Sodium-dependent noradrenaline transporter

BE0000486ProteinHumansSLC6A2

Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline), the primary signaling neurotransmitter in the autonomic sympathetic nervous system (PubMed:2008212, PubMed:8125921, PubMed:38750358). It is acted on by 123 drugs in DrugBank.

Gene name
SLC6A2
UniProtKB entry
P23975Swiss-Prot
Cellular location
Cell membrane
Residues / weight
617 residues · 69,331 Da
Also known as
NAT1 · NET · NET1 · Norepinephrine transporter · SLC6A5

Resolves to

Protein
UniProtP23975UniProt nameSC6A2_HUMAN
Gene
HGNCHGNC:11048NCBI Gene6530GenBank189258GeneCardsSLC6A2
Pharmacology
IUPHAR/GtoPdb926KEGGhsa:6530
Structure
PDB8HFEPDB8HFFPDB8HFG
Drugs

What you can answer from here — as of September 07, 2019

123DrugsApproved to experimental, with action, bond type and pharmacological action
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17Clinical trialsTrials of drugs acting on it, by phase and status
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19GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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455+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium-dependent noradrenaline transporter, how selective are they, and which programs against it are still in active trials?

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