Metastatic Non-Small Cell Lung Cancer (DBCOND0043377)

Identifiers

Synonyms
Metastatic NSCLC - Non-Small Cell Lung Cancer / Metastatic Non-small Cell Lung Cancers / Metastatic Nonsmall Cell Lung Cancer / Metastatic NSCLC / Metastatic Non-Small Cell Lung Carcinoma / Metastatic Non-small Cell Lung Cancer (NSCLC) / Metastatic non-small cell lung cancer / Non-small cell lung cancer metastatic / Metastatic non-small cell lung cancer (disorder) / Lung cancer non-small cell stage IV / Non-small cell lung cancer stage IV

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Adagrasib
A KRAS inhibitor indicated for the treatment of locally advanced or metastatic KRAS G12C-mutated non-small cell lung cancer in patients who have received at least one prior systemic therapy.
Afatinib
An antineoplastic agent used for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) with non-resistant EGFR mutations or resistance to platinum-based chemotherapy.
Amivantamab
An EGF and MET receptor targeted antibody indicated in the treatment of non-small cell lung cancer with an EGFR 20 exon insertion mutation.
Atezolizumab
A monoclonal antibody used to treat advanced or metastatic urothelial carcinoma with disease progression during or up to 12 months after platinum-containing chemotherapy.
Binimetinib
A medication used to treat metastatic melanoma with specific mutations.
Brigatinib
An anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer.
Capmatinib
A kinase inhibitor targeting c-Met receptor tyrosine kinase in the treatment of non-small cell lung cancer with MET exon 14 skipping.
Cemiplimab
A programmed death receptor-1 blocking antibody used to treat cutaneous squamous cell carcinoma, basal cell carcinoma, and non-small cell lung cancer.
Crizotinib
A receptor tyrosine kinase inhibitor used to treat metastatic non-small cell lung cancer (NSCLC) where the tumors have been confirmed to be anaplastic lymphoma kinase (ALK), or ROS1-positive.
Dabrafenib
A kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer.
Dacomitinib
A medication used to treat non small cell lung cancer with EGFR exon 19 deletion of exon 21 L858R substitution.
Durvalumab
An antineoplastic monoclonal antibody used to treat urothelial carcinoma and locally advanced, unresectable non-small cell lung cancer.
Encorafenib
A kinase inhibitor used to treat unresectable or metastatic melanoma with specific mutations.
Entrectinib
Entrectinib is indicated for the treatment of metastatic ROS1-positive non-small cell lung cancer in adults. Entrectinib is also indicated in adults and children over 12 years old for the treatment...
Erlotinib
An EGFR tyrosine kinase inhibitor used to treat certain small cell lung cancers or advanced metastatic pancreatic cancers.
Gefitinib
A tyrosine kinase inhibitor used as first-line therapy to treat non-small cell lung carcinoma (NSCLC) that meets certain genetic mutation criteria.
Ipilimumab
A human cytotoxic T-lymphocyte antigen 4 (CTLA-4) blocking antibody used to treat metastatic or unresectable melanoma.
Lazertinib
A tyrosine kinase inhibitor used in combiantion with amivantamab to treat non-small cell lung cancer with EGFR mutations.
Lorlatinib
An anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer.
Mobocertinib
An oral kinase inhibitor targeted against EGFR and used in the treatment of NSCLC with EGFR exon 20 insertion mutations.
Necitumumab
A monoclonal antibody used to treat metastatic squamous non-small cell lung cancer.
Nivolumab
A PD-1 blocking antibody used to treat melanoma, non small-cell lung cancer, renal cell cancer, head and neck cancer, and Hodgkin lymphoma.
Osimertinib
A tyrosine kinase inhibitor used in the treatment of certain types of non-small cell lung carcinoma.
Paclitaxel
A taxoid chemotherapeutic agent used as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast and lung cancer.
Pembrolizumab
A PD-1 blocking antibody used to treat various types of cancer, including metastatic melanoma, non small-cell lung cancer, cervical cancer, head and neck cancer, and Hodgkin's lymphoma.
Ramucirumab
An antineoplastic agent and direct VEGFR2 (vascular endothelial growth factor receptor 2) antagonist that blocks the binding of natural VEGF ligands, which are secreted by solid tumors to promote angiogenesis and enhance tumor blood supply.
Sotorasib
An experimental KRAS inhibitor being investigated for the treatment of KRAS G12C mutant non small cell lung cancer, colorectal cancer, and appendix cancer.
Tepotinib
An oral tyrosine kinase inhibitor targeted against MET for the treatment of metastatic non-small cell lung cancer in patients exhibiting MET exon 14 skipping mutations.
Trametinib
A kinase inhibitor used alone or in combination with dabrafenib to treat patients with cancers with specific BRAF mutations, such as melanoma and non-small cell lung cancer.
Trastuzumab deruxtecan
An antibody used to treat certain types of unresectable or metastatic HER2 positive breast cancer.
Tremelimumab
An anti-CTLA-4 antibody used to treat unresectable hepatocellular carcinoma in combination with durvalumab.
