primary adrenocoritical insufficiency (DBCOND0021956)

Identifiers

Synonyms

Primary Adrenal Insufficiency / Primary adrenocortical insufficiency / Addison's disease (disorder) / Addison Disease / Addison's disease / Disease Addison's / Primary adrenocortical insufficiency (disorder) / Primary hypoadrenalism

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Prednisolone	A glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers.	Corticosteroid-binding globulincarrier Cytochrome P450 3A4enzyme Glucocorticoid receptortarget Solute carrier organic anion transporter family member 1A2transporter ATP-dependent translocase ABCB1transporter Albumincarrier

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02277587	Dual RElease Hydrocortisone Versus conventionAl Glucocorticoid replaceMent Therapy in Hypocortisolism (DREAM)	Cortisone acetate Hydrocortisone	treatment	4	completed
NCT01450930	Pharmacokinetics of Hydrocortisone After Subcutaneous Administration in Chronic Adrenal Insufficiency	Hydrocortisone	treatment	2	completed
NCT06299020	Risks of Intermittent Fasting in Patients With Primary Adrenal Insufficiency	No drug interventions	diagnostic	Not Available	not_yet_recruiting
NCT05222152	Chronocort Versus Plenadren Replacement Therapy in Adults With Adrenal Insufficiency	Hydrocortisone	treatment	2	completed
NCT03793114	Screening and Stimulation Testing for Residual Secretion of Adrenal Steroid Hormones in Autoimmune Addison's Disease	No drug interventions	screening	Not Available	active_not_recruiting