Fissure;Anal (DBCOND0080687)

Identifiers

Synonyms

Anal Fissures / Anal Fissure / Anal fissure, unspecified / Anal sphincter tear (healed) (nontraumatic) (old) / Fissure in ano / Fissure anal / Anal fissure (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Bismuth subgallate	A medication used to deodorize flatulence and stools as well as hemostasis in soft tissue surgery.	Albumincarrier
Bufexamac	An NSAID used to treat skin conditions like atopic eczema and inflammatory dermatoses.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Histone deacetylase 6target Polyamine deacetylase HDAC10target
Carvasept	A medication used to treat hemorrhoids, anal fissures, and pruritus ani.	No drug targets
Diltiazem	A calcium channel blocker used to treat hypertension and to manage chronic stable angina.	Voltage-dependent calcium channel gamma-1 subunittarget Cytochrome P450 3A4enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2D6enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2C8enzyme Albumincarrier Alpha-1-acid glycoprotein 1carrier Voltage-dependent L-type calcium channel subunit alpha-1Ctarget Voltage-dependent calcium channel subunit alpha-2/delta-1target
Esculin	As medication, esculin is sometimes used as a vasoprotective agent. Esculin is also used in a microbiology laboratory to aid in the identification of bacterial species (especially Enterococci and Listeria),...	Glutaminase kidney isoform, mitochondrialenzyme Androgen receptortarget
Fluocinolone acetonide	A corticosteroid used to treat skin conditions, eczematous otitis externa, diabetic macular edema, and non-infectious uveitis of the posterior segment of the eye.	Corticosteroid-binding globulincarrier Glucocorticoid receptortarget Cytochrome P450 3A4enzyme Annexin A1target Annexin A2target Annexin A3target Annexin A4target Annexin A5target Phospholipase A2target
Fluocortolone caproate	A corticosteroid indicated in the treatment of hemorrhoids, anal fissures, and corticosteroid-responsive dermatoses.	No drug targets
Hydrocortisone	A glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders.	Annexin A1target Glucocorticoid receptortarget Sex hormone-binding globulincarrier Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 11B2, mitochondrialenzyme Cytochrome P450 2C8enzyme Corticosteroid-binding globulincarrier Organic anion transporter 3transporter Aldo-keto reductase family 1 member D1enzyme 3-oxo-5-alpha-steroid 4-dehydrogenase 2enzyme 11-beta-hydroxysteroid dehydrogenase type 2enzyme 11-beta-hydroxysteroid dehydrogenase 1enzyme Cytochrome P450 2A6enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme
Hydrocortisone acetate	A corticosteroid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses and ulcerative colitis.	Annexin A1target Glucocorticoid receptortarget Sex hormone-binding globulincarrier Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 11B2, mitochondrialenzyme Cytochrome P450 2C8enzyme Corticosteroid-binding globulincarrier 11-beta-hydroxysteroid dehydrogenase type 2target 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target Organic anion transporter 3transporter
Ichthammol	Ichthammol is also referred to as ammonium bituminosulfonate or ammonium bituminosulphonate. It is an ammonium salt of dark sulfonated shale oil (bituminous schists) produced via distillation of the oil followed...	No drug targets
Lidocaine	A local anesthetic used in a wide variety of superficial and invasive procedures.	Sodium channel protein type 5 subunit alphatarget Sodium channel protein type 10 subunit alphatarget Epidermal growth factor receptortarget Sodium channel protein type 9 subunit alphatarget Cytochrome P450 1A2enzyme Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Organic cation/carnitine transporter 2transporter ATP-dependent translocase ABCB1transporter Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Sodium channel protein type 4 subunit alphatarget Alpha-1-acid glycoprotein 1target Alpha-1-acid glycoprotein 2target Sodium channel protein type 11 subunit alphatarget
Nifedipine	A dihydropyridine calcium channel blocker indicated for the management of several subtypes of angina pectoris, and hypertension.	Cytochrome P450 3A4enzyme Cytochrome P450 2E1enzyme Cytochrome P450 2D6enzyme Voltage-dependent L-type calcium channel subunit alpha-1Dtarget Voltage-dependent L-type calcium channel subunit alpha-1Starget Voltage-dependent L-type calcium channel subunit alpha-1Ctarget Voltage-dependent L-type calcium channel subunit beta-2target A-type voltage-gated potassium channel KCND3target Voltage-dependent T-type calcium channeltarget Cytochrome P450 1A2enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2C8enzyme ATP-binding cassette sub-family C member 3transporter ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 2transporter Cytochrome P450 1A1enzyme Cytochrome P450 2B6enzyme Nuclear receptor subfamily 1 group I member 2target Solute carrier organic anion transporter family member 1B1transporter Bile salt export pumptransporter Cytochrome P450 2C9enzyme Albumincarrier alpha1-acid glycoproteincarrier Cytochrome P450 3A5enzyme Calmodulintarget
Oxetacaine	An antacid used to treat gastritis, peptic ulcer disease, heartburn, esophagitis, hiatus hernia, and anorexia.	Cytochrome P450 3A4enzyme Gastrintarget
Picosulfuric acid	A stimulant laxative used for cleansing of the colon as a preparation for colonoscopy in adults.	Arylsulfate sulfotransferase AssTenzyme
Prednisolone	A glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers.	Corticosteroid-binding globulincarrier Cytochrome P450 3A4enzyme Glucocorticoid receptortarget Solute carrier organic anion transporter family member 1A2transporter ATP-dependent translocase ABCB1transporter Albumincarrier

