GnRH pharmaccine

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Overview

DrugBank ID: DB05815
Type: Biotech
US Approved: NO
Other Approved: NO
Patents: 0
Indicated Conditions: 0
Clinical Trials: Phase 0
0
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0

Identification

Generic Name: GnRH pharmaccine
DrugBank Accession Number: DB05815
Background: The GnRH pharmaccine consists of synthetic peptides (constructed to "look like" GnRH), which are bound chemically to a carrier and suspended in a proprietary "delivery vehicle". The pharmaccine is administered intramuscularly to the patient by injection and induces an immune response or production of antibodies in the patient, which neutralize GnRH thus removing it from circulation.
Type: Biotech
Groups: Investigational
Biologic Classification: Protein Based Therapies
Other protein based therapies
Protein Chemical Formula: C₆₀H₇₃N₁₅O₁₃
Protein Average Weight: 1212.3143 Da
Sequences: Not Available
Synonyms: Not Available

Pharmacology

Indication: Investigated for use/treatment in prostate cancer.

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Pharmacodynamics: Not Available
Mechanism of action: The immunological neutralization of Gonadotropin Releasing Hormone (GnRH) by the antibodies induced by GnRH pharmaccine shuts down the production of testosterone in the testes. Testosterone fuels prostate cancer, both early stage, primary cancer and metastatic (spreading) cancer. Like physical castration, hormonal, or biological blockage of testosterone has been shown to be efficacious in humans for the treatment of both early and late state prostate cancer. Aphton's GnRH pharmaccine, which is expected to be reversible based on the mechanism of action (in contrast to surgical castration), induces hormonal, or biological blockage of testosterone.
Absorption: Not Available
Volume of distribution: Not Available
Protein binding: Not Available
Metabolism: Not Available
Route of elimination: Not Available
Half-life: Not Available
Clearance: Not Available
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Toxicity: Not Available
Pathways: Not Available
Pharmacogenomic Effects/ADRs: Not Available

Interactions

Drug Interactions: This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions: Not Available

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International/Other Brands: Gonadimmune

Chemical Identifiers

UNII: Not Available
CAS number: Not Available

References

General References

Jacobs E, Watson SA, Michaeli D, Ellis IO, Robertson JF: Anti-gonadotrophin releasing hormone antibodies inhibit the growth of MCF7 human breast cancer xenografts. Br J Cancer. 1999 May;80(3-4):352-9. [Article]

External Links

PubChem Substance: 347910246

Clinical Trials

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Phase	Status	Purpose	Conditions	Count	Start Date	Why Stopped	100+ additional columns
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Pharmacoeconomics

Manufacturers: Not Available
Packagers: Not Available
Dosage Forms: Not Available
Prices: Not Available
Patents: Not Available

Properties

State: Solid
Experimental Properties: Not Available

Drug created at November 18, 2007 18:28 / Updated at June 12, 2020 16:52