Perphenazine is a phenothiazine used to treat schizophrenia as well as nausea and vomiting. An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine.
- Mechanism
- Curator reviewed
Binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. The mechanism of the anti-emetic effect is due predominantly to blockage of the dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone and vomiting centre. Perphenazine also binds the alpha andrenergic receptor. This receptor's action is mediated by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
- Primary indication
- For use in the management of the manifestations of psychotic disorders and for the control of severe nausea and vomiting in adults.Curator reviewed · 12 structured indications
- Formula / weight
- C21H26ClN3OS · 403.969 g/mol (avg)
- First approval
- Canada, 2000 · United States, 1987
- Also known as
- Chlorpiprazine · Etaperazin · Etaperazine · Ethaperazine · Perfenazine
- Code names
- SC 7105 · Sch 3940
Resolves to
RGCVKNLCSQQDEP-UHFFFAOYSA-NSMILESOCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(Cl)C=C3)CC1What you can answer from here — as of September 23, 2026
Which drugs share a target with Perphenazine, and which of those have an active Phase 3 trial?
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