Triamcinolone is a glucocorticoid used to treat a wide variety of inflammatory conditions of organ systems and tissues. Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis.
- Mechanism
- Curator reviewed · 3 references
Corticosteroids like triamcinolone inhibit phospholipase A2 on cell membranes, preventing the breakdown of lysosomal membranes of leukocytes, which in turn prevent the formation of arachidonic acid, which decrease expression of cyclooxygenase and lipoxygenase, inhibiting synthesis of prostaglandins and leukotrienes. Anti-inflammatory activity occurs via reversal of vascular dilation and reducing permeability, which prevents macrophage and leukocyte migration. Triamcinolone also inhibits nuclear factor kappa-B, which decreases the production of pro-inflammatory signals such as interleukin-6, interleukin-8, and monocyte chemoattractant protein-1.
- Primary indication
- Triamcinolone hexacetonide injections are indicated for intralesional administration in alopecia areata, discoid lupus erythematosus, keloids, and necrobiosis lipoidica diabeticorum.Curator reviewed · 134 structured indications
- Formula / weight
- C21H27FO6 · 394.4339 g/mol (avg)
- First approval
- Canada, 1998 · United States, 1961
- Also known as
- Fluoxyprednisolone
- Brand names
Resolves to
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Which drugs share a target with Triamcinolone, and which of those have an active Phase 3 trial?
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