Vitamin B6 Deficiency (DBCOND0043444)

Identifiers

Synonyms

Vitamin B 6 Deficiency / Vitamin B6 deficiency / Pyridoxine deficiency / Vitamin B6 deficiency (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Cocarboxylase	The coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex.	Acetolactate synthase, catabolictarget Pyruvate dehydrogenase E1 componenttarget Pyruvate synthasetarget Indole-3-pyruvate decarboxylasetarget N(2)-(2-carboxyethyl)arginine synthasetarget Transketolase 1target RNAtarget Benzoylformate decarboxylaseenzyme Pyruvate oxidaseenzyme
Cyanocobalamin	A vitamin available in many formulations to correct vitamin B12 deficiency.	Methionine synthase reductasetarget Methylmalonic aciduria type A protein, mitochondrialtarget Methylmalonyl-CoA mutase, mitochondrialtarget Cyanocobalamin reductase / alkylcobalamin dealkylasetarget Methionine synthasetarget Methylenetetrahydrofolate reductase (NADPH)target Protein amnionlesstransporter Transcobalamin-1transporter Transcobalamin-2transporter Corrinoid adenosyltransferase MMABenzyme Cobalamin binding intrinsic factortransporter Cubilintransporter Bifunctional adenosylcobalamin biosynthesis protein CobUenzyme Low-density lipoprotein receptor-related protein 2transporter Multidrug resistance-associated protein 1transporter Pancreatic proteasesenzyme
Fursultiamine	Compound used for therapy of thiamine deficiency. It has also been suggested for several non-deficiency disorders but has not yet proven useful. Fursultiamine is a vitamin B1 derivative.	No drug targets
Pyridoxal phosphate	A vitamin available in many formulations to correct vitamin B6 deficiency.	Cystathionine beta-synthasetarget Alanine--glyoxylate aminotransferase 2, mitochondrialtarget Glutamate decarboxylase 1target Kynureninasetarget Serine hydroxymethyltransferase, cytosolictarget Cysteine desulfurasetarget Aspartate aminotransferase, cytoplasmictarget Ornithine aminotransferase, mitochondrialtarget Ornithine decarboxylasetarget Kynurenine/alpha-aminoadipate aminotransferase, mitochondrialtarget 4-aminobutyrate aminotransferase, mitochondrialtarget Pyridoxine-5'-phosphate oxidasetarget Sphingosine-1-phosphate lyase 1target Tyrosine aminotransferasetarget Kynurenine--oxoglutarate transaminase 1target Glycogen phosphorylase, liver formtarget Serine palmitoyltransferase 2target Cysteine sulfinic acid decarboxylasetarget Histidine decarboxylasetarget Antizyme inhibitor 2target L-serine dehydratase/L-threonine deaminasetarget 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrialtarget Glycine dehydrogenase (decarboxylating), mitochondrialtarget Alanine aminotransferase 1target Phosphoserine aminotransferasetarget 5-aminolevulinate synthase, non-specific, mitochondrialtarget Alanine--glyoxylate aminotransferasetarget Chronophintarget Serine palmitoyltransferase 1target Cystathionine gamma-lyasetarget Branched-chain-amino-acid aminotransferase, cytosolictarget Branched-chain-amino-acid aminotransferase, mitochondrialtarget Pyridoxal phosphate homeostasis proteintarget Aspartate aminotransferase, mitochondrialtarget Glycogen phosphorylase, brain formtarget Glycogen phosphorylase, muscle formtarget Aromatic-L-amino-acid decarboxylasetarget Serine hydroxymethyltransferasetarget Glutamate decarboxylase 2target Kynurenine--oxoglutarate transaminase 3target Acidic amino acid decarboxylase GADL1target Selenocysteine lyasetarget Immunoglobulin superfamily member 10target 5-phosphohydroxy-L-lysine phospho-lyasetarget Serine hydroxymethyltransferase, mitochondrialtarget 5-aminolevulinate synthase, erythroid-specific, mitochondrialtarget Alanine aminotransferase 2target Molybdenum cofactor sulfurasetarget Serine dehydratase-liketarget Serine racemasetarget O-phosphoseryl-tRNA(Sec) selenium transferasetarget Serine palmitoyltransferase 3target Glutamic acid decarboxylasetarget Aspartate aminotransferasetarget Prothrombintarget
Pyridoxine	A vitamin used to correct vitamin B6 deficiency and to treat nausea during pregnancy.	Pyridoxal kinasetarget Cytochrome P450 1A1enzyme Albumincarrier Pyridoxal kinaseenzyme Chronophinenzyme Alkaline phosphatase, tissue-nonspecific isozymetransporter Alkaline phosphatase, tissue-nonspecific isozymeenzyme Aromatic-L-amino-acid decarboxylasetarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01128244	Vitamin B6 Effects for Women Taking Birth Control Pills	No drug interventions	treatment	2 / 3	completed
NCT00877812	Vitamin B6 Dependence of One-Carbon Metabolism	No drug interventions	diagnostic	Not Available	completed
NCT03447275	The Vitamin B Status in Type 2 Diabetes (VITA) Study	No drug interventions	Not Available	Not Available	completed