Agitation (DBCOND0017779)

Identifiers

Synonyms
Agitational state / Agitated states / Agitated state / Excitement abnormal / Feeling agitated (finding) / Agitated

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Amoxapine
A tricyclic antidepressant used in the treatment of neurotic or reactive depressive disorders and endogenous or psychotic depression.
Aripiprazole
An atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome.
Brexpiprazole
A serotonin–dopamine activity modulator used in the treatment of major depressive disorder as an adjunct, schizophrenia, and agitation associated with dementia due to Alzheimer’s disease.
Dexmedetomidine
An alpha-2 agonist used for sedation during various procedures.
Droperidol
A butyrophenone derivative and dopamine antagonist used to prevent and treat postoperative nausea and vomiting.
Lorazepam
A short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures.
Medazepam
A long-acting benzodiazepine used for its sedative and anxiolytic properties.
Prazosin
An alpha-blocker that causes a decrease in total peripheral resistance and is used to treat hypertension.
Trifluoperazine
A phenothiazine used to treat depression, anxiety, and agitation.
Ziprasidone
An atypical antipsychotic used to manage schizophrenia, bipolar mania, and agitation in patients with schizophrenia.
Zuclopenthixol
An antipsychotic indicated for the management of schizophrenia. The acuphase formulation is indicated for initial treatment of acute psychosis or exacerbation of psychosis, while the depot formulation is best for maintenance.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT04268303
Dexmedetomidine in the Treatment of Agitation Associated With Schizophreniatreatment3completed
NCT01280890
Person- Centred Care Among Nursing Home Patients With DementiaNo drug interventionssupportive_careNot Availablecompleted
NCT06052254
Dexmedetomidine Transdermal Systems (DMTS) Treatment for Agitation Associated With Dementia of the Alzheimer's TypeNo drug interventionstreatment2not_yet_recruiting
NCT05522647
Detection of Risk Behaviors: Pilot Observational Study With Bedridden and Agitated Patients.No drug interventionsNot AvailableNot Availableunknown_status
NCT02104297
Effect of Deksmedetomidine and Remifentanil in Extubation Agitationprevention4unknown_status
NCT02118688
Efficacy and Safety of Risperidone and Trazodone Monotherapy and Combination Therapy in Critically Ill Patients With Deliriumtreatment4withdrawn
NCT00898807
Citalopram for Agitation in Alzheimer's Diseasetreatment3completed
NCT01374737
ED50 of Dexmedetomidine to Prevent Emergence Agitation in Childrenprevention4unknown_status
NCT00315900
Depakote Extended Release (ER) Versus Seroquel for Agitated Behaviors in Nursing Home Care Unit Patients With Dementiatreatment3terminated
NCT00790075
Liquid Risperidone in the Treatment of Acute Agitation in Psychiatrically Hospitalized Childrentreatment4completed
NCT06140342
A Music-Based Mobile App for People Living With Alzheimer's Disease and Related Dementias (ADRD)No drug interventionsNot AvailableNot Availablerecruiting
NCT02194036
Learning Oriented Physiotherapy - a New ApproachNo drug interventionstreatmentNot Availablecompleted
NCT06578819
Doll Therapy for Agitated Elderly Dementia PeopleNo drug interventionssupportive_careNot Availableactive_not_recruiting
NCT02203019
Study of Sedative Medications in Patients With Severe Infection and Respiratory Failuretreatment4completed
NCT01217541
Collaboration Between Department of Old Age Psychiatry and Nursing HomesNo drug interventionshealth_services_researchNot Availablecompleted
NCT00009217
Treatment of Behavioral Symptoms in Alzheimer's Diseasetreatment4completed
NCT02216396
A Naturalistic Two-year Cohort Study of Agitation and Quality of Life in Care HomesNo drug interventionsNot AvailableNot Availableunknown_status
NCT01021696
Pain in Patients With Dementia and Behavioural Disturbancestreatment2 / 3completed
NCT01848158
