Cortisone acetate is a steroid hormone used for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses and endocrine disorders associated with inadequate production of steroid hormones. Cortisone acetate was first isolate in 1935 and became more widely researched in 1949.
- Mechanism
- Curator reviewed · 5 references
The short term effects of corticosteroids are decreased vasodilation and permeability of capillaries, as well as decreased leukocyte migration to sites of inflammation. Corticosteroids binding to the glucocorticoid receptor mediates changes in gene expression that lead to multiple downstream effects over hours to days. Glucocorticoids inhibit neutrophil apoptosis and demargination; they inhibit phospholipase A2, which decreases the formation of arachidonic acid derivatives; they inhibit NF-Kappa B and other inflammatory transcription factors; they promote anti-inflammatory genes like interleukin-10. Lower doses of corticosteroids provide an anti-inflammatory effect, while higher doses are immunosuppressive. High doses of glucocorticoids for an extended period bind to the mineralocorticoid receptor, raising sodium levels and decreasing potassium levels.
- Primary indication
- Cortisone acetate is indicated to treat a wide variety of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, and gastrointestinal diseases and disorders.Curator reviewed · 61 structured indications
- Formula / weight
- C23H30O6 · 402.4807 g/mol (avg)
- First approval
- Canada, 2019 · United States, 1972
- Also known as
- Cortone acetate
Resolves to
ITRJWOMZKQRYTA-RFZYENFJSA-NSMILES[H][C@@]12CC[C@](O)(C(=O)COC(C)=O)[C@@]1(C)CC(=O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12CWhat you can answer from here — as of September 12, 2026
Which drugs share a target with Cortisone acetate, and which of those have an active Phase 3 trial?
Create a free account or log in to explore the full data card.
Create Account