Lysosomal alpha-glucosidase

BE0000876ProteinHumansGAA

Essential for the degradation of glycogen in lysosomes (PubMed:14695532, PubMed:18429042, PubMed:1856189, PubMed:7717400). It is acted on by 18 drugs in DrugBank.

Gene name
GAA
UniProtKB entry
P10253Swiss-Prot
Cellular location
Lysosome
Residues / weight
952 residues · 105,323 Da
Also known as
3.2.1.20 · Acid maltase · Aglucosidase alfa

Resolves to

Protein
UniProtP10253UniProt nameLYAG_HUMAN
Gene
HGNCHGNC:4065NCBI Gene2548GenBank31608GeneCardsGAA
Pharmacology
IUPHAR/GtoPdb2611KEGGhsa:2548
Structure
PDB5KZWPDB5KZXPDB5NN3
Drugs

What you can answer from here — as of September 07, 2019

18DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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8GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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95+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Lysosomal alpha-glucosidase, how selective are they, and which programs against it are still in active trials?

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