol	G-protein coupled receptor 12	target
Cannabidiol	Glycine receptor subunit alpha-1	target
Cannabidiol	Glycine receptor (alpha-1/beta)	target
Cannabidiol	Glycine receptor subunit alpha-3	target
Cannabidiol	N-arachidonyl glycine receptor	target
Cannabidiol	G-protein coupled receptor 55	target
Cannabidiol	5-hydroxytryptamine receptor 1A	target
Cannabidiol	5-hydroxytryptamine receptor 2A	target
Cannabidiol	Neuronal acetylcholine receptor subunit alpha-7	target
Cannabidiol	Delta-type opioid receptor	target
Cannabidiol	Mu-type opioid receptor	target
Cannabidiol	Peroxisome proliferator-activated receptor gamma	target
Cannabidiol	Cytochrome P450 3A5	enzyme
Cannabidiol	Serotonin N-acetyltransferase	enzyme
Cannabidiol	Cytochrome P450 1A1	enzyme
Cannabidiol	Fatty-acid amide hydrolase 1	enzyme
Cannabidiol	Arachidonate 5-lipoxygenase	enzyme
Cannabidiol	Arachidonate 15-lipoxygenase	enzyme
Cannabidiol	Quinone oxidoreductase	enzyme
Cannabidiol	Multidrug resistance-associated protein 1	transporter
Cannabidiol	ATP-binding cassette sub-family G member 2	transporter
Cannabidiol	Equilibrative nucleoside transporter 1	transporter
Cannabidiol	Transient receptor potential cation channel subfamily V member 1	target
Cannabidiol	Voltage-dependent T-type calcium channel subunit alpha-1G	target
Cannabidiol	Voltage-dependent T-type calcium channel subunit alpha-1H	target
Cannabidiol	Voltage-dependent T-type calcium channel subunit alpha-1I	target
Cannabidiol	Transient receptor potential cation channel subfamily A member 1	target
Cannabidiol	Transient receptor potential cation channel subfamily M member 8	target
Cannabidiol	Transient receptor potential cation channel subfamily V member 2	target
Cannabidiol	Transient receptor potential cation channel subfamily V member 3	target
Cannabidiol	Transient receptor potential cation channel subfamily V member 4	target
Cannabidiol	Voltage-dependent anion-selective channel protein 1	target
Cannabidiol	5-hydroxytryptamine receptor 3A	target
Cannabidiol	Adenosine receptor A1	target
Cannabidiol	Prostaglandin G/H synthase 1	target
Cannabidiol	Prostaglandin G/H synthase 2	target
Cannabidiol	Acetyl-CoA acetyltransferase, mitochondrial	target
Cannabidiol	Steroid 17-alpha-hydroxylase/17,20 lyase	target
Cannabidiol	3-hydroxy-3-methylglutaryl-coenzyme A reductase	target
Cannabidiol	Glutathione reductase, mitochondrial	target
Cannabidiol	Glutathione peroxidase 1	target
Cannabidiol	Indoleamine 2,3-dioxygenase 1	target
Cannabidiol	Cytochrome P450 1B1	target
Cannabidiol	NAD(P)H dehydrogenase [quinone] 1	target
Cannabidiol	Catalase	target
Cannabidiol	Cytochrome P450 3A5	target
Cannabidiol	Cytochrome P450 2D6	target
Cannabidiol	Superoxide dismutase [Cu-Zn]	target
Cannabidiol	Cytochrome P450 1A2	target
Cannabidiol	Cytochrome P450 3A7	target
Cannabidiol	Serotonin N-acetyltransferase	target
Cannabidiol	N-acylethanolamine-hydrolyzing acid amidase	target
Cannabidiol	Cytochrome P450 1A2	enzyme
Cannabidiol	Cytochrome P450 1B1	enzyme
Cannabidiol	Cytochrome P450 2A6	enzyme
