Left Ventricular Dysfunction (DBCOND0031407)

Identifiers

Synonyms
Left Ventricular Cardiac Dysfunction / Ventricular Dysfunction, Left / Reduced left ventricle ejection fraction / Dysfunction, Left Ventricular / Symptomatic left ventricular ejection fraction ≤ 35% Chronic heart failure / Left ventricular dysfunction / Impaired left ventricular function (finding) / Left ventricular cardiac dysfunction (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Enalaprilat
An antihypertensive agent used for the management of hypertension when oral therapy is not practical.
Eprosartan
An ARB used to treat hypertension, diabetic nephropathy, and congestive heart failure.
Fludeoxyglucose (18F)
A radiopharmaceutical agent used for positron emission tomography (PET) imaging in oncology, cardiology, and neurology.
Ivabradine
A HCN channel blocker used to reduce the risk of hospitalization for worsening heart failure in adult patients and for treatment of stable symptomatic heart failure as a result of dilated cardiomyopathy in pediatric patients.
Quinapril
An ACE inhibitor prodrug used to treat hypertension, congestive heart failure, and slow rate of progression of renal disease.
Trandolapril
A prodrug of an ACE inhibitor used to treat hypertension, congestive heart failure, and to improve survival following a myocardial infarction.
Valsartan
An angiotensin-receptor blocker used to manage hypertension alone or in combination with other antihypertensive agents and to manage heart failure in patients who are intolerant to ACE inhibitors.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT01510652
More Options Available With a Quadripolar LV Lead pRovidE In-clinic Solutions to CRT ChallengesNo drug interventionspreventionNot Availablecompleted
NCT00587990
Prospective Randomized Study of Mesenchymal Stem Cell Therapy in Patients Undergoing Cardiac Surgery (PROMETHEUS)No drug interventionstreatment1 / 2terminated
NCT01065454
A Study to Test the Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Left Ventricular Systolic Dysfunctiontreatment2active_not_recruiting
NCT01959828
Confirmatory Study of IK-3001 in Japanese Subjects With Peri-/Post-op Pulmonary Hypertension Assoc. With Cardiac Surgerytreatment3completed
NCT02530788
High-dose Selenium Supplementation in Patients With Left Ventricular Assisttreatment3completed
NCT00143507
The BEAUTIFUL Study: Effects of Ivabradine in Patients With Stable Coronary Artery Disease and Left Ventricular Systolic Dysfunctiontreatment3completed
NCT01172756
A Study to Test the Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Left Ventricular Diastolic Dysfunctiontreatment2terminated
NCT03385785
Ventriculo-arterial Coupling Modification Evaluated by PRAM During TAVI ProcedureNo drug interventionsNot AvailableNot Availableunknown_status
NCT00385242
PET and Recovery Following Revascularization (PARR 2)No drug interventionsdiagnostic3completed
NCT02155842
Exercise Training in Treating Diastolic Heart FailureNo drug interventionstreatmentNot Availablewithdrawn
NCT01936649
Open-label, Test-retest Study Assessing Reproducibility of Quantitative Measurements of Myocardial Uptake of AdreView.diagnostic4completed
NCT02668419
Electrical Stimulation Improves Exercise Tolerance in Patients With Advanced Heart Failure on Continuous Dobutamine UseNo drug interventionstreatmentNot Availablecompleted
NCT01780727
Echo-guided Hemodynamic Management Strategy in Elderly Patients Undergoing Noncardiac SurgeryNo drug interventionstreatmentNot Availablecompleted
NCT02428894
Characterization of the Plasma Proteome Following Left Ventricular Assist Device ImplantationNo drug interventionsNot AvailableNot Availablecompleted