Vinorelbine
A vinca alkaloid used in the treatment of metastatic non-small cell lung carcinoma (NSLC) and in conjunction with other drugs in locally advanced NSCLC.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT05403385
Study of Inupadenant (EOS100850) with Chemotherapy As Second Line Treatment for Nonsquamous Non-small Cell Lung Cancertreatment2recruiting
NCT05859217
A Study of Combining Cabozantinib and Atezolizumab for Advanced/Metastatic NSCLC (Cabatezo-1)treatment2not_yet_recruiting
NCT05478538
Observational Lung Trial to Collect Tissue to Train and Validate a Live Tumor Diagnostic PlatformNo drug interventionsNot AvailableNot Availablerecruiting
NCT05299125
Amivantamab, Lazertinib, and Pemetrexed for First-line Treatment of Recurrent/Metastatic Non-small Cell Lung Cancers With Epidermal Growth Factor Receptor Mutationstreatment2recruiting
NCT06607393
CARE Initiative: Real-world Emulation of the KEYNOTE-189 Trial [DS3]Not AvailableNot Availablecompleted
NCT06228482
Molecularly Targeted Radionuclide Therapy Via the Integrin Alphavbeta6treatment1recruiting
NCT03825510
Immunotherapy SBRT Sensitization of the Programmed Death-1 (PD-1) EffectNo drug interventionstreatment2completed
NCT03987555
Paclitaxel Therapeutic Drug Monitoring in Cancer PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT03512847
Predictive Gene Profiles and Dynamic Measurement of Treatment Response in Metastatic Non-small Cell Lung CancerNo drug interventionsNot AvailableNot Availablecompleted
NCT03415126
A Study of ASN007 in Patients With Advanced Solid TumorsNo drug interventionstreatment1completed
NCT04170634
Tumoral Bone Strength Assessment by Numerical Simulation Using Quantitative CT : the MEKANOS StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT01438307
Phase II Study of Cabazitaxel-XRP6258 in Advanced Non-Small Cell Lung Cancertreatment2completed
NCT02983500
Patient Reported Outcomes Registry in Patient With Cancer CachexiaNo drug interventionsNot AvailableNot Availablecompleted
NCT05617313
Study of GT103 in Combination With Pembrolizumab in Refractory, Metastatic Non-Small Cell Lung Cancertreatment2active_not_recruiting
NCT03589339
NBTXR3 Activated by Radiotherapy for Patients With Advanced Cancers Treated With An Anti-PD-1 Therapytreatment1recruiting
NCT05480865
SHP2 Inhibitor BBP-398 in Combination With Sotorasib in Patients With Advanced Solid Tumors and a KRAS-G12C Mutationtreatment1recruiting
NCT06159790
A Study to Compare Efficacy, Safety, and Immunogenicity of GME751 and EU-authorized Keytruda in Adult Participants With Untreated Metastatic Non-squamous Non-small Cell Lung Cancer (NSCLC)treatment3recruiting
NCT05091190
Immunotherapy Clearance and Phenotype of Circulating Tumor Cells in Lung and Head and Neck CancersNo drug interventionsotherNot Availablerecruiting
NCT05255302
De-escalation Immunotherapy mAintenance Duration Trial for Stage IV Lung Cancer Patients With Disease Control After Chemo-immunotherapy Inductiontreatment2 / 3recruiting
NCT04615884
Use of Chinese Herbal Formula Shu Yu Wan in Lung Cancer PatientsNo drug interventionssupportive_careNot Availablewithdrawn
NCT04846452
Sintilimab, Anlotinib Hydrochloride and Platinum-Containing Dual-Agent Chemotherapy in NSCLCtreatment2unknown_status
NCT03417882
GRN-1201 With Pembrolizumab in Subjects With Metastatic PD-L1+ NSCLCtreatment2terminated
NCT05339568
Patient's Whole Process Follow-up Management(HOPE-1)No drug interventionsNot AvailableNot Availablerecruiting
NCT06500481
Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM TrialNo drug interventionstreatment3not_yet_recruiting
NCT02496663
Osimertinib and Necitumumab in Treating Patients With EGFR-Mutant Stage IV or Recurrent Non-small Cell Lung Cancer Who Have Progressed on a Previous EGFR Tyrosine Kinase Inhibitortreatment1active_not_recruiting
NCT04514484
Testing the Combination of the Anti-cancer Drugs XL184 (Cabozantinib) and Nivolumab in Patients With Advanced Cancer and HIVtreatment1active_not_recruiting
NCT05786924
A Study of BDTX-4933 in Patients With KRAS, BRAF and Select RAS/MAPK Mutation-Positive CancersNo drug interventionstreatment1active_not_recruiting
NCT03225664
Trametinib and Pembrolizumab in Treating Patients With Recurrent Non-small Cell Lung Cancer That Is Metastatic, Unresectable, or Locally Advancedtreatment1 / 2active_not_recruiting
NCT03808337
Investigating the Effectiveness of Stereotactic Body Radiotherapy (SBRT) in Addition to Standard of Care Treatment for Cancer That Has Spread Beyond the Original Site of DiseaseNo drug interventionstreatment2recruiting
NCT04588246
Testing the Addition of Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in People With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgerytreatment3terminated
NCT04940299
Tocilizumab, Ipilimumab, and Nivolumab for the Treatment of Advanced Melanoma, Non-Small Cell Lung Cancer, or Urothelial Carcinomatreatment2active_not_recruiting
NCT05840770
Cemiplimab for the Treatment of Untreated Brain Metastases From PD-L1 >= 50% Non-Small Cell Lung Cancertreatment2recruiting
NCT06043713
Autologous CD8+ and CD4+ Transgenic T Cells Expressing High Affinity KRASG12V Mutation-Specific T Cell Receptors (FH-A11KRASG12V-TCR) in Treating Patients With Metastatic Pancreatic, Colorectal and Non-Small Cell Lung Cancers With KRAS G12V Mutationstreatment1recruiting
NCT06349642
Predicting Response to Immune Checkpoint Inhibitors Across Solid Tumors Using a Live Tumor Diagnostic PlatformNo drug interventionsNot AvailableNot Availablerecruiting
NCT06616623
Vismodegib and Atezolizumab for the Treatment of Recurrent or Metastatic Non-Small Cell Lung Cancertreatment1not_yet_recruiting
NCT04120454
Ramucirumab and Pembrolizumab for the Treatment of EGFR Mutant Recurrent or Metastatic Non-small Cell Lung Cancertreatment2active_not_recruiting
NCT04751747
Adaptive Radiation Planning for the Reduction of Radiation-Induced Toxicity in Patients With Stage II-IV Non-small Cell Lung CancerNo drug interventionssupportive_careNot Availablerecruiting
NCT04250545
Testing of the Anti Cancer Drugs CB-839 HCl (Telaglenastat) and MLN0128 (Sapanisertib) in Advanced Stage Non-small Cell Lung Cancertreatment1active_not_recruiting
NCT04227028
