Methylprednisolone hemisuccinate
Identification
- Summary
Methylprednisolone hemisuccinate is a water soluble corticosteroid used to treat severe allergic reactions, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematological disorders, neoplastic diseases, nervous system conditions, ophthalmic diseases, renal diseases, respiratory diseases, and rheumatic disorders.
- Brand Names
- Solu-medrol
- Generic Name
- Methylprednisolone hemisuccinate
- DrugBank Accession Number
- DB14644
- Background
A water-soluble ester of methylprednisolone used for cardiac, allergic, and hypoxic emergencies.
- Type
- Small Molecule
- Groups
- Approved
- Structure
- Weight
- Average: 474.55
Monoisotopic: 474.225368055 - Chemical Formula
- C26H34O8
- Synonyms
- Methylprednisolone hemisuccinate
- Methylprednisolone hydrogen succinate
- Methylprednisolone succinate
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
- Acute Gouty Arthritis
- Ankylosing Spondylitis (AS)
- Berylliosis
- Congenital Adrenal Hyperplasia (CAH)
- Congenital Hypoplastic Anemia
- Dermatitis bullous
- Dermatomyositis (DM)
- Edema of the cerebrum
- Hypercalcemia of Malignancy
- Immune Thrombocytopenia (ITP)
- Leukemias
- Lymphoma
- Multiple sclerosis exacerbation
- Mycosis Fungoides (MF)
- Ophthalmia, Sympathetic
- Pemphigus
- Polymyositis
- Primary adrenocortical insufficiency
- Psoriatic Arthritis
- Pure Red Cell Aplasia
- Refractory Uveitis
- Regional Enteritis
- Rheumatoid Arthritis
- Secondary adrenocortical insufficiency
- Secondary thrombocytopenia
- Stevens-Johnson Syndrome
- Systemic Lupus Erythematosus
- Temporal Arteritis
- Trichinosis
- Tuberculous Meningitis
- Ulcerative Colitis
- Acquired immune hemolytic anemia
- Acute rheumatic carditis
- Disseminated Pulmonary Tuberculosis (TB)
- Exfoliative erythroderma
- Fulminating Pulmonary Tuberculosis
- Idiopathic eosinophilic pneumonias
- Non-suppurative Thyroiditis
- Severe Allergic Reactions
- Symptomatic Sarcoidosis
- Associated Therapies
- Contraindications & Blackbox Warnings
- Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API
- Pharmacodynamics
Methylprednisolone sodium succinate (the sodium salt of methylprednisolone hemisuccinate) has the same metabolic and anti-inflammatory actions as methylprednisolone. When given parenterally and in equimolar quantities, the two compounds are equivalent in biologic activity.
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcarbose The risk or severity of hyperglycemia can be increased when Methylprednisolone hemisuccinate is combined with Acarbose. Aceclofenac The risk or severity of gastrointestinal irritation can be increased when Methylprednisolone hemisuccinate is combined with Aceclofenac. Acemetacin The risk or severity of gastrointestinal irritation can be increased when Methylprednisolone hemisuccinate is combined with Acemetacin. Acenocoumarol Methylprednisolone hemisuccinate may increase the anticoagulant activities of Acenocoumarol. Acetohexamide The risk or severity of hyperglycemia can be increased when Methylprednisolone hemisuccinate is combined with Acetohexamide. Acetyldigitoxin The risk or severity of adverse effects can be increased when Methylprednisolone hemisuccinate is combined with Acetyldigitoxin. Acetylsalicylic acid The risk or severity of adverse effects can be increased when Methylprednisolone hemisuccinate is combined with Acetylsalicylic acid. Albiglutide The risk or severity of hyperglycemia can be increased when Methylprednisolone hemisuccinate is combined with Albiglutide. Alclofenac The risk or severity of gastrointestinal irritation can be increased when Methylprednisolone hemisuccinate is combined with Alclofenac. Aldesleukin The therapeutic efficacy of Aldesleukin can be decreased when used in combination with Methylprednisolone hemisuccinate. Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- No interactions found.