NCT02931240
BioVentrix Revivent TC™ System Clinical StudyNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT00872001
The Effect Of Acadesine On Reducing Cardiovascular and Cerebrovascular Adverse Events In Coronary Artery Bypass Graft (CABG) Surgery (Study P05633 AM1)(TERMINATED)prevention3terminated
NCT00391846
Evaluation of Heart Failure Treatment Guided by N-terminal Pro B-type Natriuretic Peptide (NTproBNP) vs Clinical Symptoms and Signs Alonetreatment4completed
NCT00303979
IMPROVE HF: Registry to Improve the Use of Evidence-Based Heart Failure Therapies in the Outpatient SettingNo drug interventionsNot AvailableNot Availablecompleted
NCT01065051
Hemodynamic and Echocardiographic Assessment of Riociguat Effects on Myocardial Wall Contractility and Relaxation Kineticstreatment2terminated
NCT05784051
Prophylactic Frequent Premature Ventricular complexeS sUPPression on Left ventriculaR Function impairmEnt in aSymptomatic patientSNo drug interventionsprevention4not_yet_recruiting
NCT04939077
Treatment of Heart Failure Using Human Umbilical Cord Mesenchymal Stem Cells(hUC-MSC)treatment1 / 2unknown_status
NCT02899897
Place of Echocardiography in IV Fluid Therapy in Patients With Septic Shock and Left Ventricular Systolic DysfunctionNo drug interventionsNot AvailableNot Availablecompleted
NCT03701997
Registry to Monitor Berlin Heart EXCOR® Pediatric VAD as a Bridge to Cardiac Transplantation.No drug interventionsNot AvailableNot Availableunknown_status
NCT02972918
Preoperative levosimendán and Hip FractureNot AvailableNot Availablecompleted
NCT02147457
Prematurity as Predictor of Children's Cardiovascular-renal HealthNo drug interventionsNot AvailableNot Availablecompleted
NCT00768066
The Transendocardial Autologous Cells (hMSC or hBMC) in Ischemic Heart Failure Trial (TAC-HFT)No drug interventionstreatment1 / 2completed
NCT01800292
Characterization of LV Strain Patterns in Mildly Elevated PCWP and PAH.diagnostic4completed
NCT02381756
Ultrasound and Left Ventricular Systolic FunctionNo drug interventionsNot AvailableNot Availableterminated
NCT03089502
Efficacy of Cardio-Oncology Rehabilitation Exercise for Women With Breast Cancer and Treatment Related CardiotoxicityNo drug interventionstreatmentNot Availableterminated
NCT04397302
Role of Sacubitril/Valsartan in the Improvement of Heart Failure With Reduced Ejection FractionNo drug interventionsNot AvailableNot Availablecompleted
NCT03659851
Levosimendan In Patients Undergoing LVAD ImplantationNot AvailableNot Availableunknown_status
NCT05756751
IMPACT EU Post-Market Clinical Follow-Up StudyNo drug interventionstreatmentNot Availablerecruiting
NCT05619653
Myocardial Protection in Patients With Post-acute Inflammatory Cardiac Involvement Due to COVID-19treatment3recruiting
NCT04942353
Effects of Home-based Exercise Rehabilitation on Healthcare Utilization in HeartMate 3 PatientsNo drug interventionstreatmentNot Availablecompleted
NCT00938847
Bone Marrow Derived Mononuclear Cells For Myocardial RegenerationNo drug interventionsbasic_science3completed
NCT04337983
Hemodynamic Characteristics of Patients With SARS-CoV-2No drug interventionsNot AvailableNot Availablecompleted
NCT04752293
Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)No drug interventionsNot AvailableNot Availablerecruiting
NCT04405856
Outcome of Patients Treated With IABPNo drug interventionsNot AvailableNot Availablerecruiting
NCT06197256
Cardiac Dysfunction in Critically Ill Covid-19 PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT02687932
Pharmacological Reduction of Functional, Ischemic Mitral REgurgitationtreatment4completed
