Dopamine receptor D1

BE0000020ProteinHumansDRD1

G protein-coupled receptor for dopamine, a catecholamine neurotransmitter hormone that functions as the brain's 'reward chemical', driving motivation, reinforcement learning and pleasure (PubMed:11500503, PubMed:33571431, PubMed:33571432, PubMed:33750903, PubMed:34083522, PubMed:35676276, PubMed:35687690, PubMed:37221270). It is acted on by 56 drugs in DrugBank.

Gene name
DRD1
UniProtKB entry
P21728Swiss-Prot
Cellular location
Postsynaptic cell membrane
Residues / weight
446 residues · 49,293 Da
Also known as
D(1A) dopamine receptor · Dopamine D1 receptor

Resolves to

Protein
UniProtP21728UniProt nameDRD1_HUMAN
Gene
HGNCHGNC:3020NCBI Gene1812GenBank30397GeneCardsDRD1
Pharmacology
IUPHAR/GtoPdb214KEGGhsa:1812
Structure
PDB7CKWPDB7CKXPDB7CKY
Drugs

What you can answer from here — as of September 08, 2026

56DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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26GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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158+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dopamine receptor D1, how selective are they, and which programs against it are still in active trials?

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