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Product Ingredients
Ingredient UNII CAS InChI Key Methylprednisolone sodium succinate LEC9GKY20K 2375-03-3 FQISKWAFAHGMGT-SGJOWKDISA-M - Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Methylprednisolone Sodium Succinate for Injection Powder, for solution 1 g / vial Intramuscular; Intravenous TEVA Canada Limited 2000-03-01 Not applicable Canada Methylprednisolone Sodium Succinate for Injection Powder, for solution 500 mg / vial Intramuscular; Intravenous TEVA Canada Limited 2000-03-01 Not applicable Canada Methylprednisolone Sodium Succinate for Injection Powder, for solution 125 mg / vial Intramuscular; Intravenous TEVA Canada Limited 2000-03-01 Not applicable Canada Methylprednisolone Sodium Succinate for Injection Powder, for solution 40 mg / vial Intramuscular; Intravenous TEVA Canada Limited 2000-03-01 Not applicable Canada Methylprednisolone Sodium Succinate for Injection Powder, for solution 5 g / vial Intramuscular; Intravenous TEVA Canada Limited Not applicable Not applicable Canada Solu-Medrol Injection 2 g/30.6mL Intramuscular; Intravenous Pharmacia & Upjohn Company LLC 1959-04-02 2021-01-31 US Solu-Medrol Injection, powder, lyophilized, for solution 40 mg/1mL Intramuscular; Intravenous General Injectables & Vaccines 2010-09-01 2017-01-16 US Solu-medrol Injection, powder, for solution 1 g/1mL Intramuscular; Intravenous Pharmacia & Upjohn Company LLC 1959-04-02 Not applicable US Solu-medrol Kit; Powder 40 mg / vial Intramuscular; Intravenous Pfizer Canada Ulc 1994-12-31 2015-09-15 Canada Solu-medrol Injection, powder, for solution 125 mg/1mL Intramuscular; Intravenous Physicians Total Care, Inc. 1959-04-02 2010-06-30 US - Generic Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image A-methapred Injection, powder, for solution 125 mg/2mL Intramuscular; Intravenous Hospira, Inc. 2009-06-22 2013-05-01 US A-methapred Injection, powder, lyophilized, for solution 125 mg/2mL Intramuscular; Intravenous Hospira, Inc. 2006-10-06 2010-07-01 US A-methapred Injection, powder, for solution 40 mg/1mL Intramuscular; Intravenous Hospira, Inc. 2009-07-14 2013-05-01 US A-methapred Injection, powder, lyophilized, for solution 40 mg/1mL Intramuscular; Intravenous Hospira, Inc. 2006-10-06 2010-07-01 US Methylprednisolone Sodium Succinate Injection, powder, lyophilized, for solution 125 mg/2mL Intramuscular; Intravenous REMEDYREPACK INC. 2020-11-15 Not applicable US Methylprednisolone Sodium Succinate Injection, powder, lyophilized, for solution 125 mg/2mL Intramuscular; Intravenous Tianjin Kingyork Pharmaceuticals Co., Ltd 2021-04-20 Not applicable US Methylprednisolone Sodium Succinate Injection, powder, lyophilized, for solution 40 mg/1mL Intramuscular; Intravenous Bedford Pharmaceuticals 2007-03-01 2009-06-30 US Methylprednisolone Sodium Succinate Injection, powder, lyophilized, for solution 40 mg/1mL Intramuscular; Intravenous Fresenius Kabi USA, LLC 2004-11-30 Not applicable US Methylprednisolone Sodium Succinate Injection, powder, for solution 125 mg/1 Intramuscular; Intravenous Hikma Pharmaceuticals USA Inc. 2022-09-26 Not applicable US Methylprednisolone Sodium Succinate Injection, powder, lyophilized, for solution 125 mg/2mL Intramuscular; Intravenous Amneal Pharmaceuticals LLC 2016-11-11 Not applicable US
Categories
- Drug Categories
- Adrenal Cortex Hormones
- Adrenals
- Anti-Inflammatory Agents
- Antineoplastic Agents
- Antineoplastic Agents, Hormonal
- Central Nervous System Agents
- Compounds used in a research, industrial, or household setting
- Corticosteroids
- Cytochrome P-450 CYP3A Inducers
- Cytochrome P-450 CYP3A4 Inducers
- Cytochrome P-450 CYP3A4 Inducers (strength unknown)
- Cytochrome P-450 CYP3A5 Inducers
- Cytochrome P-450 CYP3A5 Inducers (strength unknown)
- Cytochrome P-450 Enzyme Inducers
- Fused-Ring Compounds
- Glucocorticoids
- Hormones
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Neuroprotective Agents
- Pregnadienes
- Pregnadienetriols
- Pregnanes
- Protective Agents
- Steroids