NCT04763200
Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular FunctionNo drug interventionstreatmentNot Availablerecruiting
NCT03755570
How is COGNItive Function Affected by Cardiac Resynchronisation Therapy?No drug interventionsNot AvailableNot Availablesuspended
NCT05010642
Low Ejection Fraction in Single Lead ECG- OchsnerNo drug interventionsNot AvailableNot Availablecompleted
NCT03257436
Strategic Management to Improve CRT Using Multi-Site Pacing Post Approval Study (Reference # C1918)No drug interventionsotherNot Availablecompleted
NCT03232736
InterventiOn of Biventricular Pacemaker Function on ventrIcular Function Among Patients With LVAD'sNo drug interventionsNot AvailableNot Availablecompleted
NCT01303718
INcrease Of VAgal TonE in CHFNo drug interventionstreatment3terminated
NCT02184819
Preoperative Levosimendan in CABG Patients With Poor LV Functionprevention3completed
NCT05484817
Early Assessment of Impaired Cardiac Function in Patients With Diabetes MellitusNo drug interventionsNot AvailableNot Availableunknown_status
NCT04524234
Cardiac Dysfunction in Critically Ill Patients With COVID-19No drug interventionsNot AvailableNot Availablecompleted
NCT00461734
PROTECT-PACE STUDY - The Protection of Left Ventricular Function During Right Ventricular PacingNo drug interventionstreatmentNot Availablecompleted
NCT05760924
Left Bundle Branch Pacing on Outcomes and Ventricular Remodeling in Biventricular CRT NonrespondersNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT05188222
Preoperative Maltodextrin's Effect on Cardiac Function in Cardiac Surgeryprevention4not_yet_recruiting
NCT04661657
COvid-19 LongitUdinal Multiethnic BioImaging Assessment of CARDiovascular Sequelae RegistryNo drug interventionsNot AvailableNot Availablecompleted
NCT04871126
Predictive Value of Inflammatory Indexes and CHA2DS2-VASc Score for LVT in ANT-MI With Left Ventricular DysfunctionNo drug interventionsNot AvailableNot Availablecompleted
NCT01178866
Laboratory Outcome Predictors in Coronary SurgeryNo drug interventionsNot AvailableNot Availablecompleted
NCT00919373
Substrate Modification in Stable Ventricular Tachycardia in Addition to Implantable Cardioverter Defibrillator (ICD) TherapyNo drug interventionstreatmentNot Availablecompleted
NCT06356727
Microvascular Dysfunction Assessment to Predict Left Ventricular Reverse RemodelingNo drug interventionssupportive_careNot Availablerecruiting
NCT00684060
Use of Adult Autologous Stem Cells in Treating People 2 to 3 Weeks After Having a Heart Attack (The Late TIME Study)treatment2completed
NCT00921960
St. Vincent's Screening To Prevent Heart Failure StudyNo drug interventionspreventionNot Availablecompleted
NCT06387862
Pharmacokinetics of Inhaled Levosimendanbasic_science2recruiting
NCT05939089
Cardiovascular Assessment of Pediatric Cancer SurvivorsNo drug interventionsNot AvailableNot Availablecompleted
NCT02354989
Rate RESPONSIVe Pacing in Patients With Permanent AF Underwent AV Node ABLation and bivEntricular Pacing (RESPONSIBLE)No drug interventionstreatmentNot Availablecompleted
NCT04694092
Landiolol for Rate Control in Decompensated Heart Failure Due to Atrial FibrillationtreatmentNot Availableunknown_status
NCT01114269
PRE-DETERMINE Cohort StudyNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT06088212
Reducing Cognitive Impairment by Management of Heart Failure as a Modifiable Risk FactorNo drug interventionspreventionNot Availablerecruiting
NCT01219712
Optimization Study of Cardiac Risk Patients With Hip FractureNo drug interventionspreventionNot Availableunknown_status
