XEN-2174 is a synthetic drug modeled on a peptide from the venom of a cone shell found on Australia's Great Barrier Reef. XEN-2174 represents a new class of molecules, called... XEN-2174 represents a new class of molecules, called the chi conopeptides that selectively inhibit the Norepinephrine Transporter (NET).
- Mechanism
- Curator reviewed
XEN-2174 targets the Norepinephrine Transporter (NET). Inhibition of this transporter elevates the levels of norepinephrine (NE) in the spinal cord preventing pain signals from reaching the brain. XEN-2174 acts to restore the balance by promoting the activation of inhibitory pain pathways to relieve the sensation of pain.
- Primary indication
- For the treatment of chronic cancer pain.Curator reviewed
- Code names
- XEN-2174
Resolves to
What you can answer from here — as of October 01, 2026
Which drugs share a target with XEN-2174, and which of those have an active Phase 3 trial?
Create a free account or log in to explore the full data card.
Create Account