Cannabidiol	Cytochrome P450 2B6	enzyme
Cannabidiol	Cytochrome P450 2C8	enzyme
Cannabidiol	Cytochrome P450 2E1	enzyme
Cannabidiol	Cytochrome P450 3A7	enzyme
Cannabidiol	UDP-glucuronosyltransferase 1-7	enzyme
Cannabidiol	UDP-glucuronosyltransferase 1-9	enzyme
Cannabidiol	UDP-glucuronosyltransferase 2B7	enzyme
Cannabidiol	UDP-glucuronosyltransferase 2B17	enzyme
Cannabidiol	P-glycoprotein 1	transporter
Cannabidiol	Cytochrome P450 2J2	enzyme
Cannabidiol	Liver carboxylesterase 1	enzyme
Medical Cannabis	Cannabinoid receptor 1	target
Medical Cannabis	Cannabinoid receptor 2	target
Medical Cannabis	Cytochrome P450 2C9	enzyme
Medical Cannabis	Cytochrome P450 2C19	enzyme
Medical Cannabis	Cytochrome P450 2D6	enzyme
Medical Cannabis	Cytochrome P450 3A4	enzyme
Medical Cannabis	G-protein coupled receptor 12	target
Medical Cannabis	Glycine receptor subunit alpha-1	target
Medical Cannabis	Glycine receptor (alpha-1/beta)	target
Medical Cannabis	Glycine receptor subunit alpha-3	target
Medical Cannabis	N-arachidonyl glycine receptor	target
Medical Cannabis	G-protein coupled receptor 55	target
Medical Cannabis	5-hydroxytryptamine receptor 1A	target
Medical Cannabis	5-hydroxytryptamine receptor 2A	target
Medical Cannabis	Neuronal acetylcholine receptor subunit alpha-7	target
Medical Cannabis	Delta-type opioid receptor	target
Medical Cannabis	Mu-type opioid receptor	target
Medical Cannabis	Peroxisome proliferator-activated receptor gamma	target
Medical Cannabis	Cytochrome P450 3A5	enzyme
Medical Cannabis	Cytochrome P450 3A7	enzyme
Medical Cannabis	Cytochrome P450 1A1	enzyme
Medical Cannabis	Cytochrome P450 1A2	enzyme
Medical Cannabis	Cytochrome P450 1B1	enzyme
Medical Cannabis	Arachidonate 5-lipoxygenase	enzyme
Medical Cannabis	Arachidonate 15-lipoxygenase	enzyme
Medical Cannabis	Superoxide dismutase [Cu-Zn]	enzyme
Medical Cannabis	Multidrug resistance-associated protein 1	transporter
Medical Cannabis	ATP-binding cassette sub-family G member 2	transporter
Medical Cannabis	Equilibrative nucleoside transporter 1	transporter
Medical Cannabis	Transient receptor potential cation channel subfamily V member 1	target
Medical Cannabis	Voltage-dependent T-type calcium channel subunit alpha-1G	target
Medical Cannabis	Voltage-dependent T-type calcium channel subunit alpha-1H	target
Medical Cannabis	Voltage-dependent T-type calcium channel subunit alpha-1I	target
Medical Cannabis	Transient receptor potential cation channel subfamily A member 1	target
Medical Cannabis	Transient receptor potential cation channel subfamily M member 8	target
Medical Cannabis	Transient receptor potential cation channel subfamily V member 2	target
Medical Cannabis	Transient receptor potential cation channel subfamily V member 3	target
Medical Cannabis	Transient receptor potential cation channel subfamily V member 4	target
Medical Cannabis	Voltage-dependent anion-selective channel protein 1	target
Medical Cannabis	N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D	target