NCT00910481
Balloon Pump Assisted Coronary Intervention StudyNo drug interventionstreatmentNot Availablecompleted
NCT01110395
Phosphorous Magnetic Resonance Spectroscopy of HeartNo drug interventionsbasic_scienceNot Availablecompleted
NCT00781508
Effects of Viagra on Heart Function in Patients With Heart Failuretreatment4completed
NCT05650008
Effects of Intrathecal Local Anesthetics on Left Ventricular Global Longitudinal StrainNo drug interventionsNot AvailableNot Availablecompleted
NCT01609738
Left Ventricular Septum Pacing in Patients by Transvenous Approach Through the Inter-ventricular SeptumNo drug interventionsNot AvailableNot Availablecompleted
NCT02669290
Use of 3-D Blood Pool Scintigraphy to Guide Left Ventricular Pacing Lead Placement in Patients Requiring Cardiac Resynchronization TherapyNo drug interventionstreatmentNot Availableterminated
NCT01128790
Pilot Study of Remote Ischemic Preconditioning in Heart FailureNo drug interventionstreatmentNot Availablecompleted
NCT04933890
Detection of Heart Conditions Using Artificial IntelligenceNo drug interventionsNot AvailableNot Availablecompleted
NCT00684021
Use of Adult Autologous Stem Cells in Treating People Who Have Had a Heart Attack (The TIME Study)No drug interventionstreatment2completed
NCT00487279
DEfibrillators To REduce Risk by MagnetIc ResoNance Imaging EvaluationNo drug interventionstreatmentNot Availableterminated
NCT04111133
Ivabradine in Cirrhotic CardiomyopathytreatmentNot Availablerecruiting
NCT03761654
Detection of Myocardial Dysfunction in Non-severe Subarachnoid Hemorrhage (WFNS 1-2) Using Speckle-tracking Echocardiography (STRAIN)No drug interventionsNot AvailableNot Availablecompleted
NCT05529654
IMpella-Protected cArdiaC Surgery Trial (IMPACT)No drug interventionstreatmentNot Availableenrolling_by_invitation
NCT02956577
Cardiac Function and Microcirculation: Type 2 DIABetes and ECHOcardiographic Changes Over TimeNo drug interventionsNot AvailableNot Availablecompleted
NCT05989945
HIDRAdenitis Suppurativa and HEART DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT00512005
VIVID - Valvular and Ventricular Improvement Via iCoapsys Delivery - Feasibility StudyNo drug interventionstreatment1unknown_status
NCT00824005
Effectiveness of Stem Cell Treatment for Adults With Ischemic Cardiomyopathy (The FOCUS Study)treatment2completed
NCT04561778
HIS-Purkinje Conduction System Pacing Optimized Trial of Cardiac Resynchronization TherapyNo drug interventionstreatmentNot Availablecompleted
NCT03627585
Reprogramming to Prevent Progressive Pacemaker-induced RemodellingNo drug interventionstreatmentNot Availablecompleted
NCT02013037
The De-novo Use of Eculizumab in Presensitized Patients Receiving Cardiac Transplantationtreatment3completed
NCT02543632
PARACHUTE V PercutAneous Ventricular RestorAtion in Chronic Heart FailUre Due to Ischemic HearT DiseasE.No drug interventionsNot AvailableNot Availableterminated
NCT05388032
Sodium Lowering Vascular Effects TrialNo drug interventionsbasic_scienceNot Availablerecruiting
NCT05728632
Cardioprotective Effects of Nebivolol Versus Placebo in Patients Undergoing Chemotherapy With Anthracyclinesprevention3active_not_recruiting
NCT05769036
Conventional Biventricular Versus Left Bundle Branch Pacing on Outcomes in Heart Failure PatientsNo drug interventionstreatmentNot Availablerecruiting
NCT04950218
The Psoriasis Echo StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT01076296
A Post-Marketing Study for On Label Evaluation of the GE Vscan Ultrasound Imaging SystemNo drug interventionsNot AvailableNot Availablecompleted
NCT04400435
