Tinea Capitis (DBCOND0030966)

Identifiers

Synonyms

Tinea capitis / Tinea barbae and tinea capitis / Tinea capitis (disorder) / Dermatophytosis of scalp / Scalp tinea / Ringworm of scalp

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Clioquinol	An antifungal cream used to treat a variety of fungal infections.	Kappa-type opioid receptortarget
Fenticonazole	An imidazole antifungal used to treat a variety of topical fungal infections.	No drug targets
Griseofulvin	An antifungal agent used to treat a variety of superficial tinea infections and fungal infections of the fingernails and toes.	Keratin, type I cytoskeletal 12target Cytochrome P450 1A2enzyme Cytochrome P450 3A4enzyme Tubulin beta chaintarget
Miconazole	An azole antifungal with broad-spectrum activity used to treat fungal infections affecting the vagina, mouth and skin, including candidiasis.	Cytochrome P450 2C9enzyme Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Lanosterol 14-alpha demethylasetarget Nitric oxide synthase 3target Nitric oxide synthase, inducibletarget Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2E1enzyme Nuclear receptor subfamily 1 group I member 2target Lanosterol 14-alpha demethylaseenzyme Aromataseenzyme Calcium-activated potassium channeltarget Voltage-gated Potassium Channelstarget Inward rectifier potassium channeltarget Voltage gated L-type calcium channeltarget Albumincarrier Cytochrome P450 2C8enzyme
Terbinafine	An allylamine antifungal used to treat dermatophyte infections of toenails and fingernails as well as other fungal skin infections.	Squalene monooxygenasetarget Cytochrome P450 2D6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 1A2enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C19enzyme Prostaglandin G/H synthase 1enzyme Albumincarrier alpha1-acid glycoproteincarrier ABC multidrug transporter MDR2transporter Squalene monooxygenasetarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00117754	Terbinafine Compared to Griseofulvin in Children With Tinea Capitis	Terbinafine	treatment	3	completed
NCT00645242	A Study Of Diflucan In Children With Ringworm Of The Scalp	Fluconazole	treatment	3	completed
NCT00224926	The Natural Course of Trichophyton Tonsurans Carriage and Infection: A Molecular and Biochemical Evaluation	No drug interventions	Not Available	Not Available	completed
NCT04144491	Effect of L. Rhamnosus Yoba on RTI and Other Health Outcomes Among Children (3-6 Years) in Uganda	No drug interventions	prevention	Not Available	completed
NCT02658292	Safety and Efficacy of NAFT900 in Children With Tinea Capitis	Naftifine	treatment	2	withdrawn
NCT00127868	Selenium Sulfide, Ketoconazole and Ciclopirox Shampoo as Additional Treatments for Tinea Capitis (Scalp Ringworm)	Ciclopirox Griseofulvin Ketoconazole Selenium Sulfide	treatment	Not Available	completed
NCT02725255	Design and Clinical Evaluation of a School Meal With Deworming Properties	Albendazole	treatment	2 / 3	completed
NCT02550496	Evaluation of Trichoscopy in the Diagnosis of Tinea Capitis	No drug interventions	diagnostic	Not Available	completed
NCT00117767	Terbinafine Compared to Griseofulvin in Children With Tinea Capitis	Griseofulvin Terbinafine	treatment	3	completed