Bcr-Abl Tyrosine Kinase Inhibitors

Name
Bcr-Abl Tyrosine Kinase Inhibitors
Accession Number
DBCAT005512
Description

Not Available

ATC Classification
Drugs
DrugDrug Description
NilotinibA kinase inhibitor used for the chronic phase treatment of Chronic Myeloid Leukemia (CML) that is Philadelphia chromosome positive and for the treatment of CML that is resistant to therapy containing imatinib.
ImatinibA tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors.
DasatinibA tyrosine kinase inhibitor used for the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia or chronic myeloid leukemia.
BosutinibAn antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments.
PonatinibA kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML).
AsciminibAn inhibitor of ABL/BCR-ABL1 tyrosine kinase for the treatment of patients with Philadelphia chromosome-positive CML, including those with the T315I mutation.
Drugs & Drug Targets
DrugTargetType
NilotinibTyrosine-protein kinase ABL1target
NilotinibMast/stem cell growth factor receptor Kittarget
NilotinibCytochrome P450 2D6enzyme
NilotinibCytochrome P450 2C8enzyme
NilotinibCytochrome P450 2C9enzyme
NilotinibCytochrome P450 3A4enzyme
NilotinibP-glycoprotein 1transporter
NilotinibATP-binding cassette sub-family G member 2transporter
NilotinibUDP-glucuronosyltransferase 1-1transporter
NilotinibCytochrome P450 2B6enzyme
NilotinibSolute carrier organic anion transporter family member 1B1transporter
ImatinibPlatelet-derived growth factor receptor betatarget
ImatinibTyrosine-protein kinase ABL1target
ImatinibMast/stem cell growth factor receptor Kittarget
ImatinibProto-oncogene tyrosine-protein kinase receptor Rettarget
ImatinibHigh affinity nerve growth factor receptortarget
ImatinibMacrophage colony-stimulating factor 1 receptortarget
ImatinibPlatelet-derived growth factor receptor alphatarget
ImatinibEpithelial discoidin domain-containing receptor 1target
ImatinibCytochrome P450 3A4enzyme
ImatinibBreakpoint cluster region proteintarget
ImatinibCytochrome P450 1A2enzyme
ImatinibCytochrome P450 2D6enzyme
ImatinibCytochrome P450 2C9enzyme
ImatinibCytochrome P450 2C19enzyme
ImatinibCytochrome P450 3A5enzyme
ImatinibCytochrome P450 3A7enzyme
ImatinibSolute carrier family 22 member 1transporter
ImatinibP-glycoprotein 1transporter
ImatinibSolute carrier family 22 member 2transporter
ImatinibATP-binding cassette sub-family G member 2transporter
ImatinibATP-binding cassette sub-family A member 3transporter
ImatinibSerum albumincarrier
ImatinibAlpha-1-acid glycoprotein 1carrier
ImatinibBile salt export pumptransporter
ImatinibCytochrome P450 2C8enzyme
ImatinibCanalicular multispecific organic anion transporter 1transporter
ImatinibMultidrug resistance-associated protein 1transporter
ImatinibSolute carrier family 22 member 5transporter
ImatinibSolute carrier organic anion transporter family member 1B3transporter
ImatinibMultidrug resistance-associated protein 4transporter
ImatinibSolute carrier organic anion transporter family member 1A2transporter
ImatinibDiscoidin domain-containing receptor 2target
DasatinibTyrosine-protein kinase ABL1target
DasatinibTyrosine-protein kinase ABL2target
DasatinibProto-oncogene tyrosine-protein kinase Srctarget
DasatinibTyrosine-protein kinase Fyntarget
DasatinibTyrosine-protein kinase Lcktarget
DasatinibTyrosine-protein kinase Yestarget
DasatinibMast/stem cell growth factor receptor Kittarget
DasatinibPlatelet-derived growth factor receptor betatarget
