ATP-binding cassette sub-family C member 8

BE0000207ProteinHumansABCC8

Regulator subunit of pancreatic ATP-sensitive potassium channel (KATP), playing a major role in the regulation of insulin release. It is acted on by 16 drugs in DrugBank.

Gene name
ABCC8
UniProtKB entry
Q09428Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,581 residues · 176,990 Da
Also known as
HRINS · Sulfonylurea receptor 1 · SUR · SUR1

Resolves to

Protein
UniProtQ09428UniProt nameABCC8_HUMAN
Gene
HGNCHGNC:59NCBI Gene6833GenBank1374919GeneCardsABCC8
Pharmacology
IUPHAR/GtoPdb2594KEGGhsa:6833
Structure
PDB6C3OPDB6C3PPDB7S5V
Drugs

What you can answer from here — as of September 07, 2019

16DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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25GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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86+ReferencesStructured and connected to the statements they support
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Which approved drugs act on ATP-binding cassette sub-family C member 8, how selective are they, and which programs against it are still in active trials?

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