Acupuncture to Improve Comfort of Children on a Ventilator in the Intensive Care UnitNo drug interventionstreatmentNot Availablecompleted
NCT03639558
TREC-Lebanon: A Trial for Rapid Tranquilisation for Agitated Patients in the Emergency Settingtreatment4completed
NCT02848963
Comparison of Ketamine-propofol Combinationsprevention4completed
NCT05313386
Study of BXCL501 In Agitation Associated With Delirium in ICU Patientstreatment2withdrawn
NCT05397639
Masupirdine for the Treatment of Agitation in Dementia of the Alzheimer's Typetreatment3recruiting
NCT02129348
Treatment of Psychosis and Agitation in Alzheimer's Diseasetreatment2completed
NCT00012857
Pain Management and Behavioral Outcomes in Patients With DementiaNo drug interventionstreatment2completed
NCT03773874
Assessment of Analgesia, Sedation, Physical Restraints and Delirium in Spanish Intensive Care UnitsNo drug interventionsNot AvailableNot Availablecompleted
NCT02164773
Addition of Magnesium Sulfate to Caudal to Prevent Postoperative Emergence Agitation.prevention4unknown_status
NCT00857727
Use of Dexmedetomidine to Reduce Emergence Delirium Incident in Childrentreatment3completed
NCT02525991
Phase IV to Evaluate the Safety of Self-administered ADASUVE® in Agitated Patients Outside the Hospital SettingNo drug interventionstreatment4completed
NCT02199262
Quality Improving Program on Agitation in the Surgical Intensive Care UnitNo drug interventionspreventionNot Availablecompleted
NCT02846740
Cranial Electric Stimulation to Modify Suicide Risk Factors in Psychiatric Inpatients.No drug interventionstreatmentNot Availableterminated
NCT04266340
Different Premedication in Pediatric PatientspreventionNot Availablecompleted
NCT03317067
Effects of Dexmedetomidine on Delirium Duration of Non-intubated ICU Patients (4D Trial)treatment3completed
NCT00505804
A Comparison of Dexmedetomidine and Haloperidol in Patients With Intensive Care Unit (ICU)-Associated Agitation and Deliriumtreatment2completed
NCT04039269
Long Term Memory Preoperative Preparation Reduce Post Operative Behavioral ChangeNo drug interventionspreventionNot Availableunknown_status
NCT02103881
Ketamine Versus Haloperidol for Severe Agitation Outside the Hospitaltreatment4withdrawn
NCT05165914
Midazolam Effect on Agitation Postnasal SurgerypreventionNot Availablecompleted
NCT04722614
Music and Essential Oil in AgitationNo drug interventionspreventionNot Availablecompleted
NCT01501123
Pre-hospital Agitation and Sedation Trial: A Randomized Controlled Trial of Haloperidol Versus Midazolam for the Sedation of the Agitated PatienttreatmentNot Availablecompleted
NCT04950738
The Effectiveness of Acupuncture for Complications in Critically Ill PatientsNo drug interventionssupportive_careNot Availableunknown_status
NCT01119638
Escitalopram Treatment for BPSD in Alzheimer's Disease in Comparison to Risperidonetreatment4completed
NCT01517438
Effects of Serotonin Inhibitors on Patient-controlled Analgesia Related Nausea and VomitingNo drug interventionspreventionNot Availablecompleted
NCT01976754
Safety Study of Dexmedetomidine in Septic Patientssupportive_careNot Availablecompleted
NCT00797277
Intramuscular (IM) Olanzapine Versus IM Haloperidol Plus Lorazepam for Acute Agitation in Schizophreniatreatment3completed
NCT00866645
A Study To Evaluate The Efficacy And Safety Of Intramuscular Levosulpiride In Patients With Agitation Of Schizophreniatreatment2 / 3completed
NCT04010305
Sub-Lingual Dexmedetomidine in Agitation Associated With Schizophreniatreatment1completed
NCT04908605
Emergence Agitation After Nasal Surgery: a Randomized Controlled Comparison Between Melatonin and Mirtazapineprevention4completed
NCT02720705
Transbucal Dexmedetomidine for Prevention of Sevoflurane Emergence Agitation in Pre-school Childrenprevention2 / 3completed
NCT02428283
Scalp Nerve Block on Emergence Agitationprevention4completed
NCT04312893
The Effectiveness of Acupuncture for Delirium in Critically Ill PatientsNo drug interventionstreatmentNot Availableunknown_status
