Febrile Neutropenia (DBCOND0029915)

Identifiers

Synonyms
Neutropenia and Fever / Febrile Neutropenia (FN) / Fever in Neutropenia / Fever and Neutropenia / Patients With Febrile Neutropenia / Neutropenia, Febrile / Febrile neutropenia / Febrile neutropenia (disorder) / Neutropenic fever

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Amphotericin B
An antifungal used to treat fungal infections in neutropenic patients, cryptococcal meningitis in HIV infection, fungal infections, and leishmaniasis.
Aztreonam
A beta-lactam antibiotic used to treat select aztreonam sensitive gram negative bacteria.
Caspofungin
An echinocandin used to treat a variety of fungal infections.
Cefepime
A fourth-generation cephalosporin antibiotic used in the treatment of infections caused by susceptible bacteria, such as pneumonia, urinary tract infections, and skin infections.
Ciprofloxacin
A second generation fluoroquinolone used to treat various susceptible bacterial infections.
Efbemalenograstim alfa
A granulocyte-colony stimulating factor used to treat prevent chemotherapy-induced neutropenia.
Filgrastim
A form of recombinant human granulocyte colony stimulating factor used to induce the production of granulocytes and lower infection risk after myelosuppressive therapy.
Lipegfilgrastim
A medication used to reduce the duration of chemotherapy-induced neutropenia and incidence of febrile neutropenia in cytotoxic chemotherapy.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT05108545
A Study of Amphotericin B Liposome for Injection in Patients With Persistent Neutropenia and Fevertreatment3unknown_status
NCT05689450
Probability of Optimal Target Attainment of Amikacin in Patients With Febrile Neutropenia During Treatment for a Hematological DisorderNo drug interventionsNot AvailableNot Availablecompleted
NCT01683370
Pediatric FN Definition 2012 BernNo drug interventionsNot AvailableNot Availablecompleted
NCT02324231
SPOG 2015 FN Definition. A Multi-center Non-inferiority Trial on Safety of a High Versus Low Temperature Limit Defining Fever in Pediatric Patients With Cancer at Risk for Fever in Chemotherapy-induced NeutropeniaNo drug interventionssupportive_careNot Availablecompleted
NCT03262584
Evaluation of NGS for Detection and Follow-up of Fungal Pathogens in Immunocompromised Pediatric PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT02213783
Comparison of the Pharmacodynamics of Imipenem in Patients With Febrile Neutropeniatreatment4completed
NCT04637464
Early Termination of Empirical Antibiotics in Febrile Neutropenia in Children With CancerNo drug interventionstreatmentNot Availableunknown_status
NCT05852249
Investigation of the Usability of Neutrocheck Amongst Healthy Volunteers and Healthcare Professionals.No drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT04260230
Remote Monitoring of Patients at Risk of SepsisNo drug interventionsotherNot Availableunknown_status
NCT04187755
Cefepime vs Ceftazidime as Empirical Therapy for Neutropenic Fevertreatment4completed
NCT03217721
Antibiotics Management of Septic Neutropenic Patients in the Intensive Care UnitNo drug interventionsNot AvailableNot Availablecompleted
NCT05061654
CEFtolozane-Tazobactam for the Empiric Anti-bacterial Treatment of Neutropenic Fever in Hematology Patientstreatment4withdrawn
NCT04938206
DIStinguishing ChildrEn at Low Risk of Severe infectioN in Case of Febrile Neutropenia-7: Impact Study of a Clinical Decision RuleNo drug interventionsotherNot Availablerecruiting
NCT04669418
Host RNA Signature in Children With Cancer and InfectionNo drug interventionsNot AvailableNot Availablecompleted
NCT05926063
