This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Fluocortolone caproate is a corticosteroid indicated in the treatment of hemorrhoids, anal fissures, and corticosteroid-responsive dermatoses.

Generic Name
Fluocortolone caproate
DrugBank Accession Number
DB15821
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Thumb
Weight
Average: 474.613
Monoisotopic: 474.278152519
Chemical Formula
C28H39FO5
Synonyms
  • Fluocortolone 21-caproate
  • Fluocortolone 21-hexanoate
  • Fluocortolone caproate
  • Fluocortolone hexanoate
External IDs
  • SH 770
  • SH-770

Pharmacology

Indication

Not Available

Pharmacology
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Associated Conditions
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

Products2
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International/Other Brands
Ficoid / Ultralanum
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
ULTRALAN KREM, 10 GFluocortolone caproate (0.25 %) + Fluocortolone pivalate (0.25 %)CreamTopicalBAYER TÜRK KİMYA SAN. LTD. ŞTİ.2020-08-142017-12-19Turkey flag
ULTRALAN KREM, 20 GFluocortolone caproate (0.25 %) + Difluocortolone pivalate (0.25 %)CreamTopicalBAYER TÜRK KİMYA SAN. LTD. ŞTİ.2020-08-142017-12-19Turkey flag
ULTRALAN POMAT, 10 GRFluocortolone caproate (0.25 %) + Fluocortolone (0.25 %)OintmentTopicalBAYER TÜRK KİMYA SAN. LTD. ŞTİ.2020-08-142017-12-19Turkey flag
ULTRALAN POMAT, 20 GRFluocortolone caproate (0.25 %) + Fluocortolone (0.25 %)OintmentTopicalBAYER TÜRK KİMYA SAN. LTD. ŞTİ.2020-08-142017-12-19Turkey flag
ULTRAPROCT %0,09+%0,09+%0,5 MERHEM, 10 GFluocortolone caproate (0.09 %) + Cinchocaine hydrochloride (0.5 %) + Difluocortolone pivalate (0.09 %)OintmentRectalABDİ İBRAHİM İLAÇ SAN. VE TİC. A.Ş.2020-08-142020-12-29Turkey flag
ULTRAPROCT SUPOZITUAR, 10 ADETFluocortolone caproate (0.63 mg) + Cinchocaine hydrochloride (1 mg) + Difluocortolone pivalate (0.61 mg)SuppositoryRectalABDİ İBRAHİM İLAÇ SAN. VE TİC. A.Ş.2020-08-142020-12-29Turkey flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
90893P8662
CAS number
303-40-2
InChI Key
WHZRCUIISKRTJL-YTZKRAOUSA-N
InChI
InChI=1S/C28H39FO5/c1-5-6-7-8-24(33)34-15-23(32)25-16(2)11-19-18-13-21(29)20-12-17(30)9-10-27(20,3)26(18)22(31)14-28(19,25)4/h9-10,12,16,18-19,21-22,25-26,31H,5-8,11,13-15H2,1-4H3/t16-,18+,19+,21+,22+,25-,26-,27+,28+/m1/s1
IUPAC Name
2-[(1S,2R,3aS,3bS,5S,9aR,9bS,10S,11aS)-5-fluoro-10-hydroxy-2,9a,11a-trimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-oxoethyl hexanoate
SMILES
[H][C@@]12C[C@@H](C)[C@H](C(=O)COC(=O)CCCCC)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C

References

General References
  1. AIFA: Ultralan (Fluocortolone) Topical Cream [Link]
  2. TITCK Product Information: ULTRAPROCT (cinchocaine, fluocortolone pivalate, and fluocortolone caproate) rectal [Link]
ChemSpider
16735815
RxNav
4464
ChEMBL
CHEMBL2107415
ZINC
ZINC000004213356

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
CreamTopical
EmulsionTopical
LotionTopical
OintmentTopical
OintmentRectal
SuppositoryRectal
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0017 mg/mLALOGPS
logP3.67ALOGPS
logP4.44ChemAxon
logS-5.4ALOGPS
pKa (Strongest Acidic)15.15ChemAxon
pKa (Strongest Basic)-0.23ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area80.67 Å2ChemAxon
Rotatable Bond Count8ChemAxon
Refractivity129.05 m3·mol-1ChemAxon
Polarizability52.93 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at September 09, 2020 20:13 / Updated at May 14, 2021 01:08