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 5GMR90S4KN
- CAS number
- 2921-57-5
- InChI Key
- IMBXEJJVJRTNOW-XYMSELFBSA-N
- InChI
- InChI=1S/C26H34O8/c1-14-10-16-17-7-9-26(33,20(29)13-34-22(32)5-4-21(30)31)25(17,3)12-19(28)23(16)24(2)8-6-15(27)11-18(14)24/h6,8,11,14,16-17,19,23,28,33H,4-5,7,9-10,12-13H2,1-3H3,(H,30,31)/t14-,16-,17-,19-,23+,24-,25-,26-/m0/s1
- IUPAC Name
- 4-{2-[(1R,3aS,3bS,5S,9aR,9bS,10S,11aS)-1,10-dihydroxy-5,9a,11a-trimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-oxoethoxy}-4-oxobutanoic acid
- SMILES
- [H][C@@]12CC[C@](O)(C(=O)COC(=O)CCC(O)=O)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])C[C@H](C)C2=CC(=O)C=C[C@]12C
References
- General References
- FDA Approved Drug Products: Solu-Medrol (methylprednisolone sodium succinate) for injection [Link]
- External Links
- ChemSpider
- 16034
- ChEBI
- 135765
- ChEMBL
- CHEMBL1201265
- ZINC
- ZINC000003977781
- Wikipedia
- Methylprednisolone
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Prevention Hysterectomy / Methylprednisolone / Postoperative pain 1 4 Completed Prevention Postoperative Complications 1 4 Completed Prevention Postoperative Delirium (POD) / Stress, Physiological 1 4 Completed Treatment Alopecia Totalis (AT) / Alopecia Universalis (AU) / Ophiasic Alopecia 1 4 Completed Treatment Asthma 1 4 Completed Treatment Drug Interaction Potentiation 1 4 Completed Treatment Liver Transplantation 1 4 Completed Treatment Migraine 1 4 Completed Treatment Rheumatoid Arthritis 1 4 Completed Treatment Sepsis 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Injection, powder, for solution Intramuscular; Intravenous 125 mg/2mL Solution Intravenous 165.740 mg Injection, powder, lyophilized, for solution Intravenous 500 mg Injection, solution Intramuscular; Intravenous 250 mg Solution Parenteral 165.74 mg Injection, solution Intramuscular; Intravenous Injection, powder, for solution Parenteral Injection, powder, for solution 125 mg Injection Intramuscular; Intravenous 1 g/16mL Injection Intramuscular; Intravenous 125 mg/2mL Injection Intramuscular; Intravenous 40 mg/1mL Injection Intramuscular; Intravenous 500 mg/8mL Injection, powder, for solution Intramuscular; Intravenous Injection, powder, for solution Intramuscular; Intravenous 1 g/1 Injection, powder, for solution Intramuscular; Intravenous 125 MG Injection, powder, for solution Intramuscular; Intravenous 125 mg/1 Injection, powder, for solution Intramuscular; Intravenous 40 mg/1 Injection, powder, for solution Intramuscular; Intravenous 500 MG Injection, powder, for solution Intramuscular; Intravenous 500 mg/1 Injection, powder, for solution; injection, powder, lyophilized, for solution Intramuscular; Intravenous 125 mg Injection, powder, lyophilized, for solution Injection, powder, lyophilized, for solution Intramuscular; Intravenous 1 g/16mL Injection, powder, lyophilized, for solution Intramuscular; Intravenous 1 g/8mL Injection, powder, lyophilized, for solution Intramuscular; Intravenous 125 mg/1 Injection, powder, lyophilized, for solution Intramuscular; Intravenous 125 mg/2mL Injection, powder, lyophilized, for solution Intramuscular; Intravenous 2 g/30.6mL Injection, powder, lyophilized, for solution Intramuscular; Intravenous 2 g/1 Injection, powder, lyophilized, for solution Intramuscular; Intravenous 40 mg/1 Injection, powder, lyophilized, for solution Intramuscular; Intravenous 40 mg/1mL Injection, powder, lyophilized, for solution Intramuscular; Intravenous 500 mg/8mL Injection, powder, lyophilized, for solution Intramuscular; Intravenous 500 mg/4mL Injection, powder, lyophilized, for solution Intramuscular; Intravenous 500 mg/1 Powder, for solution Intramuscular; Intravenous 1 g / vial Powder, for solution Intramuscular; Intravenous 125 mg / vial Powder, for solution Intramuscular; Intravenous 40 mg / vial Powder, for solution Intramuscular; Intravenous 5 g / vial Powder, for solution Intramuscular; Intravenous 500 mg / vial Injection, powder, lyophilized, for solution Intramuscular; Intravenous 20 mg