Brigatinib and Bevacizumab for the Treatment of ALK-Rearranged Locally Advanced, Metastatic, or Recurrent NSCLCtreatment1active_not_recruiting
NCT04285671
Necitumumab and Trastuzumab in Combination With Osimertinib for the Treatment of Refractory Epidermal Growth Factor Receptor (EGFR)-Mutated Stage IV Non-small Cell Lung Cancertreatment1 / 2active_not_recruiting
NCT05377788
Lazertinib Real-world Observational Study of in Pre-treated EGFR T790M Mutant With Advanced Non-small Cell Lung CancerNot AvailableNot Availableunknown_status
NCT04186988
[18F]-AraG for the Detection of T-Cell Activation in Advanced Non-small Cell Lung Cancer Patients Undergoing PD-1/PD-L1-Directed TherapyNo drug interventionsdiagnostic0withdrawn
NCT03134456
Pembrolizumab for Metastatic NSCLC Patients Expressing PD-L1 Who Have Their Own PDXtreatment4recruiting
NCT04762199
MRX-2843 and Osimertinib for the Treatment of Advanced EGFR Mutant Non-small Cell Lung Cancertreatment1recruiting
NCT02498613
A Phase 2 Study of Cediranib in Combination With Olaparib in Advanced Solid Tumorstreatment2active_not_recruiting
NCT02589522
Testing the Safety of M6620 (VX-970) When Given With Standard Whole Brain Radiation Therapy for the Treatment of Brain Metastases From Non-small Cell Lung Cancer, Small Cell Lung Cancer, or Neuroendocrine Tumorstreatment1active_not_recruiting
NCT05570825
SX-682 With Pembrolizumab for the Treatment of Metastatic or Recurrent Stage IIIC or IV Non-Small Cell Lung Cancertreatment2recruiting
NCT06518057
Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung CancerNo drug interventionstreatment2not_yet_recruiting
NCT05935774
OT-101 in Combination With Atezolizumab for the Treatment of Metastatic or Recurrent Non-Small Cell Lung Cancertreatment2withdrawn
NCT06249282
Carfilzomib in Combination With Sotorasib for the Treatment of Patients With KRAS G12C Mutated Advanced or Metastatic Non-small Cell Lung Cancertreatment1recruiting
NCT04007744
Sonidegib and Pembrolizumab in Treating Patients With Advanced Solid Tumorstreatment1recruiting
NCT03600701
Atezolizumab and Cobimetinib in Treating Patients With Metastatic, Recurrent, or Refractory Non-small Cell Lung Cancertreatment2active_not_recruiting
NCT02971501
Osimertinib With or Without Bevacizumab in Treating Patients With EGFR Positive Non-small Cell Lung Cancer and Brain Metastasestreatment2active_not_recruiting
NCT05045404
Poziotinib and Ramucirumab for the Treatment of EGFR Exon 20 Mutant Stage IV Non-small Cell Lung Cancertreatment2withdrawn
NCT06472804
Insomnia in Patients With Metastatic Lung CancerNo drug interventionsNot AvailableNot Availablerecruiting
NCT04789668
Bintrafusp Alfa and Pimasertib for the Treatment of Patients With Brain Metastasestreatment1 / 2completed
NCT04919369
All-Trans Retinoic Acid (ATRA) and Atezolizumab for the Treatment of Recurrent or Metastatic Non-Small Cell Lung Cancertreatment1recruiting
NCT05435846
Capmatinib Plus Trametinib for the Treatment of Metastatic Non-small Cell Lung Cancer With MET Exon 14 Skipping Mutationtreatment1terminated
NCT05269381
Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumorstreatment1 / 2recruiting
NCT02419495
Phase IB Study to Evaluate the Safety of Selinexor (KPT-330) in Combination With Multiple Standard Chemotherapy or Immunotherapy Agents in Patients With Advanced Malignanciestreatment1active_not_recruiting
NCT06500455
Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the BrainNo drug interventionstreatment3not_yet_recruiting
NCT02888743
Durvalumab and Tremelimumab With or Without High or Low-Dose Radiation Therapy in Treating Patients With Metastatic Colorectal or Non-small Cell Lung Cancertreatment2active_not_recruiting
NCT02955290
CIMAvax Vaccine, Nivolumab, and Pembrolizumab in Treating Patients With Advanced Non-small Cell Lung Cancer or Squamous Head and Neck Cancertreatment1 / 2recruiting
NCT05256290
Phase 1/2 Study of BDTX-1535 in Patients With Glioblastoma or Non-Small Cell Lung Cancer With EGFR MutationsNo drug interventionstreatment1 / 2recruiting
NCT04533451
Testing the Effects of MK-3475 (Pembrolizumab) With or Without the Usual Chemotherapy Treatment for Patients 70 Years of Age and Older With Advanced Non-small Cell Lung Cancertreatment2active_not_recruiting
NCT04639245
Genetically Engineered Cells (MAGE-A1-specific T Cell Receptor-transduced Autologous T-cells) and Atezolizumab for the Treatment of Metastatic Triple Negative Breast Cancer, Urothelial Cancer, or Non-small Cell Lung Cancertreatment1 / 2terminated
NCT05234307
PBF-1129 and Nivolumab for the Treatment of Recurrent or Metastatic Non-Small Cell Lung Cancertreatment1recruiting
NCT03025256
Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal Diseasetreatment1active_not_recruiting
NCT03831932
Telaglenastat Hydrochloride and Osimertinib in Treating Patients With EGFR-Mutated Stage IV Non-small Cell Lung Cancertreatment1 / 2active_not_recruiting
NCT02444741
Pembrolizumab and Stereotactic Body Radiation Therapy or Non-Stereotactic Wide-Field Radiation Therapy in Treating Patients With Non-small Cell Lung Cancertreatment1 / 2active_not_recruiting
NCT04197934
WSD0922-FU for the Treatment of Glioblastoma, Anaplastic Astrocytoma, or Non-small Cell Lung Cancer With Central Nervous System Metastasestreatment1recruiting
NCT04837716
Ensartinib, Carboplatin, Pemetrexed and Bevacizumab for the Treatment of Stage IIIC or IV or Recurrent ALK-Positive Non-small Cell Lung Cancertreatment1active_not_recruiting
NCT05440916
Palliative RadIotherapy of Multiple Metastatic Sites Before First Line of Systemic Therapy With Immune Checkpoint Inhibitors and Chemotherapy in Metastatic Non-Small-Cell Lung CancerNo drug interventionstreatment2recruiting
NCT03892096
Development of a Cell Free DNA Assay as a Biomarker for Predicting Early Non-response to Therapy in Metastatic CancerNo drug interventionsNot AvailableNot Availablecompleted
NCT04925986
Sitravatinib Plus Pembrolizumab in Patients With Advanced Treatment-Naïve PD-L1+ Non-Squamous NSCLCtreatment2terminated
NCT02503722
Testing the Combination of MLN0128 (TAK-228) and AZD9291 in Advanced EGFR (Epidermal Growth Factor Receptor) Mutation Positive Non-small Cell Lung Cancertreatment1active_not_recruiting
NCT02595866
