Bridged-Ring Compounds

Name
Bridged-Ring Compounds
Accession Number
DBCAT005554
Description

A broad class of substances containing carbon and its derivatives. Many of these chemicals will frequently contain hydrogen with or without oxygen, nitrogen, sulfur, phosphorus, and other elements. They exist in either carbon chain or carbon ring form.

Drugs
DrugDrug Description
AdamantaneA tricyclo bridged hydrocarbon. [PubChem]
AmantadineA medication used to treat dyskinesia in Parkinson's patients receiving levodopa, as well as extrapyramidal side effects of medications.
AdamantanoneNot Available
VildagliptinA once-daily dipeptidyl peptidase 4 (DPP-4) inhibitor used in the management of type 2 diabetes mellitus.
SQ-109Investigated for use/treatment in bacterial infection, infectious and parasitic disease (unspecified), and tuberculosis.
SaxagliptinAn DPP-4 inhibitor used for the management of type 2 diabetes mellitus.
AR-9281Investigated for use/treatment in hypertension.
1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanoneNot Available
PlatensimycinNot Available
PeficitinibPeficitinib has been used in trials studying the treatment and basic science of Psoriasis, Pharmacodynamics, Drug Interactions, Colitis, Ulcerative, and RHEUMATOID ARTHRITIS, among others.
ArtefenomelArtefenomel has been investigated for the treatment of Malaria.
ABT-384ABT-384 has been used in trials studying the treatment of Alzheimer's Disease.
AZD-9056AZD9056 has been used in trials studying the basic science and treatment of Rheumatoid Arthritis.
OpaganibOpaganib, also known as ABC294640, is a selective sphingosine kinase-2 (SK2) (https://go.drugbank.com/polypeptides/Q9NRA0) inhibitor that is orally administered. This drug has potential anticancer, anti-inflammatory, and antiviral activities, with potential applications in...
TromantadineTromantadine is marketed as Viru-Merz in the Czech Republic . It is an antiviral used in the treatment of herpes zoster and simplex.
MartinostatMartinostat is under investigation in clinical trial NCT03721211 (Imaging With [11C]Martinostat in Breast Cancer).
RimantadineAn RNA synthesis inhibitor used to prevent influenza A infection.
MecamylamineA nicotine antagonist used to treat moderate to severe essential hypertension and uncomplicated malignant hypertension.
BiperidenA muscarinic receptor antagonist used to treat parkinsonism and control extrapyramidal side effects of neuroleptic drugs.
MemantineAn NMDA receptor antagonist used to treat moderate to severe dementia in Alzheimer's.
FencamfaminFor the the treatment of depressive fatigue in convalescence and other debilitated states as well as in the treatment of depressive day-time fatigue, lack of concentration and lethargy.
CamphorA compound used topically to help relieve pain and also as a topical antiseptic. May also be used in vaporizers to help suppress coughing. This medication should not be swallowed.
ThiocamphorNot Available
NorcamphorNot Available
CamphaneNot Available
FaciniclineInvestigated for use/treatment in alzheimer's disease, neurologic disorders, and schizophrenia and schizoaffective disorders.
CenisertibInvestigated for use/treatment in solid tumors, leukemia (myeloid), myelodysplastic syndrome, and cancer/tumors (unspecified).
DeramciclaneInvestigated for use/treatment in anxiety disorders.
MethenamineA urinary tract antiseptic and antibacterial drug used for the prophylaxis and treatment of frequently recurring urinary tract infections requiring a long-term therapy.
BlinatumomabAn antineoplastic antibody used to treat Philadelphia chromosome-negative relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL).
EcamsuleA sunscreen agent found in sunscreens that absorbs UV rays.
EnzacameneAn ingredient used in sunscreen to block UVB radiation.
BorneolNot Annotated
MirogabalinMirogabalin has been used in trials studying the treatment of Post-herpetic Neuralgia, Pain Associated With Fibromyalgia, and Diabetic peripheral neuropathic pain.
