Nisoxetine

DB09186ExperimentalSmall molecule

Nisoxetine is a selective norepinephrine reuptake inhibitor (SNRI) developed in the 1970s. It was originally investigated as an antidepressant but has no current clinical applications aside from being a research... It has been used to research obesity and energy balance, and exerts some local analgesia effects.

Mechanism: Pharmacologically active on Sodium-dependent serotonin transporter
Curator reviewed
Formula / weight: C₁₇H₂₁NO₂ · 271.36 g/mol (avg)
Code names: LY-94939

Resolves to

Compound

UNII17NV064B2DCAS53179-07-0ChEMBLCHEMBL295467ChEBI73410PubChem4500KEGGD05173

Structure

InChIKeyITJNARMNRKSWTA-UHFFFAOYSA-NSMILESCNCCC(OC1=CC=CC=C1OC)C1=CC=CC=C1

Targets

P31645SLC6A4Q01959SLC6A3P23975SLC6A2

What you can answer from here — as of January 29, 2025

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

680Drug interactionsStructured to mechanism, not free text

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with Nisoxetine, and which of those have an active Phase 3 trial?

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