Dopamine receptor D2

BE0000756ProteinHumansDRD2

G protein-coupled receptor for dopamine, a catecholamine neurotransmitter hormone that functions as the brain's 'reward chemical', driving motivation, reinforcement learning and pleasure (PubMed:21645528, PubMed:32103023, PubMed:32528175, PubMed:33353947, PubMed:33571431, PubMed:37221270, PubMed:39103320). It is acted on by 197 drugs in DrugBank.

Gene name
DRD2
UniProtKB entry
P14416Swiss-Prot
Cellular location
Postsynaptic cell membrane
Residues / weight
443 residues · 50,619 Da
Also known as
Dopamine D2 receptor

Resolves to

Protein
UniProtP14416UniProt nameDRD2_HUMAN
Gene
HGNCHGNC:3023NCBI Gene1813GenBank181432GeneCardsDRD2
Pharmacology
IUPHAR/GtoPdb215KEGGhsa:1813
Structure
PDB5AERPDB6CM4PDB6LUQ
Drugs

What you can answer from here — as of September 08, 2026

197DrugsApproved to experimental, with action, bond type and pharmacological action
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11Clinical trialsTrials of drugs acting on it, by phase and status
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41GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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821+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dopamine receptor D2, how selective are they, and which programs against it are still in active trials?

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