PD-217014PD-217,014 has been used in trials studying the treatment of Pain and Irritable Bowel Syndrome.
XibornolA lipophilic antiseptic indicated as an adjunct in the treatment of susceptible oral infections.
Quaternium-15Quaternium-15 is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6 years...
Bornyl acetateNot Annotated
alpha-PineneA mono-terpene indicated in combination with other plant-derived compounds for the treatment of bladder, kidney, and urinary stones.
beta-PineneA mono-terpene indicated in combination with other plant-derived compounds for the treatment of bladder, kidney, and urinary stones.
CampheneAn excipient in medications for flavouring.
FenchoneAn ingredient used in medication to treat kidney, bladder, and urinary tract stones.
VerbenoneNot Annotated
Drugs & Drug Targets
DrugTargetType
AdamantaneCamphor 5-monooxygenasetarget
AmantadineDopamine D2 receptortarget
AmantadineMatrix protein 2target
AmantadineAromatic-L-amino-acid decarboxylaseenzyme
AmantadineAmine oxidase [flavin-containing] Benzyme
AmantadineSolute carrier family 22 member 2transporter
AmantadineSolute carrier family 22 member 1transporter
AmantadineGlutamate receptor ionotropic, NMDA 3Atarget
AmantadineNeuronal acetylcholine receptor subunit alpha-7target
AmantadineNeuronal acetylcholine receptor subunit alpha-4target
AmantadineNeuronal acetylcholine receptor subunit alpha-3target
AdamantanoneCamphor 5-monooxygenasetarget
VildagliptinDipeptidyl peptidase 4target
VildagliptinP-glycoprotein 1transporter
SaxagliptinDipeptidyl peptidase 4target
SaxagliptinCytochrome P450 3A4enzyme
SaxagliptinCytochrome P450 3A5enzyme
SaxagliptinMultidrug resistance-associated protein 1transporter
SaxagliptinSolute carrier organic anion transporter family member 4C1transporter
SaxagliptinSolute carrier family 22 member 8transporter
AR-9281Bifunctional epoxide hydrolase 2target
1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanoneHeme oxygenase 1target
Platensimycin3-oxoacyl-[acyl-carrier-protein] synthase 2target
OpaganibSphingosine kinase 2target
RimantadineMatrix protein 2target
MecamylamineNeuronal acetylcholine receptor subunit alpha-2target
MecamylamineNeuronal acetylcholine receptor subunit alpha-7target
MecamylamineNeuronal acetylcholine receptor subunit alpha-4target
MecamylamineNeuronal acetylcholine receptor subunit beta-2target
BiperidenMuscarinic acetylcholine receptor M1target
BiperidenCytochrome P450 2D6enzyme
MemantineCytochrome P450 2B6enzyme
MemantineSolute carrier family 22 member 2transporter
Memantine5-hydroxytryptamine receptor 3Atarget
MemantineAlpha-7 nicotinic cholinergic receptor subunittarget
MemantineCytochrome P450 2A6enzyme
MemantineCytochrome P450 2C19enzyme
MemantineDopamine D2 receptortarget
MemantineGlutamate receptor ionotropic, NMDA 1target
MemantineSodium/hydrogen exchanger 1transporter
MemantineSolute carrier family 22 member 4transporter
MemantineMultidrug and toxin extrusion protein 1transporter
MemantineGlutamate (NMDA) receptortarget
MemantineGABA(A) Receptortarget
MemantineGlycine receptorstarget
FencamfaminSodium-dependent dopamine transportertarget
CamphorCamphor 5-monooxygenasetarget
CamphorTransient receptor potential cation channel subfamily V member 1target
CamphorTransient receptor potential cation channel subfamily V member 3target
CamphorTransient receptor potential cation channel subfamily A member 1target
CamphorTransient receptor potential cation channel subfamily M member 8target
ThiocamphorCamphor 5-monooxygenasetarget
NorcamphorCamphor 5-monooxygenasetarget
CamphaneCamphor 5-monooxygenasetarget
CenisertibAurora kinase Atarget
Deramciclane5-hydroxytryptamine receptor 2Atarget
Deramciclane5-hydroxytryptamine receptor 2Ctarget
DeramciclaneCytochrome P450 2D6enzyme
BlinatumomabB-lymphocyte antigen CD19target
BlinatumomabT-cell surface glycoprotein CD3 delta chaintarget
EnzacameneProgesterone receptortarget
EnzacameneAndrogen receptortarget
EnzacameneEstrogen receptor betatarget
EnzacameneEstrogen receptor alphatarget