Acidosis (DBCOND0015998)

Identifiers

Synonyms

Acidosis, unspecified / Acidosis NOS / Acidosis (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Citric acid	An anti-chelation additive used in blood collection tubes and as a flavoring and preservative agent in various cosmetic and pharmaceutical products.	Beta-lactamase 2target Aldo-keto reductase family 1 member B1target Citrate synthase, mitochondrialtarget Proto-oncogene tyrosine-protein kinase Srctarget Ribonuclease pancreatictarget Isocitrate dehydrogenase [NADP]target Eosinophil cationic proteintarget Beta-lactamasetarget Fumarate hydratase class IItarget 6-phosphogluconolactonasetarget L-amino-acid oxidasetarget Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1target Cytochrome c peroxidasetarget Hepatocyte growth factor-regulated tyrosine kinase substratetarget Invasintarget Intron-associated endonuclease 1target Short tail fiber protein gp12target Malate dehydrogenase, mitochondrialtarget N5-carboxyaminoimidazole ribonucleotide mutasetarget 50S ribosomal protein L4target Carboxypeptidase Btarget Hexon proteintarget Riboflavin biosynthesis proteintarget Beta-fructosidasetarget Putative stringent starvation protein Atarget Citrate synthasetarget RNA 3'-terminal phosphate cyclasetarget U6 snRNA-associated Sm-like protein LSm6target Pleckstrin homology domain-containing family A member 1target Fe(3+)-binding periplasmic proteintarget Signal recognition particle receptor FtsYtarget Nicotinate-nucleotide adenylyltransferasetarget N utilization substance protein B homologtarget Complement component C8 gamma chaintarget Ribonucleoside-diphosphate reductase subunit betatarget Glutamine synthetase 1target 2-methylcitrate synthasetarget Prostaglandin F synthasetarget Adenine phosphoribosyltransferasetarget Glucose-1-phosphate thymidylyltransferasetarget Glyoxalase family proteintarget Laccase domain protein YfiHtarget Ribose-5-phosphate isomerase Atarget GMP synthase [glutamine-hydrolyzing]target Inosine triphosphate pyrophosphatasetarget Lysozymetarget Glycerol uptake operon antiterminator regulatory proteintarget 3-carboxy-cis,cis-muconate cycloisomerasetarget Pyruvate decarboxylasetarget Solute carrier organic anion transporter family member 2B1transporter Metallo-beta-lactamase type 2target Transient receptor potential cation channel subfamily V member 4target Lanosterol 14-alpha demethylasetarget
Malic acid	Malic acid has been used in trials studying the treatment of Xerostomia, Depression, and Hypertension.	No drug targets
Potassium lactate	Not Annotated	No drug targets
Sodium citrate	An ingredient used for the anticoagulation of whole blood as part of automated apheresis procedures.	Mitochondrial 2-oxodicarboxylate carriertransporter Solute carrier family 13 member 2transporter Na(+)/citrate cotransportertransporter Tricarboxylate transport protein, mitochondrialtransporter Carbonic anhydrase 4target
Sodium phosphate, monobasic	A source of phosphorus used prevent or correct hypophosphatemia in patients with restricted or no oral intake.	Sodium-dependent phosphate transporter 1transporter Sodium-dependent phosphate transporter 2transporter Sodium-dependent phosphate transport protein 2Atransporter Sodium-dependent phosphate transport protein 2Btransporter Sodium-dependent phosphate transport protein 2Ctransporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00905502	Intraoperative Fluid Management in Laparoscopic Bariatric Surgery	Calcium chloride Lactic acid Potassium chloride Sodium chloride	treatment	Not Available	completed
NCT04231045	The Impact of the pH on Cardiac Function in the Critically Ill Patient	No drug interventions	Not Available	Not Available	completed
NCT04459442	Placental Transfusion in the 'Natural' Delivery: Effect of Early and Late Umbilical Cord Clamping	No drug interventions	basic_science	Not Available	unknown_status
NCT03102996	Preserve-Transplant Study	No drug interventions	treatment	4	completed
NCT02862925	Introducing Fetal Scalp Stimulation as an Adjunct to Intermittent Auscultation in Low-Resource Settings.	No drug interventions	diagnostic	Not Available	completed
NCT01831492	Effects of Zeolite + Dolomite on Performance and Acidosis	No drug interventions	basic_science	Not Available	completed
NCT02809183	Evaluation of TRC101 in Subjects With Chronic Kidney Disease and Metabolic Acidosis	Veverimer	treatment	1 / 2	completed
NCT01119170	Safety of D-lactate Producing Probiotics	No drug interventions	treatment	Not Available	completed
NCT05669313	The Effects of Hypothermia and Acidosis on Coagulation During Treatment With Rivaroxaban Measured With ROTEM	Rivaroxaban	Not Available	Not Available	completed
NCT03309423	Is Venous to Arterial Conversion (v-TAC) of Blood Gas Reliable in Critical Ill Patients in the ICU?	No drug interventions	Not Available	Not Available	unknown_status