Sodium-dependent dopamine transporter

BE0000647ProteinHumansSLC6A3

Mediates sodium- and chloride-dependent transport of dopamine (PubMed:10375632, PubMed:11093780, PubMed:1406597, PubMed:15505207, PubMed:19478460, PubMed:39112701, PubMed:39112703, PubMed:39112705, PubMed:8302271). It is acted on by 81 drugs in DrugBank.

Gene name
SLC6A3
UniProtKB entry
Q01959Swiss-Prot
Cellular location
Cell membrane
Residues / weight
620 residues · 68,494 Da
Also known as
DA transporter · DAT · DAT1 · Solute carrier family 6 member 3

Resolves to

Protein
UniProtQ01959UniProt nameSC6A3_HUMAN
Gene
HGNCHGNC:11049NCBI Gene6531GenBank553260GeneCardsSLC6A3
Pharmacology
IUPHAR/GtoPdb927KEGGhsa:6531
Structure
PDB8VBYPDB8Y2CPDB8Y2D
Drugs

What you can answer from here — as of September 07, 2019

81DrugsApproved to experimental, with action, bond type and pharmacological action
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26GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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286+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium-dependent dopamine transporter, how selective are they, and which programs against it are still in active trials?

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