Testing the Addition of an Experimental Medication MK-3475 (Pembrolizumab) to Usual Anti-Retroviral Medications in Patients With HIV and Cancertreatment1completed
NCT06067776
Osimertinib, Cetuximab, and Tucatinib for the Treatment of EGFR-Mutant Stage IV or Recurrent Non-small Lung Cell Cancertreatment1not_yet_recruiting
NCT05334329
Genetically Engineered Natural Killer (NK) Cells With or Without Atezolizumab for the Treatment of Non-small Cell Lung Cancer Previously Treated With PD-1 and/or PD-L1 Immune Checkpoint Inhibitorstreatment1active_not_recruiting
NCT01932489
The Jules Bordet Institute Molecular Profiling Program Feasibility TrialNo drug interventionsotherNot Availablecompleted
NCT05498389
EMB-01 in Combination With Osimertinib in Patients With EGFR Mutant Lung Cancertreatment1 / 2not_yet_recruiting
NCT02706392
Genetically Modified T-Cell Therapy in Treating Patients With Advanced ROR1+ MalignanciesNo drug interventionstreatment1terminated
NCT04151940
PET/CT Changes During Chemoimmunotherapy and Radiation Therapy in Patients With Stage IV Non-small Cell Lung CancerNo drug interventionsotherNot Availablerecruiting
NCT04780568
Osimertinib and Tegavivint as First-Line Therapy for the Treatment of Metastatic EGFR-Mutant Non-small Cell Lung Cancertreatment1recruiting
NCT02409108
Perfusion-Induced Hyperthermia for Metastatic CarcinomaNo drug interventionsdevice_feasibilityNot Availablecompleted
NCT05013450
Dupilumab_Metastatic NSCLCtreatment1 / 2recruiting
NCT06060613
Safety and Efficacy of OBX-115 in Advanced Solid Tumorstreatment1 / 2recruiting
NCT06066138
A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosingtreatment1not_yet_recruiting
NCT06279728
Medical Access Program for Datopotamab Deruxtecan in NSCLC PatientsNot AvailableNot Availableavailable
NCT02922764
A Study of RGX-104 in Patients With Advanced Lung & Endometrial Cancertreatment1active_not_recruiting
NCT04613596
Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7treatment2 / 3recruiting
NCT04743505
Safety and Efficacy of Combining APL-101 With Frontline Osimertinib in Patients With EGFR-mutated Metastatic Non-small Cell Lung Cancer (NSCLC)treatment1 / 2recruiting
NCT05607550
Study to Compare Furmonertinib to Platinum-Based Chemotherapy for Patients with Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) with Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations (FURVENT)treatment3recruiting
NCT05635708
A Study of Tislelizumab in Combination With Investigational Agents in Participants With Non-Small Cell Lung Cancertreatment2recruiting
NCT05676749
C-TIL051 in Non-Small Cell Lung Cancertreatment1recruiting
NCT04725188
Pembrolizumab/Vibostolimab Coformulation (MK-7684A) or Pembrolizumab/Vibostolimab Coformulation Plus Docetaxel Versus Docetaxel for Metastatic Non Small Cell Lung Cancer (NSCLC) With Progressive Disease After Platinum Doublet Chemotherapy and Immunotherapy (MK-7684A-002, KEYVIBE-002)treatment2active_not_recruiting
NCT05274451
A Study to Investigate LYL797 in Adults with Solid TumorsNo drug interventionstreatment1recruiting
NCT05891197
A Biomarker Screening Protocol for Participants With Solid TumorsNo drug interventionsNot AvailableNot Availablerecruiting
NCT05984277
A Global Study of Volrustomig (MEDI5752) Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy for Participants With Metastatic Non-small Cell Lung Cancer.treatment3recruiting
NCT01966003
Efficacy and Safety Study of ABP 215 Compared With Bevacizumab in Patients With Advanced Non-Small Cell Lung Cancertreatment3completed
NCT04614103
Autologous LN-145 in Patients With Metastatic Non-Small-Cell Lung Cancertreatment2recruiting
NCT03035890
Hypofractionated Radiation Therapy to Improve Immunotherapy Response in Non-Small Cell Lung CancerNo drug interventionstreatmentNot Availablecompleted
NCT01471964
Study to Assess Safety and Tolerability of MLN8237, In Combination With Erlotinib to Treat Non-Small Cell Lung Cancertreatment1 / 2terminated
NCT02228421
Study to Evaluate Real-world Pharmacoeconomics of Crizotinib in NSCLC PatientsNo drug interventionsNot AvailableNot Availableterminated
NCT04233021
Study of Osimertinib in Patients With a Lung Cancer With Brain or Leptomeningeal Metastases With EGFR Mutationtreatment2active_not_recruiting
NCT06343402
Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancertreatment1recruiting
NCT06106802
Lazertinib & Tepotinib for EGFR Mutant NSCLC in MET Overexpressed or Amplified Who Progressed After Lazertinib Treatmenttreatment2not_yet_recruiting
NCT01705184
Re-introduction of Pemetrexed and Cisplatin With Prolonged Angiogenic Blocking by Bevacizumab in Advanced Lung Cancer.treatment2completed
NCT02019979
Metformin and Carbohydrate Restriction With Platinum Based Chemotherapy In Stage IIIB/IV Non-Squamous Non-Small Cell Lung Cancer (NS-NSCLC)treatment2terminated
NCT05853887
Liquid Biopsy Based NGS in Newly Diagnosed NSCLCNo drug interventionshealth_services_researchNot Availablerecruiting
NCT06517433
First-in-Human Dose Escalation Study of XMT-1536 in Cancers Likely to Express NaPi2btreatment1completed
NCT04511533
Dacomitinib for Treatment of Patients in India With Metastatic Non Small Cell Lung Cancer With EGFR Activating Mutationstreatment4completed
NCT02967133
A Study of Nivolumab +/- Nab-paclitaxel in Non-small Cell Lung Cancertreatment2terminated
NCT01656551
MILES-4: Study Comparing Gemcitabine and Pemetrexed, With or Without Cisplatin, in Patients With Nonsquamous Lung Cancertreatment3active_not_recruiting
NCT06068153
AMG510 (Sotorasib) Plus Lenvatinib as Second-line Treatment in Patients With KRASG12C Mutant, Metastatic NSCLCtreatment2withdrawn
NCT03727477
Efficacy of Treatment Sequences in Patients With Non-small Cell Lung Cancer Receiving LorlatinibNo drug interventionsNot AvailableNot Availablecompleted
NCT04868877
Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combinationtreatment1 / 2recruiting
NCT05889247
Circulating Tumor DNA Guided Treatment Monitoring in Advanced Lung CancerNo drug interventionstreatmentNot Availablerecruiting
NCT05226598
Study of Pembrolizumab/Vibostolimab Coformulation (MK-7684A) in Combination With Chemotherapy Versus Pembrolizumab Plus Chemotherapy in Participants With Metastatic Non-Small Cell Lung Cancer (MK-7684A-007/KEYVIBE-007)treatment3active_not_recruiting
NCT05111197
