NPS-2143

DB05695ExperimentalSmall molecule

Investigated for use/treatment in osteoporosis.

Mechanism: NPS-2143 is the prototype calcilytic drug, designed to act on calcium receptors on the surface of parathyroid glands, stimulating the release of the body's own stores of native parathyroid hormone (PTH).
Curator reviewed
Primary indication: Investigated for use/treatment in osteoporosis.Curator reviewed
Formula / weight: C₂₄H₂₅ClN₂O₂ · 408.93 g/mol (avg)
Code names: (+)-NPS-2143 · SB-262470 · SB-262470A

Resolves to

Compound

Structure

InChIKeyPZUJQWHTIRWCID-HXUWFJFHSA-NSMILESCC(C)(CC1=CC=C2C=CC=CC2=C1)NC[C@@H](O)COC1=CC=CC(Cl)=C1C#N

Targets

What you can answer from here — as of March 06, 2025

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

2+ReferencesStructured and connected to the statements they support

Which drugs share a target with NPS-2143, and which of those have an active Phase 3 trial?

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