Stopping Antibiotics After 3 Days for the Treatment of High-risk FEbrile NeutropeniaNo drug interventionssupportive_care4recruiting
NCT03511820
A Post Marketing Surveillance Study of Lipo-AB® (Amphotericin B) in Neutropenic Patients With Persistent FeverNot AvailableNot Availablecompleted
NCT03003273
Early Stoppage Versus Continuation of Antimicrobial Therapy in Low Risk Pediatric Cancer Patients With Febrile Neutropenia, Before Recovery of Counts: -DALFEN StudyNo drug interventionstreatment3terminated
NCT02474550
Multicenter Prospective Registry Study of Diffuse Large B Cell LymphomaNo drug interventionsNot AvailableNot Availableunknown_status
NCT05784844
Antimicrobial Revision in Persistent Febrile Neutropeniatreatment4withdrawn
NCT03740464
Long-acting G-CSF for Febrile Neutropeniatreatment3unknown_status
NCT03429387
PET/CT and Bacterial/Fungal PCR in High Risk Febrile NeutropeniaNo drug interventionsdiagnosticNot Availablecompleted
NCT00137787
Comparing Ciprofloxacin (CPFX) With Cefepime (CFPM) in Febrile Neutropenic Patients With Hematologic Diseasestreatment3completed
NCT01581333
Study to Reduce Duration of Antibiotic Therapy in Haematological Patients With Fever and NeutropeniaNo drug interventionsother4completed
NCT02906254
Early Antibiotic Discontinuation in FUONo drug interventionsNot AvailableNot Availablecompleted
NCT00503854
Fatigue and Symptom Burden in Low-Risk Cancer Patients Undergoing Treatment for Febrile NeutropeniaNo drug interventionsNot AvailableNot Availablecompleted
NCT02463747
Short vs Prolonged Antibiotic Treatment for Hospitalized Hemato-oncology Patients With Febrile Neutropeniatreatment4unknown_status
NCT05149547
mNGS Versus Blood Culture in FNNo drug interventionsNot AvailableNot Availableunknown_status
NCT04910698
Efficacy of Antibiotic Short Course for Bloodstream Infections in Acute Myeloid Leukemia Patients With Febrile NeutropeniaNo drug interventionsNot AvailableNot Availablecompleted
NCT03793205
G-CSF for the Prevention of Febrile Neutropenia in Gynecologic Cancer Patientstreatment4unknown_status
NCT02005783
Study of Danggui Buxue Decoction in Preventing Neutropeniaprevention2completed
NCT02702583
The Oral Cavity as a Source of Febrile NeutropeniaNo drug interventionsNot AvailableNot Availablecompleted
NCT05815628
Next-Generation-Sequencing Approach to Neutropenic SepsisNo drug interventionsNot AvailableNot Availablerecruiting
NCT00462878
Meropenem Versus Meropenem Plus Glycopeptide in Patients With Febrile Neutropenia After Allogenic Blood Stem Cell TransplantationNot AvailableNot Availablecompleted
NCT06500715
Acupuncture as add-on to G-CSF for Febrile Neutropenia-related Hospitalization in Doxorubicin-treated Patients With SarcomaNo drug interventionspreventionNot Availablenot_yet_recruiting
NCT02536599
Risk Factors & Outcomes for Clinically Documented Infections in Pediatric Cancer Patients With Fever & NeutropeniaNo drug interventionsNot AvailableNot Availablerecruiting
NCT05206006
Impact of Computerized Decision Support for ANTIBIOtic Prescription in Cancer Patients With Febrile NEutropenia in the Emergency Department on Treatment Failure.No drug interventionsotherNot Availableunknown_status
NCT01450241
Short-term Antibiotic Treatment for Unexplained Fever in Solid Cancer Patients With Febrile NeutropeniaNo drug interventionstreatmentNot Availablewithdrawn
NCT06116734
Lapelga vs Gastrofiltreatment3not_yet_recruiting
NCT04233996
Efficacy of Extended Infusion of β-lactam Antibiotics for the Treatment of Febrile Neutropenia in Hematologic Patientstreatment4unknown_status
NCT06278896
Early Neutropenic Fever De-escalation of Antibiotics StudyNo drug interventionstreatment3not_yet_recruiting
NCT00709358