Local Ablative Stereotactic Radiotherapy for Residual Hypermetabolic Lesion in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer Long-term Responders to ImmunotherapyNo drug interventionstreatment3recruiting
NCT03004183
SBRT and Oncolytic Virus Therapy Before Pembrolizumab for Metastatic TNBC and NSCLCtreatment2completed
NCT05675683
Real-World Assessment of Clinical Outcomes in Metastatic NSCLC Patients With MET Exon 14 Skipping Mutation and Brain Metastases Treated With CapmatinibNot AvailableNot Availablecompleted
NCT04951583
Fecal Microbial Transplantation Non-Small Cell Lung Cancer and MelanomaNo drug interventionstreatment2active_not_recruiting
NCT03123783
CD40 Agonistic Antibody APX005M (Sotigalimab) in Combination With Nivolumabtreatment1 / 2completed
NCT06473961
A Phase Ⅰb Study on Autologous GC101 TIL Injection for the Treatment of NSCLCtreatment1not_yet_recruiting
NCT04836728
Study of Chemotherapy and PD-1 Inhibitor Combination With Autologous CIK Cell Immunotherapy to Treat Lung Cancertreatment2unknown_status
NCT03304093
Immunotherapy by Nivolumab for HIV+ Patientstreatment2completed
NCT05689671
Pemetrexed-free vs. Pemetrexed-based Immunochemotherapy in Metastatic TTF-1 Negative Lung Adenocarcinomatreatment4recruiting
NCT03810807
Study of Dacomitinib and Osimertinib for Patients With Advanced EGFR Mutant Lung Cancertreatment1active_not_recruiting
NCT01773109
Etirinotecan Pegol (NKTR-102) in NSCLCtreatment2completed
NCT04154956
SAR408701 Versus Docetaxel in Previously Treated, Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 (CEACAM5) Positive Metastatic Non-squamous Non-small-cell Lung Cancer Patientstreatment3active_not_recruiting
NCT03436056
PembRolIzuMab and Stereotactic Body Radiotherapy In Metastatic Non-small-cell lunG Cancer Patientstreatment1terminated
NCT02793856
PD-1 Knockout Engineered T Cells for Metastatic Non-small Cell Lung Cancertreatment1completed
NCT03715985
Personalized Neo-antigen Vaccine in Advanced Solid Tumors (NeoPepVac)No drug interventionstreatment1 / 2unknown_status
NCT03363685
Verification of Novel Survival Prediction Algorithm for Patients With NSCLC Spinal MetastasisNo drug interventionsNot AvailableNot Availableunknown_status
NCT03307785
Study of Niraparib, TSR-022, Bevacizumab, and Platinum-Based Doublet Chemotherapy in Combination With TSR-042treatment1active_not_recruiting
NCT03300115
Clinical Trial of the Efficacy and Safety of AC0010 in the Treatment of EGFR T790M Patients With Advanded NSCLCtreatment2unknown_status
NCT04793815
Lung Cancer Cryo-Activation as a Novel Approach to Augment Immunotherapy Efficacy (CRYOVATE)treatmentNot Availablecompleted
NCT05722015
A Study of Subcutaneous (SC) Pembrolizumab Coformulated With Hyaluronidase (MK-3475A) vs Intravenous Pembrolizumab in Adult Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) (MK-3475A-D77)treatment3active_not_recruiting
NCT04471415
Study to Investigate DRP-104 in Adults With Advanced Solid Tumorstreatment1 / 2terminated
NCT03774732
PD-1 Inhibitor and Chemotherapy With Concurrent Irradiation at Varied Tumour Sites in Advanced Non-small Cell Lung Cancertreatment3recruiting
NCT05278052
Standard Maintenance Therapy (SMT) vs Local Consolidative Radiation Therapy and SMT in OM-NSCLCNo drug interventionstreatment3recruiting
NCT03907852
Phase 1/2 Trial of Gavo-cel (TC-210) in Patients With Advanced Mesothelin-Expressing Cancertreatment1 / 2active_not_recruiting
NCT01574300
Collaborative Advanced Stage Tissue Lung Cancer (CASTLE) NetworkNo drug interventionsNot AvailableNot Availableterminated
NCT03976375
Efficacy and Safety of Pembrolizumab (MK-3475) With Lenvatinib (E7080/MK-7902) vs. Docetaxel in Participants With Metastatic Non-Small Cell Lung Cancer (NSCLC) and Progressive Disease (PD) After Platinum Doublet Chemotherapy and Immunotherapy (MK-7902-008/E7080-G000-316/LEAP-008)treatment3active_not_recruiting
NCT04623775
A Study of Relatlimab Plus Nivolumab in Combination With Chemotherapy vs. Nivolumab in Combination With Chemotherapy as First Line Treatment for Participants With Stage IV or Recurrent Non-small Cell Lung Cancer (NSCLC)treatment2active_not_recruiting
NCT03845270
Her2-positive Lung Cancer Treated With Dedicated Drugtreatment2completed
NCT06083870
An Early Stage Study to Evaluate Oba01 for Injection in Patients With DR5 Positive LA/mNSCLCNo drug interventionstreatment1recruiting
NCT02376699
Safety Study of SEA-CD40 in Cancer Patientstreatment1terminated
NCT03240549
Effectiveness and Safety of Adding Bevacizumab to First Line Chemotherapy in Lung Cancer Patients With Stable Diseasetreatment2unknown_status
NCT03916913
TKI Followed by Thoracic Radiotherapy for Stage IV EGFR Mutant NSCLCNo drug interventionstreatmentNot Availableunknown_status
NCT05110118
Pharmacokinetic Characteristics, Safety, Tolerability and Immunogenicity of LY01008 and Avastin in Healthy Chinese Male Subjectstreatment1completed
NCT05259319
Study Evaluating the Safety and the Efficacy of Combination of Atezolizumab, Tiragolumab and and Stereotactic Body Radiation Therapy in Patients With Oligometastatic Multiorgan (IMMUNOs-SBRT)treatment1recruiting
NCT02959619
Ensartinib in Non-small Cell Lung Cancer Patients With Positive ALKtreatment1completed
NCT04646824
Almonertinib With Chemotherapy in mEGFR NSCLCtreatment2unknown_status
NCT02946216
ALK/ROS1/MET Mutations on Plasma ctDNA in Patients With NSCLCNo drug interventionsNot AvailableNot Availableunknown_status
NCT06100796
Effect of DM on Outcomes and Response Rate in Patients With Advanced NSCLC on ICINot AvailableNot Availablerecruiting
NCT00701558
A Study of First Line Treatment With Tarceva (Erlotinib) in Combination With Gemcitabine in Patients With Unresectable Advanced and/or Metastatic Non-Small Cell Lung Cancertreatment2completed
NCT01395758
Erlotinib Plus Tivantinib (ARQ 197) Versus Single Agent Chemotherapy in Locally Advanced or Metastatic Non-Small Cell Lung Cancertreatment2completed
NCT01473563
A Study of Home Administration of Pemetrexed as Maintenance Treatment for Advanced Nonsquamous Non-Small Cell Lung Cancer (NSCLC)Not Available2completed
NCT04009122
Evaluation of the Quality of Life of Patients With Metastatic Non-small Cell Lung Cancer With Supplementary Therapy With IGEN-0206No drug interventionstreatmentNot Availablecompleted
