Synovitis (DBCOND0016437)

Identifiers

Synonyms

Synovitis (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Acetylsalicylic acid	A salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Aldo-keto reductase family 1 member C1target Solute carrier family 22 member 6transporter ATP-dependent translocase ABCB1transporter Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme 5'-AMP-activated protein kinasetarget Endothelin-1 receptortarget Cellular tumor antigen p53target Endoplasmic reticulum chaperone BiPtarget Ribosomal protein S6 kinase alpha-3target NF-kappa-B inhibitor alphatarget Tumor necrosis factor-inducible gene 6 proteintarget Caspase-1target Caspase-3target Inhibitor of nuclear factor kappa-B kinase subunit betatarget Extracellular signal-regulated kinase (ERK)target G1/S-specific cyclin-D1target Myc proto-oncogene proteintarget Proliferating cell nuclear antigentarget Cyclin Atarget UDP-glucuronosyltransferase 1-6enzyme Arylamine N-acetyltransferase 2enzyme Organic anion transporter 3transporter Sialidase-1target 3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
Bupivacaine	A local anesthetic used in a wide variety of superficial and invasive procedures.	Sodium channel protein type 10 subunit alphatarget Prostaglandin E2 receptor EP1 subtypetarget Cytochrome P450 3A4enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2D6enzyme
Cortisone acetate	A steroid hormone used for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses and endocrine disorders associated with inadequate production of steroid hormones.	Glucocorticoid receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Annexin A1target Corticosteroid-binding globulincarrier Albumincarrier Solute carrier organic anion transporter family member 1A2transporter ATP-dependent translocase ABCB1transporter Organic anion transporter 3transporter Steroid hormone receptor ERR1target Steroid hormone receptor ERR2target Estrogen-related receptor gammatarget
Dexamethasone	A glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders.	Glucocorticoid receptortarget Annexin A1target Nitric oxide synthase, inducibletarget Nuclear receptor subfamily 0 group B member 1target Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Bile salt export pumptransporter ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 2transporter Solute carrier organic anion transporter family member 1A2transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Steroid 17-alpha-hydroxylase/17,20 lyaseenzyme Cytochrome P450 1A1enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A43enzyme Cytochrome P450 4A11enzyme Nuclear receptor subfamily 1 group I member 2target Cytochrome P450 11B1, mitochondrialenzyme Albumincarrier 11-beta-hydroxysteroid dehydrogenase type 2enzyme 11-beta-hydroxysteroid dehydrogenase 1enzyme Organic anion transporter 3transporter
Hydrocortisone	A glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders.	Annexin A1target Glucocorticoid receptortarget Sex hormone-binding globulincarrier Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 11B2, mitochondrialenzyme Cytochrome P450 2C8enzyme Corticosteroid-binding globulincarrier Organic anion transporter 3transporter Aldo-keto reductase family 1 member D1enzyme 3-oxo-5-alpha-steroid 4-dehydrogenase 2enzyme 11-beta-hydroxysteroid dehydrogenase type 2enzyme 11-beta-hydroxysteroid dehydrogenase 1enzyme Cytochrome P450 2A6enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme
Niflumic acid	A cyclooxygenase-2 inhibitor used to alleviate inflammation, pain, and edema associated with acute and chronic inflammatory conditions, such as rheumatoid arthritis, osteoarthritis, post-operative inflammatory conditions, and physical trauma.	Phospholipase A2target Chloride channel protein ClC-Katarget Monocarboxylate transporter 2transporter Monocarboxylate transporter 1transporter Prostaglandin G/H synthase 2target Prostaglandin G/H synthase 1target Cytosolic phospholipase A2target UDP-glucuronosyltransferase 1A9target UDP-glucuronosyltransferase 1A9enzyme
Prednisolone	A glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers.	Corticosteroid-binding globulincarrier Cytochrome P450 3A4enzyme Glucocorticoid receptortarget Solute carrier organic anion transporter family member 1A2transporter ATP-dependent translocase ABCB1transporter Albumincarrier
Triamcinolone	A glucocorticoid used to treat a wide variety of inflammatory conditions of organ systems and tissues.	Corticosteroid-binding globulincarrier Glucocorticoid receptortarget Cytochrome P450 3A4enzyme Prostaglandin G/H synthase 2enzyme Cholinesteraseenzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Albumincarrier

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00903903	Computer-Assisted Quantification of the Synovial Perfusion in Patients With Arthritis Using Two-Dimensional and Three-Dimensional Power Doppler Ultrasonography	No drug interventions	Not Available	Not Available	unknown_status
NCT00001679	Prognostic Indicators and Determinants of the 2-5 Year Outcome in a Cohort of Early Synovitis Patients	No drug interventions	Not Available	Not Available	completed
NCT02060305	Intra-articular Bevacizumab for Recurrent Hemarthroses at Target Joints With Chronic Hemophilic Synovitis	Bevacizumab	treatment	1	terminated
NCT04750993	Comparison of the Frequency of Subclinic Synovitis in the Distal Interphalangeal Joints of the Hand in Psoriasis Patients	No drug interventions	Not Available	Not Available	completed
NCT00001375	The Pathogenesis of Inflammatory Synovitis: A Study of Early Arthritis	No drug interventions	Not Available	Not Available	completed
NCT05629130	Embolization in Hereditary Coagulopathies	No drug interventions	treatment	Not Available	recruiting
NCT05700682	Perfusion MRI-targeted Joint Embolization for Chronic Musculoskeletal Pain of the Shoulder, Hip and Knee	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT02403687	Prospective Analgesic Compound Efficacy (PACE) Study	Baclofen Bupivacaine Capsaicin Cyclobenzaprine Diclofenac Flurbiprofen Gabapentin Ketamine Levomenthol Lidocaine Meloxicam Prilocaine Sumatriptan Tizanidine Topiramate	Not Available	Not Available	completed
NCT03507933	Evaluation of the Effectiveness of Surgical Treatment of Villo-nodular Synovitis of the Hip in Children	No drug interventions	Not Available	Not Available	unknown_status
NCT04641351	Corticosteroid Meniscectomy Randomized Trial	Triamcinolone	treatment	4	enrolling_by_invitation
NCT00001677	Methotrexate Alone Versus Combination of Methotrexate and Subcutaneous Fludarabine for Severe Rheumatoid Arthritis: Safety, Tolerance and Efficacy	Fludarabine Methotrexate	treatment	2	completed
NCT06352216	Prevalence of Synovitis in Patients With Haemophilia A	No drug interventions	Not Available	Not Available	recruiting
NCT00890058	A Case Control Study to Define Clinical, Immunologic and Radiographic Features of the Aromatase Inhibitor Arthralgia Syndrome	No drug interventions	Not Available	Not Available	completed
NCT00604539	Effect of Chondroitin Sulphate on Synovial Inflammation in Patients With Osteoarthritis of the Knee	Chondroitin sulfate	treatment	3	completed
NCT01272830	Double-Blinded Clinical Trial Using Apatone®B for Symptomatic Postoperative Total Joint Replacements	No drug interventions	treatment	2	completed
NCT01731262	Preliminary Study of Sonic Hedgehog Signaling Pathway in the Pathogenesis of Rheumatoid Arthritis	No drug interventions	Not Available	Not Available	unknown_status
NCT02902562	Synovitis and Therapy Response in Inflammatory Arthritis With Contrast Enhanced Ultrasound	No drug interventions	diagnostic	Not Available	completed