Paget’s Disease (DBCOND0095137)

Identifiers

Synonyms

Paget Disease / Paget's Disease / Paget's disease of bone / Osteitis deformans [Paget's disease of bone] / Osteitis Deformans

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Alendronic acid	A bisphosphonate drug that prevents osteoclastic bone resorption which is used for the prevention and treatment of osteoporosis.	Farnesyl pyrophosphate synthasetarget Tyrosine-protein phosphatase non-receptor type 4target Receptor-type tyrosine-protein phosphatase Starget Receptor-type tyrosine-protein phosphatase epsilontarget V-type proton ATPase catalytic subunit Atarget Hydroxylapatitetarget
Neridronic Acid	A bisphosphonate drug that prevents osteoclastic bone resorption which is used for the prevention and treatment of osteoporosis.	Farnesyl pyrophosphate synthasetarget
Pamidronic acid	A bisphosphonate used to treat Paget's disease, to treat hypercalcemia of malignancy, and to treat osteolytic bone lesions.	Farnesyl pyrophosphate synthasetarget Hydroxylapatitetarget Geranylgeranyl pyrophosphate synthasetarget Caspase-3target Caspase-9target
Risedronic acid	A bisphosphonate used to treat osteoporosis and Paget's disease.	Farnesyl pyrophosphate synthasetarget Hydroxylapatitetarget Prostaglandin G/H synthase 2enzyme
Salmon calcitonin	A synthetic peptide form of calcitonin used to inhibit bone resorption in the treatment of hypercalcemia, osteoporosis, and Paget's disease.	Calcitonin receptortarget
Zoledronic acid	A bisphosphonate used to treat malignancy associated hypercalcemia, multiple myeloma, and bone metastasis from solid tumors.	Farnesyl pyrophosphate synthasetarget Geranylgeranyl pyrophosphate synthasetarget Hydroxylapatitetarget Multidrug resistance-associated protein 1transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00615628	Inheritance of Osteosarcoma & Paget's Disease Through Chromosome 18:	No drug interventions	Not Available	Not Available	terminated
NCT01882231	Quantitative Imaging Biomarkers of Treatment Response in Osteosarcoma and Ewing Sarcoma	No drug interventions	diagnostic	Not Available	terminated
NCT00540566	Optical Biopsy of Human Skin in Conjunction With Laser Treatment	No drug interventions	Not Available	Not Available	completed
NCT05309954	Genetic Analysis to Predict the Development of Paget's Disease	No drug interventions	Not Available	Not Available	recruiting
NCT03438123	Data Collection Study for the Spectrum Dynamics Multi-purpose CZT SPECT Camera	No drug interventions	other	Not Available	completed
NCT03859895	Zoledronate In the Prevention of Paget's Disease: Long Term Extension	No drug interventions	Not Available	Not Available	enrolling_by_invitation