NCT05638425
Radiotherapy Combined With PD-1 Inhibitors and Chemotherapy in the Treatment of NSCLC Patients With Symptomatic Brain MetastasesNo drug interventionsNot AvailableNot Availablerecruiting
NCT05985330
Pilot Study of the Contribution of Fractional Exhaled Nitric Oxide as a Prognostic Marker of Response to Anti-PD-L1 Immunotherapy in Non-small Cell Lung CancerNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT02542930
Abscopal Effect for Metastatic Non-small Cell Lung Cancer.treatment2withdrawn
NCT02411448
A Study of Ramucirumab (LY3009806) in Combination With Erlotinib in Previously Untreated Participants With EGFR Mutation-Positive Metastatic NSCLC (RELAY)treatment3active_not_recruiting
NCT02623257
EGFR Mutations on ctDNA in Patients With Advanced NSCLCNo drug interventionsNot AvailableNot Availablecompleted
NCT05999357
JDQ443 for KRAS G12C NSCLC Brain MetastasesNo drug interventionstreatment2withdrawn
NCT03477474
Registry of Guardant360® Use and Outcomes In People With Advanced CancerNo drug interventionsNot AvailableNot Availableterminated
NCT05429320
A Study of Local Ablative Therapy (LAT) in People With Non-Small Cell Lung Cancer (NSCLC)No drug interventionstreatment2recruiting
NCT04082182
MIDRIX4-LUNG Dendritic Cell Vaccine in Patients With Metastatic Non-small Cell Lung Cancertreatment1unknown_status
NCT03732482
Temozolomide Combine With Intensity Modulated Radiation Therapy With Simultaneous Integrated Boost for Non Small Cell Lung Cancer Brain Metastasestreatment2 / 3unknown_status
NCT00872482
A Study of Nimotuzumab in Combination With Radiation Therapy in Patients With Brain Metastasestreatment2terminated
NCT06523673
Stereotactic Body Radiotherapy for Oligo-Progression Metastatic Non-Small Cell Lung Cancertreatment3recruiting
NCT05364073
Study of Furmonertinib in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Activating, Including Uncommon, Epidermal Growth Factor Receptor (EGFR) or Human Epidermal Growth Factor Receptor 2 (HER2) Mutationstreatment1active_not_recruiting
NCT03533127
A Study of LY01008 and Bevacizumab Combined With Paclitaxel and Carboplatin for Treatment of Naïve Subjects With Metastatic or Recurrent Nonsquamous Non-small Cell Lung Cancertreatment3unknown_status
NCT03926260
Early Assessment of Response to Treatment of Metastatic LUng Tumors Based on CIrculating Tumor DNANo drug interventionsotherNot Availablecompleted
NCT03469960
Double Immune Checkpoint Inhibitors in PD-L1-positive Stage IV Non-small Lung CancErtreatment3active_not_recruiting
NCT03656094
Chemotherapy With Pembrolizumab Continuation After Progression to PD-1/L1 Inhibitorstreatment2unknown_status
NCT05864794
Value of Screening MRI Brain in Stage IV Non-small Cell Lung CancerNo drug interventionsscreeningNot Availablerecruiting
NCT03424980
A Study to Evaluate Effectiveness and Safety of Tyrosine Kinase InhibitorsNot AvailableNot Availableunknown_status
NCT03265080
A Study of ADXS-NEO Expressing Personalized Tumor Antigenstreatment1terminated
NCT06585189
CARE Initiative: Real-world Emulation of the KEYNOTE-189 Trial [DS4]Not AvailableNot Availablecompleted
NCT05599789
Pembrolizumab in Combination With Plinabulin and Docetaxel For Metastatic NSCLC After ICIs (KeyPemls-004)treatment2recruiting
NCT06378892
A Study to Evaluate the Combination of Platinum-pemetrexed Based Chemotherapy Plus Lorlatinib in ALK Positive Non-Small Cell Lung Cancer (NSCLC) With Exclusively Extracranial Disease Progression on Lorlatinibtreatment2recruiting
NCT05215340
Study of Dato-DXd Plus Pembrolizumab vs Pembrolizumab Alone in the First-line Treatment of Subjects With Advanced or Metastatic NSCLC Without Actionable Genomic Alterationstreatment3recruiting
NCT06127940
K-SAB Trial - Sotorasib Followed by SBRT to 1-3 Lesions in Advanced NSCLC With KRASG12C Mutationtreatment1recruiting
NCT05472467
Camrelizumab Combination With SBRT and Concurrent Chemotherapy Treated Stage IV Oligometastatic Non-small Cell Lung Cancertreatment2unknown_status
NCT02330367
Safety, Pharmacokinetic and Preliminary Efficacy Study of AC0010 in Patients With EGFR T790M Positive NSCLCtreatment1 / 2unknown_status
NCT02812667
Nivolumab in Combination With Plinabulin in Patients With Metastatic Non-Small Cell Lung Cancer (NSCLC)treatment1active_not_recruiting
NCT03679767
A Study of INCMGA00012 in Participants With Selected Solid Tumors (POD1UM-203)treatment2completed
NCT06045767
T-Cell Repertoire Sequencing: Assessing Pembrolizumab Efficacy in Advanced Non-small Lung Cancerdiagnostic2not_yet_recruiting
NCT04187768
Immunological Profile Changes In Patients With Advanced Non-Small Cell Lung CancerNo drug interventionsNot AvailableNot Availablecompleted
NCT02041468
Study to Evaluate Resistance Mechanisms and Real-world Pharmacoeconomics of Crizotinib in NSCLC PatientsNo drug interventionsNot AvailableNot Availableunknown_status
NCT04697446
External Control, Observational, Retrospective Study Comparing Pralsetinib to Best Available Therapy in Patients With RET-Fusion Positive NSCLCNo drug interventionsNot AvailableNot Availableunknown_status
NCT04599712
Pre-Approval Access With Amivantamab (JNJ-61186372) in Participants With Metastatic Non-Small Cell Lung CancerNot AvailableNot Availableapproved_for_marketing
NCT03215810
Nivolumab and Tumor Infiltrating Lymphocytes (TIL) in Advanced Non-Small Cell Lung Cancertreatment1completed
NCT01380795
Feasibility of the Research for Mutation of K-ras and EGFR in CTCs From Metastatic Non Small Cells Bronchial CarcinomasNo drug interventionsscreening0terminated
NCT04994795
Predictive Multimodal Signatures Associated With Response to Treatment and Prognosis of Patients With Stage IV Non-small Cell Lung CancerNo drug interventionsNot AvailableNot Availablerecruiting
NCT06417814
A Study to Investigate the Efficacy and Safety of Dato-DXd With or Without Osimertinib Compared With Platinum Based Doublet Chemotherapy in Participants With EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancertreatment3not_yet_recruiting
NCT05407155
Bevacizumab Plus Nab-paclitaxel and Platinum for Immunotherapy-treated Non-squamous Non-small Cell Lung CancertreatmentNot Availableunknown_status
NCT05265650
Study of BO-112 With Radiotherapy and Nivolumab for Metastatic Refractory NSCLCtreatment1 / 2unknown_status