Diagnosis of Septicaemia by Detection of Microbial DNA in Blood in Severe InfectionsNo drug interventionsdiagnostic4completed
NCT04948463
Early Versus Late Stopping of Antibiotics in Children With Cancer and High-risk Febrile Neutropeniatreatment4recruiting
NCT05584930
Clusterin, Ptx3 and Pediatric Febrile Neutropenia (CluPPFeN)No drug interventionsdiagnosticNot Availablerecruiting
NCT02806557
Profiling Neutrophil Counts in Patients on ChemotherapyNo drug interventionsNot AvailableNot Availableunknown_status
NCT02364466
Cohort of Peripheral T Cell LymphomaNo drug interventionsNot AvailableNot Availableunknown_status
NCT01114165
Value of the LightCycler® SeptiFast Test MGRADE for the Pathogen Detection in Neutropenic Hematological PatientsNo drug interventionsdiagnostic4completed
NCT00723073
Caspofungin or Micafungin as Empiric Antifungal Therapy for Persistent Fever and NeutropeniaNo drug interventionsNot AvailableNot Availablecompleted
NCT04662892
An Analysis to Estimate Febrile Neutropenia (FN) in Patients Receiving UdenycaNot AvailableNot Availableunknown_status
NCT01401010
Pharmacokinetic/Pharmacodynamic Study of Doripenem in Febrile Neutropenic Patientstreatment4completed
NCT03078010
Choosing the Best Antibiotic to Protect Friendly Gut Bacteria During the Course of Stem Cell Transplanttreatment2recruiting
NCT03618810
Prophylactic Use of PEG-rhG-CSF in Medium-high Risk of FN in Chemotherapy of Breast CancerNo drug interventionsNot AvailableNot Availableunknown_status
NCT01344681
Micafungin Versus Intravenous Itraconazole as Empirical Antifungal Therapy for Febrile Neutropenic Patients With Hematological Diseasestreatment2completed
NCT00536081
Various G-CSF Regimens to Prevent Infection During Chemotherapyprevention3completed
NCT05786495
Short Antibiotic Treatment in High Risk Febrile NeutropeniaNo drug interventionstreatmentNot Availablerecruiting
NCT03104595
Management of Severe Chemotherapy-induced Neutropenia in Advanced Breast Cancertreatment1 / 2completed
NCT00945555
Observational Non-Interventional Study Of Febrile Neutropenia Patients To Evaluate Antibacterial Therapeutical OptionsNo drug interventionsNot AvailableNot Availablecompleted
NCT06450821
PROSpECT-PRIOR-2-CHEMO: PRIOR Dental Intervention Before Chemo to Reduce Chemotherapy ComplicationsNo drug interventionssupportive_careNot Availablenot_yet_recruiting
NCT04914702
Feasibility and Comparison of Continuously Monitored Vital Signs in Pediatric Patients With Cancer.No drug interventionsNot AvailableNot Availablecompleted
NCT00421187
Ambisome and Management of Culture-negative Neutropenic Fever Unresponsive to Antibioticstreatment4terminated
NCT05311254
A Trial of Fosfomycin vs Ciprofloxacin for Febrile NeutropeniaNo drug interventionsprevention3recruiting
NCT01611051
A Study Comparing Pegylated rhG-CSF and rhG-CSF as Support to Breast Cancer Patients Receiving ChemotherapyNo drug interventionsprevention3completed
NCT01459653
Multi-level Evaluation of Chemotherapy-induced Febrile Neutropenia Prophylaxis, Outcomes, and Determinants With Granulocyte-colony Stimulating FactorNo drug interventionsNot AvailableNot Availablecompleted
NCT06293677
Adjustment of Antibiotic Dosage in Pediatric Oncology Patients With Febrile Neutropenia and Augmented Renal Clearancetreatment4recruiting
NCT03968328
Time From Onset of Fever to Administration of Antibiotics in Neutropenic Fever PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT02685111
Intermittent G-CSF in Patients With Breast Cancer Receiving Adjuvant Docetaxel, Doxorubicin, and Cyclophosphamide (TAC)prevention2terminated
NCT03449693
Efficacy of Oral Supplementation With Magnesium to Reduce Febrile NeutropeniaNo drug interventionsprevention2unknown_status
NCT05665478
