Plague (DBCOND0000445)

Identifiers

Synonyms

Plague, unspecified / Unspecified plague / Plague (disorder) / Yersinia pestis infection / Bubonic plague / Bubonic plague (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Demeclocycline	A tetracycline antibiotic used to treat a wide variety of susceptible bacterial infections.	30S ribosomal proteintarget Vasopressin V2 receptortarget
Minocycline	A tetracycline analog used to treat a wide variety of infections in the body.	30S ribosomal protein S4target 30S ribosomal protein S9target 16S ribosomal RNAtarget Interleukin-1 betatarget Polyunsaturated fatty acid 5-lipoxygenasetarget Matrix metalloproteinase-9target Vascular endothelial growth factor A, long formtarget Caspase-1target Caspase-3target Cytochrome ctarget Solute carrier family 22 member 6transporter Solute carrier family 22 member 7transporter Outer membrane protein Ftransporter Outer membrane porin Ctransporter Mitogen-activated Protein Kinasestarget Nitric oxide synthase, inducibletarget
Moxifloxacin	A fluoroquinolone antibiotic used to treat various bacterial infections.	DNA gyrase subunit Atarget DNA topoisomerase 4 subunit Atarget DNA topoisomerase 2-alphatarget Cytochrome P450 1A2enzyme Serum paraoxonase/arylesterase 1target DNA gyrase subunit Atarget DNA gyrase subunit Btarget
Streptomycin	An aminoglycoside antibiotic indicated to treat multi-drug resistant mycobacterium tuberculosis and various non-tuberculosis infections.	30S ribosomal protein S12target 16S ribosomal RNAtarget Protein-arginine deiminase type-4target 23S ribosomal RNAtarget Bacterial outer membranetarget Cytoplasmic membranetarget
Tetracycline	An antibiotic used to treat a wide variety of susceptible infections.	16S ribosomal RNAtarget Major prion proteintarget Albumincarrier Cytochrome P450 3A4enzyme Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Solute carrier family 22 member 11transporter Solute carrier family 22 member 7transporter 30S ribosomal protein S3target 30S ribosomal protein S8target 30S ribosomal protein S19target 30S ribosomal protein S14target 30S ribosomal protein S7target Multidrug translocase MdfAtarget Protein-arginine deiminase type-4target Solute carrier organic anion transporter family member 2B1transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04688996	Yersinia Pestis Lateral Flow Immunoassay for Blood Samples	No drug interventions	Not Available	Not Available	unknown_status
NCT00246467	One Year Study to Evaluate Three Different Adjuvanted Doses of the Recombinant Plague Vaccine (rF1 and rV Antigens)	No drug interventions	prevention	1	completed
NCT05506969	Trial of the Immunogenicity, Safety, and Tolerability of rF1V Vaccine With CpG 1018® Adjuvant Compared With rF1V Vaccine in Adults 18 to 55 Years of Age	ISS-1018	prevention	2	completed
NCT02596308	Immunogenicity and Safety of Subunit Plague Vaccine	Yersinia pestis 195/p antigen (formaldehyde inactivated)	prevention	2	completed
NCT01243437	A Clinical Trial to Evaluate the Safety and Efficacy of Ciprofloxacin in the Treatment of Plague in Humans	Ciprofloxacin Doxycycline	treatment	2	unknown_status
NCT05330624	Immunogenicity and Safety of Subunit Vaccine of Plague Vaccine With Two Immunization Regimens	Yersinia pestis 195/p antigen (formaldehyde inactivated)	prevention	2	unknown_status
NCT00128466	Treatment and Diagnosis of Plague	Gentamicin Streptomycin	treatment	2 / 3	completed
NCT01381744	Dose Escalation Trial of a Plague Vaccine, Flagellin/F1/V, in Healthy Adult Volunteers	No drug interventions	prevention	1	completed
NCT04562012	Lateral Flow Assays for Pathogens of the Plague	No drug interventions	Not Available	Not Available	recruiting