NCT05668650
Double-blind Study to Evaluate the PK, Efficacy, Safety and Immunogenicity of MB12 Versus Keytruda® in Stage IV NSCLCtreatment3recruiting
NCT04563338
An Exploratory Study of Atezolizumab and Bevacizumab in Hepatocellular Carcinoma and Non-Small Cell Lung Cancer With Liver Metastases (INTEGRATE)treatment2recruiting
NCT01356303
Docetaxel Combined With Cisplatin as First Line in Patients With Metastatic Non-small Cell Lung Cancertreatment2suspended
NCT04965090
A Study of Amivantamab and Lazertinib in People With Non-Small Cell Lung Cancer (NSCLC)treatment2active_not_recruiting
NCT02314364
A Trial of Integrating SBRT With Targeted Therapy in Stage IV Oncogene-driven NSCLCNo drug interventionstreatment2completed
NCT03168464
Radiation and Immune Checkpoints Blockade in Metastatic NSCLC (BMS # CA209-632)treatment1 / 2terminated
NCT05919264
FOG-001 in Locally Advanced or Metastatic Solid TumorsNo drug interventionstreatment1 / 2recruiting
NCT04749602
Intrapleural Instillation of the Nivolumab in Cancer Patients With Pleural Effusion.treatment2completed
NCT04166487
Plasma-Adapted First-Line Pembro In NSCLCtreatment2active_not_recruiting
NCT01935154
Efficacy Study of Vx001 Vaccine in NSCLC Patientstreatment2completed
NCT06517953
Befotertinib and Icotinib for NSCLC With Uncommon EGFR Mutationstreatment2recruiting
NCT04923945
Savolitinib for Treating Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) Patientstreatment3recruiting
NCT05546905
A Study in Patients With BRAF V600E-mutant Metastatic Non-small Cell Lung Cancer (OCTOPUS)No drug interventionsNot AvailableNot Availablerecruiting
NCT04111705
Lorlatinib After Failure of First-line Second-generation ALK Kinase Inhibitor in Patients With Advanced ALK-positive Non-small Cell Lung Cancertreatment2active_not_recruiting
NCT01717105
Observational Study to Characterize the Incidence of EGFR Mutation Positive and Advanced NSCLC PatientsNo drug interventionsNot AvailableNot Availableunknown_status
NCT02035683
PET/CT Scan as a Tool to Rationalize the Treatment of of Advanced NSCLC Patients Undergoing First ChemotherapyNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT01936961
Study of Immunochemotherapy +/- Hypofractionated Radiation for Complete Response in Solid TumorsNo drug interventionstreatmentNot Availablewithdrawn
NCT03319628
First-in-Human Study of XMT-1536 in Cancers Likely to Express NaPi2btreatment1 / 2active_not_recruiting
NCT03334071
Exercise Intervention During Chemotherapy in Advanced Lung Cancer PatientsNo drug interventionstreatmentNot Availableunknown_status
NCT03224871
UCDCC#269: A Pilot Study of Interlesional IL-2 and RT in Patients With NSCLC.treatment0completed
NCT04504071
Dacomitinib in Lung Cancer With Uncommon EGFR Mutationstreatment2unknown_status
NCT04621188
Lorlatinib After Failure of First-line TKI in Patients With Advanced ROS1-positive NSCLC (ALBATROS)treatment2recruiting
NCT03976856
Safety and Efficacy of Genolimzumab (GB226) in Combination With Fruquintinibtreatment1unknown_status
NCT01798485
A Phase 3 Study of Ganetespib in Combination With Docetaxel Versus Docetaxel Alone in Patients With Advanced NSCLCtreatment3terminated
NCT02843815
Combination of Cryosurgery and NK Immunotherapy for Advanced Non-Small Cell Lung CancerNo drug interventionstreatment1 / 2completed
NCT02443337
A Study of LY3023414 and Necitumumab in Squamous Lung Cancertreatment2terminated
NCT02162537
Therapeutic Strategies in Patients With Non-squamous Non-small Cell Lung Cancer With Brain Metastasesother3terminated
NCT04163432
Staggered, Chemo-Immunotherapy With Durvalumab, MEDI4736 Pemetrexed & Carboplatin (PC) for Metastatic Non-Squamous NSCLCtreatment2recruiting
NCT05555732
Datopotamab Deruxtecan (Dato-DXd) and Pembrolizumab With or Without Platinum Chemotherapy in 1L Non-Small Cell Lung Cancer (TROPION-Lung07)treatment3recruiting
NCT06212752
A Study of Subcutaneous (SC) Pembrolizumab Coformulated With Hyaluronidase (MK-3475A) vs Intravenous Pembrolizumab in Adult Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) (MK-3475A-D77)-Japan Extensiontreatment3active_not_recruiting
NCT03445000
ALEctinib for the Treatment of Pretreated RET-rearranged Advanced Non-small Cell Lung Cancertreatment2terminated
NCT05167500
Efficacy & Safety Study of Lorlatinib in ALK/ROS1 Metastatic NSCLC Patients With Compassionate Use TreatmentNot AvailableNot Availablecompleted
NCT03007875
High-activity Natural Killer Immunotherapy for Small Metastases of Non-small Cell Lung CancerNo drug interventionstreatment1 / 2completed
NCT03353675
A Study Evaluating the Efficacy and the Safety of First-line Chemotherapy Combined With the Therapeutic Vaccine Named TG4010 and Nivolumab in Patients With Advanced Non-squamous Non-Small Cell Lung Cancer (NSCLC)treatment2completed
NCT02857270
A Study of LY3214996 Administered Alone or in Combination With Other Agents in Participants With Advanced/Metastatic Cancertreatment1completed
NCT05117242
Safety and Efficacy Study of GEN1046 as a Single Agent or in Combination With Pembrolizumab for Treatment of Recurrent (Non-small Cell) Lung Cancertreatment2active_not_recruiting
NCT04069936
Marrow Infiltrating Lymphocytes - Non-Small Cell Lung Cancer (MILs™ - NSCLC) Alone or in Combination With Nivolumab With or Without Tadalafil in Locally Advanced and Unresectable or Metastatic NSCLCtreatment2terminated
NCT01658813
5-Fluorouracil Followed by Interferon-alfa-2b in Previously-treated Metastatic Gastrointestinal, Kidney, or Lung Cancertreatment2completed
NCT01848613
Study of Patient Preference for Oral or Intravenous Vinorelbine in the Treatment of Advanced NSCLCtreatment4completed
NCT03956641
Evolution of the Physical Condition in Treated Cancer PatientsNo drug interventionssupportive_careNot Availableunknown_status
NCT02639234
Vigil™ + Nivolumab in Advanced Non-Small Cell Lung Cancertreatment2withdrawn
NCT02418234
T790M Mutation on ctDNA in Patients With NSCLC After EGFR-TKI FailureNo drug interventionsNot AvailableNot Availablecompleted
NCT04394624
Tusamitamab Ravtansine (SAR408701) in Combination With Ramucirumab or Ramucirumab and Pembrolizumab in Pretreated Patients With NSQ NSCLC (CARMEN-LC04)treatment2active_not_recruiting
NCT04410796