Population Pharmacokinetics/Pharmacodynamics of Carbapenems in Febrile Neutropenia PatientsNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT02544685
Prevention of Febrile Neutropenia by Synbiotics in Pediatric Cancer PatientsNo drug interventionsprevention2unknown_status
NCT06342115
Ceftolozane/Tazobactam Versus Meropenem for Febrile Neutropenia on Patients Colonized With or at Risk for Infection With Extended Spectrum Beta Lactamase - Producing Pathogenstreatment4not_yet_recruiting
NCT02119715
A Phase II Study Comparing Pegylated rhG-CSF(HHPG-19K) and rhG-CSF in Breast Cancer Patients Receiving Chemotherapytreatment2completed
NCT03619252
Pneumococcal Vaccination of Multiple Myeloma Patients on Novel AgentsNo drug interventionsprevention4completed
NCT04758442
Optimal Dosing of Vancomycin in an Adult Population of Hemato-oncologyNo drug interventionsbasic_scienceNot Availableunknown_status
NCT01216241
Daptomycin Versus Placebo in Patients With Neutropenia and Fevertreatment3terminated
NCT02728596
S1415CD, Trial Assessing CSF Prescribing Effectiveness and Risk (TrACER)No drug interventionshealth_services_researchNot Availablecompleted
NCT00035425
Treatment of Neutropenic Patients With Fever Who Are Suspected to Have A Gram Positive Infectiontreatment3completed
NCT04698057
Amoxicillin-clavulanate Alone or in Combination With Ciprofloxacin in Low-Risk Febrile Neutropenic Adult Patients: A Prospective, Double-blind, Randomized, Non-Inferiority Multicenter, Phase III Clinical Trial.treatment3withdrawn
NCT03364257
iDTECT Blood Performance for the Identification of Viral or Bacterial Pathogens in Febrile Neutropenic PatientsNo drug interventionsNot AvailableNot Availableunknown_status
NCT03342365
Evaluation of Intestinal Bacterial and Fungal Translocation and Intestinal Microbiota in Febrile Neutropenic Patients in Pediatric Onco-hematologyNo drug interventionsNot AvailableNot Availableterminated
NCT05576220
Remote Temperature Monitoring of Adult Subjects Undergoing Outpatient Stem Cell Transplant or CAR-T Cell TherapyNo drug interventionsdiagnosticNot Availablenot_yet_recruiting
NCT03641131
Ampholipad Real-World Data in TaiwanNo drug interventionsNot AvailableNot Availablecompleted
NCT02732327
Comparative Study of Ceftazidime-Avibactam Versus Standard of Care as Therapy in Febrile Neutropenic Adults With Cancertreatment2terminated
NCT03087227
Shared Health Information System for Febrile NeutropeniaNo drug interventionshealth_services_researchNot Availablecompleted
NCT00928291
Procalcitonin Protocol to Shorten the Antibiotic Therapy in Febrile NeutropeniaNo drug interventionstreatmentNot Availablecompleted
NCT04134429
Feasibility of Monitoring Health Data in Pediatric Patients Undergoing ChemotherapyNo drug interventionsNot AvailableNot Availablecompleted
NCT02149329
Short Versus Extended Antibiotic Treatment With a Carbapenem for High-risk Febrile Neutropenia in Hematology Patients With FUOtreatment4completed
NCT01684189
Registry of Febrile Neutropenia and Invasive Fungal InfectionsNo drug interventionsNot AvailableNot Availableunknown_status
NCT02856204
Shotgun Sequencing in Diagnosing Febrile Neutropenia in Patients With Acute Myeloid LeukemiaNo drug interventionsNot AvailableNot Availablecompleted
NCT00454272
Comparison of Teicoplanin and Vancomycin in Initial Empirical Antibiotic Regimen for Febrile Neutropenic Patientstreatment4completed
NCT05174546
New Diagnostics in NeutropeniaNo drug interventionsNot AvailableNot Availablerecruiting
NCT01560195
A Study of Pegylated rhG-CSF as Support to Advanced Non-Small-Cell Lung Cancer (NSCLC) Patients Receiving Chemotherapy Receiving ChemotherapyNo drug interventionsprevention3unknown_status