Gynecological Infection (DBCOND0073029)

Identifiers

Synonyms

Gynaecological infection / Gynecologic infection / Gynecologic infections / Gynecological infection / Female genital infection (disorder) / Genital infection female / Genital infection NOS, female

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Aztreonam	A beta-lactam antibiotic used to treat select aztreonam sensitive gram negative bacteria.	Penicillin-binding protein 3target Beta-lactamasetarget Beta-lactamase Toho-1target Peptidoglycan synthase FtsItarget
Cefotetan	An antibiotic medication used for the prophylaxis and treatment of various bacterial infections, including urinary tract infections, bone and joint infection, and lower respiratory tract infections.	Albumincarrier Penicillin-binding protein 3target
Cefoxitin	A semi-synthetic, broad-spectrum antibiotic for parenteral administration used for the treatment of serious bacterial infections, such as urinary tract infection, blood infection, bone and joint infection, and lower respiratory tract infection.	Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Peptidoglycan synthase FtsItarget D-alanyl-D-alanine carboxypeptidase DacAtarget D-alanyl-D-alanine carboxypeptidase DacBtarget D-alanyl-D-alanine carboxypeptidase DacCtarget D-alanyl-D-alanine endopeptidasetarget Beta-lactamaseenzyme Penicillin-binding protein 3target Penicillin-binding protein 1btarget Penicillin-binding protein 2atarget Penicillin-binding protein 1Atarget Penicillin-binding protein 2Btarget
Ceftazidime	An injected broad-spectrum third-generation cephalosporin beta-lactam antibiotic used to treat or prevent a variety of bacterial infections, including pneumonia, gynecological infections, bone and joint infections, and septicemia, among others.	Solute carrier family 22 member 6transporter Peptidoglycan synthase FtsItarget Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Penicillin-binding protein 2target Albumincarrier Beta-lactamase Toho-1target
Cilastatin	A renal dehydropeptidase inhibitor used to prevent degradation of imipenem. Both medications are used together to treat a variety of infections.	Dipeptidase 1target Solute carrier family 22 member 6transporter Organic anion transporter 3transporter
Clavulanic acid	A beta lactamase inhibitor used to enhance the effectiveness of beta lactam antibiotics.	Bacterial beta-lactamase enzymestarget Sodium/glucose cotransporter 1transporter Beta-lactamasetarget
Imipenem	A carbapenem antibiotic normally administered with cilastatin to treat a variety of infections.	Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Penicillin-binding protein 2target Penicillin-binding protein 3target Dipeptidase 1enzyme Penicillin-binding protein 4target Beta-lactamase SHV-1enzyme Beta-lactamase TEMenzyme Beta-lactamase CTX-Menzyme Beta-lactamaseenzyme Beta-lactamasetarget
Metronidazole	A nitroimidazole used to treat trichomoniasis, amebiasis, inflammatory lesions of rosacea, and bacterial infections, as well as prevent postoperative infections.	Oxygen-insensitive NADPH nitroreductasetarget Cytochrome P450 2C9enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme UDP-glucuronosyltransferase 1A1enzyme Anaerobic bacterial DNAtarget Protozoal DNAtarget ATP-dependent translocase ABCB1transporter Cytochrome P450 2A6enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme
Piperacillin	A penicillin antibiotic combined with tazobactam to treat piperacillin-resistant, piperacillin/tazobactam­ susceptible, β-lactamase generating strains of several bacteria.	Solute carrier family 22 member 6transporter Penicillin-binding protein 3target Penicillin-binding protein 2Btarget Penicillin-binding protein 2atarget Penicillin-binding protein 1btarget Organic anion transporter 3transporter
Sulbactam	An beta-lactamase inhibitor antibiotic combined with other antibiotics to treat a variety of susceptible bacterial infections.	Beta-lactamasetarget Solute carrier family 22 member 6transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02659072	Infectious Risk of Vaginal Ultrasound Examination: Evaluation and Modeling From Human Papillomavirus (HPV)	No drug interventions	Not Available	Not Available	completed
NCT02259309	Immune Modulation by Misoprostol	Misoprostol	basic_science	0	completed
NCT01431326	Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care	Alfentanil Amikacin Aminocaproic acid Bosentan Cefepime Cidofovir Ciprofloxacin Clozapine Fosfomycin Haloperidol Labetalol Lurasidone Methylprednisolone Molindone Nafcillin Nifedipine Oxycodone Pentobarbital Piperacillin Rocuronium Sevelamer Spironolactone Tazobactam Tobramycin Tranexamic acid Vancomycin Vecuronium Warfarin Ziprasidone Zolpidem	Not Available	Not Available	completed