Detection of Heart Conditions With Single Lead ECG Using Artificial IntelligenceNo drug interventionsNot AvailableNot Availablecompleted
NCT05317286
LVEF Prediction During ACS Using AI Algorithm Applied on Coronary Angiogram VideosNo drug interventionsNot AvailableNot Availablecompleted
NCT01971125
Left Ventricular DYsfunction in DiAbetesNo drug interventionsNot AvailableNot Availablecompleted
NCT05764057
DAPAgliflozine to Attenuate Cardiac RemOdeling afTEr aCuTe myOcardial Infarctiontreatment3recruiting
NCT04671966
Sex Differences in Myocardial Steatosis Induced Left Ventricular Dysfunctionbasic_science4recruiting
NCT01076920
Mesenchymal Stem Cells and Myocardial IschemiaNo drug interventionstreatment1 / 2completed
NCT01267331
Cell Therapy in Patients With Chronic Ischemic Heart Disease Undergoing Cardiac SurgeryNo drug interventionstreatment1 / 2unknown_status
NCT03573427
LV Endocardial CRT for Patients With Intermediate QRS WidthNo drug interventionsNot AvailableNot Availablewithdrawn
NCT00120276
RESTOR-MV: Randomized Evaluation of a Surgical Treatment for Off-Pump Repair of the Mitral ValveNo drug interventionstreatment2completed
NCT03319160
LifeVest Safety and Efficacy in Real Life Settings in FranceNo drug interventionsNot AvailableNot Availablecompleted
NCT00188994
Insulin Cardioplegia for Poor Left Ventricular FunctiontreatmentNot Availableunknown_status
NCT04034940
Correlations Between Oxidative Stress Biomarkers, h-FABP and Left Ventricular Dysfunction in Patients With Acute Myocardial Infarction Undergoing Primary PCINo drug interventionsdiagnosticNot Availableunknown_status
NCT05208567
London Valvular Heart Disease and Reduced Ejection Fraction Detection in a Multi-ethnic Community Using Cardiac UltrasoundNo drug interventionsNot AvailableNot Availablerecruiting
NCT03902067
UC-MSC Transplantation for Left Ventricular Dysfunction After AMINo drug interventionstreatment1not_yet_recruiting
NCT01093001
Tricuspid Regurgitation StudyNo drug interventionsprevention4completed
NCT04957004
Evaluation of Left Ventricular Function and Therapeutic Effect of CPAP in Patients With OSAS by 3D STENo drug interventionsNot AvailableNot Availablecompleted
NCT05860504
Acute Cardiac Dysfunction in Critical IllnesNo drug interventionsNot AvailableNot Availablerecruiting
NCT00359372
Predicting Response to Cardiac Resynchronization Therapy in Heart FailureNo drug interventionsNot AvailableNot Availablecompleted
NCT06084468
Cardiac Structure and Function in Patients With Cystic FibrosisNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT03787810
Left Ventricular Dysfunction in Critically Ill PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT00551681
Effects of Left Ventricular Pacing Optimilization on Cardiac Perfusion, Contractile Force, and Clinical Performance in Patients With Ventricular Dysfunction and Heart FailureNo drug interventionstreatmentNot Availablecompleted
NCT05010655
Low Ejection Fraction in Single Lead ECGNo drug interventionsNot AvailableNot Availablecompleted
NCT03107923
Better Patient Selection to Transcatheter Aortic Valve ImplantationNo drug interventionsNot AvailableNot Availablecompleted
NCT04774523
Evaluation of the BIOTRONIK AutoAdapt Algorithm for Continuous Automatic Adaptive Cardiac ResynchronizationNo drug interventionstreatmentNot Availablerecruiting
NCT04103008
Left Ventricular Function After Primary Percutaneous Coronary Intervention: Role of Speckle EchocardiographyNo drug interventionsNot AvailableNot Availableunknown_status
NCT01822808
Bi Treatment With Hydralazine/Nitrates Versus Placebo in Africans Admitted With Acute Heart Failuretreatment3unknown_status