Medical Cannabis	N-acylethanolamine-hydrolyzing acid amidase	target
Medical Cannabis	Serotonin N-acetyltransferase	target
Medical Cannabis	Phospholipase A2	target
Medical Cannabis	Superoxide dismutase [Cu-Zn]	target
Medical Cannabis	Fatty-acid amide hydrolase 1	target
Medical Cannabis	Catalase	target
Medical Cannabis	Quinone oxidoreductase	target
Medical Cannabis	Sphingomyelin phosphodiesterase	target
Medical Cannabis	Glutathione peroxidase 1	target
Medical Cannabis	Glutathione reductase, mitochondrial	target
Medical Cannabis	3-hydroxy-3-methylglutaryl-coenzyme A reductase	target
Medical Cannabis	Indoleamine 2,3-dioxygenase 1	target
Medical Cannabis	Prostaglandin G/H synthase 1	target
Medical Cannabis	Prostaglandin G/H synthase 2	target
Medical Cannabis	Steroid 17-alpha-hydroxylase/17,20 lyase	target
Medical Cannabis	Acetyl-CoA acetyltransferase, mitochondrial	target
Medical Cannabis	Cytochrome P450 2A6	enzyme
Medical Cannabis	Cytochrome P450 2B6	enzyme
Medical Cannabis	Cytochrome P450 2C8	enzyme
Medical Cannabis	Cytochrome P450 2E1	enzyme
Medical Cannabis	Cytochrome P450 2J2	enzyme
Medical Cannabis	UDP-glucuronosyltransferase 1-7	enzyme
Medical Cannabis	UDP-glucuronosyltransferase 1-8	enzyme
Medical Cannabis	UDP-glucuronosyltransferase 1-9	enzyme
Medical Cannabis	UDP-glucuronosyltransferase 1-10	enzyme
Medical Cannabis	UDP-glucuronosyltransferase 2B17	enzyme
Medical Cannabis	Liver carboxylesterase 1	enzyme
Medical Cannabis	P-glycoprotein 1	transporter
Medical Cannabis	UDP-glucuronosyltransferase 2B7	enzyme
Edaravone	Solute carrier family 22 member 6	transporter
Edaravone	Solute carrier family 22 member 8	transporter
Edaravone	UDP-glucuronosyltransferase 1-1	enzyme
Edaravone	UDP-glucuronosyltransferase 1-6	enzyme
Edaravone	UDP-glucuronosyltransferase 1-7	enzyme
Edaravone	UDP-glucuronosyltransferase 1-8	enzyme
Edaravone	UDP-glucuronosyltransferase 1-9	enzyme
Edaravone	UDP-glucuronosyltransferase 1-10	enzyme
Edaravone	UDP-glucuronosyltransferase 2B7	enzyme
Edaravone	UDP-glucuronosyltransferase 2B17	enzyme
Edaravone	Sulfotransferase	enzyme
Edaravone	Serum albumin	carrier
Desvenlafaxine	Cytochrome P450 3A4	enzyme
Desvenlafaxine	Sodium-dependent serotonin transporter	target
Desvenlafaxine	Sodium-dependent noradrenaline transporter	target
Desvenlafaxine	Cytochrome P450 2D6	enzyme
Desvenlafaxine	Sodium-dependent dopamine transporter	target
Desvenlafaxine	UDP-glucuronosyltransferase 1-1	enzyme
Desvenlafaxine	UDP-glucuronosyltransferase 1-3	enzyme
Desvenlafaxine	UDP-glucuronosyltransferase 2B4	enzyme
Desvenlafaxine	UDP-glucuronosyltransferase 2B15	enzyme
Desvenlafaxine	UDP-glucuronosyltransferase 2B17	enzyme
Desvenlafaxine	Cytochrome P450 2C19	enzyme
Vamorolone	Glucocorticoid receptor	target
Vamorolone	Cytochrome P450 3A4	enzyme
Vamorolone	Cytochrome P450 3A5	enzyme
Vamorolone	Cytochrome P450 2C8	enzyme
Vamorolone	UDP-glucuronosyltransferase 1-3	enzyme
Vamorolone	UDP-glucuronosyltransferase 2B7	enzyme
Vamorolone	UDP-glucuronosyltransferase 2B17	enzyme
Vamorolone	Mineralocorticoid receptor	target