hypoestrogenism (DBCOND0020874)

Identifiers

Synonyms

Estrogen Deficiency / Hypoestrogen / Oestrogen deficiency

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Androstenediol	Androstenediol is an intermediate in testosterone biosynthesis, found in the testis or the adrenal glands. Androstenediol, derived from dehydroepiandrosterone by the reduction of the 17-keto group (17-hydroxysteroid dehydrogenases), is converted...	Estrogen receptortarget Estrogen receptor betatarget
Androstenedione	A delta-4 C19 steroid that is produced not only in the testis, but also in the ovary and the adrenal cortex. Depending on the tissue type, androstenedione can serve as...	Aldo-keto reductase family 1 member C3target 17-beta-hydroxysteroid dehydrogenase type 1target 6-deoxyerythronolide B hydroxylasetarget 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target Cytochrome P450 3A4enzyme Aldo-keto reductase family 1 member C3enzyme Aromatasetarget
Conjugated estrogens	A mixture of estrogens used in estrogen replacement therapy for menopause and hypoestrogenism, used in the treatment of various malignancies, and used in the treatment of postmenopausal osteoporosis.	Estrogen receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 1A2enzyme Catechol O-methyltransferaseenzyme ATP-binding cassette sub-family C member 3transporter ATP-binding cassette sub-family C member 4transporter Multidrug resistance-associated protein 1transporter Solute carrier organic anion transporter family member 1A2transporter Hepatic sodium/bile acid cotransportertransporter Solute carrier family 22 member 10transporter Organic anion transporter 3transporter Solute carrier organic anion transporter family member 1C1transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 2B1transporter ATP-dependent translocase ABCB1transporter Solute carrier family 22 member 6transporter Organic solute transporter subunit alphatransporter Organic solute transporter subunit betatransporter ATP-binding cassette sub-family C member 2transporter Solute carrier organic anion transporter family member 4A1transporter ATP-binding cassette sub-family C member 11transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier family 22 member 11transporter Solute carrier organic anion transporter family member 3A1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Thyroxine-binding globulincarrier Sex hormone-binding globulincarrier Albumincarrier Estrogen receptor betatarget
Estradiol	An estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate.	Estrogen receptortarget Nuclear receptor subfamily 1 group I member 2target Sex hormone-binding globulincarrier Estrogen receptor betatarget Cytochrome P450 1A2enzyme UDP-glucuronosyltransferase 1A1enzyme Albumincarrier Fatty acid-binding protein, intestinalcarrier Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 2transporter Solute carrier family 22 member 3transporter ATP-binding cassette sub-family C member 10transporter Solute carrier family 22 member 11transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter ATP-dependent translocase ABCB1transporter Cytochrome P450 1A1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Organic anion transporter 3transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier organic anion transporter family member 1C1transporter Neuronal acetylcholine receptor subunit alpha-4target G-protein coupled estrogen receptor 1target ATP synthase subunit atarget Beclin-1target UDP-glucuronosyltransferase 2B15enzyme Catechol O-methyltransferaseenzyme UDP-glucuronosyltransferases (UGTs)enzyme Aromataseenzyme
Estradiol benzoate	An estrogen indicated in combination with progesterone for the treatment of irregular menstruation.	Estrogen receptortarget Nuclear receptor subfamily 1 group I member 2target Sex hormone-binding globulincarrier Estrogen receptor betatarget Cytochrome P450 1A2enzyme UDP-glucuronosyltransferase 1A1enzyme Albumincarrier Fatty acid-binding protein, intestinalcarrier Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter Solute carrier family 22 member 3transporter Solute carrier organic anion transporter family member 2B1transporter Solute carrier organic anion transporter family member 1A2transporter ATP-binding cassette sub-family C member 10transporter Solute carrier family 22 member 11transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter ATP-dependent translocase ABCB1transporter Cytochrome P450 1A1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Organic anion transporter 3transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier organic anion transporter family member 1C1transporter Solute carrier organic anion transporter family member 4A1transporter Neuronal acetylcholine receptor subunit alpha-4target Nuclear receptor coactivator 2target G-protein coupled estrogen receptor 1target ATP synthase subunit atarget Beclin-1target 17-beta-hydroxysteroid dehydrogenase type 2target Estrogen-related receptor gammatarget
