Relapsed Follicular Lymphoma (DBCOND0041364)

Identifiers

Synonyms

Not Available

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Axicabtagene ciloleucel	A CAR T-cell therapy used to treat adults with large B-cell lymphomas and follicular lymphoma.	B-lymphocyte antigen CD19target
Copanlisib	A PI3K inhibitor used to treat relapsed follicular lymphoma in adults.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformtarget Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Multidrug and toxin extrusion protein 2transporter Albumincarrier Cytochrome P450 1A1enzyme Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformtarget Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformtarget
Epcoritamab	A bispecific CD20-directed CD3 T-cell engager used to treat relapsed or refractory diffuse large B-cell lymphoma (DLBCL) in adults.	B-lymphocyte antigen CD20target T-cell surface glycoprotein CD3 epsilon chaintarget
Hyaluronidase (ovine)	A purified form of sheep hyaluronidase enzyme used as an adjunct in subcutaneous rehydration therapy and to increase absorption of other drugs and radiopaque imaging agents.	Transforming growth factor beta-1 proproteintarget Albumincarrier Hyaluronantarget
Lisocabtagene maraleucel	A CAR T-cell therapy for treatment resistant or more severe B-cell lymphomas.	B-lymphocyte antigen CD19target
Tazemetostat	A methyltransferase inhibitor indicated to treat patients 16 years and older with metastatic or locally advanced epithelioid sarcoma not eligible for complete resection.	Histone-lysine N-methyltransferase EZH2target ATP-dependent translocase ABCB1transporter Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter Cytochrome P450 3A Subfamilyenzyme Histone-lysine N-methyltransferase EZH1target Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 3A4enzyme
Tisagenlecleucel	A CAR T cell therapy for relapsed or refractory large B-cell lymphoma and diffuse large B-cell lymphoma.	B-lymphocyte antigen CD19target
Umbralisib	A kinase inhibitor used to treat rare forms of refractory lymphoma.	ATP-dependent translocase ABCB1transporter Cytochrome P450 2C9enzyme Cytochrome P450 1A2enzyme Cytochrome P450 3A4enzyme Casein kinase I isoform epsilontarget Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget Tyrosine-protein kinase ABL1target
Zanubrutinib	A kinase inhibitor used to treat mantle cell lymphoma, a type of B-cell non-Hodgkin lymphoma, in adults who previously received therapy.	Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2B6enzyme Tyrosine-protein kinase BTKtarget Epidermal growth factor receptortarget Receptor tyrosine-protein kinase erbB-2target Receptor tyrosine-protein kinase erbB-4target Tyrosine-protein kinase ITK/TSKtarget Cytoplasmic tyrosine-protein kinase BMXtarget Tyrosine-protein kinase JAK2target Tyrosine-protein kinase Tectarget Tyrosine-protein kinase Blktarget Tyrosine-protein kinase JAK3target Protein-tyrosine kinase 6target Tyrosine-protein kinase Fgrtarget Tyrosine-protein kinase FRKtarget Tyrosine-protein kinase Lcktarget Tyrosine-protein kinase TXKtarget Cytochrome P450 3A Subfamilyenzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05828589	A Study of BGB-21447, a Bcl-2 Inhibitor, in Mature B-Cell Malignancies	No drug interventions	treatment	1	recruiting
NCT03806179	Study of Safety and Efficacy of Betalutin and Rituximab in Patients With FL	Rituximab Tetulomab tetraxetan Lu-177	treatment	1	completed
NCT04191187	Reduced Intensity Flu/Mel/TBI Conditioning for HAPLO HCT Patients With Hematologic Malignancies	Fludarabine Melphalan	treatment	2	active_not_recruiting
NCT01827605	A Phase III Multicenter, Randomized Study Comparing RIT Vs ASCT in Patients With Relapsed/Refractory (FL)	No drug interventions	treatment	3	active_not_recruiting
NCT04699461	Study to Evaluate the Efficacy and Safety of Loncastuximab Tesirine Versus Idelalisib in Participants With Relapsed or Refractory Follicular Lymphoma	Idelalisib Loncastuximab tesirine	treatment	2	terminated
NCT05604417	Zandelisib + Tazemetostat in R/R Follicular Lymphoma	Tazemetostat Zandelisib	treatment	1 / 2	withdrawn
NCT02956382	Ibrutinib and Venetoclax in Relapsed and Refractory Follicular Lymphoma	Ibrutinib Venetoclax	treatment	1 / 2	active_not_recruiting
NCT05848765	Relapsed Follicular Lymphoma Randomised Trial Against Standard ChemoTherapy	Bendamustine Cyclophosphamide Doxorubicin Epcoritamab Lenalidomide Obinutuzumab Prednisone Rituximab Vincristine	treatment	2	recruiting
NCT00715208	Phase 2 Study of VELCADE (Bortezomib) in Patients With Relapsed Follicular Lymphoma	Bortezomib D-mannitol Cyclophosphamide Doxorubicin Prednisone Rituximab	treatment	2	completed