Cervicitis (DBCOND0014179)

Identifiers

Synonyms

Uterine Cervicitis / Inflammatory disease of cervix uteri / Cervix inflammation / Cervicitis NOS / Inflammation of cervix (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Azithromycin	A macrolide antibiotic used to treat a variety of bacterial infections.	23S ribosomal RNAtarget ATP-dependent translocase ABCB1transporter Cytochrome P450 3A4enzyme Protein-arginine deiminase type-4target ATP-binding cassette sub-family C member 2transporter
Estriol	A weak estrogen used to treat vaginal dryness and estrogen deficiency conditions, such as vaginitis and vulvar itching.	Estrogen receptortarget Solute carrier organic anion transporter family member 1A2transporter ATP-dependent translocase ABCB1transporter Estrogen receptor betatarget Sex hormone-binding globulintarget
Meclocycline	A tetracycline antibiotic indicated in the treatment of susceptible skin infections, bacterial vaginitis, vulvovaginitis, and cervicitis.	Outer membrane protein Ftransporter Membrane proteintransporter 30S ribosomal protein S7target TetX family tetracycline inactivation enzymeenzyme
Metronidazole	A nitroimidazole used to treat trichomoniasis, amebiasis, inflammatory lesions of rosacea, and bacterial infections, as well as prevent postoperative infections.	Oxygen-insensitive NADPH nitroreductasetarget Cytochrome P450 2C9enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme UDP-glucuronosyltransferase 1A1enzyme Anaerobic bacterial DNAtarget Protozoal DNAtarget ATP-dependent translocase ABCB1transporter Cytochrome P450 2A6enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme
Ofloxacin	An antibacterial agent used for the treatment of bacterial infections in many parts of the body, including the respiratory tract, kidney, skin, soft tissue, and urinary tract.	DNA gyrase subunit Atarget DNA topoisomerase 4 subunit Atarget DNA topoisomerase 2-alphatarget Cytochrome P450 1A2enzyme Organic cation/carnitine transporter 2transporter Multidrug resistance-associated protein 1transporter Solute carrier family 22 member 6transporter ATP-binding cassette sub-family C member 2transporter Solute carrier family 22 member 4transporter Bile salt export pumptransporter DNA gyrase subunit Atarget DNA gyrase subunit Btarget
Sitafloxacin	A fluoroquinolone antibiotic indicated in the treatment of susceptible bacterial infections.	Cytochrome P450 1A2enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01661985	Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced	Azithromycin Doxycycline Lymecycline	treatment	4	unknown_status
NCT01072136	Empiric Therapy of Mucopurulent Cervicitis (MPC)	Azithromycin Cefixime	treatment	3	terminated
NCT05675293	Cervicitis by Iontophoresis	No drug interventions	treatment	0	not_yet_recruiting
NCT05564299	Rapid Diagnostic Assay for Gonorrhea and Chlamydia	No drug interventions	diagnostic	Not Available	recruiting
NCT04809727	Histopathological Findings in Symptomatizing Patients After Supracervical Hysterectomy	No drug interventions	diagnostic	Not Available	completed