Acute Migraine (DBCOND0043723)

Identifiers

Synonyms

Migraine - Acute / Acute Migraine Headache / Migraine, Acute / Acute migraine / Acute migraine (disorder) / Migraine, unspecified / Migraine, unspecified, not intractable, without status migrainosus / Migraine NOS / Migraine headaches / Migraine headache / Migrainous headache / Migraine type headaches / Migraine Disorders / Migraine (disorder) / Migraine

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Aminophenazone	An analgesic drug used to treat acute migraine attacks in combination with ergotamine and caffeine.	Cytochrome P450 2C19enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C8enzyme Solute carrier family 22 member 6transporter Cytochrome P450 2C9enzyme Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2C18enzyme Steroid 17-alpha-hydroxylase/17,20 lyaseenzyme
Diclofenac	An NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Transthyretincarrier Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C8enzyme Albumincarrier ATP-binding cassette sub-family C member 4transporter Multidrug resistance-associated protein 1transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Solute carrier organic anion transporter family member 1C1transporter Solute carrier family 22 member 11transporter UDP-glucuronosyltransferase 2B7enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C18enzyme Cytochrome P450 2E1enzyme Solute carrier organic anion transporter family member 1B1transporter Bile salt export pumptransporter UDP-glucuronosyltransferase 1A3enzyme UDP-glucuronosyltransferase 1A9enzyme UDP-glucuronosyltransferase 2B4enzyme Polyunsaturated fatty acid 5-lipoxygenaseenzyme Sodium channel protein type 4 subunit alphatransporter Acid-sensing ion channel 1transporter Potassium voltage-gated channel subfamily KQT member 2transporter Potassium voltage-gated channel subfamily KQT member 3transporter Phospholipase A2, membrane associatedenzyme ATP-dependent translocase ABCB1transporter
Ketorolac	An NSAID used to treat moderate to severe pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders, and headaches.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target UDP-glucuronosyltransferase 2B7enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme
Naproxen	An NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Albumincarrier Cytochrome P450 2C9enzyme Cytochrome P450 1A2enzyme Solute carrier organic anion transporter family member 1A2transporter Solute carrier family 22 member 6transporter Cytochrome P450 2C8enzyme UDP-glucuronosyltransferase 2B7enzyme Peptostreptococcal albumin-binding proteintarget Bile salt export pumptransporter ATP-dependent translocase ABCB1transporter UDP-glucuronosyltransferase 1A3enzyme UDP-glucuronosyltransferase 1-6enzyme UDP-glucuronosyltransferase 1A7enzyme UDP-glucuronosyltransferase 1A8enzyme UDP-glucuronosyltransferase 1A9enzyme UDP-glucuronosyltransferase 1A10enzyme Organic anion transporter 3transporter Pancreatic triacylglycerol lipasetarget
Prochlorperazine	A phenothiazine derivative used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting.	D(2) dopamine receptortarget Cytochrome P450 2D6enzyme Histamine H1 receptortarget Alpha-1 adrenergic receptorstarget Alpha-2 adrenergic receptorstarget
Sumatriptan	A serotonin receptor agonist used to treat migraines and cluster headaches.	5-hydroxytryptamine receptor 1Dtarget 5-hydroxytryptamine receptor 1Btarget 5-hydroxytryptamine receptor 1Ftarget Amine oxidase [flavin-containing] Aenzyme 5-hydroxytryptamine receptor 1Atarget Solute carrier organic anion transporter family member 1A2transporter ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter
Zavegepant	A calcitonin gene-related peptide receptor antagonist indicated for the acute treatment of migraine with or without aura.	Calcitonin gene-related peptide type 1 receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 2D6enzyme Solute carrier organic anion transporter family member 1B3transporter Hepatic sodium/bile acid cotransportertransporter ATP-dependent translocase ABCB1transporter Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05983354	Oral Medications for the Management of Acute Migraine Headache in the Emergency Department	Ibuprofen Ketorolac Metoclopramide	treatment	Not Available	not_yet_recruiting