Injection, powder, lyophilized, for solution Intramuscular; Intravenous 250 mg Injection Intramuscular; Intravenous 250 mg Injection Intramuscular; Intravenous 40 mg Injection, solution Intramuscular; Intravenous 125 mg Injection, solution Intramuscular; Intravenous 15.78 mg Injection Intramuscular; Intravenous 20 mg Injection, powder, for solution Tablet Solution 500.000 mg Powder Intramuscular; Intravenous 1000 mg/1vial Injection, powder, for solution Intramuscular; Intravenous 1000 MG/16ML Injection, powder, for solution Intramuscular; Intravenous 2000 MG/32ML Injection, powder, for solution Intramuscular; Intravenous 40 MG/ML Injection, powder, lyophilized, for solution Intramuscular; Intravenous 500 mg Injection Intramuscular; Intravenous 2 g/30.6mL Injection, powder, for solution Intracavernous; Intramuscular 40 mg/1 Injection, powder, for solution Intramuscular; Intravenous 1 g/8mL Injection, powder, for solution Intramuscular; Intravenous 1 g/1mL Injection, powder, for solution Intramuscular; Intravenous 125 mg/1mL Injection, powder, for solution Intramuscular; Intravenous 2 g/30.6mL Injection, powder, for solution Intramuscular; Intravenous 40 mg/1mL Injection, powder, for solution Intramuscular; Intravenous 500 mg/1mL Injection, powder, for solution Intramuscular; Intravenous 500 mg/4mL Injection, powder, for solution Intravenous 1 g/1 Injection, powder, lyophilized, for solution Intramuscular; Intravenous 125 mg/1mL Kit; powder Intramuscular; Intravenous 1 g / vial Kit; powder Intramuscular; Intravenous 125 mg / vial Kit; powder Intramuscular; Intravenous 40 mg / vial Kit; powder Intramuscular; Intravenous 500 mg / vial Kit; powder, for solution Intramuscular; Intravenous 1 g / vial Kit; powder, for solution Intramuscular; Intravenous 125 mg / vial Kit; powder, for solution Intramuscular; Intravenous 40 mg / vial Kit; powder, for solution Intramuscular; Intravenous 500 mg / vial Powder, for solution Intravenous 125 mg/1mL Powder Intramuscular; Intravenous 125 mg/1vial Powder Intramuscular; Intravenous 40 mg/1vial Powder Intramuscular; Intravenous 500 mg/1vial Injection, powder, lyophilized, for solution Intramuscular; Intravenous 40 mg Injection, powder, for solution Intramuscular; Intravenous 500 mg/8ml Powder Intramuscular; Intravenous Injection Intramuscular; Intravenous Powder, for solution Intramuscular; Intravenous; Rectal 125 mg / vial Powder, for solution Intramuscular; Intravenous; Rectal 40 mg / vial Injection, powder, for solution Intramuscular; Intravenous 20 mg Injection, powder, for solution Intramuscular; Intravenous 250 mg Injection, powder, for solution Intramuscular; Intravenous 40 mg Injection Parenteral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0264 mg/mL ALOGPS logP 2.43 ALOGPS logP 1.83 Chemaxon logS -4.2 ALOGPS pKa (Strongest Acidic) 3.66 Chemaxon pKa (Strongest Basic) -2.9 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 138.2 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 123.09 m3·mol-1 Chemaxon Polarizability 49.87 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Enzymes
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inducer
- General Function
- Vitamin d3 25-hydroxylase activity
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
- Gene Name
- CYP3A4
- Uniprot ID
- P08684
- Uniprot Name
- Cytochrome P450 3A4
- Molecular Weight
- 57342.67 Da
References
- Dvorak Z, Pavek P: Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids. Drug Metab Rev. 2010 Nov;42(4):621-35. doi: 10.3109/03602532.2010.484462. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inducer
- General Function
- Oxygen binding
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
- Gene Name
- CYP3A5
- Uniprot ID
- P20815
- Uniprot Name
- Cytochrome P450 3A5
- Molecular Weight
- 57108.065 Da
References
- Dvorak Z, Pavek P: Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids. Drug Metab Rev. 2010 Nov;42(4):621-35. doi: 10.3109/03602532.2010.484462. [Article]
Drug created at September 01, 2018 21:25 / Updated at December 06, 2023 04:54