TG-C
Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- TG-C
- DrugBank Accession Number
- DB06004
- Background
Not Available
- Type
- Small Molecule
- Groups
- Investigational
- Synonyms
- Not Available
Pharmacology
- Indication
Investigated for use/treatment in arthritis and arthritic pain and osteoarthritis.
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- Pharmacodynamics
Not Available
- Mechanism of action
TG-C offers a regeneration technology that assists in the treatment of damaged tendons, ligaments, cartilages, and bones. It involves minimally invasive injections versus a surgical approach. TG-C is based on the infection of primary chondrocytes with a retroviral vector expressing transforming growth factor-beta1 (TGF-beta1), followed by the intra-articular injection of the modified cells. The vector is a MoMSV/MoMLV hybrid-based retroviral vector, which is devoid of gag, pol or env gene sequences, such that replication competent retrovirus is not generated by recombination with homologous sequences in a viral packaging system. The vector contains a CMV major immediate early gene promoter/enhancer driving expression of the TGF-beta1 gene.
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
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- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- Not Available
- CAS number
- Not Available
- InChI Key
- Not Available
- InChI
- Not Available
- IUPAC Name
- Not Available
- SMILES
- Not Available
References
- General References
- Not Available
- External Links
- Not Available
Clinical Trials
- Clinical Trials
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Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
- Not Available
- Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at November 18, 2007 18:29 / Updated at June 12, 2020 16:52