Methylprednisolone hemisuccinate

DB14644ApprovedInvestigationalSmall moleculeCorticosteroids

Methylprednisolone hemisuccinate is a water soluble corticosteroid used to treat severe allergic reactions, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematological disorders, neoplastic diseases, nervous system conditions, ophthalmic diseases, renal diseases, respiratory diseases, and rheumatic disorders. A water-soluble ester of methylprednisolone used for cardiac, allergic, and hypoxic emergencies.

Mechanism: Pharmacologically active on Glucocorticoid receptor
Curator reviewed
Formula / weight: C₂₆H₃₄O₈ · 474.55 g/mol (avg)
First approval: Canada, 2003 · United States, 1959
Also known as: Methylprednisolone hydrogen succinate · Methylprednisolone succinate
Brand names: Solu-medrol

Resolves to

Compound

UNII5GMR90S4KNCAS2921-57-5ChEMBLCHEMBL1201265ChEBI135765PubChem16923

Structure

InChIKeyIMBXEJJVJRTNOW-XYMSELFBSA-NSMILES[H][C@@]12CC[C@](O)(C(=O)COC(=O)CCC(O)=O)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])C[C@H](C)C2=CC(=O)C=C[C@]12C

Targets

P04150NR3C1

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

593Drug interactionsStructured to mechanism, not free text

127Clinical trialsPhase, status and sponsor resolved per trial

46Structured indicationsCondition, population, route and combination as fields, not prose

4ContraindicationsEach with its own population and attribute set

203Marketed productsAcross 10 countries and 66 labellers

5+ReferencesStructured and connected to the statements they support

Which drugs share a target with Methylprednisolone hemisuccinate, and which of those have an active Phase 3 trial?

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