Steroid hormone receptor ERR2

BE0005001ProteinHumansESRRB

Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity (PubMed:17920186, PubMed:19755138). It is acted on by 18 drugs in DrugBank.

Gene name
ESRRB
UniProtKB entry
O95718Swiss-Prot
Cellular location
Nucleus
Residues / weight
433 residues · 48,053 Da
Also known as
ERR beta-2 · ERR-beta · ERRB2 · ESRL2 · Estrogen receptor-like 2

Resolves to

Protein
UniProtO95718UniProt nameERR2_HUMAN
Gene
HGNCHGNC:3473NCBI Gene2103GeneCardsESRRB
Pharmacology
IUPHAR/GtoPdb623
Structure
PDB1LO1PDB6LITPDB6LN4
Drugs

What you can answer from here — as of September 07, 2019

18DrugsApproved to experimental, with action, bond type and pharmacological action
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27GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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28+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Steroid hormone receptor ERR2, how selective are they, and which programs against it are still in active trials?

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