Bromodiphenhydramine is an ethanolamine antihistamine with antimicrobial property. Bromodiphenhydramine is used in the control of cutaneous allergies. Ethanolamine antihistamines produce marked sedation in most patients.
- Mechanism
- Curator reviewed
Bromodiphenhydramine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding.
- Primary indication
- For management of symptoms related to hay fever and other types of allergy and used to help bring up phlegm, thin secretions, and make a cough productive.Curator reviewed
- Formula / weight
- C17H20BrNO · 334.251 g/mol (avg)
- First approval
- Canada, 1979
- Also known as
- Bromazine
Resolves to
Clinical / RWD
Structure
InChIKey
NUNIWXHYABYXKF-UHFFFAOYSA-NSMILESCN(C)CCOC(C1=CC=CC=C1)C1=CC=C(Br)C=C1Targets
Transporters
What you can answer from here — as of September 13, 2026
1Protein targetEach mapped to UniProt, with action and pharmacological actionListed above
1TransporterSubstrate / inhibitor direction, not just membershipListed above
Which drugs share a target with Bromodiphenhydramine, and which of those have an active Phase 3 trial?
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