Estradiol cypionate	An estradiol prodrug used to treat vasomotor symptoms and hypoestrogenisms from hypogonadism.	Estrogen receptortarget Nuclear receptor subfamily 1 group I member 2target Sex hormone-binding globulincarrier Estrogen receptor betatarget Cytochrome P450 1A2enzyme UDP-glucuronosyltransferase 1A1enzyme Albumincarrier Fatty acid-binding protein, intestinalcarrier Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter Solute carrier family 22 member 3transporter Solute carrier organic anion transporter family member 2B1transporter Solute carrier organic anion transporter family member 1A2transporter ATP-binding cassette sub-family C member 10transporter Solute carrier family 22 member 11transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter ATP-dependent translocase ABCB1transporter Cytochrome P450 1A1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Organic anion transporter 3transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier organic anion transporter family member 1C1transporter Solute carrier organic anion transporter family member 4A1transporter Neuronal acetylcholine receptor subunit alpha-4target Nuclear receptor coactivator 2target G-protein coupled estrogen receptor 1target ATP synthase subunit atarget Beclin-1target 17-beta-hydroxysteroid dehydrogenase type 2target Estrogen-related receptor gammatarget
Estradiol valerate	An estradiol prodrug used to treat some effects of menopause, hypoestrogenism, androgen dependant carcinoma of the prostate, and in combination products for endometriosis and contraception.	Estrogen receptortarget Nuclear receptor subfamily 1 group I member 2target Sex hormone-binding globulincarrier Estrogen receptor betatarget Cytochrome P450 1A2enzyme UDP-glucuronosyltransferase 1A1enzyme Albumincarrier Fatty acid-binding protein, intestinalcarrier Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter Solute carrier family 22 member 3transporter Solute carrier organic anion transporter family member 2B1transporter Solute carrier organic anion transporter family member 1A2transporter ATP-binding cassette sub-family C member 10transporter Solute carrier family 22 member 11transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter ATP-dependent translocase ABCB1transporter Cytochrome P450 1A1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Organic anion transporter 3transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier organic anion transporter family member 1C1transporter Solute carrier organic anion transporter family member 4A1transporter Neuronal acetylcholine receptor subunit alpha-4target Nuclear receptor coactivator 2target G-protein coupled estrogen receptor 1target ATP synthase subunit atarget Beclin-1target 17-beta-hydroxysteroid dehydrogenase type 2target Estrogen-related receptor gammatarget
Estriol	A weak estrogen used to treat vaginal dryness and estrogen deficiency conditions, such as vaginitis and vulvar itching.	Estrogen receptortarget Solute carrier organic anion transporter family member 1A2transporter ATP-dependent translocase ABCB1transporter Estrogen receptor betatarget Sex hormone-binding globulintarget
Estrone sulfate	An estrogen used as monotherapy or in several combination hormone replacement products for managing menopause symptoms and hormone disorders.	Cytochrome P450 1A2enzyme Cytochrome P450 3A4enzyme Estrogen receptortarget Estrogen receptor betatarget Sex hormone-binding globulincarrier Albumincarrier Cytochrome P450 2C9enzyme Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter Hepatic sodium/bile acid cotransportertransporter
