Enalaprilat is an antihypertensive agent used for the management of hypertension when oral therapy is not practical. Enalaprilat is the active metabolite of the orally available pro-drug, enalapril.
- Mechanism
- Curator reviewed
Enalaprilat is the active metabolite of the orally available pro-drug, enalapril. Used in the treatment of hypertension, enalapril is an ACE inhibitor that prevents Angiotensin Converting Enzyme (ACE) from transforming angiotensin I into angiotensin II. As angiotensin II is responsible for vasoconstriction and sodium reabsorption in the proximal tubule of the kidney, down-regulation of this protein results in reduced blood pressure and blood fluid volume
- Primary indication
- Enalaprilat injection is indicated for the treatment of hypertension when oral therapy is not practical.Curator reviewed · 4 structured indications
- Formula / weight
- C18H24N2O5 · 348.3936 g/mol (avg)
- First approval
- Canada, 2008 · United States, 2000
Resolves to
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Which drugs share a target with Enalaprilat, and which of those have an active Phase 3 trial?
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