NCT04181164
Evaluation of Bone Architecture and Bone Strength in Adults With Hypophosphatasia (HPP) No drug interventions Not Available Not Available unknown_status NCT00952484
Safety and Efficacy of Asfotase Alfa in Juvenile Patients With Hypophosphatasia (HPP) treatment 2 completed NCT02104219
Retrospective, Non-interventional Natural History of Patients With Juvenile-onset Hypophosphatasia (HPP) No drug interventions Not Available Not Available completed NCT02306720
Registry of Patients With Hypophosphatasia No drug interventions Not Available Not Available enrolling_by_invitation NCT00739505
Safety Study of Human Recombinant Tissue Non-Specific Alkaline Phosphatase Fusion Protein Asfotase Alfa in Adults With Hypophosphatasia (HPP) treatment 1 completed NCT01419028
A Retrospective Study of the Natural History of Patients With Severe Perinatal and Infantile Hypophosphatasia (HPP) No drug interventions Not Available Not Available completed NCT00744042
Safety and Efficacy Study of Asfotase Alfa in Severely Affected Infants With Hypophosphatasia (HPP) treatment 1 / 2 completed NCT01203826
Extension Study of Protocol ENB-006-09 - Study of Asfotase Alfa in Children With Hypophosphatasia (HPP) treatment 2 completed NCT06079281
Phase 3 Study of ALXN1850 Versus Placebo in Adolescent and Adult Participants With HPP Who Have Not Previously Been Treated With Asfotase Alfa No drug interventions treatment 3 recruiting NCT06079359
Phase 3 Study of ALXN1850 in Treatment-Naïve Pediatric Participants With HPP No drug interventions treatment 3 recruiting NCT06079372
Phase 3 Study of ALXN1850 in Pediatric Participants With HPP Previously Treated With Asfotase Alfa treatment 3 recruiting NCT06015750
Mitigate Immune-Mediated Loss of Therapeutic Response to Asfotase Alfa (STRENSIQ®) for Hypophosphatasia treatment 4 not_yet_recruiting NCT02797821
Pharmacokinetic and Dose Response Study of Asfotase Alfa in Adult Patients With Pediatric-Onset Hypophosphatasia (HPP) treatment 2 completed NCT02796885
Characterisation of Adult-Onset Hypophosphatasia No drug interventions Not Available Not Available completed NCT04189315
Relieving Burden of Hypophosphatasia in Adults With Functional Impairment Due to Chronic Disease treatment 4 withdrawn NCT00894075
Safety and Efficacy Study of ENB-0040 in Juvenile Patients With Hypophosphatasia (HPP) treatment 2 withdrawn NCT06161142
Characteristics of Hypophosphatasia in Adult Patients in Rheumatology No drug interventions Not Available Not Available recruiting NCT04195763
Patient Reported Outcomes in Adults With Pediatric-onset Hypophosphatasia Treated With Strensiq® (Asfotase Alfa) Not Available Not Available completed NCT05596539
Prospective, Longitudinal, Observational Registry of Adult Patients With Hypophosphatasia (REG-HYPO) No drug interventions Not Available Not Available not_yet_recruiting NCT04980248
Study of ALXN1850 in Participants With Hypophosphatasia (HPP) No drug interventions basic_science 1 completed NCT06574282
Characteristics of Hypophosphatasia in Adult Patients in Rheumatology and Their Value in Developing an Algorithm to HPP-diagnosis - the COHIR Multi-center Study No drug interventions Not Available Not Available active_not_recruiting NCT05062629
United States Hypophosphatasia Molecular Research Center No drug interventions Not Available Not Available recruiting NCT02496689
Expanded Access Program for Asfotase Alfa Treatment for Patients With Infantile- or Juvenile-onset Hypophosphatasia (HPP) Not Available Not Available approved_for_marketing NCT03418389
Evaluate and Monitor Physical Performance of Adults Treated With Asfotase Alfa for Hypophosphatasia No drug interventions Not Available Not Available completed NCT05234567
A Prospective Sub-Study of the Global Hypophosphatasia Registry Not Available Not Available recruiting NCT03655223
Early Check: Expanded Screening in Newborns No drug interventions Not Available Not Available enrolling_by_invitation NCT02456038
Safety and Efficacy of Asfotase Alfa in Patients With Hypophosphatasia (HPP) treatment 2 completed NCT04018287
Circulating miRNAs and Bone Microstructure in Adults With Hypophosphatasia No drug interventions Not Available Not Available active_not_recruiting NCT01406977
Dose Escalation Study to Evaluate the Safety and Tolerability of Multiple Infusions of BPS804 in Adults With Hypophosphatasia (HPP) treatment 2 completed NCT02291497
Burden of Disease in Hypophosphatasia (HPP) No drug interventions Not Available Not Available completed NCT02235493
Non-interventional Substudy of ALX-HPP-502 to Assess Natural History of Patients With Juvenile-onset HPP Who Served as Historical Controls in ENB-006-09 No drug interventions Not Available Not Available completed NCT04222452
The PORTRAIT Study No drug interventions Not Available Not Available unknown_status NCT01205152
Extension Study of Protocol ENB-002-08 - Study of Asfotase Alfa in Infants and Young Children With Hypophosphatasia (HPP) treatment 2 completed NCT01163149
Safety and Efficacy Study of Asfotase Alfa in Adolescents and Adults With Hypophosphatasia (HPP) treatment 2 completed NCT02237625
Natural History Study of Patients With Hypophosphatasia (HPP) No drug interventions Not Available Not Available recruiting NCT01176266
Open-Label Study of Asfotase Alfa in Infants and Children ≤ 5 Years of Age With Hypophosphatasia (HPP) treatment 2 / 3 completed NCT05890794
Pilot Trial of Single Dose Ilofotase Alfa in Hypophosphatasia treatment 1 / 2 completed NCT02531867
Post-approval Clinical Study of Asfotase Alfa Treatment for Patients With Hypophosphatasia (HPP) in Japan treatment 4 completed NCT02751801
Health Burden of Hypophosphatasia No drug interventions Not Available Not Available completed NCT04925804
Unraveling Genetics of HypoPhosPhatasia (HPP Genetics) No drug interventions Not Available Not Available completed NCT01793168
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford No drug interventions Not Available Not Available recruiting