NCT03145467	Comparison of Oral Paracetamol and Zolmitriptan Efficacy in the Treatment of Acute Migraine in Emergency Department	Acetaminophen Zolmitriptan	treatment	4	completed
NCT00573599	Prochlorperazine vs Imitrex for Acute Migraine in the Emergency Department	Prochlorperazine Sumatriptan	treatment	Not Available	completed
NCT01001234	A Study to Evaluate the Efficacy and Tolerability of Rizatriptan for Treatment of Acute Migraine in Children and Adolescents (MK-0462-082 AM7)	Rizatriptan	treatment	3	completed
NCT00269022	Use Of SB-705498 In The Acute Treatment Of Migraine	SB-705498	treatment	2	completed
NCT00573170	TREXIMET® Versus Butalbital-containing Combination Medications for the Acute Treatment of Migraine in Adults	Butalbital Naproxen Sumatriptan	treatment	3	completed
NCT02185703	Chordate System S020 Acute Migraine Clinical Investigation	No drug interventions	treatment	Not Available	terminated
NCT01267864	Valproate Versus Ketorolac Versus Metoclopramide	Ketorolac Metoclopramide Valproic acid	treatment	4	completed
NCT01112553	Treximet Migraine Brain Imaging Research Study	No drug interventions	Not Available	Not Available	terminated
NCT01973205	Efficacy and Safety of Acetaminophen and Aspirin Versus Placebo in the Acute Treatment of Migraine	Acetaminophen Acetylsalicylic acid	treatment	3	completed
NCT02684409	Safety, Pharmacokinetic, and Tolerability Study of Zecuity® in Adolescent Subjects With a History of Acute Migraine	Sumatriptan	treatment	1	completed
NCT03076515	Migraine Treatment With Nerivio Migra Neurostimulation Device	No drug interventions	treatment	Not Available	terminated
NCT05371652	A Study to Learn About the Long-term Safety of Rimegepant for the Acute Treatment of Migraine in Chinese Participants	Rimegepant	treatment	3	completed
NCT02439320	Lasmiditan Compared to Placebo in the Acute Treatment of Migraine:	Lasmiditan	treatment	3	completed
NCT02279082	DFN-02 Open Label Safety Study in Patients With Acute Migraine	No drug interventions	treatment	3	completed
NCT04408794	Long-term Safety Study of BHV-3500 (Zavegepant*) for the Acute Treatment of Migraine	Zavegepant	treatment	2 / 3	completed
NCT01358279	Transcranial Direct Current Stimulation for Migraine Attack	No drug interventions	treatment	Not Available	completed
NCT01276977	Zolmitriptan Nasal Spray Versus Eletriptan in the Acute Treatment of Migraine	Eletriptan Zolmitriptan	treatment	Not Available	completed
NCT04089761	Safety and Efficacy of Nerivio™ for the Acute Treatment of Migraine in Adolescents	No drug interventions	treatment	Not Available	terminated
NCT04153409	A Proof of Concept Study of the Efficacy and Safety of Oral LAT8881 in Acute Migraine	No drug interventions	treatment	2	completed
NCT00894556	A Study to Evaluate the Efficacy and Tolerability of Rizatriptan for Treatment of Acute Migraine (0462-087)	Rizatriptan Sumatriptan	treatment	3	completed
NCT01228552	The Efficacy and Safety of Intra-oral Topical Ketoprofen for the Treatment of Acute Migraine	Ketoprofen	treatment	3	unknown_status
NCT01730326	Intravenous Dexketoprofen and Paracetamol in the Treatment of Headache Caused by Acute Migraine Attack	Acetaminophen Dexketoprofen	treatment	4	completed
NCT04218162	Lasmiditan Compared to Placebo in the Acute Treatment of Migraine in Korean	Lasmiditan	treatment	3	completed
NCT04574362	Safety and Efficacy Trial of BHV3000 (Rimegepant) 75 mg for the Acute Treatment of Migraine	Rimegepant	treatment	3	completed
NCT01680029	PBASE-system Acute Migraine Clinical Investigation	No drug interventions	treatment	Not Available	terminated
NCT02745392	Safety and Efficacy of ZP-Zolmitriptan Intracutaneous Microneedle Systems for the Acute Treatment of Migraine	Zolmitriptan	treatment	2 / 3	completed
NCT03631550	The RIME Study - Combined Occipital and Supraorbital Transcutaneous Nerve Stimulation for Treatment of Migraine	No drug interventions	treatment	Not Available	completed