| NCT06553976
| Spastic Paraplegia - Centers of Excellence Research Network | No drug interventions | Not Available | Not Available | recruiting |
| NCT02314208
| Therapeutic Metabolic Intervention in Patients With Spastic Paraplegia SPG5 | | treatment | 2 | completed |
| NCT04712812
| Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia | No drug interventions | Not Available | Not Available | recruiting |
| NCT03206190
| The preSPG4 Study - Studying the Prodromal and Early Phase of SPG4 | No drug interventions | diagnostic | Not Available | recruiting |
| NCT04180098
| Improving Gait Adaptability in Hereditary Spastic Paraplegia | No drug interventions | basic_science | Not Available | completed |
| NCT04912609
| Trehalose Administration in Subjects With Spastic Paraplegia 11 (3AL-SPG11) | No drug interventions | Not Available | Not Available | completed |
| NCT04875416
| Phenotype, Genotype and Biomarkers 2 | No drug interventions | Not Available | Not Available | recruiting |
| NCT02604186
| Effects of Botulinum Toxin Injections in Patients With Hereditary Spastic Paraplegia | No drug interventions | treatment | 2 / 3 | completed |
| NCT05354622
| Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq) | No drug interventions | Not Available | Not Available | recruiting |
| NCT05767268
| Assessment of the Psychophysical State During Rehabilitation Treatment With Lokomat | No drug interventions | Not Available | Not Available | completed |
| NCT06572046
| STOP-HSP.Net: a Registry for Hereditary Spastic Paraplegia as an Integration Tool for Future Therapeutic Strategies | No drug interventions | Not Available | Not Available | recruiting |
| NCT05613114
| Effect of Dalfampridine in Patients With Hereditary Spastic Paraplegia | | treatment | Not Available | completed |
| NCT06478238
| Calcium Folinate Treatment of Spastic Paraplegia 56 | | treatment | 0 | recruiting |
| NCT02327845
| Phenotype, Genotype & Biomarkers in ALS and Related Disorders | No drug interventions | Not Available | Not Available | enrolling_by_invitation |
| NCT02859428
| Disease Natural History and Biomarkers of SPG3A, SPG4A, and SPG31 | No drug interventions | Not Available | Not Available | terminated |
| NCT05848271
| Natural History Study of Patients With HPDL Mutations | No drug interventions | Not Available | Not Available | recruiting |
| NCT02852278
| A Patient Centric Motor Neuron Disease Activities of Daily Living Scale | No drug interventions | Not Available | Not Available | completed |
| NCT03104088
| Studying Cognition in SPG4 | No drug interventions | Not Available | Not Available | completed |
| NCT00023075
| Nuclear Magnetic Spectroscopy Imaging to Evaluate Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis | No drug interventions | Not Available | Not Available | completed |
| NCT03961906
| Physiotherapy in Hereditary Spastic Paraplegia | No drug interventions | treatment | 2 | completed |
| NCT03627416
| Repetitive Transcranial Magnetic Stimulation as Therapy in Hereditary Spastic Paraplegia and Adrenomyeloneuropathy | No drug interventions | treatment | Not Available | completed |
| NCT06117020
| Single and Multiple Ascending Dose Study of MTR-601 in Healthy Individuals | No drug interventions | other | 1 | recruiting |
| NCT05373082
| Identification of Modifying Factors in Hereditary Spastic Paraplegia | No drug interventions | Not Available | Not Available | completed |
| NCT05411627
| A Pilot Study of Shockwave Therapy in HSP | No drug interventions | treatment | Not Available | withdrawn |
| NCT03981276
| Phenotypes, Biomarkers and Pathophysiology in Hereditary Spastic Paraplegias and Related Disorders | No drug interventions | Not Available | Not Available | recruiting |
| NCT01568658
| Genetic and Physical Study of Childhood Nerve and Muscle Disorders | No drug interventions | Not Available | Not Available | recruiting |