DasatinibEphrin type-A receptor 2target
DasatinibSignal transducer and activator of transcription 5Btarget
DasatinibCytochrome P450 3A4enzyme
DasatinibP-glycoprotein 1transporter
DasatinibATP-binding cassette sub-family G member 2transporter
DasatinibCytochrome P450 1A1enzyme
DasatinibCytochrome P450 1A2enzyme
DasatinibCytochrome P450 1B1enzyme
DasatinibCytochrome P450 3A5enzyme
DasatinibDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DasatinibTyrosine-protein kinase BTKtarget
DasatinibNuclear receptor subfamily 4 group A member 3target
DasatinibBreakpoint cluster region proteintarget
DasatinibTyrosine-protein kinase CSKtarget
DasatinibEphrin type-A receptor 5target
DasatinibEphrin type-B receptor 4target
DasatinibTyrosine-protein kinase Fgrtarget
DasatinibTyrosine-protein kinase FRKtarget
DasatinibHeat shock cognate 71 kDa proteintarget
DasatinibTyrosine-protein kinase Lyntarget
DasatinibMitogen-activated protein kinase kinase kinase MLTtarget
DasatinibMitogen-activated protein kinase 14target
DasatinibAmidophosphoribosyltransferasetarget
BosutinibTyrosine-protein kinase ABL1target
BosutinibTyrosine-protein kinase Lyntarget
BosutinibProto-oncogene tyrosine-protein kinase Srctarget
BosutinibP-glycoprotein 1transporter
BosutinibCytochrome P450 3A4enzyme
BosutinibDual specificity mitogen-activated protein kinase kinase 1target
BosutinibDual specificity mitogen-activated protein kinase kinase 2target
BosutinibMitogen-activated protein kinase kinase kinase 2target
BosutinibCalcium/calmodulin-dependent protein kinase type II subunit gammatarget
BosutinibCytochrome P450 2C8enzyme
BosutinibTyrosine-protein kinase Fgrtarget
BosutinibTyrosine-protein kinase HCKtarget
BosutinibTyrosine-protein kinase Tectarget
BosutinibSTE20-like serine/threonine-protein kinasetarget
PonatinibTyrosine-protein kinase ABL1target
PonatinibBreakpoint cluster region proteintarget
PonatinibMast/stem cell growth factor receptor Kittarget
PonatinibProto-oncogene tyrosine-protein kinase receptor Rettarget
PonatinibAngiopoietin-1 receptortarget
PonatinibReceptor-type tyrosine-protein kinase FLT3target
PonatinibCytochrome P450 3A4enzyme
PonatinibCytochrome P450 2C8enzyme
PonatinibCytochrome P450 2D6enzyme
PonatinibCytochrome P450 3A5enzyme
PonatinibP-glycoprotein 1transporter
PonatinibATP-binding cassette sub-family G member 2transporter
PonatinibFibroblast growth factor receptor 1target
PonatinibFibroblast growth factor receptor 2target
PonatinibFibroblast growth factor receptor 3target
PonatinibFibroblast growth factor receptor 4target
PonatinibTyrosine-protein kinase Lcktarget
PonatinibProto-oncogene tyrosine-protein kinase Srctarget
PonatinibTyrosine-protein kinase Lyntarget
PonatinibVascular endothelial growth factor receptor 2target
PonatinibPlatelet-derived growth factor receptor alphatarget
AsciminibCytochrome P450 3A4enzyme
AsciminibUDP-glucuronosyltransferase 2B7enzyme
AsciminibUDP-glucuronosyltransferase 2B17enzyme
AsciminibTyrosine-protein kinase ABL1target
AsciminibATP-binding cassette sub-family G member 2transporter
AsciminibUDP-glucuronosyltransferase 1-1enzyme
AsciminibCytochrome P450 2C19enzyme
AsciminibP-glycoprotein 1transporter
AsciminibSolute carrier organic anion transporter family member 1B1transporter
AsciminibSolute carrier organic anion transporter family member 1B3transporter
AsciminibSolute carrier family 22 member 1transporter
AsciminibCytochrome P450 2C9enzyme