Medroxyprogesterone acetate	A progestin used as a contraceptive and in the treatment of secondary amenorrhea, abnormal uterine bleeding, pain from endometriosis, endometrial and renal carcinomas, paraphilia in males, and GnRH-dependent precocious puberty.	Progesterone receptortarget Estrogen receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A1enzyme Albumincarrier ATP-dependent translocase ABCB1target GABA(A) Receptortarget ATP-dependent translocase ABCB1transporter
Norethisterone	A synthetic second-generation progestin used for contraception, prevention of endometrial hyperplasia in hormone replacement therapy, and in the treatment of other hormone-mediated illnesses such as endometriosis.	Progesterone receptortarget ATP-dependent translocase ABCB1transporter Cytochrome P450 2C19enzyme Albumincarrier Sex hormone-binding globulincarrier Aldo-keto reductase family 1 member C4enzyme 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme 3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme Aldo-keto reductase family 1 member D1enzyme Cytochrome P450 3A4enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2A6enzyme Glucocorticoid receptortarget Androgen receptortarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06606535	ENDO-BRAIN: Effects of Endocrine Adjuvant Therapy with Aromatase Inhibitors on the Cognitive Function of Breast Cancer Patients	No drug interventions	Not Available	Not Available	recruiting
NCT05704036	Estrogen Supplementation and Bone Health in Women With CF	Estradiol Progesterone	treatment	4	recruiting
NCT04336891	Effect of Testosterone Treatment on Clitoral Arteries' Hemodynamic Parameters.	Avobenzone Estradiol Homosalate Octisalate Octocrylene Oxybenzone Testosterone	Not Available	Not Available	completed
NCT06136208	Pharmacokinetic Aspects of 25-mg Estradiol Pellet in Climacteric Women	Estradiol	treatment	Not Available	active_not_recruiting
NCT03464266	The Kampala Women's Bone Study	No drug interventions	diagnostic	4	completed
NCT06353269	Adherence to Vaginal Estrogen Therapy in Hypoestrogenic Women With Recurrent Urinary Tract Infections	Estradiol	health_services_research	4	recruiting
NCT06497270	A 3D Bioprinted Hormone-producing Model for BRCA Mutated Patients After Risk Reducing Surgery: the DISC-OVARY Trial	No drug interventions	prevention	Not Available	not_yet_recruiting
NCT04154306	Effects of Fermented Red Clover on Muscle Strength and Muscle Mass	No drug interventions	other	Not Available	completed
NCT00572858	Estrogen Deficiency and Cardiovascular Disease in Premenopausal Women	No drug interventions	Not Available	Not Available	completed
NCT03112226	Effects of Ovarian Hormone Suppression on Vascular and Cognitive Function	No drug interventions	basic_science	Not Available	completed
NCT06544473	Determining Dose Equivalence Between Oral and Transdermal Estrogen Treatment in Women With Turner Syndrome	Estradiol	treatment	4	recruiting
NCT04245527	Use of Infrared Photomodulation for Hormonal Balance (Joovvin' for Hormonal Health)	No drug interventions	prevention	Not Available	unknown_status
NCT04419727	Estrogen Receptors and Peripheral Artery Disease	No drug interventions	Not Available	Not Available	unknown_status
NCT06570460	Long Term Effects of Oral Versus Transdermal Estrogen Replacement Therapy in Turner Syndrome	Estradiol	treatment	4	recruiting
NCT03856268	Understanding the Roles of Hormones in Adipocyte Remodeling Following Menopause	No drug interventions	Not Available	Not Available	withdrawn
NCT04513405	Estrogens Levels and Receptors Status and Skin Tears	No drug interventions	prevention	Not Available	unknown_status
NCT06343870	Estradiol and Testosterone Subdermal Implants for Menopause Treatment (ESTIME)	Testosterone	treatment	3	not_yet_recruiting
NCT03018366	Atherosclerosis, Immune Mediated Inflammation and Hypoestrogenemia in Young Women	Estradiol Progesterone	treatment	2	completed
NCT05587920	Effect of Oestrogen on Musculoskeletal Outcomes	No drug interventions	Not Available	Not Available	recruiting
NCT06264882	Cardiometabolic Consequences of the Loss of Ovarian Function	Degarelix Estradiol Gonadorelin	basic_science	4	recruiting
NCT03631680	The Role of Estrogen in Adipocyte Remodeling Following Surgical Menopause	No drug interventions	Not Available	Not Available	terminated
NCT05057546	Ovarian Hormone Regulation of Central and Cerebrovascular Hemodynamics (NoMEN Study)	Degarelix Gonadorelin	basic_science	4	active_not_recruiting