Estrogen-related receptor gamma

Details

Name
Estrogen-related receptor gamma
Kind
protein
Synonyms
  • ERR gamma-2
  • ERR3
  • ERRG2
  • Estrogen receptor-related protein 3
  • KIAA0832
  • NR3B3
  • Nuclear receptor subfamily 3 group B member 3
Gene Name
ESRRG
UniProtKB Entry
P62508Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0004094|Estrogen-related receptor gamma
MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGG
SSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYML
NSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSC
QACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSH
LLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSL
LQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMK
LEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMT
LPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV
Number of residues
458
Molecular Weight
51305.485
Theoretical pI
6.44
GO Classification
Functions
DNA-binding transcription activator activity, RNA polymerase II-specific / DNA-binding transcription factor activity, RNA polymerase II-specific / estrogen response element binding / identical protein binding / nuclear receptor activity / nuclear steroid receptor activity / sequence-specific double-stranded DNA binding
Processes
nuclear receptor-mediated steroid hormone signaling pathway / positive regulation of cold-induced thermogenesis / positive regulation of transcription by RNA polymerase II / regulation of DNA-templated transcription / regulation of transcription by RNA polymerase II / retinoic acid receptor signaling pathway
Components
chromatin
General Function
Orphan receptor that acts as a transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle
Specific Function
AF-2 domain binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0016674|Estrogen-related receptor gamma (ESRRG)
ATGTCAAACAAAGATCGACACATTGATTCCAGCTGTTCGTCCTTCATCAAGACGGAACCT
TCCAGCCCAGCCTCCCTGACGGACAGCGTCAACCACCACAGCCCTGGTGGCTCTTCAGAC
GCCAGTGGGAGCTACAGTTCAACCATGAATGGCCATCAGAACGGACTTGACTCGCCACCT
CTCTACCCTTCTGCTCCTATCCTGGGAGGTAGTGGGCCTGTCAGGAAACTGTATGATGAC
TGCTCCAGCACCATTGTTGAAGATCCCCAGACCAAGTGTGAATACATGCTCAACTCGATG
CCCAAGAGACTGTGTTTAGTGTGTGGTGACATCGCTTCTGGGTACCACTATGGGGTAGCA
TCATGTGAAGCCTGCAAGGCATTCTTCAAGAGGACAATTCAAGGCAATATAGAATACAGC
TGCCCTGCCACGAATGAATGTGAAATCACAAAGCGCAGACGTAAATCCTGCCAGGCTTGC
CGCTTCATGAAGTGTTTAAAAGTGGGCATGCTGAAAGAAGGGGTGCGTCTTGACAGAGTA
CGTGGAGGTCGGCAGAAGTACAAGCGCAGGATAGATGCGGAGAACAGCCCATACCTGAAC
CCTCAGCTGGTTCAGCCAGCCAAAAAGCCATATAACAAGATTGTCTCACATTTGTTGGTG
GCTGAACCGGAGAAGATCTATGCCATGCCTGACCCTACTGTCCCCGACAGTGACATCAAA
GCCCTCACTACACTGTGTGACTTGGCCGACCGAGAGTTGGTGGTTATCATTGGATGGGCG
AAGCATATTCCAGGCTTCTCCACGCTGTCCCTGGCGGACCAGATGAGCCTTCTGCAGAGT
GCTTGGATGGAAATTTTGATCCTTGGTGTCGTATACCGGTCTCTTTCGTTTGAGGATGAA
CTTGTCTATGCAGACGATTATATAATGGACGAAGACCAGTCCAAATTAGCAGGCCTTCTT
GATCTAAATAATGCTATCCTGCAGCTGGTAAAGAAATACAAGAGCATGAAGCTGGAAAAA
GAAGAATTTGTCACCCTCAAAGCTATAGCTCTTGCTAATTCAGACTCCATGCACATAGAA
GATGTTGAAGCCGTTCAGAAGCTTCAGGATGTCTTACATGAAGCGCTGCAGGATTATGAA
GCTGGCCAGCACATGGAAGACCCTCGTCGAGCTGGCAAGATGCTGATGACACTGCCACTC
CTGAGGCAGACCTCTACCAAGGCCGTGCAGCATTTCTACAACATCAAACTAGAAGGCAAA
GTCCCAATGCACAAACTTTTTTTGGAAATGTTGGAGGCCAAGGTCTGA
Chromosome Location
1
Locus
1q41
External Identifiers
ResourceLink
UniProtKB IDP62508
UniProtKB Entry NameERR3_HUMAN
GenBank Protein ID4092075
GenBank Gene IDAF094518
GeneCard IDESRRG
GenAtlas IDESRRG
HGNC IDHGNC:3474
PDB ID(s)1KV6, 1TFC, 1VJB, 2E2R, 2EWP, 2GP7, 2GPO, 2GPP, 2GPU, 2GPV, 2P7A, 2P7G, 2P7Z, 2ZAS, 2ZBS, 2ZKC, 5YSO, 6A6K, 6I61, 6I62, 6I63, 6I64, 6I65, 6I66, 6I67, 6K3N, 6KNR, 6XXC, 6XY5, 6Y18, 6Y1D, 6Y3W, 6Y58, 8B4Q, 8BJG, 8BJN, 8BM5, 8IFO
KEGG IDhsa:2104
IUPHAR/Guide To Pharmacology ID624
NCBI Gene ID2104
General References
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Diethylstilbestrolapproved, investigational, withdrawnyestargetagonistDetails
AfimoxifeneinvestigationalunknowntargetDetails
Troglitazoneapproved, investigational, withdrawnnotargetinverse agonistDetails
4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDEexperimentalunknowntargetDetails
p-CumylphenolexperimentalunknowntargetDetails
Bisphenol AexperimentalunknowntargetDetails
Bisphenol ZexperimentalunknowntargetDetails
Cholic AcidapprovedunknowntargetDetails
TamoxifenapprovedunknowntargetDetails
Estradiol acetateapproved, investigational, vet_approvedunknowntargetligandDetails
Estradiol benzoateapproved, investigational, vet_approvedunknowntargetligandDetails
Estradiol cypionateapproved, investigational, vet_approvedunknowntargetligandDetails
Estradiol dienanthateapproved, investigational, vet_approvedunknowntargetligandDetails
Estradiol valerateapproved, investigational, vet_approvedunknowntargetligandDetails
UlobetasolapprovedyestargetmodulatorDetails
Desonideapproved, investigationalyestargetmodulatorDetails
Fluocinonideapproved, investigationalyestargetmodulatorDetails
MedrysoneapprovedyestargetmodulatorDetails
Halcinonideapproved, investigational, withdrawnyestargetmodulatorDetails
AmcinonideapprovedyestargetmodulatorDetails
Prednicarbateapproved, investigationalyestargetmodulatorDetails
DesoximetasoneapprovedyestargetmodulatorDetails
Flumethasoneapproved, vet_approvedyestargetmodulatorDetails
Auranofinapproved, investigationalyestargetmodulatorDetails
Cortisone acetateapproved, investigationalyestargetmodulatorDetails
Loteprednol etabonateapprovedyestargetmodulatorDetails
FlurandrenolideapprovedyestargetmodulatorDetails