NCT05273671
Nalbuphine Versus Dexmedetomidine for Prevention of Emergence Agitation in Pediatricsprevention4unknown_status
NCT05665088
Dexmedetomidine in the Treatment of Agitation Associated With Dementia (TRANQUILITY III)treatment3terminated
NCT05557409
A Study to Assess the Efficacy and Safety of AXS-05 in Subjects With Alzheimer's Disease AgitationNo drug interventionstreatment3recruiting
NCT03554915
Ketamine Versus Midazolam for Prehospital AgitationNo drug interventionsNot AvailableNot Availablecompleted
NCT05271552
Dexmedetomidine in the Treatment of Agitation Associated With Dementia (TRANQUILITY II)treatment3completed
NCT00833300
Haloperidol vs Olanzapine for the Management of ICU DeliriumtreatmentNot Availableterminated
NCT03398759
Butorphanol Mitigate Emergence Agitation in Patients Undergoing Functional Endoscopic Sinus SurgerypreventionNot Availableunknown_status
NCT00590499
Agitation in Post Operative Neurosurgical PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT00351299
Randomized Controlled Trial of Dexmedetomidine for the Treatment of Intensive Care Unit (ICU) Deliriumtreatment2completed
NCT01715506
Continuing Education in Nursing Home Dementia CareNo drug interventionssupportive_careNot Availablecompleted
NCT03044249
A Study of MP-101 in Dementia-Related Psychosis and/or Agitation and Aggressiontreatment2terminated
NCT01329536
The Occurrence of the ApoE4 Allele in Agitated In-Patients With Late-Onset Alzheimer's DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT01400113
Treating Acutely Agitated Patients With Asenapine Sublingual Tabletstreatment4completed
NCT00786318
Ziprasidone vs Standard Therapy for Agitated Patients in the EDtreatment4withdrawn
NCT01747824
Stress Biomarkers Among Patients Undergoing Treatment for Excited Delirium and Severe Pain in the Emergency DepartmentNo drug interventionsNot AvailableNot Availablecompleted
NCT05276830
An Efficacy, and Safety Study Of BXCL501 For The Treatment Of Agitation Associated With Dementiatreatment2terminated
NCT04516057
Nabilone for Agitation Blinded Intervention Trialtreatment3recruiting
NCT00457366
A Comparison Study of the Efficacy of Quetiapine and Haloperidol in Agitated Adults in Emergency Roomtreatment4completed
NCT00417482
Antipsychotic Discontinuation in Alzheimer's Diseasetreatment4completed
NCT02351882
Safety and Efficacy of Nabilone in Alzheimer's Diseasetreatment2 / 3completed
NCT05974527
Pilot Study 1: Efficacy and Safety of Sublingual Dexmedetomidine (BXCL501) for the Treatment of Agitation in the Emergency Departmenttreatment4not_yet_recruiting
NCT01904760
Dexmedetomidine to Prevent Agitation After Free Flap Surgeryprevention4completed
NCT05644262
Life's End Benefits of Cannabidiol and Tetrahydrocannabinoltreatment2recruiting
NCT06037629
Premature Enhanced Automated Capture of Comfort KnowledgeNo drug interventionsNot AvailableNot Availablerecruiting
NCT02590744
Effects of Preoperative Using of Eye Patches on Prevention of Emergence Agitation After Cataract SurgeryNo drug interventionspreventionNot Availableunknown_status
NCT01584440
Efficacy, Safety and Tolerability Study of AVP-923 (Dextromethorphan/Quinidine) for Treatment of Symptoms of Agitation in Participants With Alzheimer's Diseasetreatment2completed
NCT01524367
Effect of Single-dose Dexmedetomidine on Emergence Excitement in Adults With Nasotracheal Intubation After Orthognathic Surgeryprevention4completed
NCT01856010
Study of Electroconvulsive Therapy (ECT) Treatment for Agitation and Aggression in DementiaNo drug interventionsNot AvailableNot Availablecompleted
NCT02863081
Helping Older Persons Emerge StrongerNo drug interventionsNot AvailableNot Availablecompleted
NCT01440114
The Effect of Intravenous Fentanyl Prior the End of Surgery on Emergence Agitation in Paediatric Patients After General AnesthesiapreventionNot Availablecompleted
NCT02877108
Naturalistic Adasuve Clinical Trial StudyNo drug interventionsNot AvailableNot Availableunknown_status