severe Psoriasis (DBCOND0021323)

Identifiers

Synonyms

Not Available

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Acitretin	An oral retinoid used in the treatment of severe psoriasis.	Retinoic acid receptor alphatarget Retinoic acid receptor RXR-betatarget Retinoic acid receptor gammatarget Retinoic acid receptor betatarget Retinoic acid receptor RXR-gammatarget Retinoic acid receptor RXR-alphatarget Albumincarrier Retinol-binding protein 1target Retinoic acid receptor RXRtarget Signal transducer and activator of transcription 3target
Corticotropin	A diagnostic agent used in the screening of patients presumed to have adrenocortical insufficiency.	Adrenocorticotropic hormone receptortarget Corticoliberintarget 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialenzyme 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme Cytochrome P450 3A4enzyme
Cortisone acetate	A steroid hormone used for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses and endocrine disorders associated with inadequate production of steroid hormones.	Glucocorticoid receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Annexin A1target Corticosteroid-binding globulincarrier Albumincarrier Solute carrier organic anion transporter family member 1A2transporter ATP-dependent translocase ABCB1transporter Organic anion transporter 3transporter Steroid hormone receptor ERR1target Steroid hormone receptor ERR2target Estrogen-related receptor gammatarget
Cyclosporine	A steroid-sparing immunosuppressant used in organ and bone marrow transplants as well as inflammatory conditions such as ulcerative colitis, rheumatoid arthritis, and atopic dermatitis.	Guided entry of tail-anchored proteins factor CAMLGtarget Peptidyl-prolyl cis-trans isomerase Atarget Calcineurin subunit B type 2target Cytochrome P450 3A5enzyme Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Bile salt export pumptransporter Ileal sodium/bile acid cotransportertransporter Hepatic sodium/bile acid cotransportertransporter Solute carrier family 22 member 6transporter ATP-binding cassette sub-family C member 10transporter ATP-binding cassette sub-family C member 2transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter Cytochrome P450 2C19enzyme Cytochrome P450 2D6enzyme Peptidyl-prolyl cis-trans isomerase F, mitochondrialtarget Solute carrier organic anion transporter family member 1B3transporter Protein phosphatase 3 catalytic subunit alphatarget
Dexamethasone	A glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders.	Glucocorticoid receptortarget Annexin A1target Nitric oxide synthase, inducibletarget Nuclear receptor subfamily 0 group B member 1target Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Bile salt export pumptransporter ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 2transporter Solute carrier organic anion transporter family member 1A2transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Steroid 17-alpha-hydroxylase/17,20 lyaseenzyme Cytochrome P450 1A1enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A43enzyme Cytochrome P450 4A11enzyme Nuclear receptor subfamily 1 group I member 2target Cytochrome P450 11B1, mitochondrialenzyme Albumincarrier 11-beta-hydroxysteroid dehydrogenase type 2enzyme 11-beta-hydroxysteroid dehydrogenase 1enzyme Organic anion transporter 3transporter
Hydrocortisone	A glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders.	Annexin A1target Glucocorticoid receptortarget Sex hormone-binding globulincarrier Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 11B2, mitochondrialenzyme Cytochrome P450 2C8enzyme Corticosteroid-binding globulincarrier Organic anion transporter 3transporter Aldo-keto reductase family 1 member D1enzyme 3-oxo-5-alpha-steroid 4-dehydrogenase 2enzyme 11-beta-hydroxysteroid dehydrogenase type 2enzyme 11-beta-hydroxysteroid dehydrogenase 1enzyme Cytochrome P450 2A6enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme
Methotrexate	An antineoplastic agent used the treatment of a wide variety of cancers as well as severe psoriasis, severe rheumatoid arthritis, and juvenile rheumatoid arthritis.	Dihydrofolate reductasetarget Aldehyde oxidaseenzyme Methylenetetrahydrofolate reductase (NADPH)enzyme Albumincarrier ATP-binding cassette sub-family C member 3transporter ATP-binding cassette sub-family C member 4transporter Multidrug resistance-associated protein 1transporter Solute carrier family 22 member 6transporter ATP-binding cassette sub-family C member 10transporter Organic anion transporter 3transporter ATP-binding cassette sub-family C member 2transporter ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Monocarboxylate transporter 1transporter ATP-binding cassette sub-family C member 11transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier family 22 member 11transporter Solute carrier organic anion transporter family member 1C1transporter Solute carrier organic anion transporter family member 3A1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier family 22 member 7transporter Solute carrier organic anion transporter family member 1B1transporter 6-phosphogluconate dehydrogenase, decarboxylatingenzyme Proton-coupled folate transportertransporter Folylpolyglutamate synthase, mitochondrialenzyme Gamma-glutamyl hydrolaseenzyme Dihydrofolate reductaseenzyme Thymidylate synthaseenzyme Bifunctional purine biosynthesis protein ATICenzyme Solute carrier organic anion transporter family member 4C1transporter Reduced folate transportertransporter Folate receptor alphatransporter Cytochrome P450 3A4enzyme Thymidylate synthasetarget Bifunctional purine biosynthesis protein ATICtarget Folate receptor betatransporter Solute carrier family 15 member 1transporter Proton-coupled amino acid transporter 1transporter Carboxypeptidase G2enzyme Proton-coupled folate transportertarget Reduced folate transportertarget
Methoxsalen	A furocoumarin used to treat psoriasis and vitiligo.	DNAtarget Cytochrome P450 2A6enzyme Cytochrome P450 1A2enzyme Cytochrome P450 1A1enzyme Cytochrome P450 2A13enzyme Cytochrome P450 2A6target
Methylprednisolone	A corticosteroid used to treat inflammation or immune reactions across a variety of organ systems, endocrine conditions, and neoplastic diseases.	Glucocorticoid receptortarget Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 3A Subfamilyenzyme Cytochrome P450 2A6enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Annexin A1target 20-ketosteroid reductase (20-hydroxysteroid dehydrogenase)enzyme 11beta-hydroxysteroid dehydrogenaseenzyme Albumincarrier
Prednisolone	A glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers.	Corticosteroid-binding globulincarrier Cytochrome P450 3A4enzyme Glucocorticoid receptortarget Solute carrier organic anion transporter family member 1A2transporter ATP-dependent translocase ABCB1transporter Albumincarrier
Prednisone	A corticosteroid used to treat inflammation or immune-mediated reactions and to treat endocrine or neoplastic diseases.	Glucocorticoid receptortarget Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Cytochrome P450 2C19enzyme Albumincarrier Cytochrome P450 3A5enzyme Corticosteroid-binding globulincarrier Cytochrome P450 3A Subfamilyenzyme Cytochrome P450 2A6enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme 11-beta-hydroxysteroid dehydrogenase 1enzyme

Clinical Trials

Not Available