ATP-sensitive inward rectifier potassium channel 8

BE0002441ProteinHumansKCNJ8

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it (PubMed:20558321, PubMed:21836131, PubMed:24700710, PubMed:28842488). It is acted on by 7 drugs in DrugBank.

Gene name
KCNJ8
UniProtKB entry
Q15842Swiss-Prot
Cellular location
Membrane
Residues / weight
424 residues · 47,967 Da
Also known as
Inward rectifier K(+) channel Kir6.1 · Potassium channel, inwardly rectifying subfamily J member 8 · uKATP-1

Resolves to

Protein
UniProtQ15842UniProt nameKCNJ8_HUMAN
Gene
HGNCHGNC:6269NCBI Gene3764GeneCardsKCNJ8
Pharmacology
KEGGhsa:3764
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on ATP-sensitive inward rectifier potassium channel 8, how selective are they, and which programs against it are still in active trials?

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