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02961855	Efficacy and Safety of CLIFE1 Gel in Benign Anorectal Surgery	Diclofenac Lidocaine	treatment	4	completed
NCT00160290	Trial to Evaluate Effect of Lactulose on Hard Stools in Patients With Hemorrhoids or Anal Fissures	Lactulose	treatment	4	terminated
NCT05409820	Comparative Analysis of Hypobaric Versus Hyperbaric Bupivacaine for Spinal Anesthesia in Day-Case Anorectal Surgery	No drug interventions	Not Available	Not Available	completed
NCT06633185	Effect of Phenytoin Cream on Wound Healing After Anal Fissure Surgery.	Phenytoin	treatment	1	completed
NCT01039051	Diet and Lifestyle Intervention Study in Postpartum Women in China	No drug interventions	prevention	2 / 3	unknown_status
NCT03780998	Effects of Sodium Pentaborat Based Gel on Perianal Benign Diseases	No drug interventions	Not Available	Not Available	unknown_status
NCT03345511	Ultrasound Guided Caudal Block for Benign Anal Surgery	No drug interventions	treatment	Not Available	completed
NCT04153032	Comparative Evaluation of MEBO Ointment and Topical Diltiazem Ointment in the Treatment of Acute Anal Fissure	Diltiazem	treatment	2	recruiting
NCT03426449	Posterolateral Versus Lateral Internal Anal Sphincterotomy for Chronic Anal Fissure	No drug interventions	treatment	Not Available	completed
NCT05405634	Microbiota in Chronic Anal Fissure and Its Association With Prognosis	No drug interventions	Not Available	Not Available	unknown_status
NCT06049524	Could Preoperative Assessment of Physical and Psychological Status Help Predict Pain After Anorectal Surgery?	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT02667535	PK, PD and Safety Comparative Trial of Isosorbide Mononitrate Gel in Healthy Participants and With Anal Fissure	Isosorbide mononitrate	treatment	1	withdrawn
NCT02579330	Trial on Use of Coloshield in Transanal and Anal Surgery	No drug interventions	treatment	Not Available	unknown_status
NCT05736926	Anal Fissure Among Survivors of COVID-19 Virus Infection.	No drug interventions	Not Available	Not Available	completed
NCT05341180	Efficacy of Polyethylene Glycol vs Lactulose With Isabgol in Acute Fissure-in-Ano: PEGASIS Trial	Lactulose Polyethylene glycol	treatment	2 / 3	completed
NCT00210444	Efficacy Study of Dysport® in the Treatment of Anal Fissure.	Botulinum toxin type A	treatment	2	completed
NCT03528772	Topical Minoxidil Versus Topical Glyceryl Trinitrate in Treatment of Chronic Anal Fissure	Minoxidil Nitroglycerin	treatment	Not Available	completed
NCT02023047	An Open Label Multi-Dose Study to Examine the Effect of Coated Nifedipine Suppository on Anal Fissure Pain and Healing	Nifedipine	treatment	1 / 2	terminated
NCT05038605	Topical vs Oral Metronidazole After Benign Anorectal Surgery	Metronidazole	treatment	Not Available	completed
NCT04428697	Sungurtekin Technique vs. Closed Lateral Internal Sphincterotomy Technique	No drug interventions	prevention	Not Available	unknown_status
NCT00827736	Comparison of Treatment Success of Botox Injection in the Internal Sphincter Versus Isosorbidedinitrate Ointment in Patients With an Anal Fissure	No drug interventions	treatment	4	completed
NCT05709717	Regenerative Therapy With Autologous Stromal Vascular Fraction Derived Mesenchymal Stem Cells and Platelet-rich Plasma to Treat Complex Perianal Diseases	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT02628522	A Novel Method for Chronic Anal Fissure Treatment	No drug interventions	treatment	Not Available	completed
NCT04173130	Monocentric Feasibility Study for a New Medical Device for the Treatment of Anal Fissure With Botulinum Toxin	No drug interventions	device_feasibility	Not Available	completed
NCT01920074	Pharmacokinetic,Safety and Exploratory Efficacy of RECTIV® in Adolescents With Chronic Anal Fissure	Nitroglycerin	treatment	4	withdrawn
NCT00980369	The Importance of Lateral Internal Sphincterotomy Incision: Parallel or Vertical	No drug interventions	Not Available	Not Available	unknown_status
NCT05616455	Efficacy and Safety of Propionibacterium Extract Gel Versus 0.4% Glyceryl Trinitrate Ointment in the Treatment of Chronic Anal Fissure: a Randomised Controlled Trial	Nitroglycerin Propionibacterium acnes	treatment	4	completed
NCT06216223	Laser Versus Surgery in Anal Diseases in Inflammatory Bowel Patients	No drug interventions	treatment	Not Available	completed