Osimertinib Alone or With Chemotherapy for EGFR-Mutant Lung Cancerstreatment2recruiting
NCT04685135
Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutationtreatment3active_not_recruiting
NCT00806286
Study of Carboplatin/Paclitaxel With or Without Investigational Drug (CS-7017) in Subjects With Metastatic Non-small Cell Lung Cancertreatment2completed
NCT01405586
MILES-3: Cisplatin in Combination With Gemcitabine for Elderly Patients With Lung Cancertreatment3active_not_recruiting
NCT06428422
The Impact of Probiotic on Survival and Treatment Response in Metastatic Non-small Cell Lung Cancer PatientsNo drug interventionstreatmentNot Availablerecruiting
NCT04863248
Trilaciclib, a CDK 4/6 Inhibitor, in Patients Receiving Docetaxel for Metastatic Non-Small Cell Lung Cancer (NSCLC) (PRESERVE 4)treatment2terminated
NCT01348126
Study of Ganetespib (STA-9090) + Docetaxel in Advanced Non Small Cell Lung Cancertreatment2 / 3terminated
NCT04331626
Low-dose Gemcitabine Combined With Nivolumab for Second-line and Above Line Treatment of NSCLCtreatment4unknown_status
NCT02818426
Universal Cancer Peptide-based Vaccination in Metastatic NSCLCtreatment1 / 2active_not_recruiting
NCT03235765
Cancer Panel From Blood of Lung Cancer PatientsNo drug interventionsNot AvailableNot Availableunknown_status
NCT02299765
Intercalating and Maintenance Gefitinib in Combination With Chemotherapy for Advanced EGFR-mutant NSCLCtreatment4terminated
NCT03732274
Phase 1b/2a, Open-label Study of Vactosertib in Combination With Durvalumab in Advanced NSCLCtreatment1 / 2unknown_status
NCT02705820
Switch Maintenance Pembrolizumab in Patients With NSCLC After First Line Platinum Doublet Chemotherapytreatment2active_not_recruiting
NCT04884282
Efficacy of Tedopi Plus Docetaxel or Tedopi Plus Nivolumab as Second-line Therapy in Metastatic Non-small-cell Lung Cancer Progressing After First-line Chemo-immunotherapy (Combi-TED)treatment2recruiting
NCT04340882
Phase 2 DoceRamPem for Patients With Metastatic or Recurrent NSCLC Who Progressed on Platinum-Doublet and PD-1/PD-L1 Blockadetreatment2recruiting
NCT05657873
A Study of Targeted Radiation Therapy in People With Non-Small Cell Lung Cancer (NSCLC)treatment2recruiting
NCT01999673
Phase 3 Study of Bavituximab Plus Docetaxel Versus Docetaxel Alone in Patients With Late-stage Non-squamous Non-small-cell Lung Cancertreatment3completed
NCT03977194
Atezolizumab in Elderly Patients With Advanced Non-Small-Cell Lung Cancer and Receiving Carboplatin Paclitaxel Chemotherapytreatment3active_not_recruiting
NCT01703091
A Study of Docetaxel and Ramucirumab Versus Docetaxel and Placebo in the Treatment of Stage IV Non-Small Cell Lung Cancertreatment2completed
NCT03808662
Randomized Study of Stereotactic Body Radiation Therapy (SBRT) in Patients With Oligoprogressive Metastatic Cancers of the Breast and LungNo drug interventionstreatment2active_not_recruiting
NCT03386929
Survival Prolongation by Rationale Innovative Genomicstreatment1 / 2terminated
NCT06207292
Stereotactic Ablative Radiotherapy in Synchronous and Metachronous Oligo-Metastatic Non Small Cell Lung CancerNo drug interventionstreatmentNot Availablerecruiting
NCT04470440
Thyroid Dysfunction and Nivolumab Reponse in NSCLCNo drug interventionsNot AvailableNot Availablecompleted
NCT01523340
A Prospective Observational Study Evaluating c-MET Expression and EGFR Gene Mutation Correlation With Erlotinib ResponseNo drug interventionsNot AvailableNot Availablecompleted
NCT02117167
SAFIR02_Lung - Efficacy of Targeted Drugs Guided by Genomic Profiles in Metastatic NSCLC Patientstreatment2completed
NCT03497767
A Randomised Phase II Trial of Osimertinib With or Without SRS for EGFR Mutated NSCLC With Brain Metastasestreatment2completed
NCT01320501
Experience of Erlotinib in Patients With Advanced Non-Small Cell Lung Cancertreatment4suspended
NCT06216301
LUNAR-2: TTFields With Pembrolizumab + Platinum-based Chemotherapy for Metastatic NSCLCtreatment3recruiting
NCT04619004
HERTHENA-Lung01: Patritumab Deruxtecan in Subjects With Metastatic or Locally Advanced EGFR-mutated Non-Small Cell Lung CancerNo drug interventionstreatment2active_not_recruiting
NCT02978404
Combining Radiosurgery and Nivolumab in the Treatment of Brain Metastasestreatment2completed
NCT03164772
Phase 1/2 Study of Combination Immunotherapy and Messenger Ribonucleic Acid (mRNA) Vaccine in Subjects With NSCLCtreatment1 / 2completed
NCT03133546
Osimertinib and Bevacizumab Versus Osimertinib Alone as Second-line Treatment in Stage IIIb-IVb NSCLC With Confirmed EGFRm and T790M (BOOSTER)treatment2unknown_status
NCT03846310
A Study to Evaluate Immunotherapy Combinations in Participants With Lung Cancertreatment1active_not_recruiting
NCT02622581
Clinical Research Platform Into Molecular Testing, Treatment and Outcome of (Non-)Small Cell Lung Carcinoma PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT05223595
A Study of Gentuximab in Combination With Almonertinib in EGFR Mutation-positive Metastatic NSCLCtreatment1unknown_status
NCT01060514
Pazopanib + Vinorelbine in Non Small Cell Lung Cancer (NSCLC) and Breast Cancertreatment1terminated
NCT03377023
Phase I/II Study of Nivolumab and Ipilimumab Combined With Nintedanib in Non Small Cell Lung Cancertreatment1 / 2active_not_recruiting
NCT01752023
A Randomized Phase II Study of SUBATM-itraconazole in Patients With Untreated Squamous NSCLC.treatment2terminated
NCT05800223
Armatinib Alone or in Combination With SRT for Brain Metastases EGFR-mutated Non-small Cell Lung Cancertreatment3recruiting
NCT05566223
CISH Inactivated TILs in the Treatment of NSCLCtreatment1 / 2not_yet_recruiting
NCT05236608
A Study to Evaluate the Combination of Nivolumab With ADG106 in Metastatic NSCLCtreatment1 / 2unknown_status
NCT03611738
Ceritinib Plus Docetaxel in ALK-Negative, EGFR WT Advanced NSCLCtreatment1active_not_recruiting
NCT04466917
A Study of ABP 215 Versus Bevacizumab in Chinese Subjects With Advanced Non-Squamous Non-Small Cell Lung Cancertreatment3withdrawn
NCT03158883
UCDCC#270: Avelumab and Stereotactic Ablative Radiotherapy in Non-responding and Progressing NSCLC Patientstreatment0completed
NCT03819465
A Study of Novel Anti-cancer Agents in Patients With Previously Untreated NSCLCtreatment1active_not_recruiting