Metabolic Alkalosis (DBCOND0055468)

Identifiers

Synonyms

Alkalosis, Metabolic / Metabolic alkalosis / Alkalosis / Metabolic alkalosis (disorder) / Alkalosis metabolic / Metabolic alkaloses

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Acetazolamide	A carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma.	Carbonic anhydrase 1target Aquaporin-1target Carbonic anhydrase 14target Solute carrier family 22 member 6transporter Carbonic anhydrase 2target Carbonic anhydrase 3target Carbonic anhydrase 4target Cytochrome P450 3A4enzyme Carbonic anhydrase 7target Carbonic anhydrase 12target
Amiloride	A pyrizine compound used to treat hypertension and congestive heart failure.	Amiloride-sensitive sodium channel subunit betatarget Acid-sensing ion channel 1target Diamine oxidase [copper-containing]target Amiloride-sensitive sodium channel subunit alphatarget Amiloride-sensitive sodium channel subunit gammatarget Sodium/hydrogen exchanger 1target Acid-sensing ion channel 2target Amiloride-sensitive sodium channel subunit deltatarget Urokinase-type plasminogen activatortarget Solute carrier family 22 member 2transporter Solute carrier family 22 member 4transporter Diamine oxidase [copper-containing]enzyme Amiloride-sensitive amine oxidase [copper-containing]enzyme
Ammonium chloride	Expectorant in cough syrups. The ammonium ion (NH4+) in the body plays an important role in the maintenance of acid-base balance. The kidney uses ammonium (NH4+) in place of sodium...	No drug targets
Dextrose, unspecified form	A form of glucose used for caloric supply and the replenishment of fluid in total parenteral nutrition and other therapies as well as for the treatment of hypoglycemic episodes.	Hexokinase-4enzyme Hexokinase-1enzyme Solute carrier family 2, facilitated glucose transporter member 1transporter Solute carrier family 2, facilitated glucose transporter member 2transporter Solute carrier family 2, facilitated glucose transporter member 3transporter Solute carrier family 2, facilitated glucose transporter member 4transporter Solute carrier family 2, facilitated glucose transporter member 6transporter Solute carrier family 2, facilitated glucose transporter member 7transporter Solute carrier family 2, facilitated glucose transporter member 8transporter Solute carrier family 2, facilitated glucose transporter member 9transporter Solute carrier family 2, facilitated glucose transporter member 10transporter Solute carrier family 2, facilitated glucose transporter member 11transporter Solute carrier family 2, facilitated glucose transporter member 12transporter Sodium/glucose cotransporter 1transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01131377	Acetazolamide Facilitates Ventilator Weaning	Acetazolamide	treatment	Not Available	unknown_status
NCT03837886	Effects of Sodium Bicarbonate Supplementation on Intermittent and Intense Task	No drug interventions	other	Not Available	unknown_status
NCT01499485	Treatment of Metabolic Alkalosis With Acetazolamide. Effect on the Length of Mechanical Ventilation.	Acetazolamide	treatment	3	completed
NCT04740242	Metabolic Alkalosis in Heart Failure	